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Article ; Online: Conducting multiple mini-interviews in the midst of COVID-19 pandemic.

Kok, Kenneth Yy / Chen, Lie / Idris, Fazean Irdayati / Mumin, Nuramalina H / Ghani, Hazim / Zulkipli, Ihsan Nazurah / Lim, Mei Ann

Medical education online

2021 Volume 26, Issue 1, Page(s) 1891610

Abstract: Multiple mini-interview (MMI) is a 'multiple sample-based' approach comprising multiple focused encounters intended to access and assess a range of attributes in order to gain more objectively multiple impressions of an applicant's interpersonal skills, ... ...

Abstract	Multiple mini-interview (MMI) is a 'multiple sample-based' approach comprising multiple focused encounters intended to access and assess a range of attributes in order to gain more objectively multiple impressions of an applicant's interpersonal skills, thoughtfulness and general demeanour. It is designed to focus on four domains that are not considered to be comprehensive, but are considered to be vital for a successful career in the health sciences: critical thinking, ethical decision making, communication and knowledge of the healthcare system. Traditionally, the MMI is conducted face-to-face, but with COVID-19 pandemic and the implementation of social distancing measures, no onsite or campus teaching, banning of mass gatherings and cancellation of face-to-face interviews, Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences at Universiti Brunei Darussalam explored the feasibility of conducting MMI through virtual means. This report provides an account of our experience in conducting internet-MMI for the selection of new applicants into the August 2020 cohort of the Medicine programme. We also aimed to determine whether the scores derived from internet-MMI were reliable and equivalent to the scores derived from traditional MMI.
MeSH term(s)	COVID-19/epidemiology ; Communication ; Decision Making ; Ethics, Medical ; Health Knowledge, Attitudes, Practice ; Humans ; Interviews as Topic/methods ; Pandemics ; SARS-CoV-2 ; School Admission Criteria ; Schools, Medical/organization & administration ; Thinking
Language	English
Publishing date	2021-02-22
Publishing country	United States
Document type	Journal Article
ISSN	1087-2981
ISSN (online)	1087-2981
DOI	10.1080/10872981.2021.1891610
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Conducting multiple mini-interviews in the midst of COVID-19 pandemic

Kenneth Yy Kok / Lie Chen / Fazean Irdayati Idris / Nuramalina H Mumin / Hazim Ghani / Ihsan Nazurah Zulkipli / Mei Ann Lim

Medical Education Online, Vol 26, Iss

2021 Volume 1

Abstract: Multiple mini-interview (MMI) is a ‘multiple sample-based’ approach comprising multiple focused encounters intended to access and assess a range of attributes in order to gain more objectively multiple impressions of an applicant’s interpersonal skills, ... ...

Abstract	Multiple mini-interview (MMI) is a ‘multiple sample-based’ approach comprising multiple focused encounters intended to access and assess a range of attributes in order to gain more objectively multiple impressions of an applicant’s interpersonal skills, thoughtfulness and general demeanour. It is designed to focus on four domains that are not considered to be comprehensive, but are considered to be vital for a successful career in the health sciences: critical thinking, ethical decision making, communication and knowledge of the healthcare system. Traditionally, the MMI is conducted face-to-face, but with COVID-19 pandemic and the implementation of social distancing measures, no onsite or campus teaching, banning of mass gatherings and cancellation of face-to-face interviews, Pengiran Anak Puteri Rashidah Sa’adatul Bolkiah Institute of Health Sciences at Universiti Brunei Darussalam explored the feasibility of conducting MMI through virtual means. This report provides an account of our experience in conducting internet-MMI for the selection of new applicants into the August 2020 cohort of the Medicine programme. We also aimed to determine whether the scores derived from internet-MMI were reliable and equivalent to the scores derived from traditional MMI.
Keywords	multiple mini-interview ; internet ; selection ; medicine programme ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: World Society of Emergency Surgery (WSES) guidelines for management of skin and soft tissue infections.

Sartelli, Massimo / Malangoni, Mark A / May, Addison K / Viale, Pierluigi / Kao, Lillian S / Catena, Fausto / Ansaloni, Luca / Moore, Ernest E / Moore, Fred A / Peitzman, Andrew B / Coimbra, Raul / Leppaniemi, Ari / Kluger, Yoram / Biffl, Walter / Koike, Kaoru / Girardis, Massimo / Ordonez, Carlos A / Tavola, Mario / Cainzos, Miguel /

Di Saverio, Salomone / Fraga, Gustavo P / Gerych, Igor / Kelly, Michael D / Taviloglu, Korhan / Wani, Imtiaz / Marwah, Sanjay / Bala, Miklosh / Ghnnam, Wagih / Shaikh, Nissar / Chiara, Osvaldo / Faro, Mario Paulo / Pereira, Gerson Alves / Gomes, Carlos Augusto / Coccolini, Federico / Tranà, Cristian / Corbella, Davide / Brambillasca, Pietro / Cui, Yunfeng / Segovia Lohse, Helmut A / Khokha, Vladimir / Kok, Kenneth Yy / Hong, Suk-Kyung / Yuan, Kuo-Ching

World journal of emergency surgery : WJES

2014 Volume 9, Issue 1, Page(s) 57

Abstract: Skin and soft tissue infections (SSTIs) encompass a variety of pathological conditions ranging from simple superficial infections to severe necrotizing soft tissue infections. Necrotizing soft tissue infections (NSTIs) are potentially life-threatening ... ...

Abstract	Skin and soft tissue infections (SSTIs) encompass a variety of pathological conditions ranging from simple superficial infections to severe necrotizing soft tissue infections. Necrotizing soft tissue infections (NSTIs) are potentially life-threatening infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Successful management of NSTIs involves prompt recognition, timely surgical debridement or drainage, resuscitation and appropriate antibiotic therapy. A worldwide international panel of experts developed evidence-based guidelines for management of soft tissue infections. The multifaceted nature of these infections has led to a collaboration among surgeons, intensive care and infectious diseases specialists, who have shared these guidelines, implementing clinical practice recommendations.
Language	English
Publishing date	2014
Publishing country	England
Document type	Journal Article ; Review
ISSN	1749-7922
ISSN	1749-7922
DOI	10.1186/1749-7922-9-57
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: WSES guidelines for emergency repair of complicated abdominal wall hernias.

Sartelli, Massimo / Coccolini, Federico / van Ramshorst, Gabrielle H / Campanelli, Giampiero / Mandalà, Vincenzo / Ansaloni, Luca / Moore, Ernest E / Peitzman, Andrew / Velmahos, George / Moore, Fredrick Alan / Leppaniemi, Ari / Burlew, Clay Cothren / Biffl, Walter / Koike, Kaoru / Kluger, Yoram / Fraga, Gustavo P / Ordonez, Carlos A / Di Saverio, Salomone / Agresta, Ferdinando /

Sakakushev, Boris / Gerych, Igor / Wani, Imtiaz / Kelly, Michael D / Gomes, Carlos Augusto / Faro, Mario Paulo / Taviloglu, Korhan / Demetrashvili, Zaza / Lee, Jae Gil / Vettoretto, Nereo / Guercioni, Gianluca / Tranà, Cristian / Cui, Yunfeng / Kok, Kenneth Yy / Ghnnam, Wagih M / Abbas, Ashraf El-Sayed / Sato, Norio / Marwah, Sanjay / Rangarajan, Muthukumaran / Ben-Ishay, Offir / Adesunkanmi, Abdul Rashid K / Segovia Lohse, Helmut Alfredo / Kenig, Jakub / Mandalà, Stefano / Patrizi, Andrea / Scibé, Rodolfo / Catena, Fausto

World journal of emergency surgery : WJES

2013 Volume 8, Issue 1, Page(s) 50

Abstract: Emergency repair of complicated abdominal hernias is associated with poor prognosis and a high rate of post-operative complications.A World Society of Emergency Surgery (WSES) Consensus Conference was held in Bergamo in July 2013, during the 2nd Congress ...

Abstract	Emergency repair of complicated abdominal hernias is associated with poor prognosis and a high rate of post-operative complications.A World Society of Emergency Surgery (WSES) Consensus Conference was held in Bergamo in July 2013, during the 2nd Congress of the World Society of Emergency Surgery with the goal of defining recommendations for emergency repair of abdominal wall hernias in adults. This document represents the executive summary of the consensus conference approved by a WSES expert panel.
Language	English
Publishing date	2013-12-01
Publishing country	England
Document type	Journal Article
ISSN	1749-7922
ISSN	1749-7922
DOI	10.1186/1749-7922-8-50
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CD4

Frontiers in immunology

2020 Volume 11, Page(s) 580968

Abstract: Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chronic ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chronic inflammation, and CD4
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; Cytokines/blood ; Diet, High-Fat/adverse effects ; Female ; Fetal Stem Cells/transplantation ; Hepatocytes/transplantation ; Heterografts ; Humans ; Interleukin Receptor Common gamma Subunit/deficiency ; Interleukin Receptor Common gamma Subunit/genetics ; Liver Cirrhosis, Experimental/etiology ; Liver Cirrhosis, Experimental/immunology ; Liver Cirrhosis, Experimental/pathology ; Lymphocyte Depletion ; Male ; Mice ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/immunology ; Non-alcoholic Fatty Liver Disease/pathology
Chemical Substances	Cytokines ; Il2rg protein, mouse ; Interleukin Receptor Common gamma Subunit
Language	English
Publishing date	2020-09-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.580968
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy.

Gut

2018 Volume 67, Issue 10, Page(s) 1845–1854

Abstract: Objective: As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for ...

Abstract	Objective: As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immune system, particularly for human-specific drug testing. Design: Patient-derived xenograft tumours are established with type I human leucocyte antigen matched human immune system in NOD- Results: Similar to the clinical outcomes, the human immune system in our model is educated by the tumour and exhibits exhaustion phenotypes such as a significant declination of leucocyte numbers, upregulation of exhaustion markers and decreased the production of human proinflammatory cytokines. Notably, cytotoxic immune cells decreased more rapidly compared with other cell types. Tumour infiltrated T cells have much higher expression of exhaustion markers and lower cytokine production compared with peripheral T cells. In addition, tumour-associated macrophages and myeloid-derived suppressor cells are found to be highly enriched in the tumour microenvironment. Interestingly, the tumour also changes gene expression profiles in response to immune responses by upregulating immune checkpoint ligands. Most importantly, in contrast to the NSG model, our model demonstrates both therapeutic and side effects of immune checkpoint inhibitors pembrolizumab and ipilimumab. Conclusions: Our work provides a model for immune-oncology study and a useful parallel-to-human platform for anti-HCC drug testing, especially immunotherapy.
MeSH term(s)	Animals ; Antibodies, Monoclonal, Humanized/pharmacology ; Antineoplastic Agents, Immunological/pharmacology ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Cytokines/metabolism ; Disease Models, Animal ; Heterografts/immunology ; Humans ; Immunotherapy/methods ; Ipilimumab/pharmacology ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Mice ; Mice, Inbred NOD ; Tumor Microenvironment/immunology
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; Cytokines ; Ipilimumab ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2018-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2017-315201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

Young, Barnaby E / Ong, Sean W X / Ng, Lisa F P / Anderson, Danielle E / Chia, Wan Ni / Chia, Po Ying / Ang, Li Wei / Mak, Tze-Minn / Kalimuddin, Shirin / Chai, Louis Yi Ann / Pada, Surinder / Tan, Seow Yen / Sun, Louisa / Parthasarathy, Purnima / Fong, Siew-Wai / Chan, Yi-Hao / Tan, Chee Wah / Lee, Bernett / Rötzschke, Olaf /

Ding, Ying / Tambyah, Paul / Low, Jenny G H / Cui, Lin / Barkham, Timothy / Lin, Raymond Tzer Pin / Leo, Yee-Sin / Renia, Laurent / Wang, Lin-Fa / Lye, David Chien / Lim, Poh Lian / Peng Ang, Brenda Sze / Lee, Cheng Chuan / U Lee, Lawrence Soon / Ling, Li Min / Ng, Oon Tek / Chan, Monica / Marimuthu, Kalisvar / Vasoo, Shawn / Wong, Chen Seong / Lee, Tau Hong / Sadarangani, Sapna / Lin, Ray Junhao / Sadasiv, Mucheli Sharavan / Ling Ng, Deborah Hee / Choy, Chiaw Yee / En Tan, Glorijoy Shi / Tan, Yu Kit / Sutjipto, Stephanie / Lee, Pei Hua / Tay, Jun Yang / Yeo, Tsin Wen / Khoo, Bo Yan / Tay, Woo Chiao / Ng, Gabrielle / Mah, Yun Yuan / Tan, Wilnard / De, Partha Pratim / Pooja, Rao / Chia, Jonathan W Z / Constance Chen, Yuan Yi / Mendis, Shehara / Toh, Boon Kiat / Choon Fong, Raymond Kok / Lin Oh, Helen May / Fong Chien, Jaime Mei / Shafi, Humaira / Cheong, Hau Yiang / Tan, Thean Yen / Tan, Thuan Tong / Tan, Ban Hock / Wijaya, Limin / Venkatachalam, Indumathi / Chua, Ying Ying / Zhi Cherng, Benjamin Pei / Zi Chan, Yvonne Fu / Wong, Hei Man / Thien, Siew Yee / Meng Goh, Kenneth Choon / Ling Tan, Shireen Yan / Ean Oon, Lynette Lin / Chan, Kian Sing / Lin, Li / Gin Chan, Douglas Su / Ooi, Say Tat / Narayana, Deepak Rama / Somani, Jyoti / Ling Oon, Jolene Ee / Yan, Gabriel Zherong / Allen, David Michael / Jureen, Roland / Yan, Benedict / Foo, Randy / Kang, Adrian / Sivalingam, Velraj / How, Wilson / Fernandez, Norman Leo / Yeo, Nicholas Kim-Wah / Chee, Rhonda Sin-Ling / Amrun, Siti Naqiah

Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

2020

Abstract: Abstract Background Key knowledge gaps remain in the understanding of viral dynamics and immune response of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods We evaluated these characteristics and established their ... ...

Abstract	Abstract Background Key knowledge gaps remain in the understanding of viral dynamics and immune response of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods We evaluated these characteristics and established their association with clinical severity in a prospective observational cohort study of 100 patients with PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% with comorbidities). Respiratory samples (n = 74) were collected for viral culture, serum samples for measurement of IgM/IgG levels (n = 30), and plasma samples for levels of inflammatory cytokines and chemokines (n = 81). Disease severity was correlated with results from viral culture, serologic testing, and immune markers. Results Fifty-seven (57%) patients developed viral pneumonia, of whom 20 (20%) required supplemental oxygen, including 12 (12%) with invasive mechanical ventilation. Viral culture from respiratory samples was positive for 19 of 74 patients (26%). No virus was isolated when the PCR cycle threshold (Ct) value was >30 or >14 days after symptom onset. Seroconversion occurred at a median (IQR) of 12.5 (9–18) days for IgM and 15.0 (12–20) days for IgG; 54/62 patients (87.1%) sampled at day 14 or later seroconverted. Severe infections were associated with earlier seroconversion and higher peak IgM and IgG levels. Levels of IP-10, HGF, IL-6, MCP-1, MIP-1α, IL-12p70, IL-18, VEGF-A, PDGF-BB, and IL-1RA significantly correlated with disease severity. Conclusions We found virus viability was associated with lower PCR Ct value in early illness. A stronger antibody response was associated with disease severity. The overactive proinflammatory immune signatures offer targets for host-directed immunotherapy, which should be evaluated in randomized controlled trials.
Keywords	Microbiology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/cid/ciaa1280
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Conducting multiple mini-interviews in the midst of COVID-19 pandemic.

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Article ; Online: Conducting multiple mini-interviews in the midst of COVID-19 pandemic

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Article: World Society of Emergency Surgery (WSES) guidelines for management of skin and soft tissue infections.

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Article: WSES guidelines for emergency repair of complicated abdominal wall hernias.

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Article ; Online: CD4

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Article ; Online: Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy.

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Article ; Online: Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

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