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Article ; Online: CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial.

Masonou, Tereza / Hokey, David A / Lahey, Timothy / Halliday, Alice / Berrocal-Almanza, Luis C / Wieland-Alter, Wendy F / Arbeit, Robert D / Lalvani, Ajit / von Reyn, C Fordham

PloS one

2019 Volume 14, Issue 5, Page(s) e0217091

Abstract: ... to prevent tuberculosis. This study examined whether DAR-901 (a) induces CD4+ T cell cytokine profiles ... signature compared to BCG or placebo.: Methods: We analysed CD4+ T cell cytokine immune responses from 10 ... placebo followed by an intradermal injection of BCG. Antigen-specific functional and phenotypic CD4+ T ...

Abstract	Background: DAR-901 is an inactivated whole cell tuberculosis booster vaccine, prepared using a new scalable, broth-grown method from the master cell bank of SRL172, a vaccine previously shown to prevent tuberculosis. This study examined whether DAR-901 (a) induces CD4+ T cell cytokine profiles previously proposed as correlates of protection and (b) has a specific vaccine-induced immunological signature compared to BCG or placebo. Methods: We analysed CD4+ T cell cytokine immune responses from 10 DAR-901 recipients, 9 BCG recipients and 9 placebo recipients from the Phase I DAR-901 MDES trial. In that study, HIV-negative, IGRA-negative participants with prior BCG immunization were randomized (double-blind) to receive three intradermal injections of DAR-901 or saline placebo or two injections of saline placebo followed by an intradermal injection of BCG. Antigen-specific functional and phenotypic CD4+ T cell responses along with effector phenotype of responder cells were measured by intracellular cytokine staining. Results: DAR-901 recipients exhibited increased DAR-901 antigen-specific polyfunctional or bifunctional T cell responses compared to baseline. Vaccine specific CD4+ IFNγ, IL2, TNFα and any cytokine responses peaked at 7 days post-dose 3. Th1 responses predominated, with most responder cells exhibiting a polyfunctional effector memory phenotype. BCG induced greater CD4+ T cell responses than placebo while the more modest DAR-901 responses did not differ from placebo. Neither DAR-901 nor BCG induced substantial or sustained Th17 /Th22 cytokine responses. Conclusion: DAR-901, a TB booster vaccine grown from the master cell bank of SRL 172 which was shown to prevent TB, induced low magnitude polyfunctional effector memory CD4+ T cell responses. DAR-901 responses were lower than those induced by BCG, a vaccine that has been shown ineffective as a booster to prevent tuberculosis disease. These results suggest that induction of higher levels of CD4+ cytokine stimulation may not be a critical or pre-requisite characteristic for candidate TB vaccine boosters. Trial registration: ClinicalTrials.gov NCT02063555.
MeSH term(s)	Adolescent ; Adult ; Aged ; BCG Vaccine/administration & dosage ; BCG Vaccine/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/metabolism ; Double-Blind Method ; Female ; Humans ; Immunization, Secondary ; Male ; Middle Aged ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis/immunology ; Tuberculosis/metabolism ; Tuberculosis/prevention & control ; Tuberculosis Vaccines/administration & dosage ; Tuberculosis Vaccines/immunology ; Tuberculosis Vaccines/standards ; Young Adult
Chemical Substances	BCG Vaccine ; Cytokines ; Tuberculosis Vaccines
Language	English
Publishing date	2019-05-23
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0217091
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Article ; Online: Genetic interaction between the non-homologous end-joining factors during B and T lymphocyte development: In vivo mouse models.

Castañeda-Zegarra, Sergio / Fernandez-Berrocal, Marion / Tkachov, Max / Yao, Rouan / Upfold, Nikki Lyn Esnardo / Oksenych, Valentyn

Scandinavian journal of immunology

2020 Volume 92, Issue 4, Page(s) e12936

Abstract: ... T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also ...

Abstract	Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double-strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing distinct effector functions of antibody heavy chain constant regions. Thus, NHEJ is important for both V(D)J recombination and CSR. NHEJ comprises core Ku70 and Ku80 subunits that form the Ku heterodimer, which binds DSBs and promotes the recruitment of accessory factors (e.g., DNA-PKcs, Artemis, PAXX, MRI) and downstream core factors (XLF, Lig4 and XRCC4). In recent decades, new NHEJ proteins have been reported, increasing complexity of this molecular pathway. Numerous in vivo mouse models have been generated and characterized to identify the interplay of NHEJ factors and their role in development of adaptive immune system. This review summarizes the currently available mouse models lacking one or several NHEJ factors, with a particular focus on early B cell development. We also underline genetic interactions and redundancy in the NHEJ pathway in mice.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; DNA End-Joining Repair/genetics ; DNA End-Joining Repair/immunology ; Immunoglobulin Class Switching/genetics ; Immunoglobulin Class Switching/immunology ; Mice ; Models, Animal ; T-Lymphocytes/immunology ; V(D)J Recombination/genetics ; V(D)J Recombination/immunology
Language	English
Publishing date	2020-08-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	120476-2
ISSN	1365-3083 ; 0300-9475
ISSN (online)	1365-3083
ISSN	0300-9475
DOI	10.1111/sji.12936
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Article ; Online: CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults

Tereza Masonou / David A Hokey / Timothy Lahey / Alice Halliday / Luis C Berrocal-Almanza / Wendy F Wieland-Alter / Robert D Arbeit / Ajit Lalvani / C Fordham von Reyn

PLoS ONE, Vol 14, Iss 5, p e

A randomized, placebo-controlled trial.

2019 Volume 0217091

Abstract: ... tuberculosis. This study examined whether DAR-901 (a) induces CD4+ T cell cytokine profiles previously proposed ... placebo. METHODS:We analysed CD4+ T cell cytokine immune responses from 10 DAR-901 recipients, 9 BCG ... by an intradermal injection of BCG. Antigen-specific functional and phenotypic CD4+ T cell responses along with effector ...

Abstract	BACKGROUND:DAR-901 is an inactivated whole cell tuberculosis booster vaccine, prepared using a new scalable, broth-grown method from the master cell bank of SRL172, a vaccine previously shown to prevent tuberculosis. This study examined whether DAR-901 (a) induces CD4+ T cell cytokine profiles previously proposed as correlates of protection and (b) has a specific vaccine-induced immunological signature compared to BCG or placebo. METHODS:We analysed CD4+ T cell cytokine immune responses from 10 DAR-901 recipients, 9 BCG recipients and 9 placebo recipients from the Phase I DAR-901 MDES trial. In that study, HIV-negative, IGRA-negative participants with prior BCG immunization were randomized (double-blind) to receive three intradermal injections of DAR-901 or saline placebo or two injections of saline placebo followed by an intradermal injection of BCG. Antigen-specific functional and phenotypic CD4+ T cell responses along with effector phenotype of responder cells were measured by intracellular cytokine staining. RESULTS:DAR-901 recipients exhibited increased DAR-901 antigen-specific polyfunctional or bifunctional T cell responses compared to baseline. Vaccine specific CD4+ IFNγ, IL2, TNFα and any cytokine responses peaked at 7 days post-dose 3. Th1 responses predominated, with most responder cells exhibiting a polyfunctional effector memory phenotype. BCG induced greater CD4+ T cell responses than placebo while the more modest DAR-901 responses did not differ from placebo. Neither DAR-901 nor BCG induced substantial or sustained Th17 /Th22 cytokine responses. CONCLUSION:DAR-901, a TB booster vaccine grown from the master cell bank of SRL 172 which was shown to prevent TB, induced low magnitude polyfunctional effector memory CD4+ T cell responses. DAR-901 responses were lower than those induced by BCG, a vaccine that has been shown ineffective as a booster to prevent tuberculosis disease. These results suggest that induction of higher levels of CD4+ cytokine stimulation may not be a critical or pre-requisite ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 570
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

González-Granado, José María / Silvestre-Roig, Carlos / Rocha-Perugini, Vera / Trigueros-Motos, Laia / Cibrián, Danay / Morlino, Giulia / Blanco-Berrocal, Marta / Osorio, Fernando Garcia / Freije, José María Pérez / López-Otín, Carlos / Sánchez-Madrid, Francisco / Andrés, Vicente

Science signaling

2014 Volume 7, Issue 322, Page(s) ra37

Abstract: ... lamins was almost negligible in resting naïve T lymphocytes, but was increased upon activation of the T ... of the immunological synapse between T cells and antigen-presenting cells. Polymerization of F-actin in T cells is a critical ... of the ERK pathway reduced lamin-A-dependent T cell activation. Moreover, mice lacking lamin ...

Abstract	In many cell types, nuclear A-type lamins regulate multiple cellular functions, including higher-order genome organization, DNA replication and repair, gene transcription, and signal transduction; however, their role in specialized immune cells remains largely unexplored. We showed that the abundance of A-type lamins was almost negligible in resting naïve T lymphocytes, but was increased upon activation of the T cell receptor (TCR). The increase in lamin-A was an early event that accelerated formation of the immunological synapse between T cells and antigen-presenting cells. Polymerization of F-actin in T cells is a critical step for immunological synapse formation, and lamin-A interacted with the linker of nucleoskeleton and cytoskeleton (LINC) complex to promote F-actin polymerization. We also showed that lamin-A expression accelerated TCR clustering and led to enhanced downstream signaling, including extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, as well as increased target gene expression. Pharmacological inhibition of the ERK pathway reduced lamin-A-dependent T cell activation. Moreover, mice lacking lamin-A in immune cells exhibited impaired T cell responses in vivo. These findings underscore the importance of A-type lamins for TCR activation and identify lamin-A as a previously unappreciated regulator of the immune response.
MeSH term(s)	Actin Cytoskeleton/genetics ; Actin Cytoskeleton/immunology ; Actins/genetics ; Actins/immunology ; Animals ; Humans ; Immunological Synapses/genetics ; Immunological Synapses/immunology ; Jurkat Cells ; Lamin Type A/genetics ; Lamin Type A/immunology ; Lymphocyte Activation/physiology ; MAP Kinase Signaling System/genetics ; MAP Kinase Signaling System/immunology ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/immunology ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/immunology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Chemical Substances	Actins ; LMNA protein, human ; Lamin Type A ; Receptors, Antigen, T-Cell ; MAPK1 protein, human (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
Language	English
Publishing date	2014-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.2004872
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Book: Radiological imaging of the digestive tract in infants and children

Berrocal, Teresa / Devos, Annick S.

(Medical radiology : diagnostic imaging)

2008

Author's details	A. S. Devos (ed.). With contrib. by T. Berrocal
Series title	Medical radiology : diagnostic imaging
Keywords	Kind ; Verdauungskanal ; Krankheit ; Radiologische Diagnostik
Subject	Diagnostische Radiologie ; Strahlendiagnostik ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Canalis alimentorius ; Verdauungstrakt ; Verdauungsorgan ; Verdauungsapparat ; Apparatus digestorius ; Verdauungssystem ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
Subject code	618.9230757
Language	English
Size	VIII, 252 S. : Zahlr. Ill., 28 cm
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
Note	Literaturangaben
HBZ-ID	HT015349585
ISBN	978-3-540-40733-1 ; 3-540-40733-2
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Article ; Online: Spanish adaptation and validation of the Dula Dangerous Driving Index (DDDI).

Sánchez-López, María T / Fernández-Berrocal, Pablo / Tagliabue, Mariaelena / Megías-Robles, Alberto

Aggressive behavior

2024 Volume 50, Issue 1, Page(s) e22129

Abstract: The Dula Dangerous Driving Index (DDDI) is a widely used questionnaire that measures the tendency to drive dangerously on the road through three different types of behaviors: aggressive driving, risky driving, and experiencing negative emotions while ... ...

Abstract	The Dula Dangerous Driving Index (DDDI) is a widely used questionnaire that measures the tendency to drive dangerously on the road through three different types of behaviors: aggressive driving, risky driving, and experiencing negative emotions while driving. This study aimed to develop a Spanish version of the DDDI and verify the reliability and validity of this questionnaire in the Spanish population. A community sample of 2174 Spanish participants (51.1% male; age range: 18-79 years) completed the 28-item Spanish version of the DDDI. Confirmatory factor analysis revealed that a three-factor model fitted adequately to the data. Analysis of internal consistency, test-retest reliability, and convergent validity showed that the Spanish adaptation of the DDDI had good psychometric properties and retains the theoretical consistency of the original scale. Gender and age differences were observed. The Spanish version of the DDDI can be considered a good instrument for assessing dangerous driving behavior, thus contributing to the cross-cultural study of these types of behaviors and the possible development of intervention programs aimed at reducing road traffic accidents.
MeSH term(s)	Humans ; Male ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Female ; Reproducibility of Results ; Dangerous Behavior ; Cross-Cultural Comparison ; Psychometrics
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	189812-7
ISSN	1098-2337 ; 0096-140X
ISSN (online)	1098-2337
ISSN	0096-140X
DOI	10.1002/ab.22129
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Article: Deficiency of naive T cells in patients with sudden deafness.

García-Berrocal, J R / Vargas, J A / Ramírez-Camacho, R A / González, F M / Gea-Banacloche, J C / Vergara, J / Durántez, A

Archives of otolaryngology--head & neck surgery

1997 Volume 123, Issue 7, Page(s) 712–717

Abstract: Background: Although there are a number of reports concerned with the role of immunity in the sudden onset of progressive sensorineural hearing loss, there are few references dealing with the involvement of immune-mediated mechanisms in sudden deafness.! ...

Abstract	Background: Although there are a number of reports concerned with the role of immunity in the sudden onset of progressive sensorineural hearing loss, there are few references dealing with the involvement of immune-mediated mechanisms in sudden deafness. Objectives: To study the phenotype of peripheral blood lymphocytes in a group of patients with sudden deafness by use of 3-color flow cytometry. Design: The study was carried out prior to the start of steroid therapy. Fourteen patients underwent a follow-up study once steroid therapy had been completed. Prospective analysis, case-control. Setting: Tertiary case referral center, ambulatory and hospitalized care. Patients: Twenty-two patients (13 men and 9 women; mean age, 45.3 years) were compared with 14 healthy control subjects (9 men and 5 women; mean age, 36 years). Patients were divided in 2 groups according to their response to steroid therapy. Results: Decreased numbers of both CD4+ helper cells (38.4% vs 45.5%; P = .04) and CD8+ cytotoxic cells (17.5% vs 22.3%; P = .02) were observed in patients and compared with those in the control subjects, as well as reduced numbers of CD4+CD45RA+ cells (14.4% vs 29.3%; P = .01) and CD8+CD45RA+ naive cells (18.2% vs 25.4%; P = .04). In the group of patients with a good response to steroid therapy (group 1), a tendency toward normalization of the CD4+ (pretreatment, 38.6%; posttreatment, 44.6%), CD4+CD45RA+ (pretreatment, 15.2%; posttreatment, 21.7%), and CD4+CD45RO+ (pretreatment, 21.1%; posttreatment, 18.2%) cell counts was observed, with a slight decrease in the CD8+ population (pretreatment, 18%; posttreatment, 15.7%). However, in patients with a poorer response (group 2), while there were increases in the CD4+ (pretreatment, 38%, posttreatment, 50%) and CD4+CD45RA+ (pretreatment, 12.8%; posttreatment, 16.7%) cell counts after steroid therapy, there was a significant increment in the CD4+CD45RO+ memory cell count (pretreatment, 14.1%; posttreatment, 28.5%) and low CD8+CD45RA+ counts (pretreatment, 14.6%; posttreatment, 15.5%). No differences were observed in the numbers of B or natural killer cells or in the presence of activation antigens CD25 and HLA-DR when pretreatment and posttreatment levels were compared. Conclusion: These results demonstrate significant abnormalities in the subpopulations of lymphocytes in patients with sudden hearing loss, suggesting the existence of immune-mediated responses in the inner ear as possible etiopathogenic factors in this entity.
MeSH term(s)	Adolescent ; Adult ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Case-Control Studies ; Female ; Flow Cytometry/methods ; Glucocorticoids/therapeutic use ; Hearing Loss, Sudden/drug therapy ; Hearing Loss, Sudden/immunology ; Humans ; Immunologic Deficiency Syndromes/drug therapy ; Immunologic Deficiency Syndromes/immunology ; Immunophenotyping ; Leukocyte Common Antigens/drug effects ; Leukocyte Common Antigens/immunology ; Male ; Methylprednisolone/therapeutic use ; Middle Aged ; Prospective Studies
Chemical Substances	Glucocorticoids ; Leukocyte Common Antigens (EC 3.1.3.48) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	1997-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632721-7
ISSN	1538-361X ; 0886-4470 ; 2168-6181
ISSN (online)	1538-361X
ISSN	0886-4470 ; 2168-6181
DOI	10.1001/archotol.1997.01900070056009
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Article ; Online: The relationship between self-reported ability emotional intelligence and risky driving behaviour: Consequences for accident and traffic ticket rate.

Megías-Robles, Alberto / Sánchez-López, María T / Fernández-Berrocal, Pablo

Accident; analysis and prevention

2022 Volume 174, Page(s) 106760

Abstract: Road safety represents one of the main public health issues worldwide, and risky driving behaviour is one of the most predominant factors in traffic road accidents. The primary objective of this research was to clarify the relationship between emotional ... ...

Abstract	Road safety represents one of the main public health issues worldwide, and risky driving behaviour is one of the most predominant factors in traffic road accidents. The primary objective of this research was to clarify the relationship between emotional intelligence (EI) abilities and the probability of engaging in risky behaviour during driving. Previous literature linking these constructs is limited, and research has yielded mixed findings. In the present study, 555 drivers from a Spanish community sample (M
MeSH term(s)	Accidents, Traffic/psychology ; Adolescent ; Adult ; Aged ; Automobile Driving/psychology ; Emotional Intelligence ; Female ; Humans ; Male ; Middle Aged ; Risk-Taking ; Self Report ; Young Adult
Language	English
Publishing date	2022-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2022.106760
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Article: Systematic review of the oral manifestations produced by the SARS-CoV-2 vaccine.

López-Carriches, Carmen / Santana-Torres, Tomás / Bahram-Taheri, Ricardo / Leco-Berrocal, Mª Isabel

Journal of clinical and experimental dentistry

2023 Volume 15, Issue 7, Page(s) e578–e583

Abstract: Background: To combat the coronavirus pandemic different vaccines have been developed. However, diverse adverse effects have been reported due to their use, including oral manifestations. Our objective is to review the existing bibliography to analyze ... ...

Abstract	Background: To combat the coronavirus pandemic different vaccines have been developed. However, diverse adverse effects have been reported due to their use, including oral manifestations. Our objective is to review the existing bibliography to analyze what complications these vaccines have caused in the oral cavity. Material and methods: A bibliographic search was conducted by two independent reviewers (TS and CL), in parallel in 6 electronic databases (PubMed, Scopus, Cochrane, Google Scholar, LILACS, BioMed Central). A total of 22 articles were analyzed. Results: The most frequent adverse effect was oral lichen planus, with a higher prevalence in women and after the Pfizer mRNA BNT162b2 vaccine. Conclusions: These complications are minor and resolve with treatment, so the benefit of the use of vaccines outweigh the potential risks associated with these.
Language	English
Publishing date	2023-07-01
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	2586647-3
ISSN	1989-5488
ISSN	1989-5488
DOI	10.4317/jced.60688
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Article: Functional and phenotypic analysis of T-lymphocytes in laryngeal carcinoma.

González, F M / Vargas, J A / Gea-Banacloche, J C / García, J R / Berrocal, E / Gorriz, C / Durántez, A

Acta oto-laryngologica

1994 Volume 114, Issue 6, Page(s) 663–668

Abstract: We studied the functional response and phenotypic characterization of peripheral blood T cells and ... and 24 healthy male controls. Peripheral blood T cells, phenotypically CD2+ CD3+, were significantly ... 2, 3) also showed a diminution of the CD4+ subpopulation of T cells. DNA synthesis by purified ...

Abstract	We studied the functional response and phenotypic characterization of peripheral blood T cells and their correlation with the clinical stage of disease in 29 males with previously untreated carcinoma of the larynx and 24 healthy male controls. Peripheral blood T cells, phenotypically CD2+ CD3+, were significantly decreased in the patients relative to the controls. Patients with advanced locoregional extension (T4 and N1, 2, 3) also showed a diminution of the CD4+ subpopulation of T cells. DNA synthesis by purified T cells showed similar blastogenic responses in patients and controls; the interleukin-2 production of phytohemagglutinin stimulated lymphocytes was also normal. We conclude that in patients with laryngeal carcinoma there is a phenotypic alteration of the T cells that is variable according to tumor stage, without functional alterations in blastogenic capacity or IL-2 production.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal ; Antigens, CD/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Movement ; Flow Cytometry ; Humans ; Interleukin-2/metabolism ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Larynx/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Phenotype ; T-Lymphocytes
Chemical Substances	Antibodies, Monoclonal ; Antigens, CD ; Interleukin-2
Language	English
Publishing date	1994-11
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0001-6489
ISSN	0001-6489
DOI	10.3109/00016489409126123
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