LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 250

Search options

  1. Article ; Online: Reply.

    Spaide, Richard F / Vavvas, Demetrios G

    Retina (Philadelphia, Pa.)

    2023  Volume 44, Issue 1, Page(s) e9–e10

    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003904
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Impact of phacoemulsification on posterior vitreous detachment formation in eyes with vitreomacular traction.

    Tieger, Marisa G / Vavvas, Demetrios G

    Digital journal of ophthalmology : DJO

    2023  Volume 29, Issue 2, Page(s) 26–30

    Abstract: Purpose: To investigate the impact of phacoemulsification on posterior vitreous detachment formation in eyes with vitreomacular traction (VMT) with or without macular holes.: Methods: A retrospective search of the medical records was conducted to ... ...

    Abstract Purpose: To investigate the impact of phacoemulsification on posterior vitreous detachment formation in eyes with vitreomacular traction (VMT) with or without macular holes.
    Methods: A retrospective search of the medical records was conducted to identify patients with VMT who underwent cataract surgery at Mass Eye and Ear from 2016 to 2021. Patient demographics, ocular comorbidities, and clinical characteristics were extracted from the record, and optical coherence tomography images were assessed to confirm VMT and the presence of a lamellar or full-thickness macular hole (FMTH). Patients who underwent vitrectomy prior to cataract surgery were excluded.
    Results: A total of 22 patients (15 women [68%]) met inclusion criteria (average age, 71 years). Fifteen eyes had an associated epiretinal membrane (63%), 7 had a lamellar hole (29%), and 8 had an FTMH (33%). Epiretinal membrane was present in 3 of 7 eyes with lamellar holes (43%) and 4 of 8 with a FTMH (50%). No eyes developed a complete posterior vitreous detachment following phacoemulsification. In 2 cases, there was progression of the macular hole stage following phacoemulsification. Ten eyes underwent subsequent pars plana vitrectomy (PPV). There was no statistically significant difference in visual acuity between eyes pre- and post-phacoemulsification; however, there was a statistically significant improvement in visual acuity pre- and post-PPV.
    Conclusions: Unlike other studies, in this case series of 24 eyes with VMT or VMT with holes, no cases of full posterior vitreous detachment occurred following unremarkable phacoemulsification or YAG capsulotomy.
    MeSH term(s) Humans ; Female ; Aged ; Phacoemulsification/adverse effects ; Vitreous Detachment/complications ; Vitreous Detachment/diagnosis ; Vitreous Detachment/surgery ; Retinal Perforations/diagnosis ; Retinal Perforations/etiology ; Retinal Perforations/surgery ; Epiretinal Membrane/diagnosis ; Epiretinal Membrane/surgery ; Retrospective Studies ; Traction ; Cataract
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2030129-7
    ISSN 1542-8958 ; 1542-8958
    ISSN (online) 1542-8958
    ISSN 1542-8958
    DOI 10.5693/djo.01.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Ocular Toxoplasmosis: A Review of Current Literature.

    Patel, Neal S / Vavvas, Demetrios G

    International ophthalmology clinics

    2022  Volume 62, Issue 2, Page(s) 231–250

    MeSH term(s) Humans ; Toxoplasmosis, Ocular/diagnosis
    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207382-1
    ISSN 1536-9617 ; 0020-8167
    ISSN (online) 1536-9617
    ISSN 0020-8167
    DOI 10.1097/IIO.0000000000000419
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 38: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: COMPLEMENT INHIBITION FOR GEOGRAPHIC ATROPHY: Review of Salient Functional Outcomes and Perspective.

    Spaide, Richard F / Vavvas, Demetrios G

    Retina (Philadelphia, Pa.)

    2023  Volume 43, Issue 7, Page(s) 1064–1069

    Abstract: Purpose: To evaluate available rationale and outcomes of randomized trial results for complement inhibition for geographic atrophy.: Methods: Data from recently completed randomized trials of complement inhibition, particularly for pegcetacoplan and ... ...

    Abstract Purpose: To evaluate available rationale and outcomes of randomized trial results for complement inhibition for geographic atrophy.
    Methods: Data from recently completed randomized trials of complement inhibition, particularly for pegcetacoplan and avacincaptad pegol, were evaluated for both the outcome, area of autofluorescence loss, and functional vision tests.
    Results: Pegcetacoplan 2 mg showed statistically significant reduction in expansion of the area of autofluorescence loss with monthly, but not every-other-month dosing, in a 12-month phase two trial. Nearly 40% of patients recruited for the monthly arm did not complete the treatment. In two parallel phase 3 studies there was a statistically significant reduction in the area of atrophy in one but not both studies as compared with untreated controls. Data released at 24 months follow-up showed statistically significant reduction in the area of autofluorescence-detected atrophy in both studies compared with sham. Patients did not show functional difference in best-corrected visual acuity, maximum reading speed, Functional Reading Independence Index, and mean microperimetry threshold sensitivities in the treatment versus sham arms. Avacincaptad pegol was evaluated in two randomized pivotal studies and showed a statistically significant reduction in the expansion of autofluorescence loss at 12 months. Patients in the treatment arms did not show any difference as compared with sham in the best-corrected visual acuity or low luminance visual acuity, the only functional outcomes mentioned. Both drugs increased the risk of macular neovascularization.
    Conclusion: Both avacincaptad pegol and pegcetacoplan show significant differences compared with sham in autofluorescence imaging but no benefit in visual function at 12 and 24 months, respectively.
    MeSH term(s) Humans ; Atrophy ; Geographic Atrophy/diagnosis ; Geographic Atrophy/drug therapy ; Macular Degeneration/drug therapy ; Visual Acuity
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003796
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: SPONTANEOUS CLOSURE AND RECURRENT OPENING TIMES TWO OF A MACULAR HOLE IN A SURGICALLY NAIVE EYE.

    Tieger, Marisa G / Kim, Leo A / Vavvas, Demetrios G

    Retinal cases & brief reports

    2023  Volume 17, Issue 5, Page(s) 581–583

    Abstract: Purpose: To report a case of an idiopathic macular hole with recurrent opening and spontaneous closure in a surgically naive eye.: Methods: A retrospective review of medical records was performed in addition to a review of the current literature.: ... ...

    Abstract Purpose: To report a case of an idiopathic macular hole with recurrent opening and spontaneous closure in a surgically naive eye.
    Methods: A retrospective review of medical records was performed in addition to a review of the current literature.
    Results: An 82-year-old man was referred for the management of a full-thickness macular hole in the right eye. Visual acuity was 20/60, and dilated fundus examination was notable for a posterior vitreous detachment, macular hole, and mild epiretinal membrane. Optical coherence tomography confirmed the presence of a full-thickness macular hole. The patient declined surgical intervention and elected to observe. Five weeks later, optical coherence tomography confirmed spontaneous closure. One year later, a recurrent partial thickness outer retinal hole was noted on dilated fundus examination and optical coherence tomography that subsequently spontaneously closed for the second time. The following year, the patient represented with a new scotoma and metamorphopsia and was found to have a full-thickness macular hole. This time the patient was elected for surgical intervention (25-gauge pars plana vitrectomy, epiretinal membrane peel, and 14% C3F8), resulting in closure of the macular hole and improvement in visual acuity to 20/25+1.
    Conclusion: This case highlights a rare presentation of a see-saw pattern of opening and closing of a macular hole in a treatment-naive eye. The presence of a posterior vitreous detachment and epiretinal membrane suggests that other factors than anterior-posterior and tangential traction may be a contributing in the formation and closure of idiopathic macular holes.
    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Retinal Perforations/diagnosis ; Retinal Perforations/etiology ; Retinal Perforations/surgery ; Epiretinal Membrane/diagnosis ; Epiretinal Membrane/surgery ; Vitreous Detachment/diagnosis ; Vitreous Detachment/surgery ; Fundus Oculi ; Scotoma
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Case Reports ; Review ; Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001244
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Reevaluating the Risk of Serious Adverse Events of Carbonic Anhydrase Inhibitors.

    Bleicher, Isaac D / Rossin, Elizabeth J / Vavvas, Demetrios G

    JAMA ophthalmology

    2022  Volume 140, Issue 7, Page(s) 745–746

    MeSH term(s) Carbonic Anhydrase Inhibitors/adverse effects ; Humans
    Chemical Substances Carbonic Anhydrase Inhibitors
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2022.1565
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Bilateral Hemorrhages in a Premature Infant With Subarachnoid Hemorrhage: An Underrecognized Etiology.

    Rossin, Elizabeth J / Vavvas, Demetrios G

    Ophthalmic surgery, lasers & imaging retina

    2020  Volume 51, Issue 10, Page(s) 596–600

    Abstract: The authors describe an 8-day-old male infant born premature at 31 weeks and 6 days (corrected gestational age: 33 weeks) with cholestatic jaundice and cytomegalovirus (CMV) viremia found to have bilateral multilaminar hemorrhages that represented a ... ...

    Abstract The authors describe an 8-day-old male infant born premature at 31 weeks and 6 days (corrected gestational age: 33 weeks) with cholestatic jaundice and cytomegalovirus (CMV) viremia found to have bilateral multilaminar hemorrhages that represented a diagnostic challenge. Fluorescein angiography (FA) ruled out vasculitis, retinitis, and neovascular process. An extensive laboratory work-up for infectious and coagulopathic etiologies was negative other than a positive systemic viral titer for CMV, but there was no retinitis based on serial exams and FA. Magnetic resonance imaging showed a right-sided subarachnoid hemorrhage, which was felt to be parturitional and confirmed the unifying diagnosis of delivery-associated retinopathy and intracranial hemorrhages in a preterm infant, a term that has been previously described. Simultaneous subarachnoid hemorrhage and vitreoretinal hemorrhage may represent an underrecognized cause of neonatal hemorrhage in preterm infants. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:596-600.].
    MeSH term(s) Brain/diagnostic imaging ; Fluorescein Angiography ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging ; Male ; Retinal Hemorrhage/diagnosis ; Retinal Hemorrhage/etiology ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnosis
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20201005-09
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: CSF1R inhibition is not specific to innate immune cells but also affects T-helper cell differentiation independently of microglia depletion.

    Lei, Fengyang / Cui, Naiwen / Zhou, Chengxin / Chodosh, James / Vavvas, Demetrios G / Paschalis, Eleftherios I

    Research square

    2023  

    Abstract: Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a specific method for microglia depletion. However, recent work revealed that in addition to microglia, CSF1R inhibition also affects other innate immune cells, such as ... ...

    Abstract Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a specific method for microglia depletion. However, recent work revealed that in addition to microglia, CSF1R inhibition also affects other innate immune cells, such as peripheral monocytes and tissue-resident macrophages of the lung, liver, spleen, and peritoneum. Here, we show that this effect is not restricted to innate immune cells only but extends to the adaptive immune compartment. CSF1R inhibition alters the transcriptional profile of bone marrow cells that control T helper cell activation.
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3308220/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Necroptosis and Neuroinflammation in Retinal Degeneration.

    Tao, Yan / Murakami, Yusuke / Vavvas, Demetrios G / Sonoda, Koh-Hei

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 911430

    Abstract: Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ... ...

    Abstract Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse neurodegenerative diseases in the central nervous system and the retina. Targeting RIPK has been proven beneficial for alleviating both neuroinflammation and degeneration in basic/preclinical studies. In this review, we discuss the role of necroptosis in retinal degeneration, including (1) the molecular pathways involving RIPK, (2) RIPK-dependent microglial activation and necroptosis, and (3) the interactions between necroptosis and retinal neuroinflammation/degeneration. This review will contribute to a renewed focus on neuroinflammation induced by necroptosis and to the development of anti-RIPK drugs against retinal degeneration.
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.911430
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Early recurrence of macular schisis in X-linked retinoschisis treated with vitrectomy for rhegmatogenous retinal detachment under silicone oil: case report and brief literature review.

    Stavrakas, Panagiotis / Tsapardoni, Foteini / Karmiris, Efthymios / Iatropoulos, Ioannis / Kounas, Konstantinos / Lygeros, Spyridon / Kozobolis, Vassilios / Vavvas, Demetrios G

    Therapeutic advances in ophthalmology

    2024  Volume 16, Page(s) 25158414241232261

    Abstract: X-linked retinoschisis (XLRS) is an inherited retinal degeneration affecting males, characterized by splitting of the retinal layers. We herein present the outcomes of surgical treatment in a case of XLRS complicated by rhegmatogenous retinal detachment ( ...

    Abstract X-linked retinoschisis (XLRS) is an inherited retinal degeneration affecting males, characterized by splitting of the retinal layers. We herein present the outcomes of surgical treatment in a case of XLRS complicated by rhegmatogenous retinal detachment (RRD). A 22-year-old male presented to the emergency department due to decreased visual acuity and visual field defect in his left eye Oculus Sinister (OS) of 1 week duration. The patient reported an early onset retinal degeneration and decreased visual acuity in both eyes since childhood in his past ocular history. Upon presentation, best corrected visual acuity (BCVA) was 6/30 on the right eye Oculus Dexter (OD) and 6/120 OS. Fundus examination revealed areas of peripheral retinal schisis, and the characteristic spoke wheel pattern on the macula of both eyes. In OS, a temporal RRD involving the macula was identified. The patient underwent surgical treatment with pars plana vitrectomy with internal limiting membrane (ILM) peeling, endolaser, and silicone oil (SO) tamponade. BCVA in OS improved to 6/60 and schistic cavities resolution was observed in the immediate postoperative period. The patient's BCVA further improved to 6/19 at 1 month, as foveal anatomy showed relative improvement. However, there was a rapid reappearance of schisis spaces in the macular area at this point, which was also followed by progressive deterioration of foveal schisis by 3 months post-operatively. The resorption and recurrence of lamellar macular schisis changes after ILM peel and presence of SO, highlights that although XLRS findings can temporarily improve upon surgical intervention, the pathogenetic mechanisms contributing to disease phenotype remain to be elucidated.
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Case Reports
    ISSN 2515-8414
    ISSN (online) 2515-8414
    DOI 10.1177/25158414241232261
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top