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Article ; Online: Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine.

Basketter, David A / White, Ian R / Kullavanijaya, Preya / Tresukosol, Poohglin / Wichaidit, Mingkwan / McFadden, John P

Contact dermatitis

2016 Volume 74, Issue 6, Page(s) 368–372

Abstract: ... products of p-phenylenediamine (PPD) and closely related substances.: Objectives: To examine ... whether prior application of the antioxidant vitamin C to the skin was able to reduce the cutaneous ... pretreated for 10 min with a vitamin C formulation.: Results: Pretreatment of skin sites with vitamin C ...

Abstract	Background: Hair dyes represent one of the most important causes of allergic contact dermatitis resulting from the use of cosmetic products. The principal causative chemistry is associated with oxidation products of p-phenylenediamine (PPD) and closely related substances. Objectives: To examine whether prior application of the antioxidant vitamin C to the skin was able to reduce the cutaneous allergic response to PPD. Methods: Twenty eight volunteers with a proven history of contact allergy to PPD were recruited. Each was tested with a range of PPD doses and PPD-containing hair dye on untreated skin and skin pretreated for 10 min with a vitamin C formulation. Results: Pretreatment of skin sites with vitamin C led to a reduction in the intensity, or even ablation, of the cutaneous allergic reaction to PPD in ∼75% of cases as compared with untreated skin. Conclusions: The results suggest that treatment of the skin adjacent to the hair-bearing area with antioxidant could form part of a strategy to reduce the burden of cosmetic allergic contact dermatitis caused by hair dyeing.
MeSH term(s)	Antioxidants/therapeutic use ; Ascorbic Acid/therapeutic use ; Coloring Agents/administration & dosage ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/prevention & control ; Hair Dyes/adverse effects ; Humans ; Patch Tests ; Phenylenediamines/adverse effects ; Premedication/methods ; Severity of Illness Index
Chemical Substances	Antioxidants ; Coloring Agents ; Hair Dyes ; Phenylenediamines ; Ascorbic Acid (PQ6CK8PD0R) ; 4-phenylenediamine (U770QIT64J)
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.12576
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Erratum: Harris, C.; White, P.J.; Mohler, V.L.; Lomax, S. Electroencephalography Can Distinguish between Pain and Anaesthetic Intervention in Conscious Lambs Undergoing Castration.

Harris, Charissa / White, Peter John / Mohler, Virginia L / Lomax, Sabrina

Animals : an open access journal from MDPI

2020 Volume 10, Issue 9

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2020-08-24
Publishing country	Switzerland
Document type	Published Erratum
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10091498
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Article: Selective Synthesis of C₁-Symmetric BINOL-phosphates and P-chiral Phosphoramides Using Directed ortho-Lithiation

Volpe, Rohan / Law, Hanson Y.-L. / White, Jonathan M. / Flynn, Bernard L.

Organic letters. 2021 Aug. 27, v. 23, no. 18

2021

Abstract: ... desymmetrization of pseudo-C₂-symmetric BINOL-N-triflylphosphoramide, affording a chiral P-group. ... substitution of BINOL-phosphoric acid and BINOL-N-triflylphosphoramide (BINOL-P-acids). It can be employed ... in the rapid assembly of either mono- or disubstituted BINOL-P-acids, including unsymmetrical disubstitution ...

Abstract	Directed ortho-lithiation (DoL) has been developed as an effective method for the ortho-substitution of BINOL-phosphoric acid and BINOL-N-triflylphosphoramide (BINOL-P-acids). It can be employed in the rapid assembly of either mono- or disubstituted BINOL-P-acids, including unsymmetrical disubstitution through iterative DoL. Most significantly, DoL has proven to be highly effective in the diastereoselective desymmetrization of pseudo-C₂-symmetric BINOL-N-triflylphosphoramide, affording a chiral P-group.
Keywords	acids ; diastereoselectivity ; methodology
Language	English
Dates of publication	2021-0827
Size	p. 7055-7058.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c02430
Database	NAL-Catalogue (AGRICOLA)

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Article: P-glycoprotein Blockers Augment the Effect of Mitomycin C on Human Tenon's Fibroblasts.

White, Andrew J R / Kelly, Elizabeth / Healey, Paul R / Crowston, Jonathan G / Mitchell, Paul / Zoellner, Hans

Translational vision science & technology

2013 Volume 2, Issue 5, Page(s) 1

Abstract: Purpose: Mitomycin C (MMC), which induces apoptosis in human Tenon's fibroblasts (HTF), is ...

Abstract	Purpose: Mitomycin C (MMC), which induces apoptosis in human Tenon's fibroblasts (HTF), is frequently used to retard wound healing after glaucoma surgery. The aim of this in vitro study was to examine whether adjunctive Verapamil and Cyclosporine could augment the cytotoxic effect of MMC on HTF. Methods: Fibroblast cell lines were established by explant culture from human tissue biopsy samples obtained during trabeculectomy procedures. Cells were exposed to MMC at varying concentrations (0.01-0.4 mg/ml) for 3 minutes, prior to washing in the presence or absence of the following drugs: Staurosporine (0.003mg/ml), Verapamil (2.5-0.25 mg/ml), or Cyclosporine (50-0.5 mg/ml). Following exposure, cells were cultured for 6 hours and surviving cells quantitated by haemocytometer counts. Results: Both Verapamil and Staurosporine exhibited mild toxic effects on their own, but greatly enhanced the apoptotic effect of MMC. Staurosporine is too toxic to be considered clinically, so its augmentive effect on the activity of MMC was not studied further here. Doses as low as 0.25 mg/ml of Verapamil continued to show significant augmentation of the apoptotic effect of MMC Cyclosporine at a clinically used concentration (5 mg/ml) exhibited modest augmentation of the effect of MMC. Conclusions: Verapamil and Cyclosporine in clinically acceptable concentrations potentiate the effect of MMC and may obviate the need for high dose antimetabolites in trabeculectomy; however, further preclinical study is required. Translational relevance: Adjunctive Verapamil or Cyclosporine may allow lower dose MMC to be used in glaucoma filtration surgery while maintaining the same antifibrotic effects.
Language	English
Publishing date	2013-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.2.5.1
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Article: Erratum: Harris, C.; White, P.J.; Mohler, V.L.; Lomax, S. Electroencephalography Can Distinguish between Pain and Anaesthetic Intervention in Conscious Lambs Undergoing Castration. Animals 2020, 10, 428

Harris, Charissa / White, Peter John / Mohler, Virginia L / Lomax, Sabrina

Animals. 2020 Aug. 24, v. 10, no. 9

2020

Abstract: The authors wish to make the following corrections to this paper [ ... ] ...

Abstract	The authors wish to make the following corrections to this paper [...]
Keywords	castration ; electroencephalography ; pain
Language	English
Dates of publication	2020-0824
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ISSN	2076-2615
DOI	10.3390/ani10091498
Database	NAL-Catalogue (AGRICOLA)

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Article: Observation of exotic meson production in the reaction pi- p --> eta'pi- p at 18 GeV/c.

Ivanov, E I / Stienike, D L / Ryabchikov, D I / Adams, G S / Adams, T / Bar-Yam, Z / Bishop, J M / Bodyagin, V A / Brown, D S / Cason, N M / Chung, S U / Cummings, J P / Danyo, K / Denisov, S P / Dorofeev, V A / Dowd, J P / Eugenio, P / Fan, X L / Hackenburg, R W /

Hayek, M / Joffe, D / Kachaev, I A / Kern, W / King, E / Kodolova, O L / Korotkikh, V L / Kostin, M A / Kuhn, J / Lipaev, V V / LoSecco, J M / Manak, J J / Napolitano, J / Nozar, M / Olchanski, C / Ostrovidov, A I / Pedlar, T K / Popov, A V / Sarycheva, L I / Seth, K K / Shen, X / Shenhav, N / Shephard, W D / Sinev, N B / Smith, J A / Taegar, S A / Tomaradze, A / Vardanyan, I N / Weygand, D P / White, D B / Willutzki, H J / Witkowski, M / Yershov, A A

Physical review letters

2001 Volume 86, Issue 18, Page(s) 3977–3980

Abstract: An amplitude analysis of an exclusive sample of 5765 events from the reaction pi- p-->eta'pi- p ... at 18 GeV/c is described. The eta'pi- production is dominated by natural parity exchange and by three ...

Abstract	An amplitude analysis of an exclusive sample of 5765 events from the reaction pi- p-->eta'pi- p at 18 GeV/c is described. The eta'pi- production is dominated by natural parity exchange and by three partial waves: those with J(PC) = 1(-+), 2(++), and 4(++). A mass-dependent analysis of the partial-wave amplitudes indicates the production of the a2(1320) meson as well as the a4(2040) meson, observed for the first time decaying to eta'pi-. The dominant, exotic (non- qq) 1(-+) partial wave is shown to be resonant with a mass of 1.597+/-0.010(+0.045)(-0.010) GeV/c2 and a width of 0.340+/-0.040+/-0.050 GeV/c2. This exotic state, the pi1(1600), is produced with a t dependence which is different from that of the a2(1320) meson, indicating differences between the production mechanisms for the two states.
Language	English
Publishing date	2001-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.86.3977
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Article ; Online: Primary total knee arthroplasty using the P.F.C Sigma®-rotating platform cruciate retaining endoprosthesis--a 6 year follow up.

Bhatt, H / Rambani, R / White, W / Chakrabarty, G

The Knee

2012 Volume 19, Issue 6, Page(s) 856–859

Abstract: Background: Mobile-bearing Total Knee Replacement allows unconstrained axial rotation. Increased articular conformity minimizes polyethylene contact stresses, thereby reducing linear wear and fatigue failure.: Methods: We prospectively reviewed a ... ...

Abstract	Background: Mobile-bearing Total Knee Replacement allows unconstrained axial rotation. Increased articular conformity minimizes polyethylene contact stresses, thereby reducing linear wear and fatigue failure. Methods: We prospectively reviewed a consecutive series of 161 patients with mobile bearing total knee replacements using the PFC Sigma Cruciate Retaining Rotating Platform System. (DePuy, Leeds, United Kingdom) with midterm follow up (minimum 6 and maximum 9 years, mean 7.2 years). One hundred forty-seven patients from February 2001 to March 2004 were followed up till date. Primary osteoarthritis 96%; was the main indication followed by rheumatoid arthritis 3% and one case of psoriatic arthritis. Fifty-seven percent were females with mean age of 69.5 years (Range 51-90 years). Oxford and American Knee Society scores were measured. Results: Mean Oxford score improved from 43 (Range 29-55) pre operatively to 21(Range 13-44) at last follow up and mean Knee Society score from 53 (Range 43-70) to 80 (Range 58-90). Range of movement improved from 91° (Range 70-110) to 113° (Range 75-130) at last follow up. One patient had dislocation of bearing needing manipulation. One patient had superficial infection treated with antibiotics. No patients had deep infection. There was one case reported of deep vein thrombosis and one of non-fatal pulmonary embolism. Conclusion: The midterm results in our series with PFC Sigma mobile bearing knee replacement are excellent with good outcome scores. Cohort will be followed for long term results. Level of Evidence IV.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthritis/diagnostic imaging ; Arthritis/physiopathology ; Arthritis/surgery ; Arthroplasty, Replacement, Knee ; Female ; Follow-Up Studies ; Humans ; Knee Joint ; Knee Prosthesis ; Male ; Middle Aged ; Prosthesis Design ; Radiography ; Range of Motion, Articular ; Recovery of Function ; Time Factors ; Treatment Outcome ; Weight-Bearing
Language	English
Publishing date	2012-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2012.03.011
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Article ; Online: Clinical correlation and molecular evaluation confirm that the MLH1 p.Arg182Gly (c.544A>G) mutation is pathogenic and causes Lynch syndrome.

Familial cancer

2012 Volume 11, Issue 3, Page(s) 509–518

Abstract: ... that carries the c.544A>G (p.Arg182Gly) alteration in the MLH1 gene and we undertook to study the variant ... from these families and other independent clinical and scientific evidence indicates that the MLH1 p.Arg182Gly (c.544A ...

Abstract	Approximately 25 % of mismatch repair (MMR) variants are exonic nucleotide substitutions. Some result in the substitution of one amino acid for another in the protein sequence, so-called missense variants, while others are silent. The interpretation of the effect of missense and silent variants as deleterious or neutral is challenging. Pre-symptomatic testing for clinical use is not recommended for relatives of individuals with variants classified as 'of uncertain significance'. These relatives, including non-carriers, are considered at high-risk as long as the contribution of the variant to disease causation cannot be determined. This results in continuing anxiety, and the application of potentially unnecessary screening and prophylactic interventions. We encountered a large Irish Lynch syndrome kindred that carries the c.544A>G (p.Arg182Gly) alteration in the MLH1 gene and we undertook to study the variant. The clinical significance of the variant remains unresolved in the literature. Data are presented on cancer incidence within five kindreds with the same germline missense variant in the MLH1 MMR gene. Extensive testing of relevant family members in one kindred, a review of the literature, review of online MMR mutation databases and use of in silico phenotype prediction tools were undertaken to study the significance of this variant. Clinical, histological, immunohistochemical and molecular evidence from these families and other independent clinical and scientific evidence indicates that the MLH1 p.Arg182Gly (c.544A>G) change causes Lynch syndrome and supports reclassification of the variant as pathogenic.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adult ; Aged ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Female ; Genetic Testing ; Humans ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Mutation ; Nuclear Proteins/genetics ; Pedigree
Chemical Substances	Adaptor Proteins, Signal Transducing ; MLH1 protein, human ; Nuclear Proteins ; MutL Protein Homolog 1 (EC 3.6.1.3)
Language	English
Publishing date	2012-07-08
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1502496-9
ISSN	1573-7292 ; 1389-9600
ISSN (online)	1573-7292
ISSN	1389-9600
DOI	10.1007/s10689-012-9544-4
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Zs.A 6099: Show issues

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Article: Increased Recognition of Non-O157 Shiga Toxin-Producing Escherichia coli Infections in the United States During 2000-2010: Epidemiologic Features and Comparison with E. coli O157 Infections. L. H. Gould, R. K. Mody, K. L. Ong, P. Clogher, A. B. Cronquist, K. N. Garman, S. Lathrop, C. Medus, N. L. Spina, T. H. Webb, P. L. White, K. Wymore, R. E. Gierke, B. E. Mahon, and P. M. Griffin, for the Emerging Infections Program Foodnet Working Group

Gould, L. H. / Mody, R. K. / Ong, K. L. / Clogher, P. / Cronquist, A. B. / Garman, K. N. / Lathrop, S. / Medus, C. / Spina, N. L. / Webb, T. H. / White, P. L. / Wymore, K. / Gierke, R. E. / Mahon, B. E. / Griffin, P. M.

Foodborne pathogens and disease

2013 Volume 10, Issue 5, Page(s) 453

Language	English
Document type	Article
ZDB-ID	2148479-X
ISSN	1535-3141
Database	Current Contents Nutrition, Environment, Agriculture

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Article: DOES "C.P. GRADE" SUCROSE CONTAIN IMPURITIES SIGNIFICANT FOR THE NUTRITION OF EXCISED TOMATO ROOTS?

White, P R

Plant physiology

2006 Volume 15, Issue 2, Page(s) 349–354

Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.15.2.349
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