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  1. Article ; Online: Linking Brain Age to Psychopathology in Adolescence.

    Kempton, Matthew J

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2021  Volume 6, Issue 4, Page(s) 383–384

    MeSH term(s) Adolescent ; Brain ; Humans ; Mental Disorders ; Psychopathology
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2021.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Concerns regarding calculation of fatality rate of Chinese samples in COVID-19 meta-analysis.

    Kempton, Matthew J

    Journal of medical virology

    2020  Volume 92, Issue 7, Page(s) 710

    MeSH term(s) Actin Depolymerizing Factors ; Betacoronavirus ; CD4-Positive T-Lymphocytes ; COVID-19 ; Coronavirus Infections ; HIV Infections ; Humans ; Immune Reconstitution ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Actin Depolymerizing Factors
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25799
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  3. Article ; Online: Concerns Regarding Strength of Conclusions in Systematic Review and Meta-Analysis of Neuroradiological Abnormalities in First-Episode Psychosis-Reply.

    Blackman, Graham / Kempton, Matthew J / McGuire, Philip

    JAMA psychiatry

    2023  Volume 81, Issue 1, Page(s) 109

    MeSH term(s) Humans ; Psychotic Disorders/diagnostic imaging ; Systematic Reviews as Topic ; Meta-Analysis as Topic
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.4399
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  5. Article ; Online: Concerns regarding calculation of fatality rate of Chinese samples in COVID‐19 meta‐analysis

    Kempton, Matthew J.

    Journal of Medical Virology

    2020  Volume 92, Issue 7, Page(s) 710–710

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25799
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Reply to: Odds and Risk Ratios: When They Are Similar and When They Are Not.

    Cullen, Alexis E / Kempton, Matthew J

    Biological psychiatry

    2019  Volume 86, Issue 1, Page(s) e3

    MeSH term(s) Autoimmune Diseases ; Humans ; Odds Ratio ; Psychotic Disorders
    Language English
    Publishing date 2019-03-27
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2019.02.012
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    Zs.A 720: Show issues Location:
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  7. Article ; Online: Meta-analysis of longitudinal neurocognitive performance in people at clinical high-risk for psychosis.

    Hedges, Emily P / See, Cheryl / Si, Shuqing / McGuire, Philip / Dickson, Hannah / Kempton, Matthew J

    Psychological medicine

    2022  Volume 52, Issue 11, Page(s) 2009–2016

    Abstract: Persons at clinical high-risk for psychosis (CHR) are characterised by specific neurocognitive deficits. However, the course of neurocognitive performance during the prodromal period and over the onset of psychosis remains unclear. The aim of this meta- ... ...

    Abstract Persons at clinical high-risk for psychosis (CHR) are characterised by specific neurocognitive deficits. However, the course of neurocognitive performance during the prodromal period and over the onset of psychosis remains unclear. The aim of this meta-analysis was to synthesise results from follow-up studies of CHR individuals to examine longitudinal changes in neurocognitive performance. Three electronic databases were systematically searched to identify articles published up to 31 December 2021. Thirteen studies met inclusion criteria. Study effect sizes (Hedges'
    MeSH term(s) Humans ; Neuropsychological Tests ; Disease Progression ; Psychotic Disorders/psychology ; Prodromal Symptoms ; Cognition Disorders ; Longitudinal Studies
    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Review
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291722001830
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  8. Article ; Online: Impact of physiological factors on longitudinal structural MRI measures of the brain.

    Zahid, Uzma / Hedges, Emily P / Dimitrov, Mihail / Murray, Robin M / Barker, Gareth J / Kempton, Matthew J

    Psychiatry research. Neuroimaging

    2022  Volume 321, Page(s) 111446

    Abstract: Longitudinal MRI is used in clinical research studies to examine illness progression, neurodevelopment, and the effect of medical interventions. Such studies typically report changes in brain volume of less than 5%. However, there is a concern that these ...

    Abstract Longitudinal MRI is used in clinical research studies to examine illness progression, neurodevelopment, and the effect of medical interventions. Such studies typically report changes in brain volume of less than 5%. However, there is a concern that these findings could be obscured or confounded by small changes in brain volume estimates caused by physiological factors such as, dehydration, blood pressure, caffeine levels, and circadian rhythm. In this study, MRI scans using the ADNI-III protocol were acquired from 20 participants (11 female) at two time points (mean interval = 20.3 days). Hydration, systolic and diastolic blood pressure, caffeine intake, and time of day were recorded at both visits. Images were processed using FreeSurfer. Three a priori hypothesised brain regions (hippocampus, lateral ventricles, and total brain) were selected, and an exploratory analysis was conducted on FreeSurfer's auto-segmented brain regions. There was no significant effect of the physiological factors on changes in the hypothesised brain regions. We provide estimates for the maximum percentage change in regional brain volumes that could be expected to occur from normal variation in each of the physiological measures. In this study, normal variations in physiological parameters did not have a detectable effect on longitudinal changes in brain volume.
    MeSH term(s) Brain/diagnostic imaging ; Female ; Hippocampus ; Humans ; Lateral Ventricles ; Longitudinal Studies ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2022-01-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7506 ; 1872-7123
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.pscychresns.2022.111446
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    Zs.A 1541: Show issues Location:
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  9. Article ; Online: Online speech assessment of the psychotic spectrum: Exploring the relationship between overlapping acoustic markers of schizotypy, depression and anxiety.

    Olah, Julianna / Diederen, Kelly / Gibbs-Dean, Toni / Kempton, Matthew J / Dobson, Richard / Spencer, Thomas / Cummins, Nicholas

    Schizophrenia research

    2023  Volume 259, Page(s) 11–19

    Abstract: Background: Remote assessment of acoustic alterations in speech holds promise to increase scalability and validity in research across the psychosis spectrum. A feasible first step in establishing a procedure for online assessments is to assess acoustic ... ...

    Abstract Background: Remote assessment of acoustic alterations in speech holds promise to increase scalability and validity in research across the psychosis spectrum. A feasible first step in establishing a procedure for online assessments is to assess acoustic alterations in psychometric schizotypy. However, to date, the complex relationship between alterations in speech related to schizotypy and those related to comorbid conditions such as symptoms of depression and anxiety has not been investigated. This study tested whether (1) depression, generalized anxiety and high psychometric schizotypy have similar voice characteristics, (2) which acoustic markers of online collected speech are the strongest predictors of psychometric schizotypy, (3) whether including generalized anxiety and depression symptoms in the model can improve the prediction of schizotypy.
    Methods: We collected cross-sectional, online-recorded speech data from 441 participants, assessing demographics, symptoms of depression, generalized anxiety and psychometric schizotypy.
    Results: Speech samples collected online could predict psychometric schizotypy, depression, and anxiety symptoms with weak to moderate predictive power, and with moderate and good predictive power when basic demographic variables were added to the models. Most influential features of these models largely overlapped. The predictive power of speech marker-based models of schizotypy significantly improved after including symptom scores of depression and generalized anxiety in the models (from R
    Conclusions: Acoustic features of online collected speech are predictive of psychometric schizotypy as well as generalized anxiety and depression symptoms. The acoustic characteristics of schizotypy, depression and anxiety symptoms significantly overlap. Speech models that are designed to predict schizotypy or symptoms of the schizophrenia spectrum might therefore benefit from controlling for symptoms of depression and anxiety.
    MeSH term(s) Humans ; Schizotypal Personality Disorder/complications ; Schizotypal Personality Disorder/diagnosis ; Depression/diagnosis ; Speech ; Cross-Sectional Studies ; Anxiety/diagnosis
    Language English
    Publishing date 2023-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2023.03.044
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  10. Article ; Online: A meta-analysis of structural MRI studies of the brain in systemic lupus erythematosus (SLE).

    Cox, Jennifer G / de Groot, Marius / Cole, James H / Williams, Steven C R / Kempton, Matthew J

    Clinical rheumatology

    2022  Volume 42, Issue 2, Page(s) 319–326

    Abstract: A comprehensive search of published literature in brain volumetry was conducted in three autoimmune diseases - systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ulcerative colitis (UC) - with the intention of performing a meta-analysis ... ...

    Abstract A comprehensive search of published literature in brain volumetry was conducted in three autoimmune diseases - systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ulcerative colitis (UC) - with the intention of performing a meta-analysis of published data. Due to the lack of data in RA and UC, the reported meta-analysis was limited to SLE. The MEDLINE database was searched for studies from 1988 to March 2022. A total of 175 papers met the initial inclusion criteria, and 16 were included in a random-effects meta-analysis. The reduction in the number of papers included in the final analysis is primarily due to the lack of overlap in measured and reported brain regions. A significantly lower volume was seen in patients with SLE in the hippocampus, corpus callosum, and total gray matter volume measurements as compared to age- and sex-matched controls. There were not enough studies to perform a meta-analysis for RA and UC; instead, we include a summary of published volumetric studies. The meta-analyses revealed structural brain abnormalities in patients with SLE, suggesting that lower global brain volumes are associated with disease status. This volumetric difference was seen in both the hippocampus and corpus callosum and total gray matter volume measurements. These results indicate both gray and white matter involvements in SLE and suggest there may be both localized and global reductions in brain volume.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/diagnostic imaging ; Lupus Erythematosus, Systemic/complications ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Arthritis, Rheumatoid/complications ; Autoimmune Diseases/complications
    Language English
    Publishing date 2022-12-19
    Publishing country Germany
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-022-06482-8
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