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Article ; Online: Multidisciplinary precision treatment of brain metastasis in breast cancer

Chang Haiyan, Cheng Jing

Xin yixue, Vol 54, Iss 2, Pp 157-

a case report

2023 Volume 162

Abstract: Human epidermal growth factor receptor-2 （HER2） -positive breast cancer is highly aggressive， with high recurrence rate and poor prognosis. Approximately 50% of patients with metastatic HER2-positive breast cancer will develop brain metastases. In recent ...

Abstract	Human epidermal growth factor receptor-2 （HER2） -positive breast cancer is highly aggressive， with high recurrence rate and poor prognosis. Approximately 50% of patients with metastatic HER2-positive breast cancer will develop brain metastases. In recent years， the emergence of targeted therapy has significantly prolonged the survival of breast cancer patients. However， how to penetrate the blood-brain barrier and improve prognostic effect of breast cancer brain metastasis is still a challenge facing researchers. Here， we reported a case of HER2-positive breast cancer patient with brain metastasis who was resistant to trastuzumab and small-molecule tyrosine kinase inhibitor （TKI） and could not be reached by trastuzumab emtansine （TDM-1）. After multidisciplinary consultation by Department of Breast Surgery， Department of Oncology， Department of Pathology and Department of Imaging， the patient was treated with inetetamab. Throughout the treatment， the patient had stable extracranial lesions and progressive intracranial lesions. Hence， systemic treatment was continued and local treatment intervention was strengthened. The progression of disease was effectively controlled. The diagnosis and treatment of this case suggest that treatment methods for patients with HER2-positive breast cancer with brain metastases should be determined according to the characteristics of brain metastases and extracranial lesions， physical and economic status and previous treatment mode. Multidisciplinary diagnosis and treatment contribute to identifying the optimal individualized treatment and improving clinical prognosis.
Keywords	\|her2 positive\|breast cancer\|brain metastasis\|inetetamab\|multidisciplinary diagnosis and treatment ; Medicine ; R
Subject code	616 ; 610
Language	Chinese
Publishing date	2023-02-01T00:00:00Z
Publisher	Editorial Office of Journal of New Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Impact of Treatment Delay on the Prognosis of Patients with Ovarian Cancer: A Population-based Study Using the Surveillance, Epidemiology, and End Results Database.

Zhao, Jing / Chen, Ruiying / Zhang, Yanli / Wang, Yu / Zhu, Haiyan

Journal of Cancer

2024 Volume 15, Issue 2, Page(s) 473–483

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.87881
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Research progress, trends, and updates on pollutants removal by Bi

Li, Sen / Liu, Yiling / Xiao, Yanbo / Ma, Haiyan / Duan, Jing

Heliyon

2024 Volume 10, Issue 5, Page(s) e27115

Abstract: In recent years, extensive research has been conducted on bismuth tungstate ( ... ...

Abstract	In recent years, extensive research has been conducted on bismuth tungstate (Bi
Language	English
Publishing date	2024-02-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27115
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Article ; Online: Molecular study of patients with odontohypophosphatasia resulting from missense mutation in ALPL.

Yue, Haitang / Cao, Haiyan / Zhi, Yusheng / Song, Guangtai / Cheng, Jing / He, Miao

Oral diseases

2024

Language	English
Publishing date	2024-04-09
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14955
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Zs.A 4427: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: A retrospective analysis of children with mild and asymptomatic Omicron infections under 14: A single-center study.

Sun, Jing / Zhang, Haiyan / Yang, Zhen

Medicine

2024 Volume 103, Issue 7, Page(s) e37149

Abstract: Omicron BA.5 subvariant has been proven to be more transmissible than other Omicron subvariants. But the studies on the spread of the Omicron BA.5 subvariant in children are still limited. This study aimed to analyze the clinical features of children ... ...

Abstract	Omicron BA.5 subvariant has been proven to be more transmissible than other Omicron subvariants. But the studies on the spread of the Omicron BA.5 subvariant in children are still limited. This study aimed to analyze the clinical features of children infected with Omicron BA.5.2 variant in the mobile cabin hospital and the influence factors of the infections. Children with mild and asymptomatic Omicron infections under 14 years old who were admitted to the mobile cabin hospital from October 30 to December 7, 2022 were retrospectively collected. A total of 741 children, 424 boys (57.2%) and 317 girls (42.8%) were enrolled, including 145 asymptomatic cases (22.7%) and 493 (77.3%) mild cases. Upper respiratory tract infection was the dominant manifestation. Fever was the most common presenting symptom (80.7%), followed by cough (52.5%). The average time to symptom disappearance was 3.76 days, and the average negative conversion time of nucleic acid was 12.3 days. Univariate analysis showed that the negative conversion time of nucleic acid differed significantly across the age groups. The multivariate analysis showed that the older the age, the longer the negative conversion time of nucleic acid. Among those with the negative conversion time of nucleic acid longer than 12 days, age was positively correlated to the negative conversion time of nucleic acid, while the number of vaccine doses received was negatively correlated to the negative conversion time of nucleic acid. Omicron infection occurred in children of any age group, with good prospect for recovery. Age and number of vaccine doses received were risk factors influencing the negative conversion time of nucleic acid.
MeSH term(s)	Male ; Child ; Female ; Humans ; Adolescent ; Retrospective Studies ; Asymptomatic Infections/epidemiology ; Cough/etiology ; Nucleic Acids ; Vaccines
Chemical Substances	Nucleic Acids ; Vaccines
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037149
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Ua VI Zs.171: Show issues

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Article: ALKBH1

Zhang, Xinxin / Zhou, Chunlei / Zhao, Yemu / Deng, Changmi / Wu, Haiyan / Zhuo, Zhenjian / He, Jing

Journal of Cancer

2024 Volume 15, Issue 2, Page(s) 526–532

Abstract: Neuroblastoma is a highly malignant extracranial solid tumor in pediatrics. ALKBH1 as a recently discovered DNA N6-methyldeoxyadenosine (6mA) demethylase closely links to tumorigenesis. Whether ... ...

Abstract	Neuroblastoma is a highly malignant extracranial solid tumor in pediatrics. ALKBH1 as a recently discovered DNA N6-methyldeoxyadenosine (6mA) demethylase closely links to tumorigenesis. Whether the
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.89271
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Palladium-Catalyzed Domino Conversion of Aryl-Thianthreniums with Anhydrides: Rapidly Building Highly Functionalized Fluorenones.

Nan, Jiang / Xiao, Haiyan / Ma, Yangmin / Fan, Liangxin / Wang, Jing

Organic letters

2024 Volume 26, Issue 16, Page(s) 3332–3337

Abstract: As a class of rising electrophilic coupling reagents, aryl-thianthreniums (aryl-TTs) have been gaining immense attention. Herein, a novel palladium-catalyzed domino annulation of aryl-TTs with anhydrides is proposed to rapidly assemble a collection of ... ...

Abstract	As a class of rising electrophilic coupling reagents, aryl-thianthreniums (aryl-TTs) have been gaining immense attention. Herein, a novel palladium-catalyzed domino annulation of aryl-TTs with anhydrides is proposed to rapidly assemble a collection of highly functionalized fluorenones. This finding presents an innovative reaction pattern of aryl-TTs wherein the domino annulation version is first involved. Heavily compared with the existing conversions with aryl-TTs, this identified process successively functions as four aryl C-H bonds.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.4c00302
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Blood Homocysteine on the Outcome of Artificial Insemination in Women with Polycystic Ovary Syndrome

Jing Cao / Haiyan Wang

BioMed Research International, Vol

2022 Volume 2022

Abstract: Background. Polycystic ovary syndrome (PCOS) is the major reason for women’s low fertility and the most frequent endocrine disorder in women of childbearing age. Homocysteine is an amino acid that contains sulfur that has been negatively correlated with ... ...

Abstract	Background. Polycystic ovary syndrome (PCOS) is the major reason for women’s low fertility and the most frequent endocrine disorder in women of childbearing age. Homocysteine is an amino acid that contains sulfur that has been negatively correlated with the reproductive outcome of polycystic women treated with IVF/ICSI. However, the impact of blood homocysteine levels on the outcome of artificial insemination in polycystic ovary syndrome women is unknown. The goal of this study is to examine the impact of serum homocysteine on the result of intrauterine insemination in females who have polycystic ovary syndrome (PCOS). Methods. 96 infertile women (129 cycles) treated with artificial insemination were collected, including 66 cases (87 cycles) in the case group (PCOS group) and 30 cases (42 cycles) in the control group (male factor infertility). The differences in general data amongst two groups, such as BMI, Hcy, and age, were compared. The case group has been classified into two groups based on serum Hcy level: LHcy group (Hcy<15) and HHcy group (Hcy≥15). The relationship among pregnancy and serum Hcy level outcome in PCOS women was compared. Results. The PCOS group had substantially increased serum homocysteine levels in comparison to the control group (P=0.019). Among PCOS women, the clinical pregnancy rates of artificial insemination in the HHcy group and LHcy group were 14.29% and 37.88%. The difference among the two groups was substantial (P=0.044). Artificial insemination frequency, ovulation induction, BMI, infertility years, AMH, serum testosterone, HOME IR, TSH, TPOAb, hCG, daily follicle size, intimal thickness, and other factors did not differ greatly between the two groups. Conclusion. Serum homocysteine levels are increased in women having PCOS. Their levels above the threshold will lower the clinical pregnancy rate of intrauterine insemination in PCOS women.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Sulfomethylation reactivity enhanced the Fenton oxidation pretreatment of bamboo residues for enzymatic digestibility and ethanol production.

Liu, Zhaoming / Zhang, Min / Hou, Qinpei / Shi, Zhengjun / Yang, Haiyan / Wang, Dawei / Yang, Jing

Frontiers in bioengineering and biotechnology

2024 Volume 12, Page(s) 1344964

Abstract: Bamboo is considered a renewable energy bioresource for solving the energy crisis and climate change. ...

Abstract	Bamboo is considered a renewable energy bioresource for solving the energy crisis and climate change.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2024.1344964
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Article ; Online: Knockdown of SETD5 inhibited glycolysis and tumor growth in gastric cancer cells by down-regulating Akt signaling pathway

Shi Jing / Yu Litao / Zhu Changhong / Zhong Haiyan

Open Life Sciences, Vol 18, Iss 1, Pp 423-

2023 Volume 35

Abstract: Gastric cancer (GC) is the 5th most common cancer and the 3rd leading cause of cancer-related death worldwide. It is of great significance to study the underlying molecular mechanism of GC, and targeting glycolysis is a good strategy to treat GC. SET ... ...

Abstract	Gastric cancer (GC) is the 5th most common cancer and the 3rd leading cause of cancer-related death worldwide. It is of great significance to study the underlying molecular mechanism of GC, and targeting glycolysis is a good strategy to treat GC. SET domain containing 5 (SETD5) contains a catalytic methyltransferase SET domain, which is known as a lysine methyltransferase that affects the progression of multiple cancers. However, its possible role in GC was still unclear. Here, we revealed that SETD5 was highly expressed in GC and was associated with a poor prognosis. Further through the in vitro experiments, we revealed that the downregulation of SETD5 inhibited the proliferation and migration of GC cells. Knockdown of SETD5 inhibited glucose consumption and glycolysis. Further studies have shown that SETD5 knockdown restrained the Akt signaling pathway. Therefore, we thought that SETD5 could act as a GC target.
Keywords	gastric cancer ; set domain containing 5 ; proliferation ; glucose consumption ; glycolysis ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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