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  1. Article ; Online: Re: Hanbing Song, Bobak Seddighzadeh, Matthew R. Cooperberg, Franklin W. Huang. Expression of ACE2 and TMPRSS2, the SARS-CoV-2 Receptor and Co-Receptor, in Prostate Epithelial Cells. Eur Urol. In press DOI: 10.1016/j.eururo.2020.04.065.

    Rizzo, Alessandro / Mollica, Veronica / Massari, Francesco

    European urology

    2020  Volume 78, Issue 5, Page(s) e205–e206

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Epithelial Cells ; Humans ; Male ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.06.034
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  2. Article: Re: Hanbing Song, Bobak Seddighzadeh, Matthew R. Cooperberg, Franklin W. Huang. Expression of ACE2 and TMPRSS2, the SARS-CoV-2 Receptor and Co-Receptor, in Prostate Epithelial Cells. Eur Urol. In press DOI: 10.1016/j.eururo.2020.04.065

    Rizzo, Alessandro / Mollica, Veronica / Massari, Francesco

    Eur Urol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612261
    Database COVID19

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  3. Article ; Online: Water removal in MR spectroscopic imaging with Casorati singular value decomposition.

    Shamaei, Amirmohammad / Starcukova, Jana / Rizzo, Rudy / Starcuk, Zenon

    Magnetic resonance in medicine

    2024  Volume 91, Issue 4, Page(s) 1694–1706

    Abstract: Purpose: Water removal is one of the computational bottlenecks in the processing of high-resolution MRSI data. The purpose of this work is to propose an approach to reduce the computing time required for water removal in large MRS data.: Methods: In ... ...

    Abstract Purpose: Water removal is one of the computational bottlenecks in the processing of high-resolution MRSI data. The purpose of this work is to propose an approach to reduce the computing time required for water removal in large MRS data.
    Methods: In this work, we describe a singular value decomposition-based approach that uses the partial position-time separability and the time-domain linear predictability of MRSI data to reduce the computational time required for water removal. Our approach arranges MRS signals in a Casorati matrix form, applies low-rank approximations utilizing singular value decomposition, removes residual water from the most prominent left-singular vectors, and finally reconstructs the water-free matrix using the processed left-singular vectors.
    Results: We have demonstrated the effectiveness of our proposed algorithm for water removal using both simulated and in vivo data. The proposed algorithm encompasses a pip-installable tool ( https://pypi.org/project/CSVD/), available on GitHub ( https://github.com/amirshamaei/CSVD), empowering researchers to use it in future studies. Additionally, to further promote transparency and reproducibility, we provide comprehensive code for result replication.
    Conclusions: The findings of this study suggest that the proposed method is a promising alternative to existing water removal methods due to its low processing time and good performance in removing water signals.
    MeSH term(s) Water/chemistry ; Reproducibility of Results ; Magnetic Resonance Spectroscopy ; Magnetic Resonance Imaging/methods ; Algorithms
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.29959
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  4. Article ; Online: Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease research.

    Sasner, Michael / Territo, Paul R / Sukoff Rizzo, Stacey J

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 19, Issue 11, Page(s) 5284–5288

    Abstract: Introduction: The second annual 5-day workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research was held October 7-11, 2019, at The Jackson Laboratory in Bar Harbor, Maine, USA, and included ... ...

    Abstract Introduction: The second annual 5-day workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research was held October 7-11, 2019, at The Jackson Laboratory in Bar Harbor, Maine, USA, and included didactic lectures and hands-on training. Participants represented a broad range of research across the Alzheimer's disease (AD) field, and varied in career stages from trainees and early stage investigators to established faculty, with attendance from the United States, Europe, and Asia.
    Methods: In line with the National Institutes of Health (NIH) initiative on rigor and reproducibility, the workshop aimed to address training gaps in preclinical drug screening by providing participants with the skills and knowledge required to perform pharmacokinetic, pharmacodynamics, and preclinical efficacy experiments.
    Results: This innovative and comprehensive workshop provided training in fundamental skill sets for executing in vivo preclinical translational studies.
    Discussion: The success of this workship is expected to translate into practical skills that will enable the goals of improving preclinical to clinical translational studies for AD.
    Highlights: Nearly all preclinical studies in animal models have failed to translate to successful efficacious medicines for Alzheimer's disease (AD) patients. While a wide variety of potential causes of these failures have been proposed,deficiencies in knowledge and best practices for translational research are not being sufficiently addressed by common training practices. Here we present proceedings from an annual NIA-sponsored workshop focused specifically on preclinical testing paradigms for AD translational research in animal models aimed at enabling improved preclinical to clinical translation for AD.
    MeSH term(s) Animals ; Humans ; United States ; Alzheimer Disease/drug therapy ; Alzheimer Disease/diagnosis ; Reproducibility of Results ; Translational Research, Biomedical ; Europe
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13093
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  5. Article ; Online: Nicotinamide Adenine Dinucleotide: The Redox Sensor in Aging-Related Disorders.

    Schiuma, Giovanna / Lara, Djidjell / Clement, James / Narducci, Marco / Rizzo, Roberta

    Antioxidants & redox signaling

    2024  

    Abstract: Significance: ...

    Abstract Significance:
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0375
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  6. Article ; Online: Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research.

    Sasner, Michael / Onos, Kristen D / Territo, Paul R / Sukoff Rizzo, Stacey J

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  

    Abstract: The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address ... ...

    Abstract The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address training gaps in preclinical translational studies for Alzheimer's disease (AD). In addition to providing fundamental knowledge and hands-on skills essential for executing rigorous in vivo studies that are designed to facilitate translation, each year the workshop aims to provide insight on state-of-the-field technological advances and new resources including novel animal models, publicly available datasets, novel biomarkers, and new medical imaging tracers. This innovative and comprehensive workshop continues to deliver training for the greater AD research community in order to provide investigators and trainees with the knowledge and skillsets essential for enabling improved preclinical to clinical translation and accelerate the process of advancing safe and effective therapeutic interventions for AD. HIGHLIGHTS: Translational research is not typically available as a course of study at academic institutions, yet there are fundamental skillsets and knowledge required to enable successful translation from preclinical experiments to clinical efficacy. It is important that there are resources and opportunities available to researchers planning preclinical translational experiments. Here we present proceedings from the fifth annual NIA-sponsored workshop focused on enabling improved preclinical to clinical translation for Alzheimer's disease research that includes didactic lectures on state-of-the-field approaches and hands-on practicums for acquiring essential translational laboratory techniques.
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13742
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  7. Article ; Online: Isolation of Acinetobacter bereziniae harbouring plasmid bla

    Merlino, John / Rizzo, Sophia / Beresford, Rohan / Gray, Timothy

    Pathology

    2023  Volume 55, Issue 6, Page(s) 867–868

    MeSH term(s) Humans ; Acinetobacter/genetics ; Plasmids/genetics ; beta-Lactamases/genetics ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests
    Chemical Substances beta-lactamase NDM-1 (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Letter
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2023.02.008
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  8. Article ; Online: A novel pulsed magnet for magnetic linear birefringence measurements.

    Béard, J / Agil, J / Battesti, R / Rizzo, C

    The Review of scientific instruments

    2021  Volume 92, Issue 10, Page(s) 104710

    Abstract: In this paper, we describe a novel pulsed magnet, called foil coil, which can deliver a field transverse to the light propagation of more than 10 T over about 0.8 m operating without cryogenic equipment. It has been designed for linear magnetic ... ...

    Abstract In this paper, we describe a novel pulsed magnet, called foil coil, which can deliver a field transverse to the light propagation of more than 10 T over about 0.8 m operating without cryogenic equipment. It has been designed for linear magnetic birefringence measurements. We report on testing the coil and also show some physics data taken in vacuum during its commissioning in the framework of the Biréfringence Magnétique du Vide (BMV) apparatus, with special attention to noise induced by the pulse itself. Finally, we compare the preliminary results obtained here with data from the previous BMV coil.
    Language English
    Publishing date 2021-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0064111
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  9. Article: SiO,

    Rizzo, J R / Cernicharo, J / Garoía-Miró, C

    The Astrophysical journal. Supplement series

    2021  Volume 253, Issue 2

    Abstract: Circumstellar environments of oxygen-rich stars are among the strongest SiO maser emitters. Physical processes such as collisions, infrared pumping and overlaps favors the inversion of level population and produce maser emission at different vibrational ... ...

    Abstract Circumstellar environments of oxygen-rich stars are among the strongest SiO maser emitters. Physical processes such as collisions, infrared pumping and overlaps favors the inversion of level population and produce maser emission at different vibrational states. Despite numerous observational and theoretical efforts, we still do not have an unified picture including all the physical processes involved in the SiO maser emission. The aim of this work is to provide homogeneous data in a large sample of oxygen-rich stars. We present a survey of 67 oxygen-rich stars from 7 to 1 mm, in their rotational transitions from
    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Journal Article
    ISSN 0067-0049
    ISSN 0067-0049
    DOI 10.3847/1538-4365/abe469
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  10. Article ; Online: Nonpenetrating Foldable Intrastromal Keratoprosthesis: A Review of the Literature.

    Kilian, Raphael / Lammer, Jan / Roberts, Philipp / Rizzo, Clara / Pedrotti, Emilio / Marchini, Giorgio / Schmidinger, Gerald

    Cornea

    2024  

    Abstract: Purpose: To review the literature focusing on the clinical outcomes of KeraKlear (KK) (KeraMed), a foldable intrastromal keratoprosthesis.: Methods: We searched 6 databases using 4 keywords: KeraKlear, Foldable Keratoprosthesis, Intrastromal ... ...

    Abstract Purpose: To review the literature focusing on the clinical outcomes of KeraKlear (KK) (KeraMed), a foldable intrastromal keratoprosthesis.
    Methods: We searched 6 databases using 4 keywords: KeraKlear, Foldable Keratoprosthesis, Intrastromal Keratoprosthesis, and Non-penetrating Keratoprosthesis. Included studies had to be conducted in vivo on humans, published until January 3, 2023, and had to investigate the implantation of the KK. Eyes were considered at high risk of keratoprosthesis retention failure whenever there was an active inflammatory ocular surface disorder or in case of previous KK failure. We aimed at recording the postoperative complications, rate of prosthesis retention, and mean improvements in visual acuity.
    Results: We identified 144 publications, 6 of which (38 eyes) met the inclusion criteria. No randomized controlled trials were found, and some studies had significant limitations regarding sample size and follow-up duration. With a mean follow-up of 28 ± 18.8 months, postoperative complications of any kind occurred between 0% and 50% and 24% had an implant extrusion/needed a reoperation. The mean postoperative visual acuity improvement on the last follow-up was -0.83 ± 0.27 LogMAR, that is, -0.57 ± 0.3 for high-risk and -1.03 ± 0.25 for low-risk eyes, whereas 1 year after implantation, 50% of the prostheses were retained in the former and 81% in the latter group. None of the eyes developed glaucoma, endophthalmitis, or expulsive hemorrhages; none had to be eviscerated/enucleated.
    Conclusions: Despite the limited quality and quantity of evidence, the available literature seems to suggest the KK to be a valuable tool in the treatment of complicated corneal disorders. Because in many parts of the world, the access to corneal transplantation is limited, this prosthesis could represent a valid alternative.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000003500
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