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  1. Article ; Online: Sclerostin: clinical insights in muscle-bone crosstalk.

    Moretti, Antimo / Iolascon, Giovanni

    The Journal of international medical research

    2023  Volume 51, Issue 8, Page(s) 3000605231193293

    Abstract: Sclerostin, a protein encoded by the sclerostin ( ...

    Abstract Sclerostin, a protein encoded by the sclerostin (
    MeSH term(s) Humans ; Hyperostosis ; Knowledge ; Muscles ; Osteoblasts ; Osteogenesis
    Chemical Substances SOST protein, human
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605231193293
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 925: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: An update on the pharmacotherapeutic options for complex regional pain syndrome.

    Iolascon, Giovanni / Snichelotto, Francesco / Moretti, Antimo

    Expert review of neurotherapeutics

    2024  Volume 24, Issue 2, Page(s) 177–190

    Abstract: Introduction: Complex regional pain syndrome (CRPS) is a rare and painful condition that has a wide range of triggering factors, often traumatic, and can present various clinical manifestations. The lack of knowledge about the underlying mechanisms has ... ...

    Abstract Introduction: Complex regional pain syndrome (CRPS) is a rare and painful condition that has a wide range of triggering factors, often traumatic, and can present various clinical manifestations. The lack of knowledge about the underlying mechanisms has led to numerous treatment approaches, both conservative and surgical, which work through different mechanisms of action.
    Areas covered: In this review, the authors explore the key aspects of CRPS, including definition, diagnostic criteria, pitfalls, pathogenic hypotheses, and treatment strategies with a focus on pharmacotherapy. The review was based on a comprehensive search of the literature using PubMed, while also considering international guidelines for managing CRPS.
    Expert opinion: Based on the available evidence, pharmacological interventions appear to be effective in treating CRPS, especially when they target peripheral mechanisms, specifically nociceptive inflammatory pain, and when administered early in the course of the disease. However, there is still a lack of reliable evidence regarding the effects of drugs on central mechanisms of chronic pain in CRPS. In our expert opinion, drug therapy should be initiated as soon as possible, particularly in warm CRPS patient clusters, to prevent significant functional limitations, psychological distress, and negative impacts on individuals' social and economic well-being.
    MeSH term(s) Humans ; Complex Regional Pain Syndromes/drug therapy ; Complex Regional Pain Syndromes/diagnosis ; Chronic Pain
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2024.2307490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6155: Show issues Location:
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  3. Article ; Online: Red cell disorders: diagnosis and treatment of common red cell defects.

    Iolascon, Achille

    HemaSphere

    2019  Volume 3, Issue Suppl, Page(s) 153

    Language English
    Publishing date 2019-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000196
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  4. Article ; Online: The Rationale for Using Neridronate in Musculoskeletal Disorders: From Metabolic Bone Diseases to Musculoskeletal Pain.

    Iolascon, Giovanni / Moretti, Antimo

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: Neridronate or ((6-amino-1-hydroxy-1-phosphonohexyl) phosphonic acid) is an amino-bisphosphonate (BP) synthetized in Italy in 1986. Bisphosphonates are molecules with a P-C-P bond in their structure that allows strong and selectively binding to ... ...

    Abstract Neridronate or ((6-amino-1-hydroxy-1-phosphonohexyl) phosphonic acid) is an amino-bisphosphonate (BP) synthetized in Italy in 1986. Bisphosphonates are molecules with a P-C-P bond in their structure that allows strong and selectively binding to hydroxyapatite (HAP) as well as osteoclasts inhibition through different mechanisms of action. Neridronate was initially used to treat Paget disease of the bone, demonstrating effectiveness in reducing bone turnover markers as well as pain. The interesting molecular properties of neridronate foster its wide use in several other conditions, such as osteogenesis imperfecta, and osteoporosis. Thanks to the unique safety and efficacy profile, neridronate has been used in secondary osteoporosis due to genetic, rheumatic, and oncological diseases, including in pediatric patients. In the last decade, this drug has also been studied in chronic musculoskeletal pain conditions, such as algodystrophy, demonstrating effectiveness in improving extraskeletal outcomes. This review highlights historical and clinical insights about the use of neridronate for metabolic bone disorders and musculoskeletal pain conditions.
    MeSH term(s) Bone Density ; Child ; Diphosphonates/therapeutic use ; Humans ; Musculoskeletal Pain/drug therapy ; Osteoporosis/drug therapy
    Chemical Substances Diphosphonates ; 6-amino-1-hydroxyhexane-1,1-diphosphonate (79778-41-9)
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23136921
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  5. Article: What are the efficacy and safety of pharmacological interventions versus placebo, no treatment or usual care for osteoporosis in people with chronic kidney disease stages 3-5D? - A Cochrane Review summary with commentary.

    Iolascon, Giovanni / Moretti, Antimo

    Journal of musculoskeletal & neuronal interactions

    2022  Volume 22, Issue 1, Page(s) 1–4

    MeSH term(s) Female ; Humans ; Male ; Osteoporosis/complications ; Osteoporosis/drug therapy ; Osteoporotic Fractures/therapy ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy
    Language English
    Publishing date 2022-03-02
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2041366-X
    ISSN 1108-7161
    ISSN 1108-7161
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5401: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Myths and Truths about Placebo Effect in Rehabilitation for Musculoskeletal Pain.

    Iolascon, Giovanni / Moretti, Antimo

    Advances in therapy

    2021  Volume 38, Issue 10, Page(s) 4995–5001

    Abstract: This commentary provides the authors' point of view about the biopsychosocial perspective of placebo effect on musculoskeletal pain in the rehabilitation field. ...

    Abstract This commentary provides the authors' point of view about the biopsychosocial perspective of placebo effect on musculoskeletal pain in the rehabilitation field.
    MeSH term(s) Exercise Therapy ; Humans ; Musculoskeletal Pain ; Placebo Effect
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-01894-5
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    Zs.A 2101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Bone involvement in the early stages of Parkinson's disease: a case-control study.

    Liguori, Sara / Moretti, Antimo / Paoletta, Marco / Gargiulo, Fiorinda / Barra, Giuseppe / Gimigliano, Francesca / Iolascon, Giovanni

    The Journal of international medical research

    2024  Volume 52, Issue 3, Page(s) 3000605241237880

    Abstract: Objective: To evaluate the qualitative and quantitative alterations of bone tissue in patients with early-stage Parkinson's disease (PD) and to measure the associations between bone mineral density (BMD), trabecular bone score (TBS) and physical ... ...

    Abstract Objective: To evaluate the qualitative and quantitative alterations of bone tissue in patients with early-stage Parkinson's disease (PD) and to measure the associations between bone mineral density (BMD), trabecular bone score (TBS) and physical performance.
    Methods: This case-control study enrolled patients with early-stage PD and age-matched controls. BMDs for the left femoral neck (L-FN) and lumbar spine (LS) were measured. Bone microarchitecture for the LS was determined using TBS. Muscle performance was assessed using the short physical performance battery (SPPB). Patients and controls were stratified in two groups based on the SPPB score: a poor performance group (SPPB score ≤8) and high performance group (SPPB > 8).
    Results: This study included 26 patients: 13 in the PD group and 13 age-matched controls. The mean ± SD BMD results in the PD group were: L1-L4 BMD = 0.935 ± 0.183 g/cm
    Conclusion: TBS might identify bone involvement earlier than BMD in the initial stages of PD.
    MeSH term(s) Humans ; Case-Control Studies ; Parkinson Disease/diagnostic imaging ; Bone Density/physiology ; Lumbar Vertebrae ; Femur Neck/diagnostic imaging ; Osteoporotic Fractures
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605241237880
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 925: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: New Insights in 9q21.13 Microdeletion Syndrome: Genotype-Phenotype Correlation of 28 Patients.

    De Falco, Alessandro / Iolascon, Achille / Ascione, Flora / Piscopo, Carmelo

    Genes

    2023  Volume 14, Issue 5

    Abstract: The implementation of array comparative genomic hybridisation (array-CGH) allows us to describe new microdeletion/microduplication syndromes which were previously not identified. 9q21.13 microdeletion syndrome is a genetic condition due to the loss of a ... ...

    Abstract The implementation of array comparative genomic hybridisation (array-CGH) allows us to describe new microdeletion/microduplication syndromes which were previously not identified. 9q21.13 microdeletion syndrome is a genetic condition due to the loss of a critical genomic region of approximately 750kb and includes several genes, such as
    MeSH term(s) Humans ; Male ; Child ; Developmental Disabilities/genetics ; Chromosome Deletion ; Intellectual Disability/genetics ; Neurodevelopmental Disorders/genetics ; Genetic Association Studies
    Language English
    Publishing date 2023-05-21
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051116
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  9. Article: Anti-sclerostin antibodies: a new frontier in fragility fractures treatment.

    Iolascon, Giovanni / Liguori, Sara / Paoletta, Marco / Toro, Giuseppe / Moretti, Antimo

    Therapeutic advances in musculoskeletal disease

    2023  Volume 15, Page(s) 1759720X231197094

    Abstract: Bone fragility is the determinant of the increased risk of minimal trauma fracture and must be treated with a multimodal approach that includes pharmacological therapy, physical exercise, and adequate nutrition. Pharmacological therapy, to date based on ... ...

    Abstract Bone fragility is the determinant of the increased risk of minimal trauma fracture and must be treated with a multimodal approach that includes pharmacological therapy, physical exercise, and adequate nutrition. Pharmacological therapy, to date based on the administration of antiresorptive drugs, such as bisphosphonates and denosumab, or osteoanabolic drugs, such as teriparatide and abaloparatide, has shown to be effective in reducing the risk of fracture in osteoporotic patients. In the context of the cellular and molecular mechanisms that regulate bone metabolism, the discovery of the Wnt signaling pathway and its role in bone tissue homeostasis has allowed the identification of sclerostin as an inhibitor of osteoblastic activity and simultaneously as a stimulator of osteoclastic activity. Therefore, the use of a monoclonal antibody, romosozumab, against this protein has been tested as a potential drug with a dual action, stimulating bone neo-apposition and inhibiting bone resorption. The efficacy of romosozumab has been demonstrated in numerous clinical trials against both placebo and other drugs commonly used in the treatment of patients affected by osteoporosis. The advantages of this drug lie above all in its rapid action which makes it particularly suitable in clinical situations where it is necessary to improve bone strength very quickly due to the imminent risk of fragility fracture. Clinical studies and guidelines suggest romosozumab as an initial drug in an ideal sequential approach from osteoanabolic to antiresorptive drugs. Some aspects of cardiovascular safety remain to be fully investigated, therefore its use in osteoporotic patients at high cardiovascular risk should be avoided until further data become available.
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X231197094
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  10. Article: Editorial: Genetics and Genomics of Red Blood Cells.

    Iolascon, Achille / Russo, Roberta / Andolfo, Immacolata

    Frontiers in physiology

    2022  Volume 12, Page(s) 822156

    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.822156
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