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  1. Article ; Online: Interventional endoscopic ultrasound

    Nikhil Sonthalia

    Apollo Medicine, Vol 18, Iss 4, Pp 275-

    An update

    2021  Volume 281

    Abstract: Endoscopic ultrasound (EUS) has come a long way in the field of interventional gastroenterology. Majority of the advancements in the field of EUS over the past 20 years has been done by the group of endoscopist who are looking to break the convention. At ...

    Abstract Endoscopic ultrasound (EUS) has come a long way in the field of interventional gastroenterology. Majority of the advancements in the field of EUS over the past 20 years has been done by the group of endoscopist who are looking to break the convention. At this time both diagnostic and interventional EUS has become the standard of care in the management of large number pancreatic, biliary, luminal gastro-intestinal, and mediastinal diseases. It is now widely available as the large number of medical institutions, have added it to their endoscopic armamentarium. Scope of interventional EUS in clinical practice is rapidly expanding. Here in the current review, we highlight the key concepts of various interventional EUS procedures like-EUS guided drainage of pancreatic fluid collection; EUS guided vascular therapy; EUS guided enteral anastomosis; EUS guided biliary drainage; Role of EUS in hepatology; EUS guided celiac plexus neurolysis and neurolysis. We also discuss the indications, technical aspects, adverse events, and future directions of each of these procedures. If looking into future, we can predict an evolution of these techniques into an exciting newer horizon in the form of EUS-guided minimally invasive surgery.
    Keywords biliary drainage ; endoscopic ultrasound-guided tumor therapy ; interventional endoscopic ultrasound ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Correction: Flat-based over-the-scope clip-assisted endoscopic full-thickness resection of a duodenal neuroendocrine tumour: a safe alternative to endoscopic submucosal dissection.

    Sonthalia, Nikhil / Shah, Bhavik Bharat / Goenka, Mahesh Kumar

    Endoscopy

    2022  Volume 54, Issue 7, Page(s) C9

    Language English
    Publishing date 2022-04-22
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1823-2120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Magnetic resonance elastography (MRE) outperforms acoustic force radiation impulse (ARFI) in predicting oesophageal varices in obese NAFLD cirrhosis.

    Roy, Akash / Verma, Nipun / Jajodia, Surabhi / Goenka, Usha / Tiwari, Awanish / Sonthalia, Nikhil / Goenka, Mahesh

    Abdominal radiology (New York)

    2024  

    Abstract: Purpose: Liver stiffness measurement (LSM) by transient elastography has been shown to underperform in high-risk varices (HRVs) prediction in obese non-alcoholic fatty liver disease (NAFLD) compensated cirrhosis (CC). LSM by magnetic resonance ... ...

    Abstract Purpose: Liver stiffness measurement (LSM) by transient elastography has been shown to underperform in high-risk varices (HRVs) prediction in obese non-alcoholic fatty liver disease (NAFLD) compensated cirrhosis (CC). LSM by magnetic resonance elastography (MRE) and acoustic force radiation impulse (ARFI) has been shown to be useful in prediction of oesophageal varices (EVs), but has limited evidence in obese NAFLD-CC.
    Methods: Obese patients with NAFLD-CC who underwent MRE and ARFI for LSM and endoscopy for screening of varices were enrolled. Performance of MRE and ARFI for predicting EVs or HRVs was evaluated using area under receiver operating characteristics (AUROC) curves and regression analyses were performed for predictor variables.
    Results: One hundred eight patients [mean age 54.7 ± 9.6 years, median BMI, 28.5 (26.4-30.0) kg/m
    Conclusion: In obese NAFLD-CC, MRE-LSM is significantly higher in patients with varices. MRE combined with PC predicts EVs and HRVs with better accuracy than ARFI.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-024-04309-5
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  4. Article ; Conference proceedings: Use of Dedicated Device Assisted versus Conventional Over-the-Scope-Clip Assisted Endoscopic Full Thickness Resection of Duodenal Sub-epithelial Lesions

    Sonthalia, Nikhil / Tewary, Awanish / Roy, Akash / Ghoshal, U. C. / Goenka, M. K.

    Journal of Digestive Endoscopy

    2024  Volume 15, Issue 01

    Event/congress ENDOCON 2024, New Delhi, 2024-04-19
    Language English
    Publishing date 2024-03-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2733732-7
    ISSN 0976-5050 ; 0976-5042 ; 0976-5050
    ISSN (online) 0976-5050
    ISSN 0976-5042 ; 0976-5050
    DOI 10.1055/s-0044-1786297
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  5. Article ; Online: Flat-based over-the-scope clip-assisted endoscopic full-thickness resection of a duodenal neuroendocrine tumour: a safe alternative to endoscopic submucosal dissection.

    Sonthalia, Nikhil / Shah, Bhavik Bharat / Goenka, Mahesh Kumar

    Endoscopy

    2021  Volume 54, Issue 7, Page(s) E391–E393

    MeSH term(s) Duodenal Neoplasms/surgery ; Endoscopic Mucosal Resection ; Humans ; Intestinal Neoplasms ; Neuroendocrine Tumors/surgery ; Pancreatic Neoplasms ; Stomach Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1546-9958
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  6. Article ; Conference proceedings: Use of Contrast-Enhanced Endoscopic-Ultrasound (CE-EUS) and Endoscopic-Ultrasound Elastography (EUS-E) Improves Diagnostic Performance of EUS-Guided Tissue Acquisition in Solid Pancreatic Masses Arising in Presence of Chronic Pancreatitis

    Sonthalia, Nikhil / Tewary, Awanish / Roy, Akash / Ghoshal, U. C. / Goenka, M. K.

    Journal of Digestive Endoscopy

    2024  Volume 15, Issue 01

    Event/congress ENDOCON 2024, New Delhi, 2024-04-19
    Language English
    Publishing date 2024-03-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2733732-7
    ISSN 0976-5050 ; 0976-5042 ; 0976-5050
    ISSN (online) 0976-5050
    ISSN 0976-5042 ; 0976-5050
    DOI 10.1055/s-0044-1786298
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  7. Article ; Online: Determinants, profile and outcomes of hepatitis A virus-associated severe acute liver injury in adults.

    Roy, Akash / Ghoshal, Uday Chand / Kulkarni, Anand V / Lohia, Kautuk / Tiwary, Indrajeet / Tiwari, Subhash / Tewari, Awanish / Sonthalia, Nikhil / Goenka, Mahesh K

    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

    2024  

    Abstract: Background and objectives: Hepatitis A virus (HAV)-related hepatitis is witnessing an epidemiological transition with increasing trends in adults. While uncomplicated hepatitis remains common, evidence suggests it to be a growing cause for acute liver ... ...

    Abstract Background and objectives: Hepatitis A virus (HAV)-related hepatitis is witnessing an epidemiological transition with increasing trends in adults. While uncomplicated hepatitis remains common, evidence suggests it to be a growing cause for acute liver failure (ALF). In between the two extremes exists severe acute liver injury (s-ALI) which has a propensity to transition to ALF. We aimed at describing the clinical profile of patients with HAV-related s-ALI and identifying potential predictors of progression to ALF.
    Methods: This was a single-center retrospective analysis of adult patients admitted with HAV-related s-ALI between April 2022 and December 2023. Demographic and laboratory parameters were compared between patients with only s-ALI and those with ALF. Predictors of progression from s-ALI to ALF were identified using logistic regression.
    Results: Forty-three patients satisfied criteria of s-ALI, of which 33 (76.7%) had only s-ALI, while 10 (23.3%) had ALF. Patients with s-ALI had lesser leukocytosis (6.3 ± 3 vs. 13.2 ± 4.8), less incidence of acute kidney injury (9.1% vs. 40%) and lower model for end-stage liver disease (MELD) (20 [18-24.5] vs. 31.5 [26-42]), arterial lactate (2.1 [1.3-3.1] vs. 6.3 [5.2-8.0]), arterial ammonia (94 [72-118] vs. 299 [188-573]), procalcitonin (0.5 [0.28-1.25] vs. 3.2 [1.2-6.1]) and ferritin (482 [213-1633] vs. 5186 [1341-11,053]) compared to HAV-ALF (p < 0.05 for all). Three patients (9.09%) with s-ALI progressed to ALF of whom one (3%) died. Baseline ammonia levels (unadjusted odds ratio [OR] 1.03 [1.01-1.06]) and leukocyte count (OR 1.00 [1.00-1.01]) tended to be associated with ALF progression, although none was significant after multi-variable adjustment. Ammonia levels had an area under receiver operating curve of 0.816 (0.64-0.93) (p = 0.009) (cut-off of 144 μmol/L). Additional comorbidities did not impact overall outcomes.
    Conclusion: HAV presents as s-ALI in young adults, with almost one in 10 progressing to ALF. Baseline ammonia may be an important predictor of progression even in s-ALI, but mandates larger well-designed studies.
    Language English
    Publishing date 2024-04-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 632595-6
    ISSN 0975-0711 ; 0254-8860
    ISSN (online) 0975-0711
    ISSN 0254-8860
    DOI 10.1007/s12664-024-01577-3
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  8. Article: Correction: Flat-based over-the-scope clip-assisted endoscopic full-thickness resection of a duodenal neuroendocrine tumour: a safe alternative to endoscopic submucosal dissection

    Sonthalia, Nikhil / Shah, Bhavik Bharat / Goenka, Mahesh Kumar

    Endoscopy

    2022  Volume 54, Issue 07, Page(s) C9–C9

    Language English
    Publishing date 2022-04-22
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1823-2120
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  9. Article: Definitive Role of Contrast-enhanced Endoscopic Ultrasound (EUS) in the Diagnosis of Hepatocellular Carcinoma With Non-diagnostic Cross-sectional Imaging: A Case Report.

    Sonthalia, Nikhil / Roy, Akash / Jajodia, Surabhi / Goenka, Usha / Sutradhar, Arpita / Tewari, Awanish / Goenka, Mahesh K

    Journal of clinical and experimental hepatology

    2023  Volume 14, Issue 3, Page(s) 101307

    Abstract: The diagnosis of hepatocellular carcinoma is usually centered around cross-sectional imaging (CSI) modalities. However, in some instances focal hepatic lesions may be missed on CSI. Endoscopic ultrasound (EUS) has an evolving role in hepatology and have ... ...

    Abstract The diagnosis of hepatocellular carcinoma is usually centered around cross-sectional imaging (CSI) modalities. However, in some instances focal hepatic lesions may be missed on CSI. Endoscopic ultrasound (EUS) has an evolving role in hepatology and have been shown to be useful in diagnosing focal lesions with advantages of tissue acquisition. We report a case hepatitis B-related cirrhosis presenting with acute decompensation, wherein EUS was used to identify HCC and perform tissue acquisition as CSI was non-diagnostic.
    Language English
    Publishing date 2023-11-25
    Publishing country India
    Document type Case Reports
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2023.101307
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  10. Article: Flat-based over-the-scope clip-assisted endoscopic full-thickness resection of a duodenal neuroendocrine tumour: a safe alternative to endoscopic submucosal dissection

    Sonthalia, Nikhil / Shah, Bhavik Bharat / Goenka, Mahesh Kumar

    Endoscopy

    2021  Volume 54, Issue 07, Page(s) E391–E393

    Language English
    Publishing date 2021-08-09
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1546-9958
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