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  1. Book: ALERT - adverse late effects of cancer treatment / 2

    Rubin, Philip / Constine, Louis S. / Marks, Lawrence B.

    2014  

    Author's details Philip Rubin ; Louis S. Constine ; Lawrence B. Marks ed
    Collection ALERT - adverse late effects of cancer treatment
    Language English
    Size XX, 700 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018136794
    ISBN 978-3-540-72313-4 ; 3-540-72313-7 ; 9783540758631 ; 3540758631
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 299 available for loan (reading room) Lesesaal EG

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  2. Book: ALERT - adverse late effects of cancer treatment / 1

    Rubin, Philip / Constine, Louis S. / Marks, Lawrence B.

    2014  

    Author's details Philip Rubin ; Louis S. Constine ; Lawrence B. Marks ed
    Collection ALERT - adverse late effects of cancer treatment
    Language English
    Size XXIV, 311 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017845432
    ISBN 978-3-540-72313-4 ; 3-540-72313-7 ; 9783540723141 ; 3540723145
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 3288 available for loan (reading room) Lesesaal EG

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  3. Book ; Collection: ALERT - adverse late effects of cancer treatment

    Rubin, Philip / Constine, Louis S. / Marks, Lawrence B.

    (Medical radiology : radiation oncology)

    2014  

    Author's details Philip Rubin ; Louis S. Constine ; Lawrence B. Marks ed
    Series title Medical radiology : radiation oncology
    Language English
    Dates of publication 2014-9999
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    HBZ-ID HT017845412
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Opioid use and risks in liver transplant candidates and recipients.

    Rubin, Jessica B / Aby, Elizabeth S / Barman, Pranab / Tincopa, Monica

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2024  

    Abstract: Opioid use is extremely prevalent among cirrhosis and liver transplant (LT) patients, despite concerns regarding opioid-related risks in this population. While there are many theoretical risks of opioids in patients with hepatic dysfunction, there is ... ...

    Abstract Opioid use is extremely prevalent among cirrhosis and liver transplant (LT) patients, despite concerns regarding opioid-related risks in this population. While there are many theoretical risks of opioids in patients with hepatic dysfunction, there is limited evidence on the effect of opioid use on clinical outcomes in cirrhosis and pre- and post-LT patients specifically. As a result there is significant center-level variability in opioid-related practice and policies. The existing data-largely based on retrospective observational studies-does suggest that opioids are associated with increased health resource utilization pre- and post-LT, and that they may precipitate hepatic encephalopathy (HE) in patients with cirrhosis and increase risk of graft loss and death post-LT. The strongest predictor of opioid use post-LT is opioid use prior to transplant; thus, a focus on safe opioid use in the pre- and peri-transplant periods is essential for minimizing opioid-related harms. We describe three strategies to guide LT providers, including: 1) Improved characterization of pain, mental health symptoms, and opioid and polysubstance use; 2) Minimization of opioid prescriptions for those at highest risk of adverse events; and 3) Safe prescribing strategies for those who do use opioids and for management of opioid use disorder (OUD). Ultimately, our goal is to improve quality of life and transplant outcomes among cirrhosis and LT patients, particularly those living with concurrent pain, mental health, and substance use disorders.
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The influence of cationic antiseptics on the processes of light energy conversion in various photosynthetic pigment-protein complexes.

    Knox, Peter P / Lukashev, Eugene P / Korvatovsky, Boris N / Mamedov, Mahir D / Strakhovskaya, Marina G / Gvozdev, Daniil A / Paschenko, Vladimir Z / Rubin, Andrew B

    Photosynthesis research

    2024  

    Abstract: The widespread use of disinfectants and antiseptics, and consequently their release into the environment, determines the relevance of studying their potential impact on the main producers of organic matter on the planet-photosynthetic organisms. The ... ...

    Abstract The widespread use of disinfectants and antiseptics, and consequently their release into the environment, determines the relevance of studying their potential impact on the main producers of organic matter on the planet-photosynthetic organisms. The review examines the effects of some biguanides and quaternary ammonium compounds, octenidine, miramistin, chlorhexidine, and picloxidine, on the functioning of the photosynthetic apparatus of various organisms (Strakhovskaya et al. in Photosynth Res 147:197-209, 2021; Knox et al. in Photosynth Res 153:103, 2022; Paschenko et al. in Photosynth Res 155:93-105, 2023a, Photosynth Res 2023b). A common feature of these antiseptics is the combination of hydrophobic and hydrophilic regions in the molecules, the latter carrying a positive charge(s). The comparison of the results obtained with intact bacterial membrane vesicles (chromatophores) and purified pigment-protein complexes (photosystem II and I) of oxygenic organisms allows us to draw conclusions about the mechanisms of the cationic antiseptic action on the functional properties of the components of the photosynthetic apparatus.
    Language English
    Publishing date 2024-03-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1475688-2
    ISSN 1573-5079 ; 0166-8595
    ISSN (online) 1573-5079
    ISSN 0166-8595
    DOI 10.1007/s11120-024-01082-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Parallel Library of all Seven A(2)+B(2)+C(2) T(h) Regioisomeric Hexakisadducts of Fullerene C(60): Inspiration from Werner's Octahedral Stereoisomerism This work was supported by a National Science Foundation Young Investigator Award (CHE-9457693), the Office of Naval Research (N00014-98-1-0035), and an Alfred P. Sloan Research Fellowship award.

    Qian / Rubin

    Angewandte Chemie (International ed. in English)

    2000  Volume 39, Issue 17, Page(s) 3133–3137

    Language English
    Publishing date 2000-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/1521-3773(20000901)39:17<3133::aid-anie3133>3.0.co;2-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Conference proceedings ; Online: CRYSTALLIZATION AND CHARACTERIZATION OF CANDIDA RUGOSA LIPASE

    Rubin, Byron / Jamison, Penny / Harrison, David

    2024  

    Abstract: ... the presenceof calcium (II) salts. The crystals with cell dimensions a=64.9(1) 7 b=97.2(1) A and b=175.8(2 ...

    Abstract A lipase isolated from the fungus Candida rugosahas beenpurified and crystallized in a form suitable for X-ray crystallographic structure determination. Several proteins with lipolytic activity having isoelectric points from 4.2 to 5.8 were separated by ion exchange chromatography.The protein having the lowestisoelectric point was crystallized from 2-methy]-2,4-pentandiol in MES bufferin the presenceof calcium (II) salts. The crystals with cell dimensions a=64.9(1) 7 b=97.2(1) A and b=175.8(2)A, grow as large colorless plates often exceeding 0.7 mm in each of two dimensions. From the diffraction pattern the apparent crystal symmetry is C222,. Experimental density determination suggests one 60,000 M,. molecule in the asymmetric unit and approximately 50% solvent by volume. Theratio unit cell volume to the molecular weightof the contents of the unit cell, Vj, is 2.3 A3/d. Diffraction is strong to a resolution of 2 A resolution and work is underway to determine the three dimensional structure of this enzyme.
    Subject code 572
    Language English
    Publishing date 2024-03-13
    Publisher GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
    Publishing country de
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Mutual insurance in the entrepreneurial landscape.

    Logvinova, Irina L / Rubin, Yury B / Lednev, Mikhail V / Mozhzhukhin, Daniel P

    Journal of innovation and entrepreneurship

    2022  Volume 11, Issue 1, Page(s) 35

    Abstract: In this article, the authors introduce mutual insurance as a constructive component of the modern entrepreneurial landscape aimed at the protection of the wealth-related interests of the participants of the mutual insurance company (mutual insurance ... ...

    Abstract In this article, the authors introduce mutual insurance as a constructive component of the modern entrepreneurial landscape aimed at the protection of the wealth-related interests of the participants of the mutual insurance company (mutual insurance society, friendly society, etc.). Analyzing mutual insurance, the authors display it from the standpoint of entrepreneurship and assume that such companies (MICs) are among the insurance market actors. The specific feature of MICs is that they form the community of their members-policyholders. As far as members of each organization of this kind are its co-owners, they carry out some critical entrepreneurial activity functions. The object of this research is represented by the insurance market of the Russian Federation, through the prism of which the degree of development of MICs was demonstrated, and the barriers to its infrastructure growth were determined.
    Language English
    Publishing date 2022-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2679760-4
    ISSN 2192-5372 ; 2192-5372
    ISSN (online) 2192-5372
    ISSN 2192-5372
    DOI 10.1186/s13731-022-00223-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Leveraging Hot Spots of TEAD-Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling.

    Zhao, Bin / Pobbati, Ajaybabu V / Rubin, Brian P / Stauffer, Shaun

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 4

    Abstract: The Hippo signaling pathway is a highly conserved pathway that plays important roles in the regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and transcriptional coregulators YAP/TAZ are the downstream effectors of the Hippo ... ...

    Abstract The Hippo signaling pathway is a highly conserved pathway that plays important roles in the regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and transcriptional coregulators YAP/TAZ are the downstream effectors of the Hippo pathway and can modulate Hippo biology. Dysregulation of this pathway is implicated in tumorigenesis and acquired resistance to therapies. The emerging importance of YAP/TAZ-TEAD interaction in cancer development makes it a potential therapeutic target. In the past decade, disrupting YAP/TAZ-TEAD interaction as an effective approach for cancer treatment has achieved great progress. This approach followed a trajectory wherein peptidomimetic YAP-TEAD protein-protein interaction disruptors (PPIDs) were first designed, followed by the discovery of allosteric small molecule PPIDs, and currently, the development of direct small molecule PPIDs. YAP and TEAD form three interaction interfaces. Interfaces 2 and 3 are amenable for direct PPID design. One direct YAP-TEAD PPID (IAG933) that targets interface 3 has entered a clinical trial in 2021. However, in general, strategically designing effective small molecules PPIDs targeting TEAD interfaces 2 and 3 has been challenging compared with allosteric inhibitor development. This review focuses on the development of direct surface disruptors and discusses the challenges and opportunities for developing potent YAP/TAZ-TEAD inhibitors for the treatment of cancer.
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16040583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Time of Day Preferences and Daily Temporal Consistency for Predicting the Sustained Use of a Commercial Meditation App: Longitudinal Observational Study.

    Berardi, Vincent / Fowers, Rylan / Rubin, Gavriella / Stecher, Chad

    Journal of medical Internet research

    2023  Volume 25, Page(s) e42482

    Abstract: ... engagement (regression coefficient B=2.76, P<.001) and long-term use (B=50.6, P<.001). The opposite was true ... for late-night meditation sessions (short-term: B=-2.06, P<.001; long-term: B=-51.7, P=.001). Significant ... associated with better short-term engagement (B=-1.64, P<.001) but worse long-term use (B=55.8, P<.001 ...

    Abstract Background: The intensive data typically collected by mobile health (mHealth) apps allows factors associated with persistent use to be investigated, which is an important objective given users' well-known struggles with sustaining healthy behavior.
    Objective: Data from a commercial meditation app (n=14,879; 899,071 total app uses) were analyzed to assess the validity of commonly given habit formation advice to meditate at the same time every day, preferably in the morning.
    Methods: First, the change in probability of meditating in 4 nonoverlapping time windows (morning, midday, evening, and late night) on a given day over the first 180 days after creating a meditation app account was calculated via generalized additive mixed models. Second, users' time of day preferences were calculated as the percentage of all meditation sessions that occurred within each of the 4 time windows. Additionally, the temporal consistency of daily meditation behavior was calculated as the entropy of the timing of app usage sessions. Linear regression was used to examine the effect of time of day preference and temporal consistency on two outcomes: (1) short-term engagement, defined as the number of meditation sessions completed within the sixth and seventh month of a user's account, and (2) long-term use, defined as the days until a user's last observed meditation session.
    Results: Large reductions in the probability of meditation at any time of day were seen over the first 180 days after creating an account, but this effect was smallest for morning meditation sessions (63.4% reduction vs reductions ranging from 67.8% to 74.5% for other times). A greater proportion of meditation in the morning was also significantly associated with better short-term engagement (regression coefficient B=2.76, P<.001) and long-term use (B=50.6, P<.001). The opposite was true for late-night meditation sessions (short-term: B=-2.06, P<.001; long-term: B=-51.7, P=.001). Significant relationships were not found for midday sessions (any outcome) or for evening sessions when examining long-term use. Additionally, temporal consistency in the performance of morning meditation sessions was associated with better short-term engagement (B=-1.64, P<.001) but worse long-term use (B=55.8, P<.001). Similar-sized temporal consistency effects were found for all other time windows.
    Conclusions: Meditating in the morning was associated with higher rates of maintaining a meditation practice with the app. This is consistent with findings from other studies that have hypothesized that the strength of existing morning routines and circadian rhythms may make the morning an ideal time to build new habits. In the long term, less temporal consistency in meditation sessions was associated with more persistent app use, suggesting there are benefits from maintaining flexibility in behavior performance. These findings improve our understanding of how to promote enduring healthy lifestyles and can inform the design of mHealth strategies for maintaining behavior changes.
    MeSH term(s) Humans ; Mobile Applications ; Meditation ; Longitudinal Studies ; Health Behavior ; Healthy Lifestyle
    Language English
    Publishing date 2023-04-10
    Publishing country Canada
    Document type Observational Study ; Journal Article
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/42482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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