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  1. Article ; Online: Extracellular vesicles isolated from Arabidopsis thaliana leaves reveal characteristics of mammalian exosomes.

    Jokhio, Sharjeel / Peng, Ian / Peng, Ching-An

    Protoplasma

    2024  

    Abstract: Plant-derived extracellular vesicles (EVs), containing a myriad of bioactive proteins, microRNAs, lipids, and secondary metabolites, have recently become the focus of rising interest due to their important roles in various applications. The widely ... ...

    Abstract Plant-derived extracellular vesicles (EVs), containing a myriad of bioactive proteins, microRNAs, lipids, and secondary metabolites, have recently become the focus of rising interest due to their important roles in various applications. The widely accepted method for isolating plant EVs is differential ultracentrifugation plus density gradient centrifugation. However, the combination of differential ultracentrifugation and density gradient centrifugation for the isolation of plant EVs is time-consuming and labor-intensive. Hence, there is a need for more efficient methods to perform the separation of plant EVs. In this study, EVs were separated from Arabidopsis thaliana leaves by a cost-effective polyethylene glycol (PEG)-based precipitation approach. The mean size of purified Arabidopsis thaliana EVs determined by dynamic light scattering was 266 nm, which is consistent with nanoparticle tracking analysis. The size was also confirmed via transmission electron microscopy with morphology of a cup-shaped appearance which is the typical mammalian exosome's morphology. Additionally, Western blotting of the purified Arabidopsis thaliana EVs, using commercially available mammalian exosomal kits, displayed surface marker tetraspanin proteins (CD9, CD63, and CD81), and endosomal sorting complexes required for transport (ESCRT)-associated proteins (TSG101 and ALIX). This demonstrates that the purified Arabidopsis thaliana EVs reveal the typical proteins reported in mammalian exosomes.
    Language English
    Publishing date 2024-04-29
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 123809-7
    ISSN 1615-6102 ; 0033-183X
    ISSN (online) 1615-6102
    ISSN 0033-183X
    DOI 10.1007/s00709-024-01954-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2366: Show issues Location:
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  2. Article ; Online: Untangling the uncertainty in B vitamins for stroke prevention: folic acid fortification, dosage, and their interaction?

    Liu, Simin / An, Peng

    The American journal of clinical nutrition

    2024  Volume 119, Issue 3, Page(s) 593–594

    MeSH term(s) Humans ; Vitamin B Complex/pharmacology ; Folic Acid ; Uncertainty
    Chemical Substances Vitamin B Complex (12001-76-2) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1016/j.ajcnut.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Micronutrients and metabolic diseases.

    An, Peng / Luo, Yongting / Yang, Aimin / Li, Jinhui

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1380743

    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1380743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Regulated cell death in glioma: promising targets for natural small-molecule compounds.

    Han, Mingyu / Li, Sui / Fan, Huali / An, Junsha / Peng, Cheng / Peng, Fu

    Frontiers in oncology

    2024  Volume 14, Page(s) 1273841

    Abstract: Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is ... ...

    Abstract Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one year. The main mechanism of regulated cell death involves organisms coordinating the elimination of damaged cells at risk of tumor transformation or cells hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, necrosis, parthanayosis, entosis, lysosome-dependent death, NETosis, oxiptosis, alkaliptosis, and disulfidaptosis. The main goal of clinical oncology is to develop therapies that promote the effective elimination of cancer cells by regulating cell death are the main goal of clinical oncology. Recently, scientists have utilized pertinent regulatory factors and natural small-molecule compounds to induce regulated cell death for the treatment of gliomas. By analyzing the PubMed and Web of Science databases, this paper reviews the research progress on the regulation of cell death and the role of natural small-molecule compounds in glioma. The aim is to provide help for the treatment of glioblastoma.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1273841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Vibrio vulnificus

    Chen, Taigui / Wang, Jun / Peng, Shijie / Li, Lianbao / An, Changxue / Li, Jun / He, Wei

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e28012

    Abstract: ... ...

    Abstract Vibrio
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Spatio-temporal evolution and driving factors of new urbanization in central China based on multi-source data.

    An, Yu / Peng, Lingtong / Geng, Liang

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0298099

    Abstract: Urbanization is an inevitable outcome of the development of human society to a certain stage, and it is also an irreversible pattern of the concentration degree of human society. Based on multi-source data such as remote sensing images, ecological ... ...

    Abstract Urbanization is an inevitable outcome of the development of human society to a certain stage, and it is also an irreversible pattern of the concentration degree of human society. Based on multi-source data such as remote sensing images, ecological environment and socio-economic data, the evaluation index system of new urbanization is constructed from multi-dimensions of population, economy, society, space and ecology. To explore the spatio temporal evolution and driving factors of urbanization in 80 prefecture-level cities in central China from 2013 to 2021 by using entropy method, spatial autocorrelation model and geographic detector. The results show that: (1) The level of new urbanization continues to grow, with the average value rising from 0.1562 in 2013 to 0.2557 in 2021, and the regional differences are obvious, forming a circle structure with Wuhan, Zhengzhou and other provincial capitals as the center and weakening radiation to surrounding cities. (2) The agglomeration of ecological urbanization is significant, and the agglomeration trend is gradually enhanced. The high-high agglomeration areas tend to Xinzhou City, most prefecture-level cities in Hubei Province and some prefecture-level cities in Southern Hunan Province, while the low-low agglomeration areas tend to Changzhi City, most prefecture level cities in Henan Province and some prefecture-level cities in Northern Anhui Province. (3) The night light index, total retail sales of consumer goods, investment in fixed assets, proportion of built-up areas and urban economic density are the main driving factors affecting the level of new urbanization. (4) The interaction of driving factors shows double factor enhancement and nonlinear enhancement effects.
    MeSH term(s) Humans ; Urbanization ; China ; Cities ; Environment ; Spatial Analysis ; Economic Development
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Inhibition of SARS-CoV-2 Spike Protein Pseudotyped Virus Infection Using ACE2-Tethered Micro/Nanoparticles.

    Alkhaldi, Soha Y / Peng, Ian / Peng, Ching-An

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: Coronavirus disease 2019 (COVID-19) has caused a global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral infection is reliant upon the binding between angiotensin-converting enzyme 2 receptor (ACE2) and spike protein (S) ...

    Abstract Coronavirus disease 2019 (COVID-19) has caused a global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral infection is reliant upon the binding between angiotensin-converting enzyme 2 receptor (ACE2) and spike protein (S). Therefore, ACE2 is a key receptor for SARS-CoV-2 to infect the host. Nonetheless, as SARS-CoV-2 is constantly mutating into new variants that cause high infection rates, the development of prophylactic and therapeutic approaches remains a necessity to continue fighting mutated SARS-CoV-2 variants. In this study, ACE2-streptavidin fusion proteins expressed by recombinant DNA technology were anchored on biotinylated fluorescent polystyrene particles of various sizes ranging from 0.15 to 5 µm. The ACE2-tethered micro/nanoparticles were shown to prevent spike protein pseudotyped lentivirus entry into ACE2-expressing HEK293T cells. Compared to ACE2 in soluble form, micro-sized particles (2 and 5 µm) immobilized with ACE2 interfered more efficiently with viral attachment, entry, and the ensuing infection. Our results showed that particles functionalized with ACE2 could be used as efficient decoys to block the infection of SARS-CoV-2 strains.
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10060652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Multiple large cystic masses in the pelvic cavity caused by large pituitary adenomas: A clinical lesson.

    Ye, Yingjian / Shang, Yu / Ji, Xianqun / An, Peng

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tumor-like concurrent pulmonary and cerebral infection caused by Nocardia farcinicas.

    Wang, Jingxian / Zhang, Haidong / Ji, Xianqun / An, Peng

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New Advances in Targeted Therapy of HER2-Negative Breast Cancer.

    An, Junsha / Peng, Cheng / Xie, Xiaofang / Peng, Fu

    Frontiers in oncology

    2022  Volume 12, Page(s) 828438

    Abstract: Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of molecular biology and genomics, molecular targeted therapy has become one of the most active areas ... ...

    Abstract Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of molecular biology and genomics, molecular targeted therapy has become one of the most active areas in breast cancer treatment research and has also achieved remarkable achievements. However, molecular targeted therapy is mainly aimed at HER2-positive breast cancer and has not yet achieved satisfactory curative effect on HER2-negative breast cancer. This article describes the potential targets that may be used for breast cancer treatment from the aspects of PI3K/AKT signaling pathway, DDR, angiogenesis, the cell cycle, breast cancer stem cells,
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.828438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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