Article: [THE BIG CHALLENGES OF PEDIATRIC NEPHROLOGY AT THE OUTSET OF THE THIRD DECADE OF THE 21ST CENTURY].
2021 Volume 160, Issue 12, Page(s) 827–832
Abstract: Introduction: Over the past few decades, there have been tremendous advancements in the field of nephrology due to developments in genetics and molecular biology, such as the ability to pinpoint the causative mutations in congenital syndromes involving ... ...
| Abstract | Introduction: Over the past few decades, there have been tremendous advancements in the field of nephrology due to developments in genetics and molecular biology, such as the ability to pinpoint the causative mutations in congenital syndromes involving the kidneys, animal models of kidney disease and an array of tools for manipulating nucleic acids. However, despite these achievements, in most cases, these sophisticated technologies have yet to translate into improved outcomes. Thus, there are still several important challenges in the field of pediatric nephrology, the most important of which are reviewed herein. These include: 1. Better understanding of the association between a specific genotype and disease phenotype in congenital anomalies of the kidney and urinary tract, and development of effective treatments for these anomalies. 2. Deeper understanding of the pathophysiology of genetic kidney diseases. 3. Application of the available molecular tools for the purpose of genetic treatments of congenital kidney disease. 4. Uncovering the underlying mechanisms of renal fibrosis and establishment of effective means of halting/preventing it. Advancements in any of these areas have a great potential to influence the prognosis of children with kidney diseases, and considering the fast pace in which new knowledge is acquired and technologies are developed, it is expected that at least some of these challenges will be met in the foreseeable future. |
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| MeSH term(s) | Animals ; Humans ; Kidney ; Kidney Diseases/diagnosis ; Kidney Diseases/genetics ; Kidney Diseases/therapy ; Nephrology ; Prognosis ; Urinary Tract |
| Language | Hebrew |
| Publishing date | 2021-12-27 |
| Publishing country | Israel |
| Document type | Journal Article ; Review |
| ZDB-ID | 953872-0 |
| ISSN | 0017-7768 |
| ISSN | 0017-7768 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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