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  1. Book: Regulatory networks in stem cells

    Rajasekhar, Vinagolu K.

    2009  

    Author's details ed. by Vinagolu K. Rajasekhar
    Keywords Stem Cells / physiology ; Cell Physiological Processes ; Stem cells ; Cell metabolism/Regulation
    Language English
    Size XXI, 601 S., [6] Bl. : Ill., graph. Darst., 29cm
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016070884
    ISBN 1-60327-226-7 ; 978-1-60327-226-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 4507 order for loan Magazin

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  2. Book: Cancer stem cells

    Rajasekhar, Vinagolu K

    2014  

    Abstract: Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how ...

    Author's details editor, Vinagolu K. Rajasekhar
    Abstract "Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic.Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology"--Provided by publisher.
    MeSH term(s) Neoplastic Stem Cells
    Language English
    Size xxxv, 508 pages :, illustrations
    Document type Book
    ISBN 9781118356166 ; 1118356160
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization.

    Ben-Chetrit, Nir / Niu, Xiang / Sotelo, Jesus / Swett, Ariel D / Rajasekhar, Vinagolu K / Jiao, Maria S / Stewart, Caitlin M / Bhardwaj, Priya / Kottapalli, Sanjay / Ganesan, Saravanan / Loyher, Pierre-Louis / Potenski, Catherine / Hannuna, Assaf / Brown, Kristy A / Iyengar, Neil M / Giri, Dilip D / Lowe, Scott W / Healey, John H / Geissmann, Frederic /
    Sagi, Irit / Joyce, Johanna A / Landau, Dan A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME, macrophages adopt ... ...

    Abstract Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME, macrophages adopt diverse phenotypic alterations, giving rise to heterogeneous immune activation states and induction of cell cycle. While the transcriptional profiles of these activation states are well-annotated across human cancers, the underlying signals that regulate macrophage heterogeneity and accumulation remain incompletely understood. Here, we leveraged a novel
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.24.563749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Analytical methods for cancer stem cells.

    Rajasekhar, Vinagolu K

    Methods in molecular biology (Clifton, N.J.)

    2007  Volume 407, Page(s) 83–95

    Abstract: The primary characteristics of adult stem cells are maintaining prolonged quiescence, ability to self-renew and plasticity to differentiate into multiple cell types. These properties are evolutionarily conserved from fruit fly to humans. Similar to ... ...

    Abstract The primary characteristics of adult stem cells are maintaining prolonged quiescence, ability to self-renew and plasticity to differentiate into multiple cell types. These properties are evolutionarily conserved from fruit fly to humans. Similar to normal tissue repair in organs, the stem cell concept is inherently impregnated in the etiology of cancer. Tumors contain a minor population of tumor-initiating cells, called "cancer stem cells". The cancer stem cells maintain some similarities in self-renewal and differentiation features of normal adult stem cells. Therefore, various methods developed originally for the analysis and characterization of adult stem cells are being extended to evaluate cancer stem cells. Relevant methods that are used generally across normal stem cells as well as cancer stem cells are summarized. Combination of two or more of these methods for validation of cancer stem cells appears to be a promising approach for the precise isolation and analysis of cancer stem cells.
    MeSH term(s) Adult Stem Cells/cytology ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cell Separation/methods ; Flow Cytometry/methods ; Fluorescent Antibody Technique/methods ; Humans ; Neoplastic Stem Cells/cytology ; Regeneration/physiology
    Language English
    Publishing date 2007
    Publishing country United States
    Document type Journal Article
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1007/978-1-59745-536-7_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Photobiomodulation effects on head and neck squamous cell carcinoma (HNSCC) in an orthotopic animal model.

    Barasch, Andrei / Li, Hongyan / Rajasekhar, Vinagolu K / Raber-Durlacher, Judith / Epstein, Joel B / Carroll, James / Haimovitz-Friedman, Adriana

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2019  Volume 28, Issue 6, Page(s) 2721–2727

    Abstract: Background: Photobiomodulation (PBM) has shown efficacy in preventing and treating cancer therapy-induced mucositis and dermatitis. However, there is contradictory information regarding the effect of PBM on (pre)malignant cells, which has led to ... ...

    Abstract Background: Photobiomodulation (PBM) has shown efficacy in preventing and treating cancer therapy-induced mucositis and dermatitis. However, there is contradictory information regarding the effect of PBM on (pre)malignant cells, which has led to questions regarding the safety of this technique. We address this issue using an orthotopic mouse model (Cal-33) with human squamous cell carcinoma of the oral cavity.
    Methods: Mice with actively growing orthotopic Cal-33 head and neck carcinoma tumors were divided into 4 groups: control, PBM only, radiation therapy (RT) only, and PBM + RT. We performed three experiments: (1) PBM at 660 nm, 18.4 J/cm
    Results: Animals treated with RT survived significantly longer and had significantly smaller tumor volume when compared with the control and PBM-only treatment groups. No significant differences were noted between the RT alone and PBM + RT groups in any of the experiments.
    Conclusion: Our results suggest that PBM at the utilized parameters does not provide protection to the tumor from the killing effects of RT.
    MeSH term(s) Animals ; Cell Line, Tumor ; Dermatitis/pathology ; Disease Models, Animal ; Humans ; Low-Level Light Therapy/adverse effects ; Low-Level Light Therapy/methods ; Mice ; Mice, Nude ; Mice, SCID ; Mucositis/pathology ; Neoplasm Transplantation ; Radiotherapy/adverse effects ; Squamous Cell Carcinoma of Head and Neck/radiotherapy ; Stomatitis/pathology ; Transplantation, Heterologous
    Language English
    Publishing date 2019-11-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-019-05060-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3697: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Substrates for Expansion of Corneal Endothelial Cells towards Bioengineering of Human Corneal Endothelium.

    Navaratnam, Jesintha / Utheim, Tor P / Rajasekhar, Vinagolu K / Shahdadfar, Aboulghassem

    Journal of functional biomaterials

    2015  Volume 6, Issue 3, Page(s) 917–945

    Abstract: Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision. Currently, transplantation is the only therapeutic option for diseases ... ...

    Abstract Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision. Currently, transplantation is the only therapeutic option for diseases affecting the corneal endothelium. Transplantation of corneal endothelium, called endothelial keratoplasty, is widely used for corneal endothelial diseases. However, corneal transplantation is limited by global donor shortage. Therefore, there is a need to overcome the deficiency of sufficient donor corneal tissue. New approaches are being explored to engineer corneal tissues such that sufficient amount of corneal endothelium becomes available to offset the present shortage of functional cornea. Although human corneal endothelial cells have limited proliferative capacity in vivo, several laboratories have been successful in in vitro expansion of human corneal endothelial cells. Here we provide a comprehensive analysis of different substrates employed for in vitro cultivation of human corneal endothelial cells. Advances and emerging challenges with ex vivo cultured corneal endothelial layer for the ultimate goal of therapeutic replacement of dysfunctional corneal endothelium in humans with functional corneal endothelium are also presented.
    Language English
    Publishing date 2015-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb6030917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms.

    Spevak, Christina C / Elias, Harold K / Kannan, Lavanya / Ali, Mohamed A E / Martin, Gaëlle H / Selvaraj, Shanmugapriya / Eng, William S / Ernlund, Amanda / Rajasekhar, Vinagolu K / Woolthuis, Carolien M / Zhao, Guangjie / Ha, Caryn J / Schneider, Robert J / Park, Christopher Y

    Cell stem cell

    2020  Volume 26, Issue 5, Page(s) 755–765.e7

    Abstract: Hematopoietic stem cells (HSCs) require highly regulated rates of protein synthesis, but it is unclear if they or lineage-committed progenitors preferentially recruit transcripts to translating ribosomes. We utilized polysome profiling, RNA sequencing, ... ...

    Abstract Hematopoietic stem cells (HSCs) require highly regulated rates of protein synthesis, but it is unclear if they or lineage-committed progenitors preferentially recruit transcripts to translating ribosomes. We utilized polysome profiling, RNA sequencing, and whole-proteomic approaches to examine the translatome in LSK (Lin
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Proteomics ; Signal Transduction ; TOR Serine-Threonine Kinases
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2019.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6589: Show issues Location:
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  8. Article ; Online: Substrates for Expansion of Corneal Endothelial Cells towards Bioengineering of Human Corneal Endothelium

    Jesintha Navaratnam / Tor P. Utheim / Vinagolu K. Rajasekhar / Aboulghassem Shahdadfar

    Journal of Functional Biomaterials, Vol 6, Iss 3, Pp 917-

    2015  Volume 945

    Abstract: Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision. Currently, transplantation is the only therapeutic option for diseases ... ...

    Abstract Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision. Currently, transplantation is the only therapeutic option for diseases affecting the corneal endothelium. Transplantation of corneal endothelium, called endothelial keratoplasty, is widely used for corneal endothelial diseases. However, corneal transplantation is limited by global donor shortage. Therefore, there is a need to overcome the deficiency of sufficient donor corneal tissue. New approaches are being explored to engineer corneal tissues such that sufficient amount of corneal endothelium becomes available to offset the present shortage of functional cornea. Although human corneal endothelial cells have limited proliferative capacity in vivo, several laboratories have been successful in in vitro expansion of human corneal endothelial cells. Here we provide a comprehensive analysis of different substrates employed for in vitro cultivation of human corneal endothelial cells. Advances and emerging challenges with ex vivo cultured corneal endothelial layer for the ultimate goal of therapeutic replacement of dysfunctional corneal endothelium in humans with functional corneal endothelium are also presented.
    Keywords cell sources ; corneal endothelium ; human corneal endothelial cells ; substrates ; tissue engineering ; Biotechnology ; TP248.13-248.65 ; Medicine (General) ; R5-920
    Subject code 570 ; 500
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book: Regulatory networks in stem cells

    Rajasekhar, Vinagolu K / Vemuri, Mohan C

    (Stem cell biology and regenerative medicine)

    2009  

    Author's details Vinagolu K. Rajasekhar, Mohan C. Vemuri, editors
    Series title Stem cell biology and regenerative medicine
    MeSH term(s) Stem Cells/physiology ; Cell Physiological Phenomena
    Language English
    Size xxi, 601 p., [12] p. of plates :, ill. (some col.) ;, 29 cm.
    Publisher Humana Press
    Publishing place New York, NY
    Document type Book
    ISBN 9781603272261 ; 1603272267 ; 9781603272278 ; 1603272275
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment.

    Fujiwara, Tomohiro / Yakoub, Mohamed A / Chandler, Andrew / Christ, Alexander B / Yang, Guangli / Ouerfelli, Ouathek / Rajasekhar, Vinagolu K / Yoshida, Aki / Kondo, Hiroya / Hata, Toshiaki / Tazawa, Hiroshi / Dogan, Yildirim / Moore, Malcolm A S / Fujiwara, Toshiyoshi / Ozaki, Toshifumi / Purdue, Ed / Healey, John H

    Molecular cancer therapeutics

    2021  Volume 20, Issue 8, Page(s) 1388–1399

    Abstract: Colony-stimulating factor 1 (CSF1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in ... ...

    Abstract Colony-stimulating factor 1 (CSF1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in understanding the role of the inflammatory tumor microenvironment, targeting the components of the sarcoma microenvironment, such as TAMs, is a viable strategy. Here, we investigated the effect of PLX3397 (pexidartinib) as a potent inhibitor of the CSF1 receptor (CSF1R). PLX3397 was recently approved by the Food and Drug Administration (FDA) to treat tenosynovial giant cell tumor and reprogram TAMs whose infiltration correlates with unfavorable prognosis of sarcomas. First, we confirmed by cytokine arrays of tumor-conditioned media (TCM) that cytokines including CSF1 are secreted from LM8 osteosarcoma cells and NFSa fibrosarcoma cells. The TCM, like CSF1, stimulated ERK1/2 phosphorylation in bone marrow-derived macrophages (BMDMs), polarized BMDMs toward an M2 (TAM-like) phenotype, and strikingly promoted BMDM chemotaxis.
    MeSH term(s) Aminopyridines/pharmacology ; Animals ; Apoptosis ; Bone Neoplasms/drug therapy ; Bone Neoplasms/immunology ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Lymphocytes, Tumor-Infiltrating/immunology ; Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Mice ; Mice, Inbred C3H ; Osteosarcoma/drug therapy ; Osteosarcoma/immunology ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; Pyrroles/pharmacology ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Tumor Cells, Cultured ; Tumor Microenvironment ; Tumor-Associated Macrophages/immunology ; Xenograft Model Antitumor Assays
    Chemical Substances Aminopyridines ; CSF1 protein, human ; CSF1R protein, human ; Pyrroles ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; pexidartinib (6783M2LV5X) ; Macrophage Colony-Stimulating Factor (81627-83-0)
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-20-0591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5750: Show issues Location:
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