LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16

Search options

  1. Article ; Online: Anti-hyperglycemic and antioxidant activities of the ayurvedic drug Nisha kathakathadhi churnam in alloxan-induced hyperglycemic rats

    Jithendra C / Muralidharan P

    International Journal of Green Pharmacy, Vol 3, Iss 1, Pp 66-

    2009  Volume 69

    Abstract: The anti-hyperglycemic and antioxidant potential of Nisha Kathakathadhi Churnam (NKC), an ayurvedic ...

    Abstract The anti-hyperglycemic and antioxidant potential of Nisha Kathakathadhi Churnam (NKC), an ayurvedic formulation, was estimated in alloxan-induced, hyperglycemic rats. Various enzymatic antioxidants, such as, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were estimated in the heart and pancreas of hyperglycemic rats. The effect of NKC on blood glucose levels was estimated on days 0, 10, 20 and 30 of a 30-day study. A marked decrease in the blood glucose levels ( P < 0.001) was observed in hyperglycemic rats and the decreased activities of the key antioxidant enzymes increased to near normal ( P < 0.01) levels and the increased lipid peroxidation decreased in diabetic rats upon NKC treatment. These results suggest that NKC has promising antidiabetic and antioxidant activities in alloxan-induced diabetes.
    Keywords Alloxan ; antioxidants ; diabetes ; Nisha kathakathadhi churnam ; Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19.

    Muralidharan, Nisha / Sakthivel, R / Velmurugan, D / Gromiha, M Michael

    Journal of biomolecular structure & dynamics

    2020  Volume 39, Issue 7, Page(s) 2673–2678

    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Drug Combinations ; Drug Repositioning ; Humans ; Lopinavir ; Oseltamivir ; Peptide Hydrolases ; Ritonavir ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Drug Combinations ; Oseltamivir (20O93L6F9H) ; Lopinavir (2494G1JF75) ; Peptide Hydrolases (EC 3.4.-) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1752802
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Therapeutic Targets and Computational Approaches on Drug Development for COVID-19.

    Shanmugam, Anusuya / Muralidharan, Nisha / Velmurugan, Devadasan / Gromiha, M Michael

    Current topics in medicinal chemistry

    2020  Volume 20, Issue 24, Page(s) 2210–2220

    Abstract: World Health Organization declared coronavirus disease (COVID-19) caused by SARS coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly spread all over the world. SARS-CoV-2 has infected more than 800,000 people and ...

    Abstract World Health Organization declared coronavirus disease (COVID-19) caused by SARS coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly spread all over the world. SARS-CoV-2 has infected more than 800,000 people and caused about 35,000 deaths so far, moreover, no approved drugs are available to treat COVID-19. Several investigations have been carried out to identify potent drugs for COVID-19 based on drug repurposing, potential novel compounds from ligand libraries, natural products, short peptides, and RNAseq analysis. This review is focused on three different aspects; (i) targets for drug design (ii) computational methods to identify lead compounds and (iii) drugs for COVID-19. It also covers the latest literature on various hit molecules proposed by computational methods and experimental techniques.
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Computational Biology ; Coronavirus Infections/drug therapy ; Drug Design ; Humans ; Molecular Docking Simulation ; Pandemics ; Pneumonia, Viral/drug therapy ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors
    Chemical Substances Antiviral Agents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026620666200710105507
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Isolation of moderately halotolerant bacterial strains, associated with coral Porites lutea from Gulf of Kachchh: Antibacterial activity and PHB production.

    Sridharan, Rajalakshmi / Krishnaswamy, Veena Gayathri / Senthil Kumar, P / Muralidharan, Manasa / Aishwarya, S / Sivamurugan, V / Rethnaraj, Chandran / Nisha, J C / Satyanarayana, Chowdula / Rangasamy, Gayathri

    Environmental research

    2022  Volume 218, Page(s) 115006

    Abstract: The marine ecosystem contains a solution for food, shelter, pharmaceutical problems and has a key role in the economy of the country as tourism. The Gulf of Kachchh, known for its high tides and the coral reefs are less explored for its antibiotic ... ...

    Abstract The marine ecosystem contains a solution for food, shelter, pharmaceutical problems and has a key role in the economy of the country as tourism. The Gulf of Kachchh, known for its high tides and the coral reefs are less explored for its antibiotic activity due to the coral bleaching and diseases. The bacterial strains in the coral Porites lutea are determined to possess antibiotic activity against bacterial strains such as E.coli, P. aeruginosa, S. aureus and S. faecalis. Among thirty bacterial strains isolated from the tissue, skeleton and mucus, two bacterial strains resulted in the better antagonistic activity. The antibiotic compound extracted from both the bacteria elucidated to be 4-[(2E)-4-hydroxypent-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one. Further, through ADMET prediction it was inferred that it is an effective drug lead as it reports less toxicity and better drug-likeliness. The study also includes the effect of Poly Hydroxy Butarate (PHB) production by the isolated bacterial strain.
    MeSH term(s) Animals ; Anthozoa/microbiology ; Ecosystem ; Staphylococcus aureus ; Coral Reefs ; Bacteria ; Anti-Bacterial Agents/toxicity
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.115006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19

    Muralidharan, Nisha / Sakthivel, R / Velmurugan, D / Gromiha, M Michael

    J Biomol Struct Dyn

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #35136
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19

    Muralidharan, Nisha / Sakthivel, R. / Velmurugan, D. / Gromiha, M. Michael

    Journal of Biomolecular Structure and Dynamics

    2020  , Page(s) 1–6

    Keywords Molecular Biology ; Structural Biology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1752802
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Hyperferritinemia in children hospitalized with scrub typhus.

    Williams, Vijai / Menon, Nisha / Bhatia, Prateek / Biswal, Manisha / Sreedharanunni, Sreejesh / Jayashree, Muralidharan / Nallasamy, Karthi

    Tropical medicine and health

    2021  Volume 49, Issue 1, Page(s) 15

    Abstract: Background: Hyperferritinemia is increasingly associated with mortality in sepsis. Studies estimating the prevalence of hyperferritinemia in pediatric scrub typhus are limited.: Methods: This was a secondary analysis of a prospective observational ... ...

    Abstract Background: Hyperferritinemia is increasingly associated with mortality in sepsis. Studies estimating the prevalence of hyperferritinemia in pediatric scrub typhus are limited.
    Methods: This was a secondary analysis of a prospective observational study (FERRIS) from a tertiary care teaching hospital in North India where 72 children with confirmed scrub typhus, 4 (5.5%) PCR positive, 55 (76.4%)-IgM ELISA positive, and 13 (18.1%)-both PCR and ELISA positive, were analyzed. Serum ferritin was measured in 62 children to identify the prevalence of hyperferritinemia and determine its association with mortality.
    Results: Hyperferritinemia (> 500 μg/L) was seen in 72.6% [n = 45] children; 26 (41.9%) were mild (500-2000 μg/L), 13 (21%) were moderate (2000-10,000 μg/L), and 6 (9.7%) were severe (> 10,000 μg/L). Early presentation to hospital (≤ 7 days of febrile illness) had more survivors than late presentation (> 7 days). Non-survivors had significantly higher PRISM III, PELOD-2, hyperlactatemia, hypoalbuminemia, organ dysfunction, need for mechanical ventilation, and need of RRT. Ferritin had poor sensitivity and specificity in predicting survival with AUC of 0.56. Organ dysfunction and risk scores as PRISM III, PELOD 2, and VIS at admission were better predictors with AUC (95% CI) of 0.72 (0.56, 0.89), 0.77 (0.63, 0.92), and 0.90 (0.78, 1.0) respectively.
    Conclusions: Hyperferritinemia is common in scrub typhus but it did not predict survival. Organ dysfunction and risk scores were better predictors of mortality than ferritin.
    Language English
    Publishing date 2021-02-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209835-5
    ISSN 1349-4147 ; 1348-8945
    ISSN (online) 1349-4147
    ISSN 1348-8945
    DOI 10.1186/s41182-021-00304-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Bed Utilization and Overcrowding in a High-Volume Tertiary Level Pediatric Emergency Department.

    Menon, Nisha Vengassery Balakrishnan / Jayashree, Muralidharan / Nallasamy, Karthi / Angurana, Suresh Kumar / Bansal, Arun

    Indian pediatrics

    2021  Volume 58, Issue 8, Page(s) 723–725

    Abstract: Objective: To measure bed utilization rate and overcrowding in a high-volume tertiary level pediatric emergency department (ED) and correlate with outcome.: Methods: All children beyond neonatal age attending the 22-bedded emergency were ... ...

    Abstract Objective: To measure bed utilization rate and overcrowding in a high-volume tertiary level pediatric emergency department (ED) and correlate with outcome.
    Methods: All children beyond neonatal age attending the 22-bedded emergency were prospectively enrolled from February to December, 2019. Number of daily admissions, boarders, discharges, ward transfers, length of stay (LOS) and unfavorable outcomes (care discontinuation and deaths) were recorded. Daily bed occupancy rate (BOR) was calculated and correlated with unfavorable outcome.
    Results: A total of 17,463 children visited the ED during the study period. The median (IQR) daily attendance and admission rate was 58 (51,65) and 22 (17,26) patients, respectively. The median (IQR) number of boarders and BOR was 48 (40-58) and 218% (181-263%), respectively. The median (IQR) LOS was 42.7 (23-71.4) hours. Unfavorable outcome correlated positively with number of boarders and BOR (P<0.001).
    Conclusions: Overcrowding of the ED was associated with increased frequency of care discontinuation and mortality. This data calls for systemic changes to tackle overcrowding.
    MeSH term(s) Bed Occupancy ; Child ; Emergency Service, Hospital ; Hospitalization ; Humans ; Infant, Newborn ; Length of Stay ; Patient Admission ; Retrospective Studies
    Language English
    Publishing date 2021-02-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 859: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Serum Ferritin Predicts Neither Organ Dysfunction Nor Mortality in Pediatric Sepsis Due to Tropical Infections.

    Williams, Vijai / Menon, Nisha / Bhatia, Prateek / Biswal, Manisha / Sreedharanunni, Sreejesh / Rawat, Amit / Jayashree, Muralidharan / Nallasamy, Karthi

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 607673

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.607673
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Therapeutic Targets and Computational Approaches on Drug Development for COVID-19

    Shanmugam, Anusuya / Muralidharan, Nisha / Velmurugan, Devadasan / Gromiha, M Michael

    Curr Top Med Chem

    Abstract: World Health Organization declared coronavirus disease (COVID-19) caused by SARS coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly spread all over the world. SARS-CoV-2 has infected more than 800,000 people and ...

    Abstract World Health Organization declared coronavirus disease (COVID-19) caused by SARS coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly spread all over the world. SARS-CoV-2 has infected more than 800,000 people and caused about 35,000 deaths so far, moreover, no approved drugs are available to treat COVID-19. Several investigations have been carried out to identify potent drugs for COVID-19 based on drug repurposing, potential novel compounds from ligand libraries, natural products, short peptides, and RNAseq analysis. This review is focused on three different aspects; (i) targets for drug design (ii) computational methods to identify lead compounds and (iii) drugs for COVID-19. It also covers the latest literature on various hit molecules proposed by computational methods and experimental techniques.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #640437
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top