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  1. Article ; Online: Correction to: Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect.

    Jeong, Gi Seok / Chang, Joon Young / Park, Ji Soo / Lee, Seung-A / Park, DoYeun / Woo, Junsung / An, Heeyoung / Lee, C Justin / Lee, Sang-Hoon

    Molecular brain

    2021  Volume 14, Issue 1, Page(s) 93

    Language English
    Publishing date 2021-06-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-021-00797-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Substance P/Heparin-Conjugated PLCL Mitigate Acute Gliosis on Neural Implants and Improve Neuronal Regeneration via Recruitment of Neural Stem Cells.

    Kim, Donghak / Park, DoYeun / Kim, Tae Hee / Chung, Justin J / Jung, Youngmee / Kim, Soo Hyun

    Advanced healthcare materials

    2021  Volume 10, Issue 18, Page(s) e2100107

    Abstract: The inflammatory host tissue response, characterized by gliosis and neuronal death at the neural interface, limits signal transmission and longevity of the neural probe. Substance P induces an anti-inflammatory response and neuronal regeneration and ... ...

    Abstract The inflammatory host tissue response, characterized by gliosis and neuronal death at the neural interface, limits signal transmission and longevity of the neural probe. Substance P induces an anti-inflammatory response and neuronal regeneration and recruits endogenous stem cells. Heparin prevents nonspecific protein adsorption, suppresses the inflammatory response, and is beneficial to neuronal behavior. Poly(l-lactide-co-ε-caprolactone) (PLCL) is a soft and flexible polymer, and PLCL covalently conjugated with biomolecules has been widely used in tissue engineering. Coatings of heparin-conjugated PLCL (Hep-PLCL), substance P-conjugated PLCL (SP-PLCL), and heparin/substance P-conjugated PLCL (Hep/SP-PLCL) reduced the adhesion of astrocytes and fibroblasts and improved neuronal adhesion and neurite development compared to bare glass. The effects of these coatings are evaluated using immunohistochemistry analysis after implantation of coated stainless steel probes in rat brain for 1 week. In particular, Hep/SP-PLCL coating reduced the activation of microglia and astrocytes, the neuronal degeneration caused by inflammation, and indicated a potential for neuronal regeneration at the tissue-device interface. Suppression of the acute host tissue response by coating Hep/SP-PLCL could lead to improved functionality of the neural prosthesis.
    MeSH term(s) Animals ; Gliosis ; Heparin ; Neural Stem Cells ; Polyesters ; Rats ; Regeneration ; Substance P ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Polyesters ; Substance P (33507-63-0) ; Heparin (9005-49-6)
    Language English
    Publishing date 2021-07-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202100107
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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  3. Article ; Online: Organ-Level Functional 3D Tissue Constructs with Complex Compartments and their Preclinical Applications.

    Lee, Jaeseo / Park, DoYeun / Seo, Yoojin / Chung, Justin J / Jung, Youngmee / Kim, Soo Hyun

    Advanced materials (Deerfield Beach, Fla.)

    2020  Volume 32, Issue 51, Page(s) e2002096

    Abstract: There is an increasing interest in organ-level 3D tissue constructs, owing to their mirroring of in vivo-like features. This has resulted in a wide range of preclinical applications to obtain cell- or tissue-specific responses. Additionally, the ... ...

    Abstract There is an increasing interest in organ-level 3D tissue constructs, owing to their mirroring of in vivo-like features. This has resulted in a wide range of preclinical applications to obtain cell- or tissue-specific responses. Additionally, the development and improvement of sophisticated technologies, such as organoid generation, microfluidics, hydrogel engineering, and 3D printing, have enhanced 3D tissue constructs to become more elaborate. In particular, recent studies have focused on including complex compartments, i.e., vascular and innervation structured 3D tissue constructs, which mimic the nature of the human body in that all tissues/organs are interconnected and physiological phenomena are mediated through vascular and neural systems. Here, the strategies are categorized according to the number of dimensions (0D, 1D, 2D, and 3D) of the starting materials for scaling up, and novel approaches to introduce increased complexity in 3D tissue constructs are highlighted. Recent advances in preclinical applications are also investigated to gain insight into the future direction of 3D tissue construct research. Overcoming the challenges in improving organ-level functional 3D tissue constructs both in vitro and in vivo will ultimately become a life-saving tool in the biomedical field.
    Language English
    Publishing date 2020-10-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202002096
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  4. Article ; Online: Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia.

    Moon, Ik Jun / Yoon, Hae Kyeong / Kim, Doyeun / Choi, Myung Eun / Han, Seung Hee / Park, June Hyun / Hong, Sun Woo / Cho, Hyesoo / Lee, Dong-Ki / Won, Chong Hyun

    Molecular pharmaceutics

    2022  Volume 20, Issue 1, Page(s) 128–135

    Abstract: Asymmetric small interfering RNAs (asiRNAs) that mediate RNA interference have been investigated for therapeutic use in various tissues, including skin tissue. Androgenetic alopecia (AGA) is caused by a combination of genetic factors, resulting in ... ...

    Abstract Asymmetric small interfering RNAs (asiRNAs) that mediate RNA interference have been investigated for therapeutic use in various tissues, including skin tissue. Androgenetic alopecia (AGA) is caused by a combination of genetic factors, resulting in sensitivity to dihydrotestosterone (DHT), which binds to the androgen receptor (AR) to mediate a series of biomolecular changes leading to hair loss. This study aimed to evaluate the therapeutic potential of a cell-penetrating, AR-targeting asiRNA (cp-asiAR) for AGA treatment, which was designed to silence the
    MeSH term(s) Mice ; Animals ; Humans ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; RNA, Small Interfering/metabolism ; Alopecia/drug therapy ; Alopecia/genetics ; Hair/metabolism ; Hair Follicle ; Disease Models, Animal ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemical Substances Receptors, Androgen ; RNA, Small Interfering ; RNA, Messenger
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00510
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  5. Article ; Online: Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration.

    Park, DoYeun / Kim, Donghak / Park, Su Jeong / Choi, Jeong Ho / Seo, Yoojin / Kim, Dong-Hwee / Lee, Sang-Hoon / Hyun, Jung Keun / Yoo, Jin / Jung, Youngmee / Kim, Soo Hyun

    NPJ Regenerative medicine

    2022  Volume 7, Issue 1, Page(s) 62

    Abstract: Guiding the regrowth of thousands of nerve fibers within a regeneration-friendly environment enhances the regeneration capacity in the case of peripheral nerve injury (PNI) and spinal cord injury (SCI). Although clinical treatments are available and ... ...

    Abstract Guiding the regrowth of thousands of nerve fibers within a regeneration-friendly environment enhances the regeneration capacity in the case of peripheral nerve injury (PNI) and spinal cord injury (SCI). Although clinical treatments are available and several studies have been conducted, the development of nerve guidance conduits (NGCs) with desirable properties, including controllable size, hundreds of nerve bundle-sized microchannels, and host stem-cell recruitment, remains challenging. In this study, the micropattern-based fabrication method was combined with stem-cell recruitment factor (substance P, SP) immobilization onto the main material to produce a size-tunable NGC with hundreds of microchannels with stem-cell recruitment capability. The SP-immobilized multiple microchannels aligned the regrowth of nerve fibers and recruited the host stem cells, which enhanced the functional regeneration capacity. This method has wide applicability in the modification and augmentation of NGCs, such as bifurcated morphology or directional topographies on microchannels. Additional improvements in fabrication will advance the regeneration technology and improve the treatment of PNI/SCI.
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-022-00257-0
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  6. Article: Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

    Park, DoYeun / Lee, Jaeseo / Chung, Justin J / Jung, Youngmee / Kim, Soo Hyun

    Trends in biotechnology. 2019,

    2019  

    Abstract: Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as ... ...

    Abstract Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.
    Keywords drugs ; innervation ; models ; organ-on-a-chip
    Language English
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2019.06.006
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
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  7. Article: A case of atypical hemolytic uremic syndrome associated with the

    Cho, Hye Jeong / Kim, Jung O / Huh, Ji Young / Park, Yong / Kim, Myung-Gyu / Oh, Doyeun

    Blood research

    2016  Volume 51, Issue 3, Page(s) 210–213

    Language English
    Publishing date 2016-09-23
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2016.51.3.210
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  8. Article ; Online: Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation.

    Park, DoYeun / Lee, Jaeseo / Chung, Justin J / Jung, Youngmee / Kim, Soo Hyun

    Trends in biotechnology

    2019  Volume 38, Issue 1, Page(s) 99–112

    Abstract: Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as ... ...

    Abstract Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.
    MeSH term(s) Animals ; Blood Vessels/cytology ; Blood Vessels/physiology ; Cells, Cultured ; Drug Discovery ; Humans ; Lab-On-A-Chip Devices ; Models, Biological ; Neovascularization, Physiologic/physiology ; Nerve Tissue/cytology ; Nerve Tissue/physiology ; Tissue Array Analysis
    Language English
    Publishing date 2019-07-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2019.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Genetic Variants of

    Kim, Jung Oh / Jun, Hak Hoon / Kim, Eo Jin / Lee, Jeong Yong / Park, Han Sung / Ryu, Chang Soo / Kim, Seungki / Oh, Doyeun / Kim, Jong Woo / Kim, Nam Keun

    Frontiers in oncology

    2020  Volume 10, Page(s) 72

    Abstract: In colorectal carcinogenesis, the unique molecular and genetic changes that occur within cells result in specific CRC phenotypes. The involvement of the long non-coding RNA, ...

    Abstract In colorectal carcinogenesis, the unique molecular and genetic changes that occur within cells result in specific CRC phenotypes. The involvement of the long non-coding RNA,
    Language English
    Publishing date 2020-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00072
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  10. Article ; Online: Author Correction: The use of microfluidic spinning fiber as an ophthalmology suture showing the good anastomotic strength control.

    Park, DoYeun / Yong, In Sung / Cho, Kyong Jin / Cheng, Jie / Jung, Youngmee / Kim, Soo Hyun / Lee, Sang-Hoon

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 13293

    Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    Abstract A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
    Language English
    Publishing date 2018-08-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-31315-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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