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Article ; Online: Reply to John Samuel Banerji's letter to the editor re: Constantijn H.J. Muselaers, Otto C. Boerman, Egbert Oosterwijk, Johannes F. Langenhuijsen, Wim J.G. Oyen, Peter F.A. Mulders. Indium-111-labeled girentuximab immunoSPECT as a diagnostic tool in clear cell renal cell carcinoma. Eur Urol 2013;63:1101-6.

Muselaers, Constantijn H J / Boerman, Otto C / Oosterwijk, Egbert / Langenhuijsen, Johan F / Oyen, Wim J G / Mulders, Peter F A

European urology

2013 Volume 64, Issue 4, Page(s) e83

MeSH term(s)	Antibodies, Monoclonal ; Antigens, Neoplasm/immunology ; Carbonic Anhydrases/immunology ; Carcinoma, Renal Cell/diagnostic imaging ; Female ; Humans ; Indium Radioisotopes ; Kidney Neoplasms/diagnostic imaging ; Male ; Radionuclide Imaging ; Radiopharmaceuticals
Chemical Substances	Antibodies, Monoclonal ; Antigens, Neoplasm ; Indium Radioisotopes ; Radiopharmaceuticals ; Carbonic Anhydrases (EC 4.2.1.1)
Language	English
Publishing date	2013-10
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2013.06.054
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Use of maximal dosage renin-angiotensin-aldosterone system inhibitors in a real life population of complicated type 2 diabetes - contraindications and opportunities.

Gant, C M / Oosterwijk, M M / Binnenmars, S H / Navis, G J / Haverkate, H / Bakker, S J L / Laverman, G D

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 240

Abstract: Objective: Pharmacological inhibition of the renin-angiotensin-aldosterone-system (RAASi) is the cornerstone of hypertension treatment, renoprotection and secondary prevention of cardiovascular disease in patients with type 2 diabetes. Although there is ...

Abstract	Objective: Pharmacological inhibition of the renin-angiotensin-aldosterone-system (RAASi) is the cornerstone of hypertension treatment, renoprotection and secondary prevention of cardiovascular disease in patients with type 2 diabetes. Although there is a dose-dependent effect of RAASi with optimum protection when using maximal dose, little is known on actual use of maximal dosage RAASi in clinical practice. Here we investigate prevalence of maximal dosage RAASi, and contraindications for, optimizing RAASi dosage, in patients with complicated type 2 diabetes in a real-life clinical setting. Research design and methods: We performed a retrospective analysis in 668 patients included in the DIAbetes and LifEstyle Cohort Twente (DIALECT). We grouped patients according to no RAASi, submaximal RAASi and maximal RAASi use. All potassium and creatinine measurements between January 1st 2000 and date of inclusion in DIALECT were extracted from patients files. We identified determinants of maximal RAASi use vs. submaximal RAASi use with multivariate logistic regression analysis. Results: Mean age was 64 ± 10 years and 61% were men. In total, 460 patients (69%) used RAASi, and 30% used maximal RAASi. Maximal RAASi use was not statistically different between different indications for RAASi (i.e. hypertension, diabetic kidney disease, coronary heart disease and cerebrovascular disease; P > 0.05). Per patient, 2 [1-4] measurements of potassium and 20 [13-31] measurements of creatinine were retrieved, retrospective follow-up time was - 3.0 [-1.4 to -5.7] years. Pre-baseline hyperkalemia > 5.0 mmol/l and acute kidney injury were found in 151 (23%) patients and 119 patients (18%), respectively. Determinants of maximal RAASi were prior acute kidney injury (OR 0.51 (0.30-0.87)), increased albuminuria (OR 1.89 (1.17-3.08)) and total number of used antihypertensives (OR 1.66 (1.33-2.06)). Conclusions: Maximal dose RAASi is used in almost one third of complicated type 2 diabetes patients in a real-life setting. The prevalence of contraindications is considerable, but relative in nature, suggesting that it is worthwhile to explore strategies aimed at maximizing RAASi while circumventing the alleged contraindications.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Female ; Renin-Angiotensin System ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Creatinine ; Retrospective Studies ; Diabetes Complications ; Acute Kidney Injury ; Contraindications ; Hypertension/drug therapy ; Hypertension/epidemiology
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03205-2
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Article ; Online: Combination of sunitinib and

Oosterwijk-Wakka, Jeannette C / de Weijert, Mirjam C A / Franssen, Gerben M / Kolev, Dimitar R / de Haan, Ton A F J / Boerman, Otto C / Mulders, Peter F A / Oosterwijk, Egbert

Neoplasia (New York, N.Y.)

2022 Volume 32, Page(s) 100826

Abstract: ... expression and performed therapy studies in Balb/c ...

Abstract	Sunitinib is an effective treatment for patients with metastatic Renal Cell Carcinoma (mRCC) but ultimately resistance occurs. The aim of this study was to investigate sunitinib resistance in RCCs and to develop therapeutic combination strategies with targeted radioimmunotherapy (RIT). We studied two RCC models, analyzed Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) and AXL/MET expression and performed therapy studies in Balb/c
MeSH term(s)	Animals ; Carcinoma, Renal Cell ; Cell Line, Tumor ; Kidney Neoplasms ; Mice ; Mice, Nude ; Radioimmunotherapy ; Sunitinib ; Vascular Endothelial Growth Factor A
Chemical Substances	Vascular Endothelial Growth Factor A ; Sunitinib (V99T50803M)
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2022.100826
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Zs.A 5203: Show issues

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Article ; Online: Combining Targeted Radionuclide Therapy and Immune Checkpoint Inhibition for Cancer Treatment.

Kleinendorst, Simone C / Oosterwijk, Egbert / Bussink, Johan / Westdorp, Harm / Konijnenberg, Mark W / Heskamp, Sandra

Clinical cancer research : an official journal of the American Association for Cancer Research

2022 Volume 28, Issue 17, Page(s) 3652–3657

Abstract: The development of immunotherapy, in particular immune checkpoint inhibitors (ICI), has revolutionized cancer treatment in the past decades. However, its efficacy is still limited to subgroups of patients with cancer. Therefore, effective treatment ... ...

Abstract	The development of immunotherapy, in particular immune checkpoint inhibitors (ICI), has revolutionized cancer treatment in the past decades. However, its efficacy is still limited to subgroups of patients with cancer. Therefore, effective treatment combination strategies are needed. Here, radiotherapy is highly promising, as it can induce immunogenic cell death, triggering the release of pro-inflammatory cytokines, thereby creating an immunogenic phenotype and sensitizing tumors to ICI. Recently, targeted radionuclide therapy (TRT) has attained significant interest for cancer treatment. In this approach, a tumor-targeting radiopharmaceutical is used to specifically deliver a therapeutic radiation dose to all tumor cells, including distant metastatic lesions, while limiting radiation exposure to healthy tissue. However, fundamental differences between TRT and conventional radiotherapy make it impossible to directly extrapolate the biological effects from conventional radiotherapy to TRT. In this review, we present a comprehensive overview of studies investigating the immunomodulatory effects of TRT and the efficacy of combined TRT-ICI treatment. Preclinical studies have evaluated a variety of murine cancer models in which α- or β-emitting radionuclides were directed to a diverse set of targets. In addition, clinical trials are ongoing to assess safety and efficacy of combined TRT-ICI in patients with cancer. Taken together, research indicates that combining TRT and ICI might improve therapeutic response in patients with cancer. Future research has to disclose what the optimal conditions are in terms of dose and treatment schedule to maximize the efficacy of this combined approach.
MeSH term(s)	Animals ; Combined Modality Therapy ; Immune Checkpoint Inhibitors ; Immunotherapy ; Mice ; Neoplasms/radiotherapy ; Radioisotopes/therapeutic use
Chemical Substances	Immune Checkpoint Inhibitors ; Radioisotopes
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-21-4332
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Zs.A 4223: Show issues

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Article ; Online: Comparison of Osteogenic Capacity and Osteoinduction of Adipose Tissue-Derived Cell Populations.

Husch, Johanna F A / Coquelin, Laura / Chevallier, Nathalie / Tiemessen, Dorien / Oosterwijk, Egbert / van Rheden, René / Woud, Charlotte / Vossen, Jurriaan / Leeuwenburgh, Sander C G / van den Beucken, Jeroen J J P

Tissue engineering. Part C, Methods

2023 Volume 29, Issue 5, Page(s) 216–227

Abstract: Stromal vascular fraction (SVF) is the primary isolate obtained after enzymatic digestion of adipose tissue that contains various cell types. Its successful application for cell-based construct preparation in an intra-operative setting for clinical bone ... ...

Abstract	Stromal vascular fraction (SVF) is the primary isolate obtained after enzymatic digestion of adipose tissue that contains various cell types. Its successful application for cell-based construct preparation in an intra-operative setting for clinical bone augmentation and regeneration has been previously reported. However, the performance of SVF-based constructs compared with traditional
MeSH term(s)	Mice ; Humans ; Animals ; Cattle ; Stromal Cells ; Mice, Nude ; Osteogenesis ; Adipose Tissue ; Adipocytes ; Cell Differentiation
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2420585-0
ISSN	1937-3392 ; 1937-3384
ISSN (online)	1937-3392
ISSN	1937-3384
DOI	10.1089/ten.TEC.2023.0039
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Zs.A 5500/C: Show issues

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Article ; Online: Shared decision-making for non-operative management versus operative management of hip fractures in selected frail older adults with a limited life expectancy: a protocol for a nationwide implementation study.

Zeelenberg, Miliaan L / Oosterwijk, Paulieke C / Willems, Hanna C / Gosens, Taco / Den Hartog, Dennis / Joosse, Pieter / Loggers, Sverre A I / Nijdam, Thomas Mp / Pel-Littel, Ruth E / Polinder, Suzanne / Schuijt, Henk Jan / Wijnen, Hugo H / Van der Velde, Detlef / Van Lieshout, Esther M M / Verhofstad, Michael H J

BMJ open

2024 Volume 14, Issue 4, Page(s) e083429

Abstract: Background and purpose: Recent research has highlighted non-operative management (NOM) as a viable alternative for frail older adults with hip fractures in the final phase of life. This study aims to guide Dutch physicians and hospitals nationwide in a ... ...

Abstract	Background and purpose: Recent research has highlighted non-operative management (NOM) as a viable alternative for frail older adults with hip fractures in the final phase of life. This study aims to guide Dutch physicians and hospitals nationwide in a standardised implementation of shared decision-making regarding surgery or NOM in selected frail older adults with a hip fracture. Methods and analysis: The patient population for implementation includes frail older adults aged ≥70 years with an acute proximal femoral fracture, nursing home care or a similar level of care elsewhere and at least one additional criterion (ie, malnutrition, severe mobility impairment or ASA≥4). The 2-year implementation study will be conducted in four phases. In phases 1 and 2, barriers and facilitators for implementation will be identified and an implementation protocol, educational materials and patient information will be developed. Phase 3 will involve an implementation pilot in 14 hospitals across the Netherlands. The protocol and educational material will be improved based on healthcare provider and patient experiences gathered through interviews. Phase 4 will focus on upscaling to nationwide implementation and the effect of the implementation on NOM rate will be measured using data from the Dutch Hip Fracture Audit. Ethics and dissemination: The study was exempted by the local Medical Research Ethics Committee (MEC-2023-0270, 10 May 2023) and Medical Ethics Committee United (W23.083, 26 April 2023). The study's results will be submitted to an open access international peer-reviewed journal. Its protocols, tools and results will be presented at several national and international academic conferences of relevant orthogeriatric (scientific) associations. Trial registration number: NCT06079905 .
MeSH term(s)	Aged ; Humans ; Frail Elderly ; Hip Fractures ; Life Expectancy ; Health Personnel ; Pelvic Bones
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-083429
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Article: Clinical and Dietary Determinants of Muscle Mass in Patients with Type 2 Diabetes: Data from the Diabetes and Lifestyle Cohort Twente.

Jalving, Annis C / Oosterwijk, Milou M / Hagedoorn, Ilse J M / Navis, Gerjan / Bakker, Stephan J L / Laverman, Gozewijn D

Journal of clinical medicine

2021 Volume 10, Issue 22

Abstract: Low muscle mass in patients with type 2 diabetes is associated with a progressively higher risk of morbidity and mortality. The aim of this study was to identify modifiable targets for intervention of muscle mass in type 2 diabetes. Cross-sectional ... ...

Abstract	Low muscle mass in patients with type 2 diabetes is associated with a progressively higher risk of morbidity and mortality. The aim of this study was to identify modifiable targets for intervention of muscle mass in type 2 diabetes. Cross-sectional analyses were performed in 375 patients of the Diabetes and Lifestyle Cohort Twente-1 study. Muscle mass was estimated by 24 h urinary creatinine excretion rate (CER, mmol/24 h). Patients were divided in sex-stratified tertiles of CER. To study determinants of CER, multivariable linear regression analyses were performed. Protein intake was determined by Maroni formula and by a semi-quantitative Food Frequency Questionnaire. The mean CER was 16.1 ± 4.8 mmol/24 h and 10.9 ± 2.9 mmol/24 h in men and women, respectively. Lower CER was significantly associated with older age (
Language	English
Publishing date	2021-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10225227
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Article ; Online: Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions.

Yuan, Hongbo / Liu, Kaizheng / Cóndor, Mar / Barrasa-Fano, Jorge / Louis, Boris / Vandaele, Johannes / de Almeida, Paula / Coucke, Quinten / Chen, Wen / Oosterwijk, Egbert / Xing, Chengfen / Van Oosterwyck, Hans / Kouwer, Paul H J / Rocha, Susana

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 15, Page(s) e2216934120

Abstract: Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bidirectional mechanical exchange is crucial for many ... ...

Abstract	Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bidirectional mechanical exchange is crucial for many cell functions, it remains poorly understood. Key challenges are that the majority of available matrices for such studies, either natural or synthetic, are difficult to control or lack biological relevance. Here, we use a synthetic, yet highly biomimetic hydrogel based on polyisocyanide (PIC) polymers to investigate the effects of the fibrous architecture and the nonlinear mechanics on cell-matrix interactions. Live-cell rheology was combined with advanced microscopy-based approaches to understand the mechanisms behind cell-induced matrix stiffening and plastic remodeling. We demonstrate how cell-mediated fiber remodeling and the propagation of fiber displacements are modulated by adjusting the biological and mechanical properties of this material. Moreover, we validate the biological relevance of our results by demonstrating that cellular tractions in PIC gels develop analogously to those in the natural ECM. This study highlights the potential of PIC gels to disentangle complex bidirectional cell-matrix interactions and to improve the design of materials for mechanobiology studies.
MeSH term(s)	Hydrogels ; Extracellular Matrix/physiology ; Cell Communication
Chemical Substances	Hydrogels
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2216934120
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Zs.A 1148: Show issues

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Article ; Online: Een man met buikpijn, diarree en rectaal bloedverlies.

Oosterwijk, A J M / van den Berg, J W / van Rossem, C C

Nederlands tijdschrift voor geneeskunde

2018 Volume 162, Page(s) D2050

Abstract: A 49-year-old man came to the emergency room with abdominal pain, vomiting, diarrhoea and rectal bleeding. Both colonoscopy and CT of the abdomen showed cecocolic intussusception caused by an appendiceal mucocele. An ileocecal resection was performed via ...

Title translation	A man with abdominal pain, diarrhoea and rectal bleeding.
Abstract	A 49-year-old man came to the emergency room with abdominal pain, vomiting, diarrhoea and rectal bleeding. Both colonoscopy and CT of the abdomen showed cecocolic intussusception caused by an appendiceal mucocele. An ileocecal resection was performed via a laparoscopic approach and microscopy of the tissue showed a low-grade mucinous neoplasm.
MeSH term(s)	Abdominal Pain/etiology ; Abdominal Pain/surgery ; Adenocarcinoma, Mucinous/complications ; Appendiceal Neoplasms/complications ; Cecal Neoplasms/complications ; Colectomy ; Colonoscopy ; Diarrhea/etiology ; Diarrhea/surgery ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Humans ; Ileal Neoplasms/complications ; Intussusception/complications ; Intussusception/surgery ; Male ; Middle Aged ; Mucocele/complications ; Mucocele/surgery ; Rectal Diseases/etiology ; Rectal Diseases/surgery ; Vomiting/etiology ; Vomiting/surgery
Language	Dutch
Publishing date	2018-04-20
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Ua VI Zs.18: Show issues

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Article: Do Preferred Risk Formats Lead to Better Understanding? A Multicenter Controlled Trial on Communicating Familial Breast Cancer Risks Using Different Risk Formats.

Henneman, Lidewij / van Asperen, Christi J / Oosterwijk, Jan C / Menko, Fred H / Claassen, Liesbeth / Timmermans, Daniëlle Rm

Patient preference and adherence

2020 Volume 14, Page(s) 333–342

Abstract: Purpose: Counselees' preferences are considered important for the choice of risk communication format and for improving patient-centered care. We here report on counselees' preferences for how risks are presented in familial breast cancer counseling and ...

Abstract	Purpose: Counselees' preferences are considered important for the choice of risk communication format and for improving patient-centered care. We here report on counselees' preferences for how risks are presented in familial breast cancer counseling and the impact of this preferred format on their understanding of risk. Patients and methods: As part of a practice-based randomized controlled trial, 326 unaffected women with a family history of breast cancer received their lifetime risk in one of five presentation formats after standard genetic counseling in three Dutch familial cancer clinics: 1) in percentages, 2) in frequencies ("X out of 100"), 3) in frequencies plus graphical format (10×10 human icons), 4) in frequencies and 10-year age-related risk and 5) in frequencies and 10-year age-related risk plus graphical format. Format preferences and risk understanding (accuracy) were assessed at 2-week follow-up by a questionnaire, completed by 279/326 women. Results: The most preferred risk communication formats were numbers combined with verbal descriptions (37%) and numbers only (26%). Of the numerical formats, most (55%) women preferred percentages. The majority (73%) preferred to be informed about both lifetime and 10-year age-related risk. Women who had received a graphical display were more likely to choose a graphical display as their preferred format. There was no significant effect between the intervention groups with regard to risk accuracy. Overall, women given risk estimates in their preferred format had a slightly better understanding of risk. Conclusion: The results suggest that the accuracy of breast cancer risk estimation is slightly better for women who had received this information in their preferred format, but the risk format used had no effect on women's risk accuracy. To meet the most frequent preference, counselors should consider providing a time frame of reference (eg, risk in the next 10 years) in a numerical format, in addition to lifetime risk.
Language	English
Publishing date	2020-02-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S232941
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