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Article ; Online: The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial.

Gan, Jingwen / Zhu, Shi-Yang / Ma, Xiao / Ding, Xue-Song / Deng, Yan / Wang, Yanfang / Sun, Ai-Jun

2023 Volume 318, Issue Pt B, Page(s) 116975

Abstract: Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known ... Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and ... 4: Conclusion: Ding-kun-dan is another available, effective and safe method for patients ...

Abstract	Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea. Materials and method: 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF Results: Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4 Conclusion: Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents.
MeSH term(s)	Female ; Humans ; Desogestrel/therapeutic use ; Dinoprostone ; Double-Blind Method ; Dysmenorrhea/drug therapy ; Dysmenorrhea/diagnosis ; Endometriosis ; Medicine, Chinese Traditional ; Prospective Studies
Chemical Substances	Desogestrel (81K9V7M3A3) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2023-07-29
Publishing country	Ireland
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116975
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Article ; Online: The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial

Gan, Jingwen / Zhu, Shi-yang / Ma, Xiao / Ding, Xue-song / Deng, Yan / Wang, Yanfang / Sun, Ai-jun

Journal of Ethnopharmacology. 2024 Jan., v. 318 p.116975-

2024

Abstract: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered ... conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). To compare the effect of Ding-kun ... kun-dan is another available, effective and safe method for patients with primary dysmenorrhea ...

Abstract	Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea. 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF₂ₐ, PGE₂, PGF₂ₐ/PGE₂ and NO during the 12 weeks intervention. Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4ᵗʰ week, 8ᵗʰ week and 12ᵗʰ week). Although Marvelon was significantly superior to DKD in reducing VAS scores, the total CMSS, CMSS severity and duration scores at each posttreatment follow-up (P < 0.01), VAS scores in the DKD group decreased significantly over time while scores in the COC group only dropped rapidly after the first two months of treatment. Efficacy gap between two interventions continuously narrowed over time and the efficacy of DKD became non-inferior at the 12ᵗʰ week compared to that of Marvelon (the difference between groups, – 0.78%; 95% confidence interval (CI), −13.67%–12.75%; non-inferiority margin, 15%). DKD group had better efficacy on mild pain compared to that of the COC group with no statistical difference (75% VS 61.9%, P > 0.05). DKD and Marvelon could effectively reduce PGF₂ₐ, PGE₂ and higher PGF₂ₐ/PGE₂ in patients with PD. There was no statistical difference in the level of PGF₂ₐ, PGE₂, PGF₂ₐ/PGE₂ and NO between DKD and Marvelon group at each follow-up. No serious adverse effect was observed. Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents.
Keywords	Oriental traditional medicine ; adverse effects ; animals ; blood serum ; confidence interval ; endometriosis ; immunity ; insulin resistance ; menstruation ; metabolism ; pain ; polycystic ovary syndrome ; therapeutics ; Primary dysmenorrhea ; Ding-kun-dan ; Marvelon ; VAS ; CMSS ; PGF2a ; PGE2 ; PGF2a/PGE2
Language	English
Dates of publication	2024-01
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116975
Database	NAL-Catalogue (AGRICOLA)

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Article: The Role of Traditional Chinese Formula Ding-Kun Pill (DKP) in Expected Poor Ovarian Response Women (POSEIDON Group 4) Undergoing

Song, Jing-Yan / Gao, Dan-Dan / Cao, Xian-Ling / Xiang, Shan / Chen, Yan-Hua / Teng, Yi-Li / Li, Xiu-Fang / Liu, Hai-Ping / Wang, Fu-Xin / Zhang, Bin / Xu, Li-Hua / Zhou, Li / Huang, Xiang-Hong / Sun, Zhen-Gao

Frontiers in endocrinology

2021 Volume 12, Page(s) 675997

Abstract: Objective: The primary objective of the study was to assess traditional Chinese formula DKP supplementation in terms of efficacy and safety on reproductive outcomes of expected poor ovarian responder (POR, POSEIDON Group 4) undergoing : Design setting ...

Abstract	Objective: The primary objective of the study was to assess traditional Chinese formula DKP supplementation in terms of efficacy and safety on reproductive outcomes of expected poor ovarian responder (POR, POSEIDON Group 4) undergoing Design setting and participants: Women eligible for IVF-ET were invited to participate in this randomized, double-blind, placebo-controlled, superiority trial at academic fertility centers of ten public hospitals in Chinese Mainland. A total of 462 patients (35-44 years) equally divided between DKP and placebo groups with antral follicle count (AFC) <5 or anti-müllerian hormone (AMH) <1.2 ng/ml were randomized. Interventions: All participants were given DKP or 7 g placebo twice daily on the previous menstrual cycle day 5 until oocyte retrieval, which took approximately 5 to 6 weeks. Main outcome measure: The primary outcome was the ongoing pregnancy defined as more than 20 gestational weeks of an intrauterine living fetus confirmed by pelvic ultrasonography. Results: Demographic characteristics were equally distributed between the study populations. Intention-to-treat (ITT) analysis revealed that ongoing pregnancy rate (OPR) was not significantly different between DKP and placebo groups [26.4% (61/231) versus 24.2% (56/231); relative risk (RR) 1.09, 95% confidence interval (CI) 0.80 to 1.49, Conclusion: This well-designed randomized controlled trial (RCT) offers new high-quality evidence to supplement existing retrospective literature concerning DKP performance in expected PORs. DKP could be recommended as a safe and natural remedy for expected PORs (aged 35-37 years) who fulfill the POSEIDON group 4 criteria. However, additional interventional clinical studies are undoubtedly required to be conducted in the future to validate this hypothesis. Clinical trial registration: www.chictr.org.cn, identifier ChiCTR1900026614.
MeSH term(s)	Adult ; China/epidemiology ; Double-Blind Method ; Embryo Transfer/methods ; Female ; Fertilization in Vitro/drug effects ; Follow-Up Studies ; Humans ; Infertility, Female/drug therapy ; Infertility, Female/epidemiology ; Medicine, Chinese Traditional/methods ; Oocyte Retrieval ; Ovulation Induction/standards ; Pregnancy ; Pregnancy Rate ; Prognosis
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.675997
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nimodipine attenuates dibutyl phthalate-induced learning and memory impairment in kun ming mice: An in vivo study based on bioinformatics analysis.

Yan, Biao / Ma, Ping / Chen, Shaohui / Cheng, Hongguo / Tang, Min / Sun, Yanling / Yang, Xu / Wu, Yang / Cheng, Menglin

Environmental toxicology

2020 Volume 36, Issue 5, Page(s) 821–830

Abstract: Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that ... ...

Abstract	Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that nimodipine (Nim) palys a neuropharmacological and psychopharmacological role in neurons, the attenuating effects of Nim on learning and memory impairment induced by DBP exposure remain unknown. Based on bioinformatics analysis we found that the biological processes affected by both DBP and Nim may involve the calcium signaling pathway, the MAPK signaling pathway and the apoptosis pathway. The results of an in vivo study confirmed that DBP affects the levels of Ca
MeSH term(s)	Animals ; Computational Biology ; Dibutyl Phthalate/toxicity ; Memory Disorders/chemically induced ; Mice ; Nimodipine/toxicity ; Plasticizers
Chemical Substances	Plasticizers ; Dibutyl Phthalate (2286E5R2KE) ; Nimodipine (57WA9QZ5WH)
Language	English
Publishing date	2020-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23084
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Article: Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.

Xing, Yu / Liu, Yan-Xia / Liu, Xin / Wang, Shu-Lin / Li, Ping / Lin, Xiao-Hua / Sui, Cong-Lu / Xu, Cai / Qi, Bing / Tong, Qing

Experimental and therapeutic medicine

2017 Volume 13, Issue 6, Page(s) 3567–3573

Abstract: ... with the traditional Chinese medicine formula Gui Zhu Yi Kun formula (GZYKF), in the treatment of polycystic ovary syndrome (PCOS ...

Abstract	The aim of the present study was to investigate the molecular mechanism associated with the traditional Chinese medicine formula Gui Zhu Yi Kun formula (GZYKF), in the treatment of polycystic ovary syndrome (PCOS). In this study, granulosa cells (GCs) of rats with PCOS were cultured and treated with testosterone propionate (TP) alone or with serum from rats treated with different doses of GZYKF. The effect of TP on cell growth was assayed using the MTT method. Expression levels of Beclin-1, light chain (LC)3, mechanistic target of rapamycin (mTOR), tumor suppressor p53 (p53), adenosine monophosphate-activated protein kinase (AMPK), sestrin2 and tuberous sclerosis protein 1/2 were evaluated using quantitative polymerase chain reaction and western blotting. It was demonstrated that TP increased the expression of Beclin-1 and LC3, whereas GZYKF significantly decreased the TP-induced expression of Beclin-1 (P<0.01). Additionally, GCs treated with GZYKF exhibited significant increases in mTOR, phosphorylated mTOR and AMPKα expression levels, and significant reductions in p53 and sestrin2 expression levels were observed. In conclusion, the findings of the present study suggest that a reduction in ovarian GCs in rats with PCOS may be associated with GC autophagy. Furthermore, the effects of GZYKF in mediating the p53/AMPK pathway may inhibit GC autophagy, which suggests a possible novel mechanism underlying the treatment of PCOS with GZYKF.
Language	English
Publishing date	2017-04-26
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2017.4384
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Article ; Online: The Role of Traditional Chinese Formula Ding-Kun Pill (DKP) in Expected Poor Ovarian Response Women (POSEIDON Group 4) Undergoing In Vitro Fertilization-Embryo Transfer

Jing-Yan Song / Dan-Dan Gao / Xian-Ling Cao / Shan Xiang / Yan-Hua Chen / Yi-Li Teng / Xiu-Fang Li / Hai-Ping Liu / Fu-Xin Wang / Bin Zhang / Li-Hua Xu / Li Zhou / Xiang-Hong Huang / Zhen-Gao Sun

Frontiers in Endocrinology, Vol

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

2021 Volume 12

Abstract: ObjectiveThe primary objective of the study was to assess traditional Chinese formula DKP supplementation in terms of efficacy and safety on reproductive outcomes of expected poor ovarian responder (POR, POSEIDON Group 4) undergoing in vitro ... ...

Abstract	ObjectiveThe primary objective of the study was to assess traditional Chinese formula DKP supplementation in terms of efficacy and safety on reproductive outcomes of expected poor ovarian responder (POR, POSEIDON Group 4) undergoing in vitro fertilization-embryo transfer (IVF-ET).Design, Setting, and ParticipantsWomen eligible for IVF-ET were invited to participate in this randomized, double-blind, placebo-controlled, superiority trial at academic fertility centers of ten public hospitals in Chinese Mainland. A total of 462 patients (35–44 years) equally divided between DKP and placebo groups with antral follicle count (AFC) <5 or anti-müllerian hormone (AMH) <1.2 ng/ml were randomized.InterventionsAll participants were given DKP or 7 g placebo twice daily on the previous menstrual cycle day 5 until oocyte retrieval, which took approximately 5 to 6 weeks.Main Outcome MeasureThe primary outcome was the ongoing pregnancy defined as more than 20 gestational weeks of an intrauterine living fetus confirmed by pelvic ultrasonography.ResultsDemographic characteristics were equally distributed between the study populations. Intention-to-treat (ITT) analysis revealed that ongoing pregnancy rate (OPR) was not significantly different between DKP and placebo groups [26.4% (61/231) versus 24.2% (56/231); relative risk (RR) 1.09, 95% confidence interval (CI) 0.80 to 1.49, P = 0.593]. No significant differences between groups were observed for the secondary outcomes. The additional per protocol (PP) analysis was in line with ITT results: OPR in DKP group was 27.2% (61/224) versus 24.1% (55/228) in placebo group [RR 1.13, 95%CI (0.82 to 1.55), P = 0.449]. After subgroup analysis the findings concluded that POR population of 35–37 years had a significantly higher OPR after 5–6 weeks of oral DKP (41.8%, 33/79) versus placebo (25.4%, 18/71) [RR 1.65, 95% CI (1.02 to 2.65), P = 0.034, P for interaction = 0.028].ConclusionThis well-designed randomized controlled trial (RCT) offers new high-quality evidence to supplement existing retrospective literature concerning DKP performance in expected PORs. DKP could be recommended as a safe and natural remedy for expected PORs (aged 35–37 years) who fulfill the POSEIDON group 4 criteria. However, additional interventional clinical studies are undoubtedly required to be conducted in the future to validate this hypothesis.Clinical Trial Registrationwww.chictr.org.cn, identifier ChiCTR1900026614.
Keywords	POSEIDON criteria ; low prognosis ; Ding-Kun Pill ; traditional Chinese medicine ; poor ovarian response ; in vitro fertilization-embryo transfer ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Examples of Professor MA Kun's treatment of infertility caused by hyperprolactinemia with kidney deficiency and blood stasis].

Ma, Kun / Liu, Xiao-Qian / Chen, Yan-Xia / Wang, Jie-Nan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 11, Page(s) 2629–2633

Abstract: ... a refractory gynecological disease and seriously affects female reproductive function. Professor MA Kun has ... and can promote the progress of the disease. In view of this, Professor MA Kun took the therapy ...

Abstract	Hyperprolactinemia(HPRL) is one of the diseases leading to anovulatory infertility, which is a refractory gynecological disease and seriously affects female reproductive function. Professor MA Kun has summarized his experience in clinical and scientific studies for many years. And believes that kidney deficiency is the pathogenesis of HPRL and blood stasis is the dominant pathological manifestation of HPRL and can promote the progress of the disease. In view of this, Professor MA Kun took the therapy of kidney-tonifying and blood-activating as the principle for treating anovulatory infertility caused by HPRL, with soothing the liver and promoting Qi as adjuvant therapies. She has also summarized and refined the prescriptions for tonifying kidney and inducing ovulation, which have a remarkable clinical efficacy.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Hyperprolactinemia/drug therapy ; Infertility, Female/drug therapy ; Infertility, Female/etiology ; Kidney ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2021-07-22
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20210309.501
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Article ; Online: Bilayer STING goes head to head to stay put.

Yang, Kun / Yan, Nan

Molecular cell

2023 Volume 83, Issue 9, Page(s) 1372–1374

Abstract: In this issue, Liu et al. ...

Abstract	In this issue, Liu et al.
MeSH term(s)	Membrane Proteins/metabolism ; Protein Domains
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.04.004
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Article ; Online: A New Surgical Approach for Obese Patients with Hiatal Hernia.

Zhang, Kun / Sun, Shaochuan / Yan, Bing

Obesity surgery

2024 Volume 34, Issue 5, Page(s) 1956–1957

MeSH term(s)	Humans ; Hernia, Hiatal/complications ; Hernia, Hiatal/surgery ; Obesity, Morbid/surgery ; Obesity/complications ; Obesity/surgery ; Gastroesophageal Reflux/surgery ; Laparoscopy ; Herniorrhaphy ; Treatment Outcome ; Surgical Mesh
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Letter
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-024-07167-8
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Article ; Online: Nickel-Catalyzed Reductive

Yan, Denghong / Wen, Shun / Xing, Yunxin / Bu, Jie / Shen, Kun

The Journal of organic chemistry

2024 Volume 89, Issue 4, Page(s) 2223–2231

Abstract: A nickel-catalyzed ... ...

Abstract	A nickel-catalyzed reductive
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02120
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