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  1. Article ; Online: Launch of the International Living Donor Liver Transplantation Outcomes Registry.

    Staubli, Sebastian / Grover, Alexander Steen / Turner, Benedict R H / Raptis, Dimitri A / Spiro, Michael / Tinguely, Pascale / Berenguer, Marina / Rela, Mohamed

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 8, Page(s) 698–699

    MeSH term(s) Humans ; Liver Transplantation ; Living Donors ; Registries
    Language English
    Publishing date 2023-06-22
    Publishing country Netherlands
    Document type Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00185-1
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  2. Book ; Online: Chemical composition of surface layer bottom sediments from the White Sea collected in Cruises 49 and 80 of R/V Professor Shtockman, supplementary data to: Kuz'mina, Tatyana G; Lein, Alla Yu; Luchsheva, LN; Murdmaa, Ivar O; Novigatsky, Alexander N; Shevchenko, Vladimir P (2009): Chemical composition of surface sediments of the White Sea. Translated from Litologiya i Poleznyye Iskopaemyye, 2009, 44(2), 115-132, Lithology and Mineral Resources, 44(2), 103-119

    Kuz'mina, Tatyana G / Lein, Alla Yu / Luchsheva, LN / Murdmaa, Ivar O / Novigatsky, Alexander N / Shevchenko, Vladimir P

    2009  

    Abstract: Contents of major elements in surface layer bottom sediments of the White Sea were determined ...

    Abstract Contents of major elements in surface layer bottom sediments of the White Sea were determined by the X-ray fluorescence method. Application of the statistical analysis (principal component method and cluster analysis) made it possible to divide the sediments into more or less homogeneous seven groups with different chemical and grain size compositions. In general, the groups corresponded to sediment lithotypes based on the P.P. Shirshov Institute of Oceanology classification. Contents of Si and Al are controlled by sand-silt and pelite fraction ratio, while variations in Mn (and Fe in part) content are governed by redistribution of elements during redox processes of early diagenesis.
    Language English
    Dates of publication 2009-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1134/S0024490209020011
    DOI 10.1594/PANGAEA.777351
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: CDKN2A/B

    Yuile, Alexander / Satgunaseelan, Laveniya / Wei, Joe Q / Rodriguez, Michael / Back, Michael / Pavlakis, Nick / Hudson, Amanda / Kastelan, Marina / Wheeler, Helen R / Lee, Adrian

    Current issues in molecular biology

    2023  Volume 45, Issue 7, Page(s) 5276–5292

    Abstract: Genomic alterations ... ...

    Abstract Genomic alterations of
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45070335
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  4. Article: A single-lead ECG based cardiotoxicity detection in patients on polychemotherapy.

    Mesitskaya, Dinara F / Fashafsha, Zaki Z A / Poltavskaya, Maria G / Andreev, Denis A / Levshina, Anna R / Sultygova, Elizaveta A / Gognieva, Daria / Chomakhidze, Petr / Kuznetsova, Natalia / Suvorov, Alexander / Marina I, Sekacheva / Poddubskaya, Elena / Novikova, Alena / Bykova, Aleksandra / Kopylov, Philipp

    International journal of cardiology. Heart & vasculature

    2024  Volume 50, Page(s) 101336

    Abstract: Background: Anti-cancer treatment can be fraught with cardiovascular complications, which is the most common cause of death among oncological survivors. Without appropriate cardiomonitoring during anti-cancer treatment, it becomes challenging to detect ... ...

    Abstract Background: Anti-cancer treatment can be fraught with cardiovascular complications, which is the most common cause of death among oncological survivors. Without appropriate cardiomonitoring during anti-cancer treatment, it becomes challenging to detect early signs of cardiovascular complications. In order to achieve higher survival rates, it is necessary to monitor oncological patients outpatiently after anti-cancer treatment administration. In this regard, we aim to evaluate the efficacy of single-lead ECG remote monitoring to detect cardiotoxicity in cancer patients with minimal cardiovascular diseases after the first cycle of polychemotherapy.
    Materials and methods: The study included patients 162 patients over 18 years old with first diagnosed different types of solid tumors, planed for adjuvant (within 8 weeks after surgery) or neoadjuvant polychemotherapy. All patients were monitored, outpatiently, during 14-21 days (depending on the regimen of polychemotherapy) after polychemotherapy administration using single-lead ECG.
    Results: QTc > 500 mc prolongation was detected in 8 patients (6.6 %), first-diagnosed arial fibrillation was detected in 11 patients (9 %) in period after chemotherapy administration. Moreover, left ventricular diastolic dysfunction using single-lead ECG after polychemotherapy was detected in 49 (40.1 %) patients with sensitivity 80 %, specificity 95 %, AUC 0.88 (95 % CI, 0.82-0.93).
    Conclusions: The side effects of cancer treatment may cause life-threatening risks. Early identification of cardiotoxicity plays a vital role in the solution of this problem. Using portable devices to detect early cardiotoxicity is a simple, convenient and affordable screening method, that can be used for promptly observation of patients.
    Language English
    Publishing date 2024-01-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2024.101336
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  5. Article: The use of Sonidegib in the adjuvant and advanced phases of Sonic Hedge Hog Mutant Medulloblastomas.

    Yuile, Alexander K / Kastelan, Marina / Lee, Adrian Ps / Back, Michael / Drummond, James / Wheeler, Helen R

    Oxford medical case reports

    2022  Volume 2022, Issue 3, Page(s) omac019

    Abstract: Medulloblastomas are rare embryonal primary brain tumours originating in the cerebellum. Most medulloblastomas arising in adults are associated with mutations in the Sonic Hedge Hog (SHH) pathway. Patient 1 was prescribed Sonidegib for recurrent ... ...

    Abstract Medulloblastomas are rare embryonal primary brain tumours originating in the cerebellum. Most medulloblastomas arising in adults are associated with mutations in the Sonic Hedge Hog (SHH) pathway. Patient 1 was prescribed Sonidegib for recurrent metastatic SHH mutated medulloblastoma multiple lines of treatment. His leptomeningeal disease responded after 3 months of therapy. The drug was continued for a further 3 months until progressive central nervous system (CNS) and leptomeningeal disease arose. Progression free survival (PFS) from initiation of Sonidegib of 3 months was observed (overall survival 8.8 years). Patient 2 presented with un-resectable SHH mutated meduloblastoma with high risk of relapse who received 14 months of adjuvant Sonidegib. Following biopsy she was treated with chemotherapy and cranio-spinal radiotherapy, followed by 14 months of adjuvant Sonigedib. She remains free of disease over 51 months later. Both clinical scenarios are poorly described in the literature or evaluated in clinical trials with Sonidegib.
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omac019
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  6. Book ; Online: Methane measurements in the Laptev Sea, Arctic Ocean, supplementary data to: Schr?der, Hartwig (2000): Methan in der marinen Wassers?ule der Laptev See, Prozesse und Verteilung. Diploma Thesis, Institut f?r Geologie und Mineralogie der Friedrich-Alexander Universit?t Erlangen-N?rnberg, 89 pp

    Schr?der, Hartwig / Damm, Ellen / Erlangen, Institut f?r Geologie und Mineralogie, Friedrich Alexander Universit?t

    2000  

    Abstract: ... waren.
    Sicherlich ist die COz-Reduktion im Sediment in der Laptew See eine Hauptquelle f?r marines ... Ursachen. F?r die s?dliche Lapt ew See konnte eine Methananomalie innerhalb des Lenaausstrorns nachgewiesen ... bodennahes Methan. Die Ergebnisse. zeigen, da? dieser Bildungsproze? vor allem f?r die k?stennahen Bereiche ...

    Abstract In der Wassers?ule der Laptew See haben die Bildungs- und Verteilungsbedingungen vielfliltige Ursachen. F?r die s?dliche Lapt ew See konnte eine Methananomalie innerhalb des Lenaausstrorns nachgewiesen werden, die im direkten Zusammenhang mit dem Flu?wasser stehen mu?. Mit den hohen Konzentrationen am Kontinentalhang ergab sich ein Hinweis auf eventuell vorhandene Gashydrate an der Sole eines zum Hang hin auskeilenden Permafrosts oder auf Gashydrate in den Sedimenten des Kontinentalhangs selbst. Ob es entlang der reliktisch vorhandenen, ehemaligen Flu?l?ufe auf dem Schel f ebenfalls zu Entgasungen kommt, bleibt allerdings weiter unklar, da dieses Ph?nomen nicht beobachtet wurde oder die Anomalien nicht eindeutig diesem Proze? zuzuordnen waren.
    Sicherlich ist die COz-Reduktion im Sediment in der Laptew See eine Hauptquelle f?r marines, bodennahes Methan. Die Ergebnisse. zeigen, da? dieser Bildungsproze? vor allem f?r die k?stennahen Bereiche wahrscheinlich ist. Dennoch gibt es auch Bereiche, wo die Zuordnung zu einer expliziten Methanquelle nicht eindeutig ist. F?r eine genauere Bewertung der Herkunft der Gase sollten in k?nftigen Untersuchungen die Methankonzentrationen des Sediments einbezogen werden. Aber auch die Isotopensignaturen des Gases im Sediment k?nnen wertvolle Hinweise auf die Genese geben, vor allem wenn die Wasserstoffisotopie mituntersucht wird. Dies erscheint sinnvoll, da sich dur ch leichtes, bodennahes, Methan in der Wassers?ule Hinweise auf biogene Bildungen ergaben, dieser Befund k?nnte durch weitere Untersuchungen pr?zisiert werden. Dies gilt aber auch f?r die CH4-Anomalien des OberfI?chenwassers. Auch hier ergaben sich durch leicht KohIenstoffsignaturen Hinweise auf biogene in situ-Produktion. Mit detaillierteren Methankonzentrations- und d13C- CH4-Isotopenprofilen der Wassers?ule k?nnte dieser Bildungspfad eindeutiger beschrieben werden.
    Es konnte ferner gezeigt werden, da? die Lapt ew See w?hrend der Sommermonate eine Quelle f?r atmosph?risches CI L darstellt. Das emittierte Gas geht neben vereinzelten Bodenquellen auch auf in situ-Produktion in der Wassers?ule zur?ck. Abgesehen von der n?rdlichen Region geht das Methan bodennaher Anomalien innerhalb der Wassers?ule sehr schnell zur?ck und nur ein kleiner Teil gelangt so schlie?lich in die Atmosph?re. Der w?hrend der ARK-XIV Expedition getestete Methansensor hat sich als ungeeignet f?r den Einsatz gemeinsam mit der CTD erwiesen. Es hat sich gezeigt, da? der Sensor unter diesen Bedingungen nicht gen?gend Zeit hat, um sein Me?signal zu stabilisieren. M?glicherweise kann er aber in modifizierter For m und mit einer Kalibration f?r niedrigere Konzentrationsbereiche als station?res Me?ger?t eingesetzt werden. F?r hohe CH4-Konzentrationen, wie man sie an Pockmarks antrifft, ist die Methansensormessung sicherlich auch jetzt schon eine geeignete Methode.

    REFERENCE:
    Jokat, Wilfried (1999): ARCTIC 98: The expedition ARK-XIV/1a of RV Polarstern in 1998. Berichte zur Polarforschung (Reports on Polar Research), 308, 159 pp
    Fahrbach, Eberhard (1999): Die Expedition ARKTIS XIV/2 des Forschungsschiffes Polarstern 1998 (The Expedition ARKTIS XIV/2 of the Research Vessel Polarstern in 1998). Berichte zur Polarforschung (Reports on Polar Research), 326, 114 pp
    Language English
    Dates of publication 2000-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is cited by hdl:10013/epic.10311 ; This dataset is cited by hdl:10013/epic.10329 ; This dataset is supplement to hdl:10013/epic.30826.d001
    DOI 10.1594/PANGAEA.701302
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Geothermal Explosion at the 2014 Landslide-Covered Area of the Geyser Valley, Kamchatka, Russian Far East

    Masoud Allahbakhshi / Alina V. Shevchenko / Alexander B. Belousov / Marina G. Belousova / Horst Kämpf / Thomas R. Walter

    GeoHazards, Vol 4, Iss 5, Pp 60-

    2023  Volume 76

    Abstract: Geyser geothermal fields are scenic volcanic landforms that often contain tens to hundreds of thermal spot vents that erupt boiling water or contain bubbling mud pools. The fields are potentially hazardous sites due to boiling water temperatures and ... ...

    Abstract Geyser geothermal fields are scenic volcanic landforms that often contain tens to hundreds of thermal spot vents that erupt boiling water or contain bubbling mud pools. The fields are potentially hazardous sites due to boiling water temperatures and changes in vent locations and eruption dynamics, which are poorly understood. Here we report on the rapid and profound changes that can affect such a geyser field and ultimately lead to a dangerous, unanticipated eruption. We studied the Geyser Valley, Kamchatka Peninsula, which is a field of geysers and other thermal features and boiling pools. Using high-resolution tri-stereo satellite data and unmanned aerial systems (UAS) with optical and thermal infrared cameras in 2018 and 2019, we were able to identify a newly emerging explosion site. Structure-from-motion analysis of data acquired before and after the explosion reveals morphological and thermal details of the new vent. The explosion site produced an aureole zone of more than 150 m 3 of explosively redeposited gravel and clay, a slightly elliptical crater with a diameter of 7.5 m and a crater rim 0.30 m high. However, comparison with archives of photogrammetric data suggests that this site was thermally active years earlier and contained a crater that was obscured and covered by landslides and river sediments. The results allow us to develop a conceptual model and highlight the hazard potential of thermal features buried by landslides and clastic deposits. Sudden explosions may occur at similar sites elsewhere, highlighting the need for careful assessment and monitoring of geomorphological and hydrological changes at geyser sites in other regions.
    Keywords geyser geothermal field ; slope instability ; explosion hazard ; Environmental sciences ; GE1-350
    Subject code 550
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A Combination of Library Screening and Rational Mutagenesis Expands the Available Color Palette of the Smallest Fluorogen-Activating Protein Tag nanoFAST.

    Baleeva, Nadezhda S / Bogdanova, Yulia A / Goncharuk, Marina V / Sokolov, Anatolii I / Myasnyanko, Ivan N / Kublitski, Vadim S / Smirnov, Alexander Yu / Gilvanov, Aidar R / Goncharuk, Sergey A / Mineev, Konstantin S / Baranov, Mikhail S

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: NanoFAST is the smallest fluorogen-activating protein, consisting of only 98 amino acids, used as a genetically encoded fluorescent tag. Previously, only a single fluorogen with an orange color was revealed for this protein. In the present paper, using ... ...

    Abstract NanoFAST is the smallest fluorogen-activating protein, consisting of only 98 amino acids, used as a genetically encoded fluorescent tag. Previously, only a single fluorogen with an orange color was revealed for this protein. In the present paper, using rational mutagenesis and in vitro screening of fluorogens libraries, we expanded the color palette of this tag. We discovered that E46Q is one of the key substitutions enabling the range of possible fluorogens to be expanded. The introduction of this and several other substitutions has made it possible to use not only orange but also red and green fluorogens with the modified protein.
    MeSH term(s) Fluorescent Dyes/chemistry ; Proteins
    Chemical Substances Fluorescent Dyes ; Proteins
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25053054
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  9. Article ; Online: Implications of Concurrent

    Yuile, Alexander / Satgunaseelan, Laveniya / Wei, Joe / Kastelan, Marina / Back, Michael F / Lee, Maggie / Wei, Heng / Buckland, Michael E / Lee, Adrian / Wheeler, Helen R

    Current issues in molecular biology

    2022  Volume 44, Issue 10, Page(s) 5117–5125

    Abstract: ... ...

    Abstract Both
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb44100348
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  10. Article ; Online: Synthesis and Biological Evaluation of Novel

    Ivanenkov, Yan A / Kukushkin, Maxim E / Beloglazkina, Anastasia A / Shafikov, Radik R / Barashkin, Alexander A / Ayginin, Andrey A / Serebryakova, Marina S / Majouga, Alexander G / Skvortsov, Dmitry A / Tafeenko, Viktor A / Beloglazkina, Elena K

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 3

    Abstract: Novel variously substituted thiohydantoin- ... ...

    Abstract Novel variously substituted thiohydantoin-based
    MeSH term(s) Humans ; Animals ; Mice ; Structure-Activity Relationship ; Oxindoles/pharmacology ; Molecular Docking Simulation ; Mice, Nude ; HEK293 Cells ; Antineoplastic Agents/chemistry ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Molecular Structure
    Chemical Substances Oxindoles ; VP1-001 ; Antineoplastic Agents
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28031325
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