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  1. Article ; Online: Polygenic risk score for peripheral artery disease: A tool to refine risk stratification.

    Kullo, Iftikhar J

    Vascular medicine (London, England)

    2022  Volume 27, Issue 3, Page(s) 228–229

    MeSH term(s) Ankle Brachial Index ; Coronary Artery Disease ; Humans ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/genetics ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X221080191
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4409: Show issues Location:
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  2. Article ; Online: Familial Hypercholesterolemia: A Reportable Disorder.

    Kullo, Iftikhar J

    Circulation

    2020  Volume 142, Issue 21, Page(s) 1999–2001

    MeSH term(s) Genetic Testing/ethics ; Genetic Testing/standards ; Humans ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/genetics ; Mutation/genetics ; Public Health Practice/ethics ; Public Health Practice/standards ; Truth Disclosure/ethics
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.050548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lipoprotein(a) lowering and cardiovascular risk reduction by PCSK9 inhibitors.

    Safarova, Maya S / Kullo, Iftikhar J

    Atherosclerosis

    2022  Volume 361, Page(s) 30–31

    MeSH term(s) Humans ; PCSK9 Inhibitors ; Lipoprotein(a) ; Proprotein Convertase 9 ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Risk Factors ; Anticholesteremic Agents/therapeutic use ; Heart Disease Risk Factors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Chemical Substances PCSK9 Inhibitors ; Lipoprotein(a) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Anticholesteremic Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2022-10-21
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2022.10.010
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    Zs.A 226: Show issues Location:
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  4. Article ; Online: A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease.

    Norland, Kristjan / Schaid, Daniel J / Kullo, Iftikhar J

    European journal of human genetics : EJHG

    2023  Volume 32, Issue 2, Page(s) 209–214

    Abstract: Polygenic scores (PGS) for coronary heart disease (CHD) are constructed using GWAS summary statistics for CHD. However, pleiotropy is pervasive in biology and disease-associated variants often share etiologic pathways with multiple traits. Therefore, ... ...

    Abstract Polygenic scores (PGS) for coronary heart disease (CHD) are constructed using GWAS summary statistics for CHD. However, pleiotropy is pervasive in biology and disease-associated variants often share etiologic pathways with multiple traits. Therefore, incorporating GWAS summary statistics of additional traits could improve the performance of PGS for CHD. Using lasso regression models, we developed two multi-PGS for CHD: 1) multiPGS
    MeSH term(s) Adult ; Humans ; Coronary Disease/genetics ; Risk Factors ; Phenotype
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-023-01463-0
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    Zs.A 3589: Show issues Location:
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  5. Article ; Online: Implementing Reporting Standards for Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease.

    Smith, Johanna L / Schaid, Daniel J / Kullo, Iftikhar J

    Current atherosclerosis reports

    2023  Volume 25, Issue 6, Page(s) 323–330

    Abstract: Purpose of review: There is considerable interest in using polygenic risk scores (PRSs) for assessing risk of atherosclerotic cardiovascular disease (ASCVD). A barrier to the clinical use of PRSs is heterogeneity in how PRS studies are reported. In this ...

    Abstract Purpose of review: There is considerable interest in using polygenic risk scores (PRSs) for assessing risk of atherosclerotic cardiovascular disease (ASCVD). A barrier to the clinical use of PRSs is heterogeneity in how PRS studies are reported. In this review, we summarize approaches to establish a uniform reporting framework for PRSs for coronary heart disease (CHD), the most common form of ASCVD.
    Recent findings: Reporting standards for PRSs need to be contextualized for disease specific applications. In addition to metrics of predictive performance, reporting standards for PRSs for CHD should include how cases/control were ascertained, degree of adjustment for conventional CHD risk factors, portability to diverse genetic ancestry groups and admixed individuals, and quality control measures for clinical deployment. Such a framework will enable PRSs to be optimized and benchmarked for clinical use.
    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Risk Factors ; Atherosclerosis/genetics ; Coronary Disease ; Genome-Wide Association Study ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-023-01104-3
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    Zs.A 5534: Show issues Location:
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  6. Article: Joint Association of Polygenic Risk and Social Determinants of Health with Coronary Heart Disease in the United States.

    Norland, Kristjan / Schaid, Daniel J / Naderian, Mohammadreza / Na, Jie / Kullo, Iftikhar J

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: The joint effects of polygenic risk and social determinants of health (SDOH) on coronary heart disease (CHD) in the United States are unknown.: Methods: In 67,256 All of Us (AoU) participants with available SDOH data, we ascertained self- ... ...

    Abstract Background: The joint effects of polygenic risk and social determinants of health (SDOH) on coronary heart disease (CHD) in the United States are unknown.
    Methods: In 67,256 All of Us (AoU) participants with available SDOH data, we ascertained self-reported race/ethnicity and calculated a polygenic risk score for CHD (PRS
    Results: SDOH
    Conclusions: Increased odds of CHD in self-reported black people are likely due to higher SDOH burden. SDOH and PRS were independently associated with CHD in the US. Our findings emphasize the need to consider both PRS and SDOH for equitable disease risk assessment.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.10.24301105
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  7. Article ; Online: Implementation Science to Increase Adoption of Genomic Medicine

    Hana Bangash / Iftikhar J. Kullo

    Journal of Personalized Medicine, Vol 11, Iss 19, p

    An Urgent Need

    2021  Volume 19

    Abstract: Advances in genomics have the potential to improve human health [.] ...

    Abstract Advances in genomics have the potential to improve human health [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Implementation Science to Increase Adoption of Genomic Medicine: An Urgent Need.

    Bangash, Hana / Kullo, Iftikhar J

    Journal of personalized medicine

    2020  Volume 11, Issue 1

    Abstract: Advances in genomics have the potential to improve human health [ ... ]. ...

    Abstract Advances in genomics have the potential to improve human health [...].
    Language English
    Publishing date 2020-12-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11010019
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  9. Article ; Online: Polygenic Risk Scores for Diverse Ancestries: Making Genomic Medicine Equitable.

    Kullo, Iftikhar J / Dikilitas, Ozan

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 6, Page(s) 715–718

    MeSH term(s) Asian Continental Ancestry Group ; Coronary Artery Disease ; Genome-Wide Association Study ; Genomics ; Humans ; Medicine ; Multifactorial Inheritance ; Risk Factors
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.06.028
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  10. Article ; Online: A call for training programmes in cardiovascular genomics.

    Safarova, Maya S / Ackerman, Michael J / Kullo, Iftikhar J

    Nature reviews. Cardiology

    2021  Volume 18, Issue 8, Page(s) 539–540

    MeSH term(s) Cardiovascular Diseases/genetics ; Genomics/education ; Humans
    Language English
    Publishing date 2021-06-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-021-00586-5
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