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  1. Book ; Thesis: Die Rolle der Zelladhäsionsmoleküle Neph2 und Neph3 im glomerulären Filter der Niere

    Pulido Guevara, Barbara Annika / Schermer, Bernhard / Wodarz, Andreas

    2022  

    Institution Universitätsklinikum Köln / Klinik II für Innere Medizin
    Author's details vorgelegt von Barbara Annika Pulido Guevara ; 1. Gutachter: Professor Dr. med. B. Schermer, 2. Gutachter: Universitätsprofessor Dr. rer. nat. Wodarz ; aus dem Zetrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin II der Universität zu Köln
    Subject code 610
    Language German
    Size 77 Blätter, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2022
    HBZ-ID HT021600001
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 572 order for loan Magazin

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  2. Book ; Thesis: Bedeutung des Aktin- und Myosinbindeproteins Caldesmon für die pränatale Entwicklung der Maus

    Frohn, Marina / Pfitzer, Gabriele / Wodarz, Andreas

    2020  

    Institution Zentrum Physiologie und Pathophysiologie
    Author's details vorgelegt von Marina Frohn ; 1. Gutachterin: Universitätsprofessorin Dr. med. G. Pfitzer, 2. Gutachter: Universitätsprofessor Dr. rer. nat. A. Wodarz ; aus dem Zentrum für Physiologie und Pathophysiologie der Universität zu Köln, Institut für Vegetative Physiologie
    Subject code 610
    Language German
    Size 135 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    HBZ-ID HT020989323
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
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  3. Article ; Online: Transcriptional Control of Apical-Basal Polarity Regulators.

    Rust, Katja / Wodarz, Andreas

    International journal of molecular sciences

    2021  Volume 22, Issue 22

    Abstract: Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is ... ...

    Abstract Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is controlled by three protein complexes that interact with and co-regulate each other: The Par-, Crumbs-, and Scrib-complexes. The localization and activity of the components of these complexes is predominantly controlled by protein-protein interactions and protein phosphorylation status. Increasing evidence accumulates that, besides the regulation at the protein level, the precise expression control of polarity determinants contributes substantially to cell polarity regulation. Here we review how gene expression regulation influences processes that depend on the induction, maintenance, or abolishment of cell polarity with a special focus on epithelial to mesenchymal transition and asymmetric stem cell division. We conclude that gene expression control is an important and often neglected mechanism in the control of cell polarity.
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Asymmetric Cell Division/genetics ; Cell Cycle Proteins/metabolism ; Cell Polarity/genetics ; Epithelial-Mesenchymal Transition/genetics ; Eye Proteins/metabolism ; Gene Expression ; Gene Expression Regulation ; Humans ; Membrane Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Protein Interaction Maps/genetics ; Signal Transduction/genetics ; Transcription, Genetic/genetics ; Tumor Suppressor Proteins/metabolism ; cdc42 GTP-Binding Protein/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; CRB1 protein, human ; Cell Cycle Proteins ; Eye Proteins ; Membrane Proteins ; Nerve Tissue Proteins ; PARD3 protein, human ; PARD6A protein, human ; SCRIB protein, human ; Tumor Suppressor Proteins ; CDC42 protein, human (EC 3.6.5.2) ; cdc42 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222212340
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  4. Book ; Online ; Thesis: „Dynamische Darstellung und Analyse der Oberlidanatomie mittels Ultraschall-Biomikroskopie“

    Kowanz, Dominik Helmut [Verfasser] / Heindl, Ludwig [Gutachter] / Wodarz, Andreas [Gutachter]

    2023  

    Author's details Dominik Helmut Kowanz ; Gutachter: Ludwig Heindl, Andreas Wodarz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
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  5. Book ; Online ; Thesis: Quantifizierung der Aktivität von Typ II Proteinkinase A unter Einfluss von Opioid- und Serotoninrezeptor-spezifischen Liganden mittels „High Content Screening“ (HCS)-Mikroskopie

    Fuchs, Tim Arkascha [Verfasser] / Hucho, Tim [Gutachter] / Wodarz, Andreas [Gutachter]

    2023  

    Author's details Tim Arkascha Fuchs ; Gutachter: Tim Hucho, Andreas Wodarz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Transcriptional Control of Apical-Basal Polarity Regulators

    Katja Rust / Andreas Wodarz

    International Journal of Molecular Sciences, Vol 22, Iss 12340, p

    2021  Volume 12340

    Abstract: Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is ... ...

    Abstract Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is controlled by three protein complexes that interact with and co-regulate each other: The Par-, Crumbs-, and Scrib-complexes. The localization and activity of the components of these complexes is predominantly controlled by protein-protein interactions and protein phosphorylation status. Increasing evidence accumulates that, besides the regulation at the protein level, the precise expression control of polarity determinants contributes substantially to cell polarity regulation. Here we review how gene expression regulation influences processes that depend on the induction, maintenance, or abolishment of cell polarity with a special focus on epithelial to mesenchymal transition and asymmetric stem cell division. We conclude that gene expression control is an important and often neglected mechanism in the control of cell polarity.
    Keywords cell polarity ; gene expression ; transcriptional regulation ; Par complex ; Scrib complex ; Crumbs complex ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571 ; 612
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Notch Signaling: Where Is the Action?

    Januschke, Jens / Wodarz, Andreas

    Current biology : CB

    2017  Volume 27, Issue 15, Page(s) R760–R762

    Abstract: It has been a long-standing question as to whether the activation of Notch by its ligands occurs in a specific region of the plasma membrane. A study now shows that this is indeed the case in the Drosophila sensory organ precursor cell lineage. ...

    Abstract It has been a long-standing question as to whether the activation of Notch by its ligands occurs in a specific region of the plasma membrane. A study now shows that this is indeed the case in the Drosophila sensory organ precursor cell lineage.
    MeSH term(s) Animals ; Drosophila/cytology ; Drosophila Proteins ; Membrane Proteins ; Receptors, Notch ; Signal Transduction
    Chemical Substances Drosophila Proteins ; Membrane Proteins ; N protein, Drosophila ; Receptors, Notch
    Language English
    Publishing date 2017-08-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2017.06.072
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Extraction and immunoblotting of proteins from embryos.

    Wodarz, Andreas

    Methods in molecular biology (Clifton, N.J.)

    2008  Volume 420, Page(s) 335–345

    Abstract: For many decades, Drosophila has been used as a model system primarily for studies in the fields of genetics and developmental biology. Relatively little attention has been given to the potential of Drosophila as a model system for biochemistry. However, ...

    Abstract For many decades, Drosophila has been used as a model system primarily for studies in the fields of genetics and developmental biology. Relatively little attention has been given to the potential of Drosophila as a model system for biochemistry. However, Drosophila embryos as a source for biochemical material offer some unique advantages as compared with cultured cells or tissue samples. For instance, mutant Drosophila embryos can be sorted before protein extraction and compared with wild-type embryos by using green fluorescent protein-marked balancer chromosomes. Studies of this kind can give important information on the effect of a mutation on the biochemical properties of a protein, which cannot be obtained in experiments using cultured cells or conventional tissue samples (1,2). Transgenic Drosophila embryos expressing a tagged version of a protein can be used to isolate and identify interaction partners of the tagged protein from a whole organism rather than from a specific cell line that expresses only a limited set of genes (3,4). Thus, it is the combination of genetics and transgenic approaches that offers unique opportunities for biochemical studies in the fruit fly. In this chapter, I describe methods to extract proteins under denaturing and nondenaturing conditions from embryos, and to perform sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunoblotting, and coimmunoprecipitation.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Developmental Biology/methods ; Drosophila Proteins/metabolism ; Drosophila melanogaster/embryology ; Embryo, Nonmammalian/metabolism ; Embryo, Nonmammalian/physiology ; Gene Expression Regulation, Developmental ; Genes, Insect ; Genetic Techniques ; Green Fluorescent Proteins/metabolism ; Immunoblotting/methods ; Luminescent Proteins/metabolism ; Models, Biological ; Transgenes
    Chemical Substances Drosophila Proteins ; Luminescent Proteins ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1007/978-1-59745-583-1_21
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  9. Article: Molecular profiling of stem cell-like female germ line cells in

    Tiwari, Manu D / Zeitler, Daniela M / Meister, Gunter / Wodarz, Andreas

    Biology open

    2019  Volume 8, Issue 11

    Abstract: Stem cells can self-renew and produce daughter cells destined for differentiation. The precise control of the balance between these two outcomes is essential to ensure tissue homeostasis and to prevent uncontrolled proliferation resulting in tumor ... ...

    Abstract Stem cells can self-renew and produce daughter cells destined for differentiation. The precise control of the balance between these two outcomes is essential to ensure tissue homeostasis and to prevent uncontrolled proliferation resulting in tumor formation. As self-renewal and differentiation are likely to be controlled by different gene expression programs, unraveling the underlying gene regulatory networks is crucial for understanding the molecular logic of this system. In this study, we have characterized by next generation RNA sequencing (RNA-seq) the transcriptome of germline stem cell (GSC)-like cells isolated from
    Language English
    Publishing date 2019-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2632264-X
    ISSN 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.046789
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  10. Book ; Online ; Thesis: Functional and structural characterization of the Drosophila gene smallish during epithelial morphogenesis

    Peek, Irina [Verfasser] / Wodarz, Andreas [Gutachter] / Roth, Siegfried [Gutachter]

    2019  

    Author's details Irina Peek ; Gutachter: Andreas Wodarz, Siegfried Roth
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
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