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Book: Radiological imaging of the digestive tract in infants and children

Berrocal, Teresa / Devos, Annick S.

(Medical radiology : diagnostic imaging)

2008

Author's details	A. S. Devos (ed.). With contrib. by T. Berrocal
Series title	Medical radiology : diagnostic imaging
Keywords	Kind ; Verdauungskanal ; Krankheit ; Radiologische Diagnostik
Subject	Diagnostische Radiologie ; Strahlendiagnostik ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Canalis alimentorius ; Verdauungstrakt ; Verdauungsorgan ; Verdauungsapparat ; Apparatus digestorius ; Verdauungssystem ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
Subject code	618.9230757
Language	English
Size	VIII, 252 S. : Zahlr. Ill., 28 cm
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
Note	Literaturangaben
HBZ-ID	HT015349585
ISBN	978-3-540-40733-1 ; 3-540-40733-2
Database	Catalogue ZB MED Medicine, Health

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2004 A 6925	order for loan	Magazin
2008 A 812	order for loan	Magazin

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Article ; Online: COVID-19: Up to 82% critically ill patients had low Vitamin C values.

Tomasa-Irriguible, Teresa Maria / Bielsa-Berrocal, Lara

Nutrition journal

2021 Volume 20, Issue 1, Page(s) 66

Abstract: There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria ...

Abstract	There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.
MeSH term(s)	Adult ; Aged ; Ascorbic Acid/blood ; COVID-19/blood ; Critical Illness ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Vitamins/blood
Chemical Substances	Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2091602-4
ISSN	1475-2891 ; 1475-2891
ISSN (online)	1475-2891
ISSN	1475-2891
DOI	10.1186/s12937-021-00727-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of Stepwise Recruitment Maneuvers on Cerebral Hemodynamics: Experimental Study in Neonatal Model.

Torre Oñate, Teresa / Romero Berrocal, Antonio / Bilotta, Federico / Badenes, Rafael / Santos Gonzalez, Martin / de Reina Perez, Laura / Garcia Fernandez, Javier

Journal of personalized medicine

2023 Volume 13, Issue 8

Abstract: Background: Lung recruitment maneuvers (LRMs) have been demonstrated to be effective in avoiding atelectasis during general anesthesia in the pediatric population. Performing these maneuvers is safe at the systemic hemodynamic and respiratory levels.: ...

Abstract	Background: Lung recruitment maneuvers (LRMs) have been demonstrated to be effective in avoiding atelectasis during general anesthesia in the pediatric population. Performing these maneuvers is safe at the systemic hemodynamic and respiratory levels. Aims: We aimed to evaluate the impact of a stepwise LRM and individualized positive end-expiratory pressure (PEEP) on cerebral hemodynamics in an experimental neonatal model. Methods: Eleven newborn pigs (less than 72 h old, 2.56 ± 0.18 kg in weight) were included in the study. The LRM was performed under pressure-controlled ventilation with a constant driving pressure (15 cmH Results: All LRMs were safely performed as scheduled without any interruptions. Systemic hemodynamic stability was maintained during the lung recruitment maneuver. No changes in ICP occurred. We observed an improvement in rSO Conclusions: Stepwise LRMs are a safe tool to avoid atelectasis. We did not observe an impairment in cerebral hemodynamics but an improvement in cerebral oxygenation.
Language	English
Publishing date	2023-07-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13081184
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Article: COVID-19: Up to 82% critically ill patients had low Vitamin C values

Tomasa-Irriguible, Teresa Maria / Bielsa-Berrocal, Lara

Nutrition journal. 2021 Dec., v. 20, no. 1

2021

Abstract	There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.
Keywords	COVID-19 infection ; adults ; ascorbic acid ; epidemiological studies ; nutrition ; observational studies ; therapeutics
Language	English
Dates of publication	2021-12
Size	p. 66.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2091602-4
ISSN	1475-2891
ISSN	1475-2891
DOI	10.1186/s12937-021-00727-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: On the contribution of psychological flexibility to predict adjustment to breast cancer.

Berrocal Montiel, Carmen / Rivas Moya, Teresa / Venditti, Francesca / Bernini, Olivia

Psicothema

2016 Volume 28, Issue 3, Page(s) 266–271

Abstract: Background: This study explored the contribution of Psychological Flexibility (PF) to predict adjustment to breast cancer.: Method: Sixty-four females with breast cancer completed self-report measures of PF and adjustment (anxiety, depression, ... ...

Abstract	Background: This study explored the contribution of Psychological Flexibility (PF) to predict adjustment to breast cancer. Method: Sixty-four females with breast cancer completed self-report measures of PF and adjustment (anxiety, depression, negative and positive affect) at baseline, and forty-two patients returned for assessment six months later. Results: Higher flexibility at baseline significantly contributed to predict lower anxiety, depression and negative affect at follow-up. The effect sizes ranged from moderate to large. Conclusions: Results provide evidence for targeting PF to prevent enhanced psychological distress in patients with breast cancer, and add to a growing body of research supporting PF as a common protective factor across different contexts and populations.
MeSH term(s)	Adaptation, Psychological ; Adult ; Aged ; Breast Neoplasms/psychology ; Female ; Forecasting ; Humans ; Middle Aged ; Prospective Studies ; Young Adult
Language	English
Publishing date	2016-08
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2421645-8
ISSN	1886-144X ; 0214-9915
ISSN (online)	1886-144X
ISSN	0214-9915
DOI	10.7334/psicothema2015.271
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Article: Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave.

Tomasa-Irriguible, Teresa-Maria / Bielsa-Berrocal, Lara / Bordejé-Laguna, Luisa / Tural-Llàcher, Cristina / Barallat, Jaume / Manresa-Domínguez, Josep-Maria / Torán-Monserrat, Pere

Metabolites

2021 Volume 11, Issue 9

Abstract: We report an observational study performed between March and May 2020 in a Spanish university hospital during the SARS-CoV-2 pandemic. The main objective was to analyse the association between the levels of micronutrients in severe COVID-19 patients and ... ...

Abstract	We report an observational study performed between March and May 2020 in a Spanish university hospital during the SARS-CoV-2 pandemic. The main objective was to analyse the association between the levels of micronutrients in severe COVID-19 patients and their outcome. Adult patients with a positive polymerase-chain-reaction (PCR) for SARS-CoV-2 in the nasopharyngeal swab or in tracheal aspirate culture in the case of intubation were included. Micronutrient data were obtained from plasma analysis of a standard nutritional assessment performed within the first 24 h of hospital admission. Vitamins A, B
Language	English
Publishing date	2021-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11090565
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Article: Crystal structure of (NH4)2[Fe(II) 5(HPO3)6], a new open-framework phosphite.

Berrocal, Teresa / Mesa, Jose Luis / Larrea, Edurne / Arrieta, Juan Manuel

Acta crystallographica. Section E, Structure reports online

2014 Volume 70, Issue Pt 11, Page(s) 309–311

Abstract: Di-ammonium hexa-phosphito-penta-ferrate(II), (NH4)2[Fe5(HPO3)6], was synthesized under mild hydro-thermal conditions and autogeneous pressure, yielding twinned crystals. The crystal structure exhibits an [Fe(II) 5(HPO3)6](2-) open framework with NH4 (+) ...

Abstract	Di-ammonium hexa-phosphito-penta-ferrate(II), (NH4)2[Fe5(HPO3)6], was synthesized under mild hydro-thermal conditions and autogeneous pressure, yielding twinned crystals. The crystal structure exhibits an [Fe(II) 5(HPO3)6](2-) open framework with NH4 (+) groups as counter-cations. The anionic skeleton is based on (001) sheets of [FeO6] octa-hedra (one with point-group symmetry 3.. and one with .2.) linked along [001] through [HPO3](2-) oxoanions. Each sheet is constructed from 12-membered rings of edge-sharing [FeO6] octa-hedra, giving rise to channels with a radius of ca 3.1 Å in which the disordered NH4 (+) cations are located. The IR spectrum shows vibrational bands typical for phosphite and ammonium groups.
Language	English
Publishing date	2014-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	1600-5368
ISSN	1600-5368
DOI	10.1107/S1600536814021783
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Article ; Online: Nivolumab Plus Ipilimumab for Treatment-Naïve Metastatic Uveal Melanoma: An Open-Label, Multicenter, Phase II Trial by the Spanish Multidisciplinary Melanoma Group (GEM-1402).

Piulats, José María / Espinosa, Enrique / de la Cruz Merino, Luis / Varela, Mar / Alonso Carrión, Lorenzo / Martín-Algarra, Salvador / López Castro, Rafael / Curiel, Teresa / Rodríguez-Abreu, Delvys / Redrado, Miriam / Gomà, Montserrat / Rullán, Antonio José / Calvo González, Alfonso / Berrocal-Jaime, Alfonso

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2021 Volume 39, Issue 6, Page(s) 586–598

Abstract: Purpose: This study aimed to assess the efficacy of the combination of nivolumab (nivo) plus ipilimumab (ipi) as a first-line therapy with respect to the 12-month overall survival (OS) in patients with metastatic uveal melanoma (MUM) who are not ... ...

Abstract	Purpose: This study aimed to assess the efficacy of the combination of nivolumab (nivo) plus ipilimumab (ipi) as a first-line therapy with respect to the 12-month overall survival (OS) in patients with metastatic uveal melanoma (MUM) who are not eligible for liver resection. Methods: This was a single-arm, phase II trial led by the Spanish Multidisciplinary Melanoma Group (GEM) on nivo plus ipi for systemic treatment-naïve patients of age > 18 years, with histologically confirmed MUM, Eastern Cooperative Oncology Group-PS 0/1, and confirmed progressive metastatic disease (M1). Nivo (1 mg/kg once every 3 weeks) and ipi (3 mg/kg once every 3 weeks) were administered during four inductions, followed by nivo (3 mg/kg once every 2 weeks) until progressive disease, toxicity, or withdrawal. The primary end point was 12-month OS. OS, progression-free survival (PFS), and overall response rate were evaluated every 6 weeks using RECIST (v1.1). Safety was also evaluated. Logistic regression and Cox proportional hazard models comprising relevant clinical factors were used to evaluate the potential association with response to treatment and survival. Cytokines were quantified in serum samples for their putative role in immune modulation/angiogenesis and/or earlier evidence of involvement in immunotherapy. Results: A total of 52 patients with a median age of 59 years (range, 26-84 years) were enrolled. Overall, 78.8%, 56%, and 32% of patients had liver M1, extra-liver M1, and elevated lactate dehydrogenase. Stable disease was the most common outcome (51.9%). The primary end point was 12-month OS, which was 51.9% (95% CI, 38.3 to 65.5). The median OS and PFS were 12.7 months and 3.0 months, respectively. PFS was influenced by higher LDH values. Conclusions: Nivo plus ipi in the first-line setting for MUM showed a modest improvement in OS over historical benchmarks of chemotherapy, with a manageable toxicity profile.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Ipilimumab/pharmacology ; Ipilimumab/therapeutic use ; Male ; Melanoma/drug therapy ; Melanoma/mortality ; Middle Aged ; Nivolumab/pharmacology ; Nivolumab/therapeutic use ; Survival Analysis ; Uveal Neoplasms/drug therapy ; Uveal Neoplasms/mortality
Chemical Substances	Ipilimumab ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2021-01-08
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.20.00550
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Article ; Online: Current status of nuclear cardiology practice in Latin America and the Caribbean, in the era of multimodality cardiac imaging approach: 2022 update.

Nuclear medicine communications

2022 Volume 43, Issue 12, Page(s) 1163–1170

Abstract: Cardiovascular diseases (CVDs) are the leading cause of mortality in Latin America and the Caribbean (LAC), with the risk in men being slightly higher than in women. The coronavirus disease 2019 (COVID-19) pandemic caused a significant reduction in the ... ...

Abstract	Cardiovascular diseases (CVDs) are the leading cause of mortality in Latin America and the Caribbean (LAC), with the risk in men being slightly higher than in women. The coronavirus disease 2019 (COVID-19) pandemic caused a significant reduction in the number of cardiac diagnostic procedures globally and in particular in LAC. Nuclear cardiology is available in the region, but there is variability in terms of existing technology, radiopharmaceuticals, and human resources. In the region, there are 2385 single photon emission computed tomography (SPECT) and 315 PET scanners, Argentina and Brazil have the largest number. There is an increasing number of new technologies such as cadmium-zinc-telluride (CZT) cardiac-dedicated gamma cameras, SPECT/computed tomography (CT), and PET/CT. All countries performed myocardial perfusion imaging studies, mainly gated-SPECT; the rest are multi-gated acquisition, mainly for cardiac toxicity; detection of viability; rest gated SPECT in patients with dilated cardiomyopathy, and bone-avid tracer cardiac scintigraphy for transthyretin cardiac amyloidosis diagnosis. Regarding other non-nuclear cardiac imaging modalities, Argentina, Colombia, and Chile have the highest ratio of CT scanners, while Brazil, Argentina, and Chile show the highest ratio of MRI scanners. The development of nuclear cardiology and other advanced imaging modalities is challenged by the high cost of equipment, lack of equipment maintenance and service, insufficient-specific training both for imaging specialists and referring clinicians, and lack of awareness of cardiologists or other referring physicians on the clinical applications of nuclear cardiology. Another important aspect to consider is the necessity of implementing cardiac imaging multimodality training. A joint work of nuclear medicine specialists, radiologists, cardiologists, and clinicians, in general, is mandatory to achieve this goal. National, regional, and international cooperation including support from scientific professional societies such as the American Society of Nuclear Cardiology and Latin American Association of Biology and Nuclear Medicine Societies, cardiological societies, and organizations such as the International Atomic Energy Agency, and Pan American Health Organization, as well as government commitment are key factors in the overall efforts to tackle the burden of cardiovascular diseases in the region.
MeSH term(s)	Male ; Humans ; Female ; Latin America ; Cardiovascular Diseases/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; COVID-19/diagnostic imaging ; Cardiology ; Myocardial Perfusion Imaging ; Tomography, Emission-Computed, Single-Photon/methods ; Caribbean Region
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000001630
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Article ; Online: Phase II LEAP-004 Study of Lenvatinib Plus Pembrolizumab for Melanoma With Confirmed Progression on a Programmed Cell Death Protein-1 or Programmed Death Ligand 1 Inhibitor Given as Monotherapy or in Combination.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 41, Issue 1, Page(s) 75–85

Abstract: Purpose: Effective treatments are needed for melanoma that progresses on inhibitors of programmed cell death protein-1 (PD-1) or its ligand (PD-L1). We conducted the phase II LEAP-004 study to evaluate the combination of the multikinase inhibitor ... ...

Abstract	Purpose: Effective treatments are needed for melanoma that progresses on inhibitors of programmed cell death protein-1 (PD-1) or its ligand (PD-L1). We conducted the phase II LEAP-004 study to evaluate the combination of the multikinase inhibitor lenvatinib and the PD-1 inhibitor pembrolizumab in this population (ClinicalTrials.gov identifier: NCT03776136). Methods: Eligible patients with unresectable stage III-IV melanoma with confirmed progressive disease (PD) within 12 weeks of the last dose of a PD-1/L1 inhibitor given alone or with other therapies, including cytotoxic T-cell lymphocyte-associated antigen 4 (CTLA-4) inhibitors, received lenvatinib 20 mg orally once daily plus ≤ 35 doses of pembrolizumab 200 mg intravenously once every 3 weeks until PD or unacceptable toxicity. The primary end point was objective response rate (ORR) per RECIST, version 1.1, by independent central review. Results: A total of 103 patients were enrolled and treated. The median study follow-up was 15.3 months. ORR in the total population was 21.4% (95% CI, 13.9 to 30.5), with three (2.9%) complete responses and 19 (18.4%) partial responses. The median duration of response was 8.3 months (range, 3.2-15.9+). ORR was 33.3% in the 30 patients with PD on prior anti-PD-1 plus anti-CTLA-4 therapy. The median progression-free survival and overall survival in the total population were 4.2 months (95% CI, 3.8 to 7.1) and 14.0 months (95% CI, 10.8 to not reached), respectively. Grade 3-5 treatment-related adverse events occurred in 47 (45.6%) patients, most commonly hypertension (21.4%); one patient died from a treatment-related event (decreased platelet count). Conclusion: Lenvatinib plus pembrolizumab provides clinically meaningful, durable responses in patients with advanced melanoma with confirmed PD on prior PD-1/L1 inhibitor-based therapy, including those with PD on anti-PD-1 plus anti-CTLA-4 therapy. The safety profile was as expected. These data support lenvatinib plus pembrolizumab as a potential regimen for this population of high unmet need.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; B7-H1 Antigen ; Melanoma/drug therapy ; Apoptosis Regulatory Proteins/therapeutic use ; Melanoma, Cutaneous Malignant
Chemical Substances	pembrolizumab (DPT0O3T46P) ; lenvatinib (EE083865G2) ; Immune Checkpoint Inhibitors ; B7-H1 Antigen ; Apoptosis Regulatory Proteins
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.00221
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