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  1. Article ; Online: Conference Scene: chromatin, replication and chromosomal stability.

    Helmrich, Anne

    Epigenomics

    2011  Volume 3, Issue 5, Page(s) 543–546

    Abstract: The Chromatin, Replication and Chromosomal Stability Conference took place on June 20-21 in Stockholm, Sweden. In this article, I outline the broad scientific program of the meeting which reflected the wide diversity in epigenetics research. Distinct ... ...

    Abstract The Chromatin, Replication and Chromosomal Stability Conference took place on June 20-21 in Stockholm, Sweden. In this article, I outline the broad scientific program of the meeting which reflected the wide diversity in epigenetics research. Distinct histone modifications are linked with specific chromatin structures and intranuclear positioning, thereby impacting replication timing and replication initiation, which in turn are related to gene expression and cell differentiation. Interference in any of these interconnected mechanisms can result in DNA breakage and lead to the activation of repair pathways. The DNA repair mechanisms again are influenced by the chromatin structure. In summary, the conference highlighted the functional implication of epigenetics in chromatin compaction, transcription regulation, replication control and DNA repair. The tight control of all these mechanisms defines the final cellular character.
    MeSH term(s) Chromatin/physiology ; Chromosomal Instability ; Congresses as Topic ; DNA Repair/physiology ; DNA Replication/physiology ; DNA Replication Timing/physiology ; Epigenomics/methods ; Epigenomics/trends
    Chemical Substances Chromatin
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1750-192X
    ISSN (online) 1750-192X
    DOI 10.2217/epi.11.77
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Genomweite molekular-zytogenetische Charakterisierung INK4A-ARF-defizierter Mauslymphome und Untersuchungen zur evolutionären Konservierung von common fragile sites

    Helmrich, Anne

    2005  

    Author's details von Anne Helmrich
    Language German
    Size 113 S, Ill., graph. Darst, 30 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss (Nicht für den Austausch)--Dresden, 2005
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Pharmacologic Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4

    Helmrich, Nora / Roderfeld, Martin / Baier, Anne / Windhorst, Anita / Herebian, Diran / Mayatepek, Ertan / Dierkes, Christian / Ocker, Matthias / Glebe, Dieter / Christ, Bruno / Churin, Yuri / Irungbam, Karuna / Roeb, Elke

    Cellular and molecular gastroenterology and hepatology

    2021  Volume 13, Issue 4, Page(s) 1041–1055

    Abstract: Background & aims: The endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via cannabinoid receptor (CB)1 and CB2. We hypothesized that the pharmacologic ... ...

    Abstract Background & aims: The endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via cannabinoid receptor (CB)1 and CB2. We hypothesized that the pharmacologic antagonization of CB1 receptor improves cholestasis in Abcb4
    Methods: After weaning, male Abcb4
    Results: Cholestasis-induced symptoms such as liver damage, bile duct proliferation, and enhanced circulating bile acids were improved by CB1 antagonization. Rimonabant treatment also improved Phosphoenolpyruvat-Carboxykinase expression and reduced inflammation and the acute-phase response. The carcinogenesis-associated cellular-Jun N-terminal kinase/cellular-JUN and signal transducer and activator of transcription 3 signaling pathways activated in Abcb4
    Conclusions: We showed a protective effect of oral CB1 antagonization in chronic cholestasis using the established Abcb4
    MeSH term(s) Animals ; Carcinogenesis ; Cholestasis/drug therapy ; Inflammation ; Male ; Mice ; Receptor, Cannabinoid, CB1 ; Rimonabant/pharmacology
    Chemical Substances Receptor, Cannabinoid, CB1 ; Rimonabant (RML78EN3XE)
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2021.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study.

    van der Vlegel, Marjolein / Mikolić, Ana / Lee Hee, Quentin / Kaplan, Z L Rana / Retel Helmrich, Isabel R A / van Veen, Ernest / Andelic, Nada / Steinbuechel, Nicole V / Plass, Anne Marie / Zeldovich, Marina / Wilson, Lindsay / Maas, Andrew I R / Haagsma, Juanita A / Polinder, Suzanne

    Injury

    2022  Volume 53, Issue 8, Page(s) 2774–2782

    Abstract: Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an ... ...

    Abstract Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.
    Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.
    Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.
    Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.
    MeSH term(s) Aged ; Brain Injuries, Traumatic ; Glasgow Outcome Scale ; Humans ; Patient Acceptance of Health Care ; Prospective Studies ; Quality of Life/psychology
    Language English
    Publishing date 2022-05-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2022.05.009
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  5. Article ; Online: Transcription-replication encounters, consequences and genomic instability.

    Helmrich, Anne / Ballarino, Monica / Nudler, Evgeny / Tora, Laszlo

    Nature structural & molecular biology

    2013  Volume 20, Issue 4, Page(s) 412–418

    Abstract: To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between ... ...

    Abstract To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses.
    MeSH term(s) DNA Replication ; Genomic Instability ; Transcription, Genetic
    Language English
    Publishing date 2013-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/nsmb.2543
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  6. Book ; Online ; Thesis: Genomweite molekular-zytogenetische Charakterisierung INK4A/ARF-defizienter Mauslymphome und Untersuchungen zur evolutionären Konservierung von Common fragile sites

    Helmrich, Anne

    2005  

    Abstract: Im ersten Teil dieser Arbeit wurden mittels molekular-zytogenetischer Methoden die chromosomalen Aberrationen in c-myc aktivierten ARFnull- und INK4a/ARFnull-Mauslymphomen untersucht. Die zytogenetischen Ergebnisse wurden mit dem Therapieverlauf der ... ...

    Author's details von Anne Helmrich
    Abstract Im ersten Teil dieser Arbeit wurden mittels molekular-zytogenetischer Methoden die chromosomalen Aberrationen in c-myc aktivierten ARFnull- und INK4a/ARFnull-Mauslymphomen untersucht. Die zytogenetischen Ergebnisse wurden mit dem Therapieverlauf der Mäuse nach Cyclophosphamid-Behandlung verglichen. In den ARFnull-Lymphomen erkannten wir den Gewinn des Chromosoms 14 als einen Marker für gute und den Gewinn des Chromosoms 6 als Marker für schlechte Behandlungserfolge. Auf den Chromosomen 6 und 14 der Maus liegen demnach bisher unbekannte Gene, welche für die Wahl der Behandlungsmethode ARF-defizienter Tumore von entscheidender Bedeutung sind...
    Language German
    Size Online-Ressource
    Publisher Niedersächsische Staats- und Universitätsbibliothek
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss--Dresden, 2005
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book ; Online ; Thesis: Genomweite molekular-zytogenetische Charakterisierung INK4A/ARF-defizienter Mauslymphome und Untersuchungen zur evolutionären Konservierung von Common fragile sites

    Helmrich, Anne [Verfasser]

    2005  

    Author's details von Anne Helmrich
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.

    Helmrich, Anne / Ballarino, Monica / Tora, Laszlo

    Molecular cell

    2011  Volume 44, Issue 6, Page(s) 966–977

    Abstract: We show that the time required to transcribe human genes larger than 800 kb spans more than one complete cell cycle, while their transcription speed equals that of smaller genes. Independently of their expression status, we find the long genes to ... ...

    Abstract We show that the time required to transcribe human genes larger than 800 kb spans more than one complete cell cycle, while their transcription speed equals that of smaller genes. Independently of their expression status, we find the long genes to replicate late. Regions of concomitant transcription and replication in late S phase exhibit DNA break hot spots known as common fragile sites (CFSs). This CFS instability depends on the expression of the underlying long genes. We show that RNA:DNA hybrids (R-loops) form at sites of transcription/replication collisions and that RNase H1 functions to suppress CFS instability. In summary, our results show that, on the longest human genes, collisions of the transcription machinery with a replication fork are inevitable, creating R-loops and consequent CFS formation. Functional replication machinery needs to be involved in the resolution of conflicts between transcription and replication machineries to ensure genomic stability.
    MeSH term(s) Cell Cycle/genetics ; Chromosome Fragile Sites/genetics ; DNA/genetics ; DNA/metabolism ; DNA Replication ; DNA Topoisomerases, Type I/metabolism ; Genes/genetics ; Genomic Instability/genetics ; Humans ; RNA/genetics ; RNA/metabolism ; RNA Polymerase II/metabolism ; Ribonuclease H/metabolism ; Time Factors ; Transcription, Genetic
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2) ; RNA Polymerase II (EC 2.7.7.-) ; ribonuclease HII (EC 3.1.26.-) ; Ribonuclease H (EC 3.1.26.4) ; DNA Topoisomerases, Type I (EC 5.99.1.2)
    Language English
    Publishing date 2011-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2011.10.013
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    Zs.A 5055: Show issues Location:
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  9. Article ; Online: IL-13 as Target to Reduce Cholestasis and Dysbiosis in

    Hahn, Luisa / Helmrich, Nora / Herebian, Diran / Mayatepek, Ertan / Drebber, Uta / Domann, Eugen / Olejniczak, Stefan / Weigel, Markus / Hain, Torsten / Rath, Timo / Wirtz, Stefan / Mollenkopf, Hans-Joachim / Schmidt, Nadine / Ewers, Christa / Baier, Anne / Churin, Yuri / Windhorst, Anita / Weiskirchen, Ralf / Steinhoff, Ulrich /
    Roeb, Elke / Roderfeld, Martin

    Cells

    2020  Volume 9, Issue 9

    Abstract: The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in ... ...

    Abstract The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an
    MeSH term(s) Animals ; Cholestasis, Intrahepatic/therapy ; Disease Models, Animal ; Dysbiosis/therapy ; Humans ; Interleukin-13/metabolism ; Mice ; Mice, Knockout
    Chemical Substances Interleukin-13
    Language English
    Publishing date 2020-08-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9091949
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  10. Article: Health care utilization and outcomes in older adults after traumatic brain injury

    CENTER-TBI Participants and Investigators / van der Vlegel, Marjolein / Mikolic, Ana / Hee, Quentin Lee / Kaplan, Z. L. Rana / Retel Helmrich, Isabel R. A. / van Veen, Ernest / Andelic, Nada / von Steinbuechel, Nicole / Plass, Anne Marie / Zeldovich, Marina / Wilson, Lindsay / Maas, Andrew I. R. / Haagsma, Juanita A. / Polinder, Suzanne

    Injury

    A CENTER-TBI study

    2022  Volume 53, Issue 8, Page(s) 2774–2782

    Abstract: Abstract not released by publisher. ...

    Title translation Inanspruchnahme des Gesundheitswesens und Ergebnisse bei älteren Erwachsenen nach einem Schädel-Hirn-Trauma: Eine CENTER-TBI-Studie
    Abstract Abstract not released by publisher.
    Keywords Aging ; Altern ; Gesundheitsbezogene Lebensqualität ; Health Care Utilization ; Health Related Quality of Life ; Inanspruchnahme von Gesundheitseinrichtungen ; Mental Health ; Psychische Gesundheit ; Public Health ; Traumatic Brain Injury ; Traumatische Hirnverletzung ; Öffentliche Gesundheit
    Language English
    Document type Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2022.05.009
    Database PSYNDEX

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