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Article ; Online: Approach to large adrenal tumors.

Ambroziak, Urszula

Current opinion in endocrinology, diabetes, and obesity

2021 Volume 28, Issue 3, Page(s) 271–276

Abstract: Purpose of review: To summarize the data concerning approach to large adrenal tumors (LAT's), since recent guidelines published in 2016 recommend individual approach rather than clear size cut-off of a tumor that should be removed.: Recent findings: ... ...

Abstract	Purpose of review: To summarize the data concerning approach to large adrenal tumors (LAT's), since recent guidelines published in 2016 recommend individual approach rather than clear size cut-off of a tumor that should be removed. Recent findings: Although the risk of malignancy clearly correlates with the size of a lesion, tumor size of more than 4 cm in diameter represents only 31-61% specificity for the diagnosis of malignant tumor. Therefore, the risk of malignancy and decision about surgery should not be based only on the size of a tumor but assessed in terms of imaging studies, growth pattern during follow-up and new tool that is urine/serum steroid metabolomics. Summary: Approach to patients with LAT's should be individualized. Patients with LAT's should be managed by an expert multidisciplinary team, that includes an endocrinologist, a radiologist, a pathologist, and an adrenal surgeon.
MeSH term(s)	Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/metabolism ; Adrenal Gland Neoplasms/pathology ; Adrenal Gland Neoplasms/therapy ; Humans ; Metabolomics ; Patient Care Team ; Practice Guidelines as Topic
Language	English
Publishing date	2021-03-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2272017-0
ISSN	1752-2978 ; 1752-296X
ISSN (online)	1752-2978
ISSN	1752-296X
DOI	10.1097/MED.0000000000000631
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Article: Characteristics of Congenital Adrenal Hyperplasia Diagnosed in Adulthood: A Literature Review and Case Series.

Hubska, Joanna / Kępczyńska-Nyk, Anna / Czady-Jurszewicz, Katarzyna / Ambroziak, Urszula

Journal of clinical medicine

2023 Volume 12, Issue 2

Abstract: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. CAH, depending on its clinical form, is usually diagnosed in the neonatal period, later in childhood, in adolescence, or in ... ...

Abstract	Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. CAH, depending on its clinical form, is usually diagnosed in the neonatal period, later in childhood, in adolescence, or in young adults. Herein, we report a case series of eight individuals in whom CAH was diagnosed between the ages of 18 and 81 years. Methods: We report on clinical presentations, hormonal tests, adrenal/gonadal imaging, and genetic findings. The clinical data of eight people with CAH, including four women (46, XX) and four men (46, XY), were reviewed. A genetic analysis of the cytochrome P450 family 21 subfamily A member 2 ( Case series: Partial cortisol deficiency was found in all patients. The most frequent genotype was the homozygotic I173N mutation in Conclusions: The clinical presentations of different forms of CAH overlapped. Genotype-phenotype correlations were strong but not absolute. The management of CAH should be individualized and based on clinical and laboratory findings. Furthermore, the assessment of the cortisol response to adrenocorticotrophic hormone stimulation should be mandatory in all adults with CAH. Additionally, the regular long-term screening of cardiometabolic status is required in the CAH population.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12020653
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Article ; Online: The role of antithyroid antibodies in thyroid dysfunction after allogeneic hematopoietic stem cell transplantation.

Rajner, Magdalena / Jasiński, Marcin / Karakulska-Prystupiuk, Ewa / Ambroziak, Urszula / Jędrzejczak, Wiesław W / Basak, Grzegorz W

Polish archives of internal medicine

2023 Volume 133, Issue 11

MeSH term(s)	Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Thyroid Diseases/etiology
Language	English
Publishing date	2023-10-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16588
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Article ; Online: The regulation of cyclin D promoters - review.

Pawlonka, Jan / Rak, Beata / Ambroziak, Urszula

Cancer treatment and research communications

2021 Volume 27, Page(s) 100338

Abstract: Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery. ... ...

Abstract	Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery. Dysregulation of cyclins expression results in impaired development, abnormal cell growth or tumorigenesis. In this review we summarize current knowledge about regulatory role of the cyclin D promoters, transcriptional factors: regulators, co-activators and adaptor proteins necessary to their activation. We focused on the intracellular signaling pathways vital to cell growth, differentiation and apoptosis including transcription factor families: activator protein 1 (AP1), nuclear factor (NFκB), signal transducer and activator of transcription (STAT), cAMP response element-binding protein (CREB) and Sp/NF-Y, with a special insight into the tissue specific cyclin representation.
MeSH term(s)	Animals ; Apoptosis/genetics ; Carcinogenesis/genetics ; Cell Differentiation/genetics ; Cell Division/genetics ; Cyclin D/genetics ; Cyclin D/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Neoplasms/genetics ; Neoplasms/mortality ; Neoplasms/pathology ; Prognosis ; Promoter Regions, Genetic/genetics ; Signal Transduction/genetics ; Transcription Factors/metabolism
Chemical Substances	Cyclin D ; Transcription Factors
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2021.100338
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Article ; Online: Sarcoid-like Lung Disease as a Reaction to Silica from Exposure to Bentonite Cat Litter Complicated by End-Stage Renal Failure-A Case Report.

Hubska, Joanna / Shahnazaryan, Urszula / Rosłon, Marek / Szczepankiewicz, Benedykt / Nikiforow, Kostiantyn / Pisarek, Marcin / Barnaś, Małgorzata / Ambroziak, Urszula

International journal of environmental research and public health

2022 Volume 19, Issue 19

Abstract: A 44-year-old woman was admitted to hospital with end-stage renal failure, productive cough, and decreased exercise tolerance. She had owned nine cats, which resulted in long-term exposure (18 years) to silica-containing bentonite cat litter. High- ... ...

Abstract	A 44-year-old woman was admitted to hospital with end-stage renal failure, productive cough, and decreased exercise tolerance. She had owned nine cats, which resulted in long-term exposure (18 years) to silica-containing bentonite cat litter. High-resolution computed tomography of the chest showed micronodular lesions in the lungs, and mild mediastinal lymphadenopathy. A lung biopsy revealed multinucleated giant cells, some of which had birefringent material and Schaumann bodies. X-ray photoelectron spectroscopy revealed the presence of silicon in the lung biopsy specimen, as well as in the patient's cat litter. The pulmonary condition was suggestive of sarcoid-like lung disease, rather than silicosis, sarcoidosis, or hypersensitivity pneumonitis, according to the clinicopathological findings. Renal failure appeared to be a result of chronic hypercalcemia due to extrarenal calcitriol overproduction in activated alveolar macrophages. Ultimately, the patient was diagnosed with sarcoid-like lung disease complicated by end-stage renal failure from exposure to bentonite cat litter. Therapy with steroids, in addition to elimination of the bentonite cat litter exposure, resulted in a significant improvement in the health condition. At a follow-up visit after 4 months, an almost complete resolution of the lung lesions and a significant improvement in renal function were observed.
MeSH term(s)	Bentonite ; Calcitriol ; Female ; Humans ; Kidney Failure, Chronic ; Lung Diseases ; Sarcoidosis/diagnosis ; Silicon ; Silicon Dioxide/toxicity ; Skin Diseases
Chemical Substances	Bentonite (1302-78-9) ; Silicon Dioxide (7631-86-9) ; Calcitriol (FXC9231JVH) ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2022-10-09
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191912921
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Article ; Online: Huge Hematoma as First Manifestation of Adrenocortical Carcinoma: A Case Report.

Świeczkowski-Feiz, Siavash / Kaszczewski, Piotr / Gelo, Remigiusz / Krajewska, Ewa / Celejewski, Krzysztof / Toutounchi, Sadegh / Ambroziak, Urszula / Pogorzelski, Ryszard / Gałązka, Zbigniew

The American journal of case reports

2023 Volume 24, Page(s) e937569

Abstract: BACKGROUND Adrenocortical carcinoma (ACC) is a rare malignancy associated with unfavorable prognosis. It is mainly diagnosed in the fifth or sixth decade of life. Symptoms of ACC are associated with hormonal activity, presence of metastases, and size of ... ...

Abstract	BACKGROUND Adrenocortical carcinoma (ACC) is a rare malignancy associated with unfavorable prognosis. It is mainly diagnosed in the fifth or sixth decade of life. Symptoms of ACC are associated with hormonal activity, presence of metastases, and size of the tumor. The treatment and prognosis depend on the stage of the disease assessed with the ENSAT staging system. CASE REPORT A 38-year-old White man was admitted to our department from the city hospital due to a huge hematoma of the right adrenal gland (130×100 mm). On admission, the patient's condition was stable, and no active bleeding or other complications were present. Therefore, initially, conservative treatment was performed. The control CT scan showed reduction of the hematoma (90×80 mm). Due to the unknown character of the tumor and the sudden onset of bleeding, the patient was prepared for elective surgery according to the phaeochromocytoma surgery protocol. Following preparation, the patient underwent right-sided adrenalectomy. In the postoperative histopathological examination, adrenocortical carcinoma was diagnosed, which allowed the patient to receive appropriate oncological treatment. CONCLUSIONS There is currently no clear algorithm for the management of adrenal hemorrhage. A hemodynamically unstable patient requires urgent surgical treatment. Patients in good general condition should be prepared for early elective surgery.
MeSH term(s)	Male ; Humans ; Adult ; Adrenocortical Carcinoma/complications ; Adrenocortical Carcinoma/surgery ; Adrenocortical Carcinoma/diagnosis ; Adrenal Cortex Neoplasms/complications ; Adrenal Cortex Neoplasms/surgery ; Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/surgery ; Prognosis ; Adrenalectomy/methods ; Hematoma/etiology
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.937569
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Article ; Online: Why novel methods are not always the best? - Multifactorial analysis of hyperandrogenism in women:

Gajda, Sylwia / Sieńko, Damian / Ambroziak, Urszula

Porto biomedical journal

2017 Volume 2, Issue 5, Page(s) 176

Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Journal Article
ISSN	2444-8672
ISSN (online)	2444-8672
DOI	10.1016/j.pbj.2017.07.005
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Article: A very rare origin of a tumor in the right atrium.

Cienszkowska, Katarzyna / Ludwiczak, Marta / Wrzaszczyk, Maciej / Nawrocka, Izabela / Ambroziak, Urszula / Jędrusik, Piotr / Gurba, Hubert

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2021 Volume 48, Issue 288, Page(s) 443–445

Abstract: Primary cardiac tumors are extremely uncommon but metastases can result from direct invasion from the mediastinum, hematogenous spread or extension of the tumor into the vena cava and the right atrium.: A case report: A 37-year-old male with no ... ...

Abstract	Primary cardiac tumors are extremely uncommon but metastases can result from direct invasion from the mediastinum, hematogenous spread or extension of the tumor into the vena cava and the right atrium. A case report: A 37-year-old male with no previous history of chronic diseases was admitted to the hospital due to non-specific chest discomfort, non-productive cough and weakness lasting for several weeks. Physical examination was unremarkable except for tachycardia and bibasal rales. Chest radiogram revealed multiple pulmonary lesions suggesting metastases. A mass in the right adrenal gland was found on abdominal ultrasound and CT scan. In addition, a pathological lesion in the inferior vena cava extending to the right atrium was detected. Echocardiography revealed a pedunculated mass measuring 2.3x1.5 cm, located in the right atrium, which originated from the inferior vena cava. During the diastole, it prolapsed to the right ventricle but did not significantly affect blood flow through the tricuspid valve. Adrenal tumor biopsy revealed adrenocortical cancer and treatment with mitotane was started. After a seizure episode, brain MRI was performed and showed metastases surrounded by edema. Due to the patient's poor general condition and progression of the disease during mitotane treatment was later withdrawn and the patient was referred for the hospice care where he died 2 months later. Conclusions: Adrenocortical cancer is a rare malignant neoplasm with an estimated annual incidence of 4-12 cases per 1,000,000. It is characterized by a tendency for local invasion and multiple metastases to the lungs, liver and bones. In the literature, there are only a few cases of adrenocortical cancer directly extending from the inferior vena cava to the right atrium.
MeSH term(s)	Adrenal Cortex Neoplasms ; Adrenocortical Carcinoma ; Adult ; Heart Atria/diagnostic imaging ; Heart Neoplasms/diagnostic imaging ; Humans ; Male ; Vena Cava, Inferior/diagnostic imaging
Language	English
Publishing date	2021-01-02
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
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Article ; Online: The Relationship between Searches for COVID-19 Vaccines and Dynamics of Vaccinated People in Poland: An Infodemiological Study.

Kłak, Anna / Furmańczyk, Konrad / Nowicka, Paulina Maria / Mańczak, Małgorzata / Barańska, Agnieszka / Religioni, Urszula / Siekierska, Anna / Ambroziak, Martyna / Chłopek, Magdalena

International journal of environmental research and public health

2022 Volume 19, Issue 20

Abstract: Background: Google Trends has turned out to be an appropriate tool for evaluating correlations and prognostic modelling regarding infectious diseases. The possibility of selecting a vaccine against COVID-19 has increased social interest in particular ... ...

Abstract	Background: Google Trends has turned out to be an appropriate tool for evaluating correlations and prognostic modelling regarding infectious diseases. The possibility of selecting a vaccine against COVID-19 has increased social interest in particular vaccines. The objective of this study was to show dependencies between the frequency of searches for COVID-19 vaccinations and the number of vaccinated people in Poland, along with epidemiological data. Methods: Data were collected regarding Google searches for COVID-19 vaccines, the number of people in Poland vaccinated against COVID-19, the number of new cases, and the number of deaths due to COVID-19. Data were filtered from 27 December 2020 to 1 September 2021. Results: The number of new vaccinations smoothed per million correlated most strongly with searches for the word 'Pfizer' in Google Trends (Kendall's tau = 0.46, Conclusions: A significant increase in interest in COVID-19 vaccines was observed from February to June 2021, i.e., in the period of gradually extended access to vaccinations, as well as a considerable increase in the number of new cases and new deaths due to COVID-19. The use of Google Trends with relevant keywords and a comparison with the course of the COVID-19 pandemic facilitates evaluation of the relationship between the frequency and types of searches for COVID-19 vaccines and epidemiological data.
MeSH term(s)	Humans ; COVID-19 Vaccines/therapeutic use ; Pandemics/prevention & control ; COVID-19/epidemiology ; COVID-19/prevention & control ; Poland/epidemiology ; Search Engine
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-10-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192013275
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Article ; Online: The influence of Graves' orbitopathy treatment with intravenous glucocorticoids on adrenal function.

Ambroziak, Urszula / Bluszcz, Gabriela / Bednarczuk, Tomasz / Miśkiewicz, Piotr

Endokrynologia Polska

2017 Volume 68, Issue 4, Page(s) 430–433

Abstract: Introduction: Graves' orbitopathy (GO) is the commonest extrathyroidal feature of Graves' disease. For active, moderate to severe GO intravenous glucocorticoid pulse therapy (ivGCS) is the first-line treatment, which might be followed by oral ... ...

Abstract	Introduction: Graves' orbitopathy (GO) is the commonest extrathyroidal feature of Graves' disease. For active, moderate to severe GO intravenous glucocorticoid pulse therapy (ivGCS) is the first-line treatment, which might be followed by oral glucocorticoid therapy. Glucocorticoid treatment, especially in the time of withdrawal, carries a risk of adrenal insufficiency. The aim of this study was to assess the pituitary-adrenal axis function in patients with GO before and at the cessation of ivGCS, and after further oral glucocorticoid therapy. Material and methods: Twenty patients received treatment in accordance with the EUGOGO protocol (500 mg methylprednisolone once a week for six weeks, then 250 mg once a week for another six weeks) followed by oral prednisone at a gradually decreasing dose from 30 mg/day over a three-month period. Adrenal function was evaluated directly before the ivGCS, before the last pulse, and after oral glucocorticoid intake. The assessment consisted of clinical evaluation, and measurements of morning total serum cortisol (TSC) and plasma adrenocorticotropic hormone (ACTH). Patients with decreased cortisol level underwent ACTH stimulation test with TSC measurements before, and 30 minutes and 60 minutes after the administration of synthetic ACTH. Results: All patients before and at the cessation of ivGCS treatment demonstrated intact adrenal function. One patient after prednisone therapy presented decreased adrenal reserve. TSC concentration was significantly lower after the ivGCS (p = 0.025) and oral glucocorticoid therapy (p = 0.0006) in comparison to evaluation before therapy. Conclusions: Therapy with ivGCS for GO does not lead to secondary adrenocortical insufficiency. Further low-dose oral glucocorticoid therapy may result in secondary adrenocortical insufficiency in some patients.
Language	English
Publishing date	2017
Publishing country	Poland
Document type	Journal Article
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
DOI	10.5603/EP.a2017.0036
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