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Article ; Online: Quadricuspid Aortic Valve with Ruptured Sinus of Valsalva Aneurysm: a Case Report.

Huang, Shuran / Liu, Xiaolong / Sun, Zhanguo

Brazilian journal of cardiovascular surgery

2023 Volume 38, Issue 1

Abstract: Quadricuspid aortic valve (QAV) and sinus of Valsalva aneurysm (SVA) are rare congenital anomalies. We report an elderly patient with QAV associated with a ruptured SVA to the right atrium. Transthoracic echocardiographic and computed tomographic images ... ...

Abstract	Quadricuspid aortic valve (QAV) and sinus of Valsalva aneurysm (SVA) are rare congenital anomalies. We report an elderly patient with QAV associated with a ruptured SVA to the right atrium. Transthoracic echocardiographic and computed tomographic images are presented. We emphasize the important role of computed tomography angiography in establishing and confirming the diagnosis and facilitating treatment planning. The patient was successfully operated by a minimally invasive approach.
MeSH term(s)	Humans ; Aged ; Quadricuspid Aortic Valve ; Sinus of Valsalva/diagnostic imaging ; Sinus of Valsalva/surgery ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve/abnormalities ; Aortic Aneurysm/complications ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/surgery ; Echocardiography
Language	English
Publishing date	2023-02-10
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2031026-2
ISSN	1678-9741 ; 1678-9741
ISSN (online)	1678-9741
ISSN	1678-9741
DOI	10.21470/1678-9741-2020-0735
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Article: False-negative factors of percutaneous transluminal clamp biopsy for suspected malignant biliary stricture: 194 cases analyzed from a single center.

Zhang, Chengzhi / Li, Yipu / Song, Mengyao / Sun, Zhanguo / Han, Xinwei / Ren, Jianzhuang / Jiao, Dechao

Insights into imaging

2024 Volume 15, Issue 1, Page(s) 108

Abstract: Objective: To study the predictive factors of false negatives in the diagnosis of biliary stricture (BS) by percutaneous transluminal clamp biopsy (PTCB).: Method: From January 2016 to January 2021, 194 patients with a high suspicion of malignant ... ...

Abstract	Objective: To study the predictive factors of false negatives in the diagnosis of biliary stricture (BS) by percutaneous transluminal clamp biopsy (PTCB). Method: From January 2016 to January 2021, 194 patients with a high suspicion of malignant tumors due to BS underwent PTCB during biliary drainage at our department. The final diagnosis was confirmed by postoperative pathology, other tissue or cell evidence, or medical imaging follow-up. Univariate and multivariate regression analyses were performed on the pathological results, summarizing the independent risk factors for false-negative value (FNV) to help further clinical diagnosis and treatment. Results: Of the 194 cases, 176 and 18 cases were finally diagnosed as malignant and benign BS, respectively, compared to 144 and 50 cases by PTCB, including 32 false-negative cases. The sensitivity, specificity, false-positive value, and FNV of PTCB were 81.8%, 100%, 0%, and 18.2%, respectively. Multivariate analysis showed that non-cholangiocarcinoma BS was an independent risk factor for FNV of PTCB (odds ratio 7.5 (95% CI 1.74-32.6), p < 0.01). Conclusion: PTCB is an effective minimally invasive interventional technique for BS diagnosis. Non-cholangiocarcinoma BS is an independent risk factor for FNV. Critical relevance statement: Identifying factors that are predictive of false-negative results by percutaneous transluminal clamp biopsy in the setting of biliary stricture may have a guiding effect on clinical practice. Key points: • Factors predictive of false negatives in the diagnosis of biliary stricture etiology by PTCB may aid in the interpretation of results. • Non-cholangiocarcinoma BS is an independent risk factor for FNV on PTCB. • PTCB is an effective minimally invasive interventional technique for BS diagnosis.
Language	English
Publishing date	2024-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-024-01675-y
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Article ; Online: IVIM and DCE-MRI in Predicting Phenotypic Subtypes and Nottingham Prognostic Index of Breast Cancer.

Sun, Zhanguo / Zhou, Zhe / Wang, Lei / Zhu, Laimin / Chen, Yueqin / Liu, Qiaolu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2024 Volume 34, Issue 4, Page(s) 400–406

Abstract: Objective: To explore the value of intravoxel incoherent motion (IVIM) and dynamic contrast enhanced MRI (DCE-MRI) for predicting phenotypic subtypes and Nottingham prognostic index (NPI) of breast cancer.: Study design: Descriptive study. Place and ... ...

Abstract	Objective: To explore the value of intravoxel incoherent motion (IVIM) and dynamic contrast enhanced MRI (DCE-MRI) for predicting phenotypic subtypes and Nottingham prognostic index (NPI) of breast cancer. Study design: Descriptive study. Place and Duration of the Study: Department of Radiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China, from March 2020 to January 2022. Methodology: One hundred and forty-one breast cancer patients with preoperative IVIM and DCE imaging were collected. IVIM parameters of D, D, f, and DCE-MRI parameters of Ktrans, Kep, and Ve were measured. Receiver operating characteristic curves were conducted to assess the diagnostic efficacies. Additionally, 40 patients collected from February 2022 to July 2022 were enrolled as validation cohort. Results:* The D value in HER2-enriched (HER2-E) was lower than that in non-HER-E, while D, Ktrans, and Ve values were higher than that in non-HER-E (p < 0.001, 0.046, < 0.001, and < 0.001, respectively). D + Ktrans + Ve showed an optimal diagnostic efficiency (AUC = 0.868). Meanwhile, D and f values of triple-negative breast cancer (TNBC) were higher than those of non-TNBC, and Ve value of TNBC was lower than that of non-TNBC (p = 0.013, 0.006, and < 0.001, respectively). D* + f + Ve showed the best prediction performance (AUC = 0.849). Additionally, D and Kep were independent predictors of NPI (p < 0.001, and 0.002, respectively). D + Kep showed a good diagnostic efficiency (AUC = 0.818). Conclusion: The combined IVIM and DCE-MRI model showed enhanced diagnostic efficiency in predicting phenotypic subtypes and NPI of breast cancer, and might thus be considered efficient in therapy decision-making for patients. Key words: Breast neoplasms, Intravoxel incoherent motion, Dynamic contrast enhanced magnetic resonance imaging, Phenotypic subtypes, Nottingham prognostic index.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Prognosis ; Triple Negative Breast Neoplasms ; Contrast Media ; Magnetic Resonance Imaging/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2024-04-05
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2024.04.400
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Article ; Online: Impact of sex and serum lipids interaction on working memory: A large-scale brain networks study.

Zhang, Shujun / Li, Xuezhen / Sun, Zhanguo / Chen, Yueqin / Yu, Yongqiang

Brain and behavior

2023 Volume 13, Issue 7, Page(s) e3054

Abstract: Backgrounds: Previous studies have demonstrated that both serum lipid levels and sex are crucial factors associated with individual cognition. However, the impact of sex and serum lipid interaction effects on the brain and cognition remains largely ... ...

Abstract	Backgrounds: Previous studies have demonstrated that both serum lipid levels and sex are crucial factors associated with individual cognition. However, the impact of sex and serum lipid interaction effects on the brain and cognition remains largely unknown. This study aimed to explore the underlying neural mechanisms among sex, serum lipids, and cognition using large-scale brain networks. Methods: Resting-state functional MRI data were collected from 157 young healthy adults. Independent component analysis was used to examine large-scale inter- and intra-network functional connectivity (FCs). Peripheral venous blood samples were collected to measure serum lipid levels. The three-back task was employed to assess cognition (i.e., working memory). General linear model, correlation, and mediation analyses were conducted to examine the interaction effects of sex and serum lipids on large-scale brain networks and their relationship with working memory. Results: We found that inter-network connectivity with the executive control network at its core was more susceptible to sex and triglyceride interaction effects. The intra-network connectivity in the dorsal attention networks (DANs), lateral visual networks, and anterior default mode networks was influenced by the interaction effects of sex and total cholesterol (TC)/low-density lipoprotein cholesterol. Specifically, correlations between serum lipids and affected brain networks were found to be sex-specific. In addition, higher intra-network FC in the right inferior parietal (R-IPL) of the DAN correlated with a longer three-back reaction time in females. More importantly, the relationship between serum TC levels and three-back reaction time was mediated by intra-network connectivity in the R-IPL of the DAN. Conclusions: Our findings describe the impact of sex and serum lipid interaction effects on large-scale brain networks, as well as on cognitive function. Our data suggest that sex-specific usage of serum lipids or brain networks would be beneficial for monitoring and therapy in dyslipidemia-related cognition decline.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Memory, Short-Term ; Brain Mapping ; Neural Pathways ; Brain/diagnostic imaging ; Cognition ; Cholesterol ; Lipids ; Magnetic Resonance Imaging ; Nerve Net/diagnostic imaging
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Lipids
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3054
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Article ; Online: Construction of heteroaryl-bridged NIR AIEgens for specific imaging of lipid droplets and its application in photodynamic therapy.

Sun, Zhanguo / Shi, Shuman / Guan, Pengli / Liu, Bin

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2022 Volume 272, Page(s) 120946

Abstract: As a kind of subcellular organelle, lipid droplets (LDs) play a critical role in the body's normal metabolism. LDs have gained increasing attention as a fluorescent photodynamic target site. Near-infrared (NIR) organic light-emitting luminescent ... ...

Abstract	As a kind of subcellular organelle, lipid droplets (LDs) play a critical role in the body's normal metabolism. LDs have gained increasing attention as a fluorescent photodynamic target site. Near-infrared (NIR) organic light-emitting luminescent materials, with aggregation-induced emission (AIE)-active feature, preeminent LD-imaging ability, and effective reactive oxygen species (ROS) production property, have been widely used for photodynamic therapy (PDT) in diagnostic therapeutics, but its application remains challenging. In the present work, three novel NIR organic compounds with AIE-active feature, namely, TPET-Is, TPET-Fu, and TPEF-Is, were developed and synthesized. These heteroaryl-bridged molecules possess a donor-donor-π-acceptor structure and strong intramolecular charge transfer character. These AIEgens are capable of high-fidelity LD imaging in living cells (Pearson's coefficient values: 0.94, 0.96, 0.97) due to their biocompatibility, good photostability, and strong lipophilicity (LogP values: 9.39, 7.89, 8.03), respectively. Moreover, they can be also applied in bright imaging the LDs of oil-rich plant tissues, such as those of sunflower seeds. The respective AIEgens TPET-Fu of these compounds can also produce ROS in the condition of white light to effectively kill live Hela cells. The present study thus provides a potential strategy through heteroaryl-bridged molecular engineering for LD-targeted imaging and PDT application.
MeSH term(s)	Diagnostic Imaging ; HeLa Cells ; Humans ; Light ; Lipid Droplets ; Photochemotherapy/methods
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2022.120946
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Article: Efficacy and safety of raltitrexed-eluting CalliSpheres

Sun, Zhanguo / Jiao, Dechao / Fang, Yi / Liu, Yiming / Xu, Kaihao / Zhang, Chengzhi / Huang, Yuanhao / Han, Xinwei

Therapeutic advances in medical oncology

2024 Volume 16, Page(s) 17588359241229661

Abstract: Background: The most common loadable chemotherapeutic drugs in drug-eluting bead transarterial chemoembolization (DEB-TACE) include doxorubicin, epirubicin, etc. CalliSpheres: Objectives: To assess the efficacy and safety of raltitrexed-loaded DEB- ... ...

Abstract	Background: The most common loadable chemotherapeutic drugs in drug-eluting bead transarterial chemoembolization (DEB-TACE) include doxorubicin, epirubicin, etc. CalliSpheres Objectives: To assess the efficacy and safety of raltitrexed-loaded DEB-TACE in patients with intermediate-stage HCC. Design: The study was conducted as a single-arm prospective study. Methods: This study was a prospective, single-arm trial conducted between June 2019 and June 2022. CalliSpheres Results: The 6-month ORR and disease control rates were 90.1% and 93.8%, respectively. The median OS was 33.0 months. The 1-, 2-, and 3-year survival rates were 95.1%, 82.1%, and 43.6%, respectively. Child-Pugh class and bilobar disease occurrence were identified as independent OS predictors. The median TTP and PFS were 22.7 and 19.8 months, respectively. Eleven (11.5%) patients experienced at least one grade 3 AE, and serious AEs were reported in five participants (5.2%). No patient experienced grade 4 or 5 AEs. Conclusion: Raltitrexed-loaded DEB-TACE is feasible, safe, and effective in patients with intermediate-stage HCC. Trial registration: This trial was registered at www.chictr.org.cn under the identifier: 1900024097 on 25 June 2019.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359241229661
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Article: Percutaneous microwave ablation for lung tumors: a retrospective case-control study of conventional CT and C-arm CT guidance.

Du, Kepu / Liu, Yiming / Wu, Kunpeng / Sun, Zhanguo / Han, Xinwei / Jiao, Dechao

Quantitative imaging in medicine and surgery

2023 Volume 13, Issue 9, Page(s) 5737–5747

Abstract: Background: Although conventional computed tomography (cCT) is the mainstream guidance equipment for lung microwave ablation (MWA), C-arm CT can provide 3-dimensional (3D) CT-like images reconstructed from 2-dimensional (2D) digital subtraction ... ...

Abstract	Background: Although conventional computed tomography (cCT) is the mainstream guidance equipment for lung microwave ablation (MWA), C-arm CT can provide 3-dimensional (3D) CT-like images reconstructed from 2-dimensional (2D) digital subtraction angiography (DSA) information within 8 seconds, highlighting its utility as a new guidance tool. This retrospective case-control study was performed to evaluate the clinical performance of percutaneous MWA for lung tumors using cCT and C-arm CT guidance. Methods: From April 2015 to April 2020, 101 consecutive patients with solitary lung tumors who underwent percutaneous MWA at our single center (Zhengzhou, China) were divided into 2 groups: the cCT group (n=56), with unarmed puncture, and the C-arm CT group (n=45), with iGuide navigation-assisted puncture. The primary endpoints were technical success, technical efficacy, puncture scoring (PS), and complete ablation (CA) rate. The secondary endpoints were complications, median progression-free survival (mPFS), and median overall survival (mOS). Results: The technical success rates were 100% in both the C-arm CT group and cCT group. The technical efficacies were 93.3% and 91.1% in the C-arm CT group and cCT group, respectively, with no statistical difference (P=0.67). The PS (2.9 Conclusions: C-arm CT guidance is as feasible and effective as cCT for lung tumor MWA, which can increase PS and decrease TPT.
Language	English
Publishing date	2023-08-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-985
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Article ; Online: Low-dose IL-2 for patients with systemic lupus erythematosus.

He, Jing / Sun, Xiaolin / Li, Zhanguo

The Lancet. Rheumatology

2019 Volume 1, Issue 4, Page(s) e203

Language	English
Publishing date	2019-11-07
Publishing country	England
Document type	Letter
ISSN	2665-9913
ISSN (online)	2665-9913
DOI	10.1016/S2665-9913(19)30107-9
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Article ; Online: Clinical and CT Imaging Differences Between Gastric Schwannoma and Gastric Leiomyoma.

Zhao, Luping / Xue, Hongfeng / Sun, Zhanguo / Chen, Yueqin / Yu, Hao / Mao, Sen

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 4, Page(s) 369–373

Abstract: Objective: To determine whether computed tomography (CT) imaging features can be used to differentiate gastric schwannoma (GS) from gastric leiomyoma (GL) and to develop a nomogram as a predictive model.: Study design: Retrospective study. Place and ... ...

Abstract	Objective: To determine whether computed tomography (CT) imaging features can be used to differentiate gastric schwannoma (GS) from gastric leiomyoma (GL) and to develop a nomogram as a predictive model. Study design: Retrospective study. Place and Duration of the Study: Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, Shandong, China, from July 2009 to June 2022. Methodology: Clinical and imaging data of 43 patients with GS and 57 patients with GL were analysed retrospectively. The independent factors for differentiating GS and GL were obtained by the logistic regression analysis. Receiver operating characteristic curve (ROC) was plotted, area under curve (AUC) and calibration tests were used to evaluate the diagnostic efficiency of the model. Results: The GS group had more females and was older than the GL group (p <0.05). There were statistical differences between the two groups in tumour location, growth mode, LD/SD ratio, necrosis, ulcers, the presence of tumour-associated lymph nodes, enhancement degree, and the HU (Hounsfield units) values of tumour in the venous phase and delayed phase (p <0.05). Logistic regression analysis showed that tumour location, growth mode, LD/SD (long and short diameters) ratio, and the presence of tumour-associated lymph nodes were independent factors in differentiating GS from GL, and a nomogram model was established accordingly. When the model threshold was >0.319, the AUC was 0.987 (95% confidence interval [CI] 0.941~0.999). The sensitivity and specificity were 97.7% and 94.7%, respectively. Conclusion: The proposed nomogram model based on CT imaging features can be used to differentiate GS from GL. Key words: Gastric leiomyoma, Gastric schwannoma, Computed tomography, Diagnosis.
MeSH term(s)	Female ; Humans ; Retrospective Studies ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/pathology ; Tomography, X-Ray Computed/methods ; Leiomyoma/diagnostic imaging ; Neurilemmoma/diagnostic imaging
Language	English
Publishing date	2023-05-16
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.04.369
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Article: Efficacy and Safety of Drug-Eluting Bead Bronchial Arterial Chemoembolization Plus Anlotinib in Patients With Advanced Non-small-Cell Lung Cancer.

Liu, Juanfang / Zhang, Wenguang / Ren, Jianzhuang / Li, Zhen / Lu, Huibin / Sun, Zhanguo / Han, Xinwei

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 768943

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2021-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.768943
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