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  1. Article: Medication strategies in childhood aggression: a review.

    Bassarath, Lindley

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2003  Volume 48, Issue 6, Page(s) 367–373

    Abstract: Objective: To review studies of psychopharmacological management of aggression in common childhood psychiatric disorders.: Method: Using OVID software, we searched Medline for studies that were undertaken in the last 30 years. Controlled and ... ...

    Abstract Objective: To review studies of psychopharmacological management of aggression in common childhood psychiatric disorders.
    Method: Using OVID software, we searched Medline for studies that were undertaken in the last 30 years. Controlled and uncontrolled data are summarized for each condition.
    Results: A paucity of evidence-based information currently exists. Even so, specific indications from the existing literature can be suggested for several classes of psychotropics, particularly in conduct disorder (CD), attention-deficit hyperactivity disorder (ADHD), mood disorders, and other conditions.
    Conclusions: Clinicians can use findings from reviewed controlled and, where necessary, uncontrolled studies to inform pharmacologic practice. This review offers suggestions for future research directions that will aid clinical practice.
    MeSH term(s) Aggression/psychology ; Anxiety Disorders/drug therapy ; Anxiety Disorders/psychology ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Child ; Conduct Disorder/drug therapy ; Controlled Clinical Trials as Topic ; Evidence-Based Medicine ; Humans ; Mood Disorders/drug therapy ; Mood Disorders/psychology ; Psychotropic Drugs/adverse effects ; Psychotropic Drugs/therapeutic use
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2003-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0706-7437 ; 0008-4824
    ISSN (online) 1497-0015
    ISSN 0706-7437 ; 0008-4824
    DOI 10.1177/070674370304800602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Neuroimaging studies of antisocial behaviour.

    Bassarath, L

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2001  Volume 46, Issue 8, Page(s) 728–732

    Abstract: Objective: To review recent neuroimaging studies of antisocial behaviour, including criminality, psychopathy, sexual offending, aggression, and violence.: Method: Using OVID software, Psycinfo and Medline were searched for studies undertaken in the ... ...

    Abstract Objective: To review recent neuroimaging studies of antisocial behaviour, including criminality, psychopathy, sexual offending, aggression, and violence.
    Method: Using OVID software, Psycinfo and Medline were searched for studies undertaken in the last 15 years. A brief outline of each technology is followed by a survey of published reports from refereed journals. Where indicated, critical appraisal is offered.
    Results: Converging evidence from multiple studies of structure and function indicates that abnormal prefrontal (and probably subcortical) circuitry are very likely involved in antisocial behaviour.
    Conclusions: Clinicians should be aware of emerging findings from biological studies of antisociality. Future neuroimaging and other biologically based work, especially when combined with psychosocial initiatives, should yield fruit in attempts to better understand, treat, and prevent such socially devastating and destructive behaviour.
    MeSH term(s) Antisocial Personality Disorder/physiopathology ; Brain/diagnostic imaging ; Brain/pathology ; Brain/physiopathology ; Frontal Lobe/blood supply ; Humans ; Magnetic Resonance Imaging ; Tomography, Emission-Computed ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
    Language English
    Publishing date 2001-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0706-7437 ; 0008-4824
    ISSN (online) 1497-0015
    ISSN 0706-7437 ; 0008-4824
    DOI 10.1177/070674370104600805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Conduct disorder: a biopsychosocial review.

    Bassarath, L

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2001  Volume 46, Issue 7, Page(s) 609–616

    Abstract: Objective: To review published works on the epidemiology, risk factors, protective factors, typologies, and genetic aspects of conduct disorder (CD).: Method: Findings from refereed journal articles and current texts in the field are briefly ... ...

    Abstract Objective: To review published works on the epidemiology, risk factors, protective factors, typologies, and genetic aspects of conduct disorder (CD).
    Method: Findings from refereed journal articles and current texts in the field are briefly summarized.
    Results: CD is commonly encountered in clinical practice. Factors strongly predictive of future delinquency include past offenses, antisocial peers, impoverished social ties, early substance use, male sex, and antisocial parents. Factors that moderately predict recidivism include early aggression, low socioeconomic status (SES), psychological variables such as risk taking and impulsivity, poor parent-child relationships, poor academic performance, early medical insult, and neuropsychological variables such as poor verbal IQ. Mildly predictive variables include other family characteristics such as large family size, family stress, discord, broken home, and abusive parenting, particularly neglect. Protective factors include individual factors such as skill competence (in social and other arenas), adult relationships, prosocial and proeducational values, and strong social programs and supports.
    Conclusions: We know a great deal about psychosocial risk factors for CD. Some research into protective factors and genetic contributions exists but is in its early stages. Future work will increase our knowledge about subtypes, developmental pathways, and CD treatment.
    MeSH term(s) Adolescent ; Catechol O-Methyltransferase/metabolism ; Child ; Conduct Disorder/genetics ; Conduct Disorder/metabolism ; Conduct Disorder/prevention & control ; Family/psychology ; Female ; Humans ; Juvenile Delinquency/prevention & control ; Male ; Monoamine Oxidase/metabolism ; Parent-Child Relations ; Parents/psychology ; Peer Group ; Risk Factors ; Sex Factors ; Socioeconomic Factors ; X Chromosome/genetics
    Chemical Substances Monoamine Oxidase (EC 1.4.3.4) ; Catechol O-Methyltransferase (EC 2.1.1.6)
    Language English
    Publishing date 2001-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0706-7437 ; 0008-4824
    ISSN (online) 1497-0015
    ISSN 0706-7437 ; 0008-4824
    DOI 10.1177/070674370104600704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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