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  1. Article ; Online: Lung-Cancer Screening and the NELSON Trial.

    Kennedy, Marcus P

    The New England journal of medicine

    2020  Volume 382, Issue 22, Page(s) 2164–2165

    MeSH term(s) Cone-Beam Computed Tomography ; Early Detection of Cancer ; Humans ; Lung ; Lung Neoplasms ; Mass Screening
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2004224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  2. Article ; Online: Hypoxia Related to Malignant Airway Obstruction: From Zero to Infinity.

    Kennedy, Marcus P / George, Eapen A

    Journal of bronchology & interventional pulmonology

    2022  Volume 29, Issue 2, Page(s) e27–e30

    MeSH term(s) Airway Obstruction/etiology ; Bronchoscopy ; Humans ; Hypoxia/etiology
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4027: Show issues Location:
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  3. Article ; Online: A Pilot Clinical Evaluation of a New Single Use Bronchoscope.

    O'Reilly, Emily Margaret / Sweeney, Anne-Marie / Deasy, Kevin F / Kennedy, Marcus P

    Journal of bronchology & interventional pulmonology

    2023  Volume 30, Issue 4, Page(s) 381–382

    MeSH term(s) Humans ; Bronchoscopes ; Bronchoscopy ; Equipment Design
    Language English
    Publishing date 2023-10-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4027: Show issues Location:
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  4. Article ; Online: Single-use Bronchoscopes: Applications in COVID-19 Pandemic.

    Barron, Sarah / Kennedy, Marcus P

    Journal of bronchology & interventional pulmonology

    2020  Volume 28, Issue 1, Page(s) e3–e4

    MeSH term(s) Bronchoscopes ; Bronchoscopy/instrumentation ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Cross Infection/prevention & control ; Cross Infection/virology ; Disease Transmission, Infectious/prevention & control ; Disposable Equipment/supply & distribution ; Humans ; Infection Control/methods ; SARS-CoV-2/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000685
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  5. Article ; Online: Hyponatremia and hypercalcemia: a study of a large cohort of patients with lung cancer.

    Chan, Vanessa W Q / Henry, Michael T / Kennedy, Marcus P

    Translational cancer research

    2022  Volume 9, Issue 1, Page(s) 222–230

    Abstract: ... n=42; 41.2%; P=0.001). Hypercalcemia occurred most commonly in patients ... with non-small cell lung carcinoma (NSCLC) squamous subtype (n=27; 12.2%; P=0.003). The incidence of hyponatremia and hypercalcemia ... were significantly higher in the advanced stages (P<0.041), except in SCLC where no difference ...

    Abstract Background: Hyponatremia and hypercalcemia are reported to be associated with poorer prognosis in lung cancer. Our study assessed the incidence of hyponatremia and hypercalcemia in a recent large cohort of patients diagnosed with lung cancer in an academic institution and correlated incidence with patient and tumour parameters.
    Methods: All patients presented at our regional lung cancer multidisciplinary team meeting between January 2011 and December 2016 were included. The incidence of hyponatremia (serum sodium ≤135 mEq/L) and hypercalcemia (serum calcium >2.62 mmol/L), including severity (mild, moderate or severe) was evaluated and stratified by tumour subtype and stage, and correlated with patient parameters.
    Results: A total of 624 patients (mean age, 67.4 years; 59.3% male) diagnosed with tissue-proven lung cancer were included. Hyponatremia and hypercalcemia were present in 31.6% (n=197) and 7.1% (n=44) at time of diagnosis. Hyponatremia occurred most commonly in patients with small cell lung carcinoma (SCLC) (n=42; 41.2%; P=0.001). Hypercalcemia occurred most commonly in patients with non-small cell lung carcinoma (NSCLC) squamous subtype (n=27; 12.2%; P=0.003). The incidence of hyponatremia and hypercalcemia were significantly higher in the advanced stages (P<0.041), except in SCLC where no difference in hypercalcemia incidence across the stages was observed (P=0.573). The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score was positively correlated with severity of hyponatremia at the early stage of NSCLC (Spearman correlation coefficient =0.325; P=0.003).
    Conclusions: Hyponatremia is a common association in lung cancer, especially in SCLC. Hypercalcemia is an uncommon but significant association in the NSCLC squamous subtype. Hyponatremia might contribute to poorer ECOG-PS scores at the early stage of NSCLC.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.12.72
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  6. Article ; Online: Embolization of a Proximal Pulmonary Artery Pseudoaneurysm in a Cavitary Lung Cancer.

    O'Reilly, Marc F / Kennedy, Marcus P / Power, Stephen P

    Journal of vascular and interventional radiology : JVIR

    2022  Volume 33, Issue 6, Page(s) 741

    MeSH term(s) Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Embolization, Therapeutic ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/therapy ; Pulmonary Artery/diagnostic imaging
    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2022.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3720: Show issues Location:
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  7. Article ; Online: Meta-Analysis on Utility of Bronchoscopy in Addition to Computed Tomography Thorax in the Investigation of Lung Cancer in Patients with Haemoptysis.

    O'Mahony, Aoife Caitriona / Kennedy, Marcus P

    Respiration; international review of thoracic diseases

    2022  Volume 101, Issue 12, Page(s) 1139–1147

    Abstract: ... respectively. The sensitivity of CT was higher than that of bronchoscopy (p < 0.001). The pooled specificities ...

    Abstract Background: In patients with haemoptysis, many healthcare systems support bronchoscopy regardless of computed tomography (CT) findings.
    Objective: This meta-analysis aimed to address whether a normal CT alone is sufficient to out-rule lung cancer in patients with haemoptysis.
    Methods: A search was performed of the following databases: EBSCO (Medline), PubMed, Academic Search Complete, CINAHL, Cochrane Library, and Embase. Meta-Disc 1.4 and RevMan software were used to test for heterogeneity, risk of bias, and to summarize the test performance characteristics using forest plots and summary receiver operating characteristic (SROC) curves. SPSS was used to compare the diagnostic accuracy of CT and bronchoscopy.
    Results: A total of 14 studies (2,960 patients) were included. The pooled sensitivities for detection of lung cancer using CT scan and bronchoscopy were 0.99 (95% CI: 0.97-1.00) and 0.84 (95% CI: 0.78-0.88), respectively. The sensitivity of CT was higher than that of bronchoscopy (p < 0.001). The pooled specificities for CT scan and bronchoscopy were 0.99 (95% CI: 0.99-1.00) and 1.00 (95% CI: 0.99-1.00), respectively. Of 2,960 patients, 257 had lung cancer (8.7%) at initial investigation. 254 of these had a CT thorax, and the CT scan was false negative in 4/255 (1.6%), with bronchoscopy only identifying one cancer with a normal CT (0.4%).
    Conclusion: CT scan showed a higher diagnostic accuracy than bronchoscopy. This study indicated that bronchoscopy offers an insignificant additional value in the investigation of lung cancer in patients with haemoptysis and a negative CT scan.
    MeSH term(s) Humans ; Bronchoscopy ; Hemoptysis/diagnostic imaging ; Hemoptysis/etiology ; Tomography, X-Ray Computed/methods ; Lung Neoplasms/diagnosis ; Lung Neoplasms/diagnostic imaging ; Thorax ; Sensitivity and Specificity
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Meta-Analysis
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000527101
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    Uh II Zs.138: Show issues Location:
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  8. Article ; Online: Single-Use (Disposable) Flexible Bronchoscopes: The Future of Bronchoscopy?

    Barron, Sarah P / Kennedy, Marcus P

    Advances in therapy

    2020  Volume 37, Issue 11, Page(s) 4538–4548

    Abstract: The coronavirus disease (COVID-19) pandemic has highlighted the importance of reducing occupational exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The reprocessing procedure for reusable flexible bronchoscopes (RFBs) involves ... ...

    Abstract The coronavirus disease (COVID-19) pandemic has highlighted the importance of reducing occupational exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The reprocessing procedure for reusable flexible bronchoscopes (RFBs) involves multiple episodes of handling of equipment that has been used during an aerosol-generating procedure and thus is a potential source of transmission. Single-use flexible bronchoscopes (SUFBs) eliminate this source. Additionally, RFBs pose a risk of nosocomial infection transmission between patients with the identification of human proteins, deoxyribonucleic acid (DNA) and pathogenic organisms on fully reprocessed bronchoscopes despite full adherence to the guidelines. Bronchoscopy units have been hugely impacted by the pandemic with restructuring of pre- and post-operative areas, altered patient protocols and the reassessment of air exchange and cleaning procedures. SUFBs can be incorporated into these protocols as a means of improving occupational safety. Most studies on the efficacy of SUFBs have occurred in an anaesthetic setting so it remains to be seen whether they will perform to an acceptable standard in complex respiratory procedures such as transbronchial biopsies and cryotherapy. Here, we outline their potential uses in a respiratory setting, both during and after the current pandemic.
    MeSH term(s) Betacoronavirus ; Bronchoscopes/trends ; Bronchoscopy/trends ; COVID-19 ; Coronavirus Infections/diagnosis ; Disposable Equipment ; Equipment Contamination/prevention & control ; Humans ; Microbiological Techniques/trends ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-020-01495-8
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  10. Article ; Online: Broncholithiasis and Primary Ciliary Dyskinesia: An Association Not Identified in Other Chronic Airway Inflammatory Disorders.

    Kennedy, Marcus P / Noone, Peadar G / Knowles, Michael R

    Chest

    2020  Volume 157, Issue 3, Page(s) 737

    MeSH term(s) Bronchial Diseases ; Humans ; Kartagener Syndrome ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2020-02-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.10.055
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