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  1. Article: Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study.

    Chen, Hsin-Hung / Wu, Chien-Tung / Tsai, Yueh-Ting / Ho, Chun-Wei / Hsieh, Ming-Chia / Lai, Jung-Nien

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 1298487

    Abstract: ... commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence ...

    Abstract Introduction: Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use.
    Materials and methods: This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model.
    Results: In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56-0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82-0.90) and presented a dose-dependent effect.
    Conclusion: The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes.
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/1298487
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  2. Article ; Online: Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan

    Hsin-Hung Chen / Chien-Tung Wu / Yueh-Ting Tsai / Chun-Wei Ho / Ming-Chia Hsieh / Jung-Nien Lai

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Nationwide Study

    2021  Volume 2021

    Abstract: ... commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence ...

    Abstract Introduction. Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. Materials and Methods. This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. Results. In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56–0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82–0.90) and presented a dose-dependent effect. Conclusion. The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
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  3. Article ; Online: Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San.

    Chin, Lengsu William / Cheng, Yu-Wen / Lin, Shih-Shen / Lai, Ya-Yun / Lin, Long-Yau / Chou, Ming-Yung / Chou, Ming-Chih / Yang, Chi-Chiang

    Archives of virology

    2010  Volume 155, Issue 12, Page(s) 1933–1941

    Abstract: ... of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity ... rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore ... the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 ...

    Abstract Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects.
    MeSH term(s) Animals ; Antiviral Agents/analysis ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; Berberine/analysis ; Berberine/isolation & purification ; Berberine/pharmacology ; Berberine/toxicity ; Cercopithecus aethiops ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Plants, Medicinal/chemistry ; Simplexvirus/drug effects ; Vero Cells ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Coptidis rhizoma extract ; Drugs, Chinese Herbal ; Berberine (0I8Y3P32UF)
    Language English
    Publishing date 2010-12
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-010-0779-9
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  4. Book: Nai mi wei li zuo ye ren yuan jian kang wei hai liu xing bing xue diao cha

    Lai, Jinhuang

    The epidemiological investigation of helath effects in nanotechnological industry

    (Lao gong an quan wei sheng yan jiu bao gao)

    2008  

    Title variant Epidemiological investigation of helath effects in nanotechnological industry
    Author's details yan jiu cho chi ren Lai Jinhuang, Lin Mingxiu
    Series title Lao gong an quan wei sheng yan jiu bao gao
    MeSH term(s) Nanoparticles/adverse effects ; Occupational Exposure/adverse effects ; Lung Diseases/etiology
    Keywords Taiwan
    Language Chinese
    Size x, 124 p. :, ill.
    Edition Yi ban.
    Publisher Xing zheng yuan lao gong wei yuan hui lao gong an quan wei sheng yan jiu suo
    Publishing place Taibei Xian Xizhi Shi
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: Effects of Wei Chang An on expression of multiple genes in human gastric cancer grafted onto nude mice.

    Zhao, Ai-Guang / Li, Ting / You, Sheng-Fu / Zhao, Hai-Lei / Gu, Ying / Tang, Lai-Di / Yang, Jin-Kun

    World journal of gastroenterology

    2008  Volume 14, Issue 5, Page(s) 693–700

    Abstract: Aim: To investigate the expression of multiple genes in Chinese jianpi herbal recipe Wei Chang ...

    Abstract Aim: To investigate the expression of multiple genes in Chinese jianpi herbal recipe Wei Chang An (WCA) in human gastric cancer cell line SGC-7901.
    Methods: A human gastric adenocarcinoma cell line SGC-7901 grafted onto nude mice was used as the animal model. The mice were randomly divided into 3 groups, one control and the two representing experimental conditions. Animals in the two experimental groups received either WCA over a 34-d period or 5-fluorouracil (5-FU) over 6-d period starting at 8th d after grafting. Control animals received saline on an identical schedule. Animals were killed 41 d after being grafted. The expression profiles in paired WCA treated gastric cancer samples and the N.S. control samples were studied by using a cDNA array representing 14181 cDNA clusters. The alterations in gene expression levels were confirmed by Real-time Quantitative polymerase chain reaction (qPCR).
    Results: When compared with controls, the average tumor inhibitory rate in WCA group was 44.32% +/- 5.67% and 5-FU 47.04% +/- 11.33% (P < 0.01, respectively). The average labeling index (LI) for PCNA in WCA group and 5-FU group was significantly decreased compared with the control group. Apoptotic index (AI) was significantly increased to 9.72% +/- 4.51% using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling (TUNEL) method in WCA group compared with the controls 2.45% +/- 1.37%. 5-FU group was also found to have a significantly increased AI compared with the controls. The expression of cleaved Caspase-3 in WCA group and 5-FU group was significantly increased compared with the control group respectively. There were 45 different expressed sequence tags (ESTs) among the control sample pool and WCA sample pool. There were 24 ESTs up-regulated in WCA samples and 21 ESTs down-regulated. By using qPCR, the expression level of Stat3, rap2 interacting protein x (RIPX), regulator of differentiation 1 (ROD1) and Bcl-2 was lower in WCA group than that in control group respectively. By using SP immunohistochemical method the expression of Phospho-Stat3 (Tyr705) and Bcl-2 in WCA group and 5-FU group was significantly decreased compared with the control group respectively.
    Conclusion: WCA could inhibit gastric cancer cell SGC-7901 growth in vivo. WCA could induce gastric cancer cell apoptosis and suppress proliferation. Its mechanisms might be involved in the down-regulation of Stat3, RIPX, ROD1 and Bcl-2 gene.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Animals ; Atractylodes ; Cell Line, Tumor ; Drugs, Chinese Herbal/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Polyporales ; Prunella ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Xenograft Model Antitumor Assays
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2008-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.14.693
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    Zs.A 6039: Show issues Location:
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  6. Article: Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San

    Chin, Lengsu William / Cheng, Yu-Wen / Lin, Shih-Shen / Lai, Ya-Yun / Lin, Long-Yau / Chou, Ming-Yung / Chou, Ming-Chih / Yang, Chi-Chiang

    Archives of virology. 2010 Dec., v. 155, no. 12

    2010  

    Abstract: ... of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity ... rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore ... the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 ...

    Abstract Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects.
    Keywords antiviral properties ; berberine ; herbal medicines ; herpes simplex ; high performance liquid chromatography ; medicine ; quantitative analysis ; virus replication ; viruses
    Language English
    Dates of publication 2010-12
    Size p. 1933-1941.
    Publisher Springer Vienna
    Publishing place Vienna
    Document type Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-010-0779-9
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 70/128: Show issues

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  7. Article ; Online: Effects of Wei Chang An on expression of multiple genes in human gastric cancer grafted onto nude mice

    Ai-Guang Zhao, Ting Li, Sheng-Fu You, Hai-Lei Zhao, Ying Gu, Lai-Di Tang, Jin-Kun Yang

    World Journal of Gastroenterology, Vol 14, Iss 5, Pp 693-

    2008  Volume 700

    Abstract: AIM: To investigate the expression of multiple genes in Chinese jianpi herbal recipe Wei Chang ...

    Abstract AIM: To investigate the expression of multiple genes in Chinese jianpi herbal recipe Wei Chang An (WCA) in human gastric cancer cell line SGC-7901.METHODS: A human gastric adenocarcinoma cell line SGC-7901 grafted onto nude mice was used as the animal model. The mice were randomly divided into 3 groups, one control and the two representing experimental conditions. Animals in the two experimental groups received either WCA over a 34-d period or 5-fluorouracil (5-FU) over 6-d period starting at 8th d after grafting. Control animals received saline on an identical schedule. Animals were killed 41 d after being grafted. The expression profiles in paired WCA treated gastric cancer samples and the N.S. control samples were studied by using a cDNA array representing 14 181 cDNA clusters. The alterations in gene expression levels were confirmed by Real-time Quantitative polymerase chain reaction (qPCR).RESULTS: When compared with controls, the average tumor inhibitory rate in WCA group was 44.32% ± 5.67% and 5-FU 47.04% ± 11.33% (P < 0.01, respectively). The average labeling index (LI) for PCNA in WCA group and 5-FU group was significantly decreased compared with the control group. Apoptotic index (AI) was significantly increased to 9.72% ± 4.51% using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling (TUNEL) method in WCA group compared with the controls 2.45% ± 1.37%. 5-FU group was also found to have a significantly increased AI compared with the controls. The expression of cleaved Caspase-3 in WCA group and 5-FU group was significantly increased compared with the control group respectively. There were 45 different expressed sequence tags (ESTs) among the control sample pool and WCA sample pool. There were 24 ESTs up-regulated in WCA samples and 21 ESTs down-regulated. By using qPCR, the expression level of Stat3, rap2 interacting protein x (RIPX), regulator of differentiation 1 (ROD1) and Bcl-2 was lower in WCA group than that in control group respectively. By using SP immunohistochemical method the expression of Phospho-Stat3 (Tyr705) and Bcl-2 in WCA group and 5-FU group was significantly decreased compared with the control group respectively.CONCLUSION: WCA could inhibit gastric cancer cell SGC-7901 growth in vivo. WCA could induce gastric cancer cell apoptosis and suppress proliferation. Its mechanisms might be involved in the down-regulation of Stat3, RIPX, ROD1 and Bcl-2 gene.
    Keywords Gastric cancer ; Chinese Jianpi herbs ; Expressions of multiple genes ; Real-time quantitative PCR ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 570
    Language English
    Publishing date 2008-02-01T00:00:00Z
    Publisher Baishideng Publishing Group Co. Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Minimally invasive (endoscopic & robotic) breast surgery

    Lai, Hung-Wen / Mok, Chi Wei

    2020  

    Author's details Chi Wei Mok, Hung-Wen Lai
    Keywords Breast/Endoscopic surgery
    Subject code 618.190597
    Language English
    Size xvii, 244 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online
    HBZ-ID HT020351237
    ISBN 978-0-323-73405-9 ; 0-323-73405-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 303 available for loan (reading room) Lesesaal EG

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  9. Article ; Online: Comment on "Effect of serum uric acid and gout on the incidence of colorectal cancer: A meta-analysis".

    Lai, Shih-Wei

    The American journal of the medical sciences

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.04.007
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  10. Article ; Online: Retrospect of the Two-Year Debate: What Fuels the Evolution of SARS-CoV-2: RNA Editing or Replication Error?

    Wei, Lai

    Current microbiology

    2023  Volume 80, Issue 5, Page(s) 151

    Abstract: Mutation is one of the mechanisms of the evolutionary divergence of an organism. Under this global COVID-19 pandemic, the fast evolution of SARS-CoV-2 became one of the most worrying issues. Some researchers believed that the hosts' RNA deamination ... ...

    Abstract Mutation is one of the mechanisms of the evolutionary divergence of an organism. Under this global COVID-19 pandemic, the fast evolution of SARS-CoV-2 became one of the most worrying issues. Some researchers believed that the hosts' RNA deamination systems (APOBECs and ADARs) are the major source of mutations and have driven the evolution of SARS-CoV-2. However, apart from RNA editing, the RDRP (RNA-dependent RNA polymerase)-mediated replication errors may also contribute to the mutation of SARS-CoV-2 (just like the single-nucleotide polymorphisms/variations in eukaryotes caused by DNA replication errors). Unfortunately, it is technically unable to distinguish RNA editing and replication errors (SNPs) in this RNA virus. Here comes a fundamental question: we indeed observed the fast evolution of SARS-CoV-2, but what exactly fuels its evolution: RNA editing or replication errors? This debate lasts for 2 years. In this piece, we will retrospect the 2-year debate on RNA editing versus SNPs.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; RNA Editing ; Pandemics ; Mutation
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Letter
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03279-z
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