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Article: A propos de voies d'abord utilisées en chirurgie carcinologique O.R.L

Baron, F / Legent, F / Gallois, J R

Revue de laryngologie - otologie - rhinologie

1973 Volume 94, Issue 11, Page(s) 521–525

Title translation	Approaches used in E.N.T. oncological surgery.
MeSH term(s)	Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/surgery ; Humans ; Methods ; Neck Dissection ; Necrosis ; Neoplasm Metastasis ; Postoperative Complications/prevention & control ; Radiation Injuries/prevention & control
Language	French
Publishing date	1973-11
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	80330-3
ISSN	0035-1334 ; 0376-2157 ; 0302-1394
ISSN	0035-1334 ; 0376-2157 ; 0302-1394
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Ul II Zs.159: Show issues

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Article ; Online: Long-Term (>24 Months) Duration of Symptoms Negatively Impacts Patient-Reported Outcomes Following Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy.

Liu, Eva / Persad, Amit R L / Baron, Nathan / Fourney, Daryl R

Spine

2023 Volume 49, Issue 8, Page(s) 519–529

Abstract: Study design: Retrospective cohort study.: Objective: To investigate the impact of long symptom duration (>24 mo) on patient self-reported outcomes for pain, function, and quality of life following anterior cervical discectomy and fusion (ACDF) for ... ...

Abstract	Study design: Retrospective cohort study. Objective: To investigate the impact of long symptom duration (>24 mo) on patient self-reported outcomes for pain, function, and quality of life following anterior cervical discectomy and fusion (ACDF) for cervical radiculopathy. Summary of background data: ACDF is an effective treatment to relieve the symptoms of cervical radiculopathy. However, there is no consensus on whether prolonged preoperative length of symptoms negatively impacts postoperative outcomes. Methods: This study included consecutive patients who underwent ACDF for cervical radiculopathy from May 1, 2012 to Dec 1, 2019 by a single surgeon. Patients were stratified by short (<24 mo) and long (>24 mo) duration of symptoms. Outcomes including visual analog scale (VAS) neck and arm, neck disability index (NDI), EuroQol-5D (EQ-5D), and overall state of health (EQ-VAS) were compared between cohort both for absolute values and percentage of patients achieving minimal clinically important difference. Results: A total of 111 consecutive patients were included in our study, including 59 patients in the short symptom duration group and 52 patients in the long symptom duration group. The mean age of the patients was 51.4±9.4 and 41 (36.9%) were female. The baseline VAS neck and arm, NDI, EQ-5D, and EQ-VAS were similar between groups. Patients in both long and short symptom duration groups had clinical improvement following surgery. However, patients with short symptom duration had better VAS Neck and EQ-5D outcomes, and were more likely to meet minimal clinically important difference for NDI, EQ-5D, or any outcome. Multivariate analysis confirmed symptom duration <24 months as an independent predictor for better patient-reported outcomes. Conclusion: We appreciated better clinical outcomes in patients with shorter symptom duration who received ACDF for cervical radiculopathy. On the basis of this data, we advocate for prompt treatment of cervical radiculopathy to avoid the potential for long-term impairment. Level of evidence: Level 3.
MeSH term(s)	Humans ; Female ; Male ; Radiculopathy/surgery ; Quality of Life ; Retrospective Studies ; Cervical Vertebrae/surgery ; Diskectomy ; Treatment Outcome ; Patient Reported Outcome Measures ; Spinal Fusion/adverse effects ; Neck Pain/surgery
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000004896
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Zs.A 1305: Show issues

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Article ; Online: Assessment of Screening Mammography Recommendations.

Baron, Paul L / Margenthaler, Julie A / Dietz, Jill R

JAMA internal medicine

2021 Volume 181, Issue 9, Page(s) 1261–1262

MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Early Detection of Cancer ; Female ; Humans ; Mammography
Language	English
Publishing date	2021-07-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2021.3532
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Ua VI Zs.119: Show issues

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Article: Etude de 72 observations de cancers amydgaliens; du Centre René-Gauducheau et du Service O.-R.-L. du C.H.R., Nantes.

TARDIVEAU, J / LAINE, R / BARON, F

Journal de radiologie, d'electrologie & archives d'electricite medicale

1956 Volume 37, Issue 3-4, Page(s) 226–227

Title translation	Study of 72 observations of tonsillar cancer; from the René-Gauducheau Center and the O.R.L. Service of C.H.R., Nantes.
MeSH term(s)	Computer Systems ; Palatine Tonsil ; Radiotherapy ; Tonsillar Neoplasms
Language	French
Publishing date	1956-03
Publishing country	France
Document type	Journal Article
ZDB-ID	3143-4
ISSN	0368-394X
ISSN	0368-394X
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Ue I Zs.58: Show issues

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Article: Essais therapeutiques de l'hydroxocobalamine à 5,000 gamma sur les algies de la sphere O.R.L.

Baron, F / Pressard / Mitard, J J / Marsaudon, R

Journal francais d'oto-rhino-laryngologie, audio-phonologie et chirurgie maxillo-faciale

1967 Volume 16, Issue 8, Page(s) 609–612

Title translation	Therapeutic trials with hydroxocobalamin at 5000 gamma in pain of the O.R.L. area.
MeSH term(s)	Adult ; Aged ; Analgesics/therapeutic use ; Ear Neoplasms/drug therapy ; Esophageal Neoplasms/drug therapy ; Facial Neoplasms/drug therapy ; Female ; Humans ; Hydroxocobalamin/therapeutic use ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/drug therapy ; Otorhinolaryngologic Diseases/drug therapy ; Pharyngeal Neoplasms/drug therapy ; Tongue Neoplasms/drug therapy
Chemical Substances	Analgesics ; Hydroxocobalamin (Q40X8H422O)
Language	French
Publishing date	1967-11
Publishing country	France
Document type	Journal Article
ZDB-ID	80406-x
ISSN	0021-8332 ; 0398-9771
ISSN	0021-8332 ; 0398-9771
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Zs.A 179: Show issues

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Article ; Online: Declining hip fracture burden in Sweden 1998-2019 and consequences for projections through 2050.

Michaëlsson, Karl / Baron, John A / Byberg, Liisa / Larsson, Susanna C / Melhus, Håkan / Gedeborg, Rolf

Scientific reports

2024 Volume 14, Issue 1, Page(s) 706

Abstract: We aimed to estimate the absolute and age-standardized number of hip fractures in Sweden during the past two decades to produce time trends and future projections. We used nationwide register data from 1998 to 2019 and a validated algorithm to calculate ... ...

Abstract	We aimed to estimate the absolute and age-standardized number of hip fractures in Sweden during the past two decades to produce time trends and future projections. We used nationwide register data from 1998 to 2019 and a validated algorithm to calculate the annual absolute and age-standardized number of incident hip fractures over time. The total hip fracture burden was 335,399 incident events over the 22 years, with a change from 16,180 in 1998 to 13,929 in 2019, a 14% decrease. One decade after the index hip fracture event, 80% of the patients had died, and 11% had a new hip fracture. After considering the steady growth of the older population, the decline in the age-standardized number of hip fractures from 1998 through 2019 was 29.2% (95% CI 28.1-30.2%) in women and 29.3% (95% CI 27.5-30.7%) in men. With a continued similar reduction in hip fracture incidence, we can predict that 14,800 hip fractures will occur in 2034 and 12,000 in 2050 despite doubling the oldest old (≥ 80 years). Without an algorithm, a naïve estimate of the total number of hip fractures over the study period was 539,947, with a second 10-year hip fracture risk of 35%. We note an ongoing decline in the absolute and age-standardized actual number of hip fractures in Sweden, with consequences for future projections.
MeSH term(s)	Male ; Aged, 80 and over ; Humans ; Female ; Sweden/epidemiology ; Hip Fractures/epidemiology ; Algorithms ; Death
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51363-6
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Article ; Online: Subgrouping of facilitatory or inhibitory conditioned pain modulation responses in patients with chronic knee pain. Explorative analysis from a multicentre trial.

Larsen, J B / Madeleine, P / Sørensen, L B / Sachau, J / Otto, J C / Baron, R / Arendt-Nielsen, L

European journal of pain (London, England)

2023 Volume 28, Issue 2, Page(s) 335–351

Abstract: Background: Facilitatory and inhibitory conditioned pain modulation (CPM) responses are observed in healthy volunteers and chronic pain patients, but the clinical implications for phenotyping are unknown. This study aimed to subgroup and compare chronic ...

Abstract	Background: Facilitatory and inhibitory conditioned pain modulation (CPM) responses are observed in healthy volunteers and chronic pain patients, but the clinical implications for phenotyping are unknown. This study aimed to subgroup and compare chronic knee pain patients according to their CPM responses. Methods: This explorative, cross-sectional study included 127 patients with chronic knee pain (osteoarthritis or following total knee arthroplasty). Individual CPM responses were categorized as facilitatory (test stimuli pain intensity increased when conditioning stimuli were applied), as inhibitory (test stimuli pain intensity decreased) or as no change (defined as less than 5.3% change in pain intensity). Outcomes were clinical pain intensities, temporal summation, widespread pain, self-reported physical function, PainDETECT questionnaire and Pain Quality Assessment Scale. Data were analysed as comparisons between the inhibitory and the facilitatory groups and using multivariate linear regression models. Results: Fifty-four patients had facilitatory CPM responses, 49 had inhibitory CPM responses, and 24 showed no change in CPM response. A between-group difference was observed for self-reported physical function, with the facilitatory CPM group reporting better function (54.4 vs. 46.0, p = 0.028) and the facilitatory CPM group reported more deep pain sensations (3.2 vs. 2.0, p = 0.021). The remaining outcomes showed no between-group differences. Higher clinical pain intensity and facilitated temporal summation were associated in the facilitated CPM group but not in the inhibitory CPM group. Conclusion: These explorative findings indicated that quantitative clinical and experimental differences exist between facilitatory or inhibitory CPM responses in a chronic knee pain patient population. Differences in patients' CPM responses should be further investigated to unravel possible clinical importance. Significance: Our findings confirm that conditioned pain modulation consist of inhibitory and facilitatory responders among a patient population with chronic knee pain. This explorative study indicates that patients with either facilitatory or inhibitory conditioned pain modulation could exhibit differences in pain outcomes. Subgrouping of chronic pain patients depending on individual conditioned pain modulation responses could be considered in phenotyping patients prior to inclusion in clinical trials or used for personalizing the management regime.
MeSH term(s)	Humans ; Chronic Pain ; Cross-Sectional Studies ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/drug therapy ; Pain Measurement ; Pain Threshold/physiology ; Multicenter Studies as Topic
Language	English
Publishing date	2023-09-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1390424-3
ISSN	1532-2149 ; 1090-3801
ISSN (online)	1532-2149
ISSN	1090-3801
DOI	10.1002/ejp.2185
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Zs.A 5194: Show issues

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Article: Bladder paraganglioma: Case report and review of the literature.

Pérez Barón, Laura / Guerrero Acosta, Nicolas / Granados González, Guillermo / Aldana, Juan Carlos / Mantilla Espinosa, Rodolfo / Carmona, German Andrés

Radiology case reports

2023 Volume 19, Issue 1, Page(s) 213–217

Abstract: Pheochromocytoma is a tumor that originates from the chromaffin cells of the adrenal medulla and is responsible for the production of catecholamines. However, when it occurs outside the adrenal glands, it is called a paraganglioma and accounts for 10%-15% ...

Abstract	Pheochromocytoma is a tumor that originates from the chromaffin cells of the adrenal medulla and is responsible for the production of catecholamines. However, when it occurs outside the adrenal glands, it is called a paraganglioma and accounts for 10%-15% of cases. In this report, we present the case of a 27-year-old male patient with a history of hypertension, who presented hematuria and dizziness on urination with a diagnosis of bladder paraganglioma. Contrast-enhanced computed tomography revealed the presence of a bladder tumor. Bladder paraganglioma is a rare condition, and understanding possible imaging findings is crucial to raising suspicion of this diagnosis and expanding our knowledge of this rare disease.
Language	English
Publishing date	2023-11-02
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.10.021
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Article ; Online: Malaria diagnosis using a combined system of a simple and fast extraction method with a lyophilised Dual-LAMP assay in a non-endemic setting.

Martín Ramírez, Alexandra / Barón Argos, Lourdes / Lanza Suárez, Marta / Carmona Rubio, Claudia / Pérez-Ayala, Ana / Hisam, Shamilah R / Rubio, José M

Pathogens and global health

2023 Volume 118, Issue 1, Page(s) 80–90

Abstract: Malaria is a parasitic disease distributed in tropical areas but with a high number of imported cases in non-endemic countries. The most specific and sensitive malaria diagnostic methods are PCR and LAMP. However, both require specific equipment, ... ...

Abstract	Malaria is a parasitic disease distributed in tropical areas but with a high number of imported cases in non-endemic countries. The most specific and sensitive malaria diagnostic methods are PCR and LAMP. However, both require specific equipment, extraction procedures and a cold chain. This study aims to solve some limitations of LAMP method with the optimization and validation of six LAMP assays, genus and species-specific, using an easy and fast extraction method, the incorporation of a reaction control assay, two ways (Dual) of result reading and reagent lyophilization. The Dual-LAMP assays were validated against the Nested-Multiplex Malaria PCR. A conventional column and saline extraction methods, and the use of lyophilized reaction tubes were also assessed. A new reaction control Dual-LAMP-RC assay was designed. Dual-LAMP-
MeSH term(s)	Humans ; Reproducibility of Results ; Malaria/diagnosis ; Malaria/parasitology ; Nucleic Acid Amplification Techniques/methods ; Molecular Diagnostic Techniques/methods ; Sensitivity and Specificity ; Multiplex Polymerase Chain Reaction
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2625162-0
ISSN	2047-7732 ; 2047-7724
ISSN (online)	2047-7732
ISSN	2047-7724
DOI	10.1080/20477724.2023.2232595
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Ud II Zs.196: Show issues

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Article ; Online: Citizen involvement in COVID-19 contact tracing with digital tools: a qualitative study to explore citizens' perspectives and needs.

van der Meer, A / Helms, Y B / Baron, R / Crutzen, R / Timen, A / Kretzschmar, M E E / Stein, M L / Hamdiui, N

BMC public health

2023 Volume 23, Issue 1, Page(s) 1804

Abstract: Background: Contact tracing (CT) is a key strategy when dealing with outbreaks of infectious diseases such as COVID-19. The scale of the COVID-19 pandemic has often left public health professionals (PHPs), who are responsible for the execution of CT, ... ...

Abstract	Background: Contact tracing (CT) is a key strategy when dealing with outbreaks of infectious diseases such as COVID-19. The scale of the COVID-19 pandemic has often left public health professionals (PHPs), who are responsible for the execution of CT, unable to keep up with the rapid and largescale spread of the virus. To enhance or support its execution, and potentially lower the workload for PHPs, citizens may be more actively involved in CT-tasks that are commonly executed by PHPs (referred to as 'self-led CT'). There is limited insight into citizens' perspectives on and needs for self-led CT for COVID-19. This study aims to explore the perspectives and needs of Dutch citizens on taking more responsibilities in the execution of CT for COVID-19, potentially through the use of digital tools. Methods: An exploratory qualitative study was performed, in which online semi-structured interviews were conducted. Questions were based on the Reasoned Action Approach and Health Belief Model. Interviews were audio-recorded and transcribed verbatim. A thematic analysis was conducted to identify citizens' perspectives and needs to participate in self-led CT. Results: We conducted 27 interviews with Dutch citizens. Seven main themes were identified from the interviews: 1) 'Citizens' perspectives on self-led CT are influenced by prior experiences with regular CT', 2) 'Citizens' felt responsibilities and the perceived responsibilities of the PHS in CT shape their perspectives on self-led CT', 3) 'Anticipated impacts of self-led CT on the CT-process', 4) 'Citizens' attitude towards the application of self-led CT depends on their own perceived skills and the willingness and skills of others', 5) 'Shame and social stigma may hamper participation in self-led CT', 6) 'Concerns about privacy and data security: a barrier for self-led CT', and 7) 'Citizens' perspectives and anticipated needs for the implementation and application of self-led CT in practice'. Conclusions: Most interviewees hold a positive attitude towards self-led CT and using digital tools for this purpose. However, their intention for self-led CT may depend on various factors, such as prior experiences with regular CT, and their perceived self-efficacy to participate. Perspectives and needs of citizens should be considered for the future implementation of self-led CT in practice.
MeSH term(s)	Humans ; Contact Tracing ; COVID-19 ; Pandemics/prevention & control ; Disease Outbreaks ; Emotions
Language	English
Publishing date	2023-09-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16664-x
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