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  1. Article ; Online: Inspiratory Muscle Training Improves Aerobic Fitness in Active Children.

    Lin, Ching-Hsin / Lee, Chih-Wei / Huang, Chien-Hui

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: Research on the effect of inspiratory muscle training (IMT) on exercise performance is inconsistent. IMT has not been applied to fit child athletes, who are more likely to develop inspiratory muscle fatigue, and, consequently, to benefit from IMT. ... ...

    Abstract Research on the effect of inspiratory muscle training (IMT) on exercise performance is inconsistent. IMT has not been applied to fit child athletes, who are more likely to develop inspiratory muscle fatigue, and, consequently, to benefit from IMT. Methods: Thirty children (mean age: 10.7 ± 1.2 years) were recruited and randomly assigned to a high-intensity (HG), a low-intensity (LG), or a control group (CG). For both training groups, a double-blind procedure was applied. In the HG, 80% of maximal inspiratory pressure (MIP) was used as the level of training intensity. The LG used 30% MIP. Training groups were trained at 6 breaths a set, 4 sets a day, totaling 24 breaths a day for 6 weeks. Exercise capacity outcomes include maximal and submaximal aerobic capacity, as measured as VO
    MeSH term(s) Child ; Humans ; Respiratory Muscles/physiology ; Breathing Exercises/methods ; Respiratory Therapy ; Exercise/physiology ; Exercise Tolerance
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192214722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tumor protease-activated theranostic nanoparticles for MRI-guided glioblastoma therapy.

    Huang, Ching-Hsin / Chang, Edwin / Zheng, Li / Raj, Joe Gerald Jesu / Wu, Wei / Pisani, Laura J / Daldrup-Link, Heike E

    Theranostics

    2023  Volume 13, Issue 6, Page(s) 1745–1758

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Mice ; Animals ; Glioblastoma/diagnostic imaging ; Glioblastoma/drug therapy ; Precision Medicine ; Ferrosoferric Oxide/therapeutic use ; Peptide Hydrolases ; Mice, Nude ; Magnetic Resonance Imaging ; Nanoparticles/chemistry ; Endopeptidases ; Iron ; Cell Line, Tumor
    Chemical Substances Ferrosoferric Oxide (XM0M87F357) ; Peptide Hydrolases (EC 3.4.-) ; Endopeptidases (EC 3.4.-) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-03-13
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.79342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice.

    Chou, Ming-Yu / Wong, Yue-Ching / Wang, Shih-Yi / Chi, Ching-Hsin / Wang, Teng-Hsu / Huang, Mao-Jung / Huang, Ping-Hsiu / Li, Po-Hsien / Wang, Ming-Fu

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1235780

    Abstract: Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 ( ... ...

    Abstract Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 (SAMP8) mice, 48 in total, randomly divided into 3 groups including control, Huáng qí extract [820 mg/kg Body weight (BW)/day], and Huáng qí complexes (6.2 mL /kg BW/day), where each group consisted of males (
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1235780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Single-cell analysis of castration-resistant prostate cancers to identify potential biomarkers for diagnosis and prognosis of neuroendocrine prostate cancer.

    Hong, Yung-Chih / Hu, Tze-Yun / Hsu, Chih-Sin / Yeh, Wayne W / Wong, Wei-Ze / Shen, Tsai-Wen / Chang, Ching-Hsin / Hua, Kate / Tung, Chien-Yi / Peng, Yu-Ching / Huang, William J / Chang, Pei-Ching / Lin, Tzu-Ping

    American journal of cancer research

    2023  Volume 13, Issue 10, Page(s) 4560–4578

    Abstract: The high heterogeneity and low percentage of neuroendocrine cells in prostate cancer limit the utility of traditional bulk RNA sequencing and even single-cell RNA sequencing to find better biomarkers for early diagnosis and stratification. Re-clustering ... ...

    Abstract The high heterogeneity and low percentage of neuroendocrine cells in prostate cancer limit the utility of traditional bulk RNA sequencing and even single-cell RNA sequencing to find better biomarkers for early diagnosis and stratification. Re-clustering of specific cell-type holds great promise for identification of intra-cell-type heterogeneity. However, this has not yet been used in studying neuroendocrine prostate cancer heterogeneity. Neuroendocrine cluster(s) were individually identified in each castration-resistant prostate cancer specimen and combined for trajectory analysis. Three neuroendocrine states were identified. Neuroendocrine state 2 with the highest AR score was considered the initial starting state of neuroendocrine transdifferentiation. State 1 and state 3 with distinct high neuroendocrine scores and marker genes enriched in N-Myc and REST target genes, respectively, were considered as two different types of neuroendocrine differentiated cancer cells. These two states contained distinct groups of prostate cancer biomarkers and a strong distinguishing ability of normal versus cancerous prostate across different pathological grading was found in the N-Myc-associated state. Our data highlight the central role of N-Myc and REST in mediating lineage plasticity and classifying neuroendocrine phenotypes.
    Language English
    Publishing date 2023-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Safety and effectiveness of high-power thulium laser enucleation of the prostate in patients with glands larger than 80 mL.

    Chang, Ching-Hsin / Lin, Tzu-Ping / Huang, Jung-Yao

    BMC urology

    2019  Volume 19, Issue 1, Page(s) 8

    Abstract: Background: The efficacy of thulium laser prostate enucleation (ThuLEP) for large prostates is unclear. This study aimed to explore the expanded utility of 150-200-W ThuLEP by studying patients with a large prostate (> 80 mL).: Methods: We ... ...

    Abstract Background: The efficacy of thulium laser prostate enucleation (ThuLEP) for large prostates is unclear. This study aimed to explore the expanded utility of 150-200-W ThuLEP by studying patients with a large prostate (> 80 mL).
    Methods: We retrospectively reviewed records of 125 patients with large prostate glands (> 80 mL) who underwent ThuLEP performed by a single surgeon from June 2012 to June 2016. The ThuLEP data from our previous pilot study were used as the control. Operative variables, patient profiles, preoperative and postoperative urine flow rates, prostate volume, and the international prostate symptom score (IPSS) were recorded and analyzed using Student's t-test, the z-test, and logistic regression analysis.
    Results: Of 366 patients who underwent ThuLEP, 125 (34.15%) were enrolled. The ages and estimated prostate volumes were compared with those of the control. Overall, 39.2% underwent Foley placement and 4% received an anticoagulant agent preoperatively. Maximum urinary flow rates before and 3 and 12 months postoperatively were 9.93, 23.20, and 19.00 mL/s, respectively, which were generally equal to those of the control groups (P = 0.68, 0.18, 0.98, respectively). Preoperative and postoperative IPSSs were 27.09 and 7.35, respectively. The postoperative prostate-specific antigen was reduced by 85.59% in comparison to the preoperative level. The estimated prostate size was reduced by 74.17% postoperatively. The modified Clavien-Dindo classification system was used to identify the overall rate of complications, which was approximately 22.4%. The mortality rate was 0.8%.
    Conclusions: High-power ThuLEP is safe and effective for patients with large prostate glands (> 80 mL). Prostate enucleation using a high-power thulium laser is feasible for patients who exhibit contraindications for surgery.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Laser Therapy/methods ; Male ; Middle Aged ; Organ Size/physiology ; Pilot Projects ; Prostate/diagnostic imaging ; Prostate/surgery ; Prostatic Hyperplasia/diagnostic imaging ; Prostatic Hyperplasia/surgery ; Retrospective Studies ; Thulium/administration & dosage ; Treatment Outcome
    Chemical Substances Thulium (8RKC5ATI4P)
    Language English
    Publishing date 2019-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-019-0437-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unveiling the Incidence and Graft Survival Rate in Kidney Transplant Recipients With

    Hsiung, Chien-Ya / Chen, Hsin-Yu / Wang, Shih-Han / Huang, Ching-Ying

    Transplant international : official journal of the European Society for Organ Transplantation

    2024  Volume 37, Page(s) 12168

    Abstract: ... De ... ...

    Abstract De novo
    MeSH term(s) Humans ; Graft Survival ; Incidence ; Kidney ; Kidney Transplantation ; Thrombotic Microangiopathies/complications
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2024.12168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bidirektionale Assoziationen zwischen Psoriasis und Migräne: Eine systematische Übersicht und Metaanalyse.

    Huang, I-Hsin / Hung, Wei-Kai / Chi, Ching-Chi

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 5, Page(s) 493–503

    Language German
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14994_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Do Cardiac Causes Predominate in the Etiological Classification of Out-of-Hospital Cardiac Arrest (OHCA)?

    Chen, Ching-Yu / Chen, Chi-Hsin / Fan, Cheng-Yi / Sung, Chih-Wei / Pei-Chuan Huang, Edward

    Resuscitation

    2024  , Page(s) 110231

    Language English
    Publishing date 2024-05-03
    Publishing country Ireland
    Document type Letter
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2024.110231
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  9. Article ; Online: MegaPro, a clinically translatable nanoparticle for

    Suryadevara, Vidyani / Hajipour, Mohammad Javad / Adams, Lisa C / Aissaoui, Nour Mary / Rashidi, Ali / Kiru, Louise / Theruvath, Ashok J / Huang, Ching-Hsin / Maruyama, Masahiro / Tsubosaka, Masanori / Lyons, Jennifer K / Wu, Wei Emma / Roudi, Raheleh / Goodman, Stuart B / Daldrup-Link, Heike E

    Theranostics

    2023  Volume 13, Issue 8, Page(s) 2710–2720

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Animals ; Swine ; Ferrosoferric Oxide ; Stem Cells ; Cartilage Diseases ; Cartilage ; Nanoparticles ; Magnetic Resonance Imaging/methods ; Cell Differentiation ; Mesenchymal Stem Cell Transplantation/methods ; Cell Tracking/methods
    Chemical Substances Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2023-04-29
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.82620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.

    Fang, Li-Pao / Zhao, Na / Caudal, Laura C / Chang, Hsin-Fang / Zhao, Renping / Lin, Ching-Hsin / Hainz, Nadine / Meier, Carola / Bettler, Bernhard / Huang, Wenhui / Scheller, Anja / Kirchhoff, Frank / Bai, Xianshu

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1394

    Abstract: Cortical neural circuits are complex but very precise networks of balanced excitation and inhibition. Yet, the molecular and cellular mechanisms that form the balance are just beginning to emerge. Here, using conditional γ-aminobutyric acid receptor B1- ... ...

    Abstract Cortical neural circuits are complex but very precise networks of balanced excitation and inhibition. Yet, the molecular and cellular mechanisms that form the balance are just beginning to emerge. Here, using conditional γ-aminobutyric acid receptor B1- deficient mice we identify a γ-aminobutyric acid/tumor necrosis factor superfamily member 12-mediated bidirectional communication pathway between parvalbumin-positive fast spiking interneurons and oligodendrocyte precursor cells that determines the density and function of interneurons in the developing medial prefrontal cortex. Interruption of the GABAergic signaling to oligodendrocyte precursor cells results in reduced myelination and hypoactivity of interneurons, strong changes of cortical network activities and impaired social cognitive behavior. In conclusion, glial transmitter receptors are pivotal elements in finetuning distinct brain functions.
    MeSH term(s) Animals ; Cognition ; Communication ; Interneurons/physiology ; Mice ; Oligodendrocyte Precursor Cells/metabolism ; Parvalbumins/metabolism
    Chemical Substances Parvalbumins
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29020-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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