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  1. Article: ELIXIR - damit der datenfluss nicht ins stocken kommt. Interview mit Niklas Blomberg

    Garzón, Marcus / Grimm, Vera / Blomberg, Niklas

    Systembiologie.de

    2016  Volume -, Issue 10 April, Page(s) 28

    Language German
    Document type Article
    ZDB-ID 2558263-X
    ISSN 2191-2505
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6877: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Roadmap for a European cancer data management and precision medicine infrastructure.

    Nikolski, Macha / Hovig, Eivind / Al-Shahrour, Fatima / Blomberg, Niklas / Scollen, Serena / Valencia, Alfonso / Saunders, Gary

    Nature cancer

    2024  Volume 5, Issue 3, Page(s) 367–372

    MeSH term(s) Humans ; Data Management ; Precision Medicine ; Biomedical Research ; Neoplasms
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00717-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Connecting data, tools and people across Europe: ELIXIR's response to the COVID-19 pandemic.

    Blomberg, Niklas / Lauer, Katharina B

    European journal of human genetics : EJHG

    2020  Volume 28, Issue 6, Page(s) 719–723

    Abstract: ELIXIR, the European research infrastructure for life science data, provides open access to data, tools and workflows in the response to the COVID-19 pandemic. ELIXIR's 23 nodes have reacted swiftly to support researchers in their combined efforts ... ...

    Abstract ELIXIR, the European research infrastructure for life science data, provides open access to data, tools and workflows in the response to the COVID-19 pandemic. ELIXIR's 23 nodes have reacted swiftly to support researchers in their combined efforts against the pandemic setting out three joint priorities: 1. Connecting national COVID-19 data platforms to create federated European COVID-19 Data Spaces; 2. Fostering good data management to make COVID-19 data open, FAIR and reusable over the long term; 3. Providing open tools, workflows and computational resources to drive reproducible and collaborative science. ELIXIR's strategy is based on the support given by our national nodes - collectively spanning over 200 institutes - to research projects and on partnering with community initiatives to drive development and adoption of good data practice and community driven standards. ELIXIR Nodes provide support activities locally and internationally, from provisioning compute capabilities to helping collect viral sequence data from hospitals. Some Nodes have prioritised access to their national cloud and compute facilities for all COVID-19 research projects, while others have developed tools to search, access and share all data related to the pandemic in a national healthcare setting.
    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; Biomedical Research/organization & administration ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/genetics ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Datasets as Topic ; Europe/epidemiology ; Humans ; Information Dissemination/ethics ; Information Dissemination/methods ; International Cooperation/legislation & jurisprudence ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/genetics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Public Health/economics ; SARS-CoV-2 ; Workflow
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-020-0637-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: ELIXIR-EXCELERATE: establishing Europe's data infrastructure for the life science research of the future.

    Harrow, Jennifer / Hancock, John / Blomberg, Niklas

    The EMBO journal

    2021  Volume 40, Issue 6, Page(s) e107409

    Abstract: A new inter-governmental research infrastructure, ELIXIR, aims to unify bioinformatics resources and life science data across Europe, thereby facilitating their mining and (re-)use. ...

    Abstract A new inter-governmental research infrastructure, ELIXIR, aims to unify bioinformatics resources and life science data across Europe, thereby facilitating their mining and (re-)use.
    MeSH term(s) Biological Science Disciplines ; Biomedical Research ; Computational Biology ; Europe ; Humans ; Information Storage and Retrieval
    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2020107409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 100: Show issues

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  5. Article ; Online: Characteristics and critical care interventions in drowning patients treated by the Danish Air Ambulance from 2016 to 2021: a nationwide registry-based study with 30-day follow-up.

    Breindahl, Niklas / Wolthers, Signe A / Møller, Thea P / Blomberg, Stig N F / Steinmetz, Jacob / Christensen, Helle C

    Scandinavian journal of trauma, resuscitation and emergency medicine

    2024  Volume 32, Issue 1, Page(s) 17

    Abstract: Background: Improving oxygenation and ventilation in drowning patients early in the field is critical and may be lifesaving. The critical care interventions performed by physicians in drowning management are poorly described. The aim was to describe ... ...

    Abstract Background: Improving oxygenation and ventilation in drowning patients early in the field is critical and may be lifesaving. The critical care interventions performed by physicians in drowning management are poorly described. The aim was to describe patient characteristics and critical care interventions with 30-day mortality as the primary outcome in drowning patients treated by the Danish Air Ambulance.
    Methods: This retrospective cohort study with 30-day follow-up identified drowning patients treated by the Danish Air Ambulance from January 1, 2016, through December 31, 2021. Drowning patients were identified using a text-search algorithm (Danish Drowning Formula) followed by manual review and validation. Operational and medical data were extracted from the Danish Air Ambulance database. Descriptive analyses were performed comparing non-fatal and fatal drowning incidents with 30-day mortality as the primary outcome.
    Results: Of 16,841 dispatches resulting in a patient encounter in the six years, the Danish Drowning Formula identified 138 potential drowning patients. After manual validation, 98 drowning patients were included in the analyses, and 82 completed 30-day follow-up. The prehospital and 30-day mortality rates were 33% and 67%, respectively. The National Advisory Committee for Aeronautics severity scores from 4 to 7, indicating a critical emergency, were observed in 90% of the total population. They were significantly higher in the fatal versus non-fatal group (p < 0.01). At least one critical care intervention was performed in 68% of all drowning patients, with endotracheal intubation (60%), use of an automated chest compression device (39%), and intraosseous cannulation (38%) as the most frequently performed interventions. More interventions were generally performed in the fatal group (p = 0.01), including intraosseous cannulation and automated chest compressions.
    Conclusions: The Danish Air Ambulance rarely treated drowning patients, but those treated were severely ill, with a 30-day mortality rate of 67% and frequently required critical care interventions. The most frequent interventions were endotracheal intubation, automated chest compressions, and intraosseous cannulation.
    MeSH term(s) Humans ; Air Ambulances ; Drowning ; Follow-Up Studies ; Retrospective Studies ; Critical Care ; Denmark/epidemiology
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2455990-8
    ISSN 1757-7241 ; 1757-7241
    ISSN (online) 1757-7241
    ISSN 1757-7241
    DOI 10.1186/s13049-024-01189-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Connecting data, tools and people across Europe

    Blomberg, Niklas / Lauer, Katharina B.

    European Journal of Human Genetics

    ELIXIR’s response to the COVID-19 pandemic

    2020  Volume 28, Issue 6, Page(s) 719–723

    Keywords Genetics(clinical) ; Genetics ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-020-0637-5
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: ELIXIR: providing a sustainable infrastructure for life science data at European scale.

    Harrow, Jennifer / Drysdale, Rachel / Smith, Andrew / Repo, Susanna / Lanfear, Jerry / Blomberg, Niklas

    Bioinformatics (Oxford, England)

    2021  Volume 37, Issue 16, Page(s) 2506–2511

    Language English
    Publishing date 2021-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btab481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: Connecting data, tools and people across Europe: ELIXIR's response to the COVID-19 pandemic

    Blomberg, Niklas / Lauer, Katharina B

    Eur J Hum Genet

    Abstract: ELIXIR, the European research infrastructure for life science data, provides open access to data, tools and workflows in the response to the COVID-19 pandemic. ELIXIR's 23 nodes have reacted swiftly to support researchers in their combined efforts ... ...

    Abstract ELIXIR, the European research infrastructure for life science data, provides open access to data, tools and workflows in the response to the COVID-19 pandemic. ELIXIR's 23 nodes have reacted swiftly to support researchers in their combined efforts against the pandemic setting out three joint priorities: 1. Connecting national COVID-19 data platforms to create federated European COVID-19 Data Spaces; 2. Fostering good data management to make COVID-19 data open, FAIR and reusable over the long term; 3. Providing open tools, workflows and computational resources to drive reproducible and collaborative science. ELIXIR's strategy is based on the support given by our national nodes - collectively spanning over 200 institutes - to research projects and on partnering with community initiatives to drive development and adoption of good data practice and community driven standards. ELIXIR Nodes provide support activities locally and internationally, from provisioning compute capabilities to helping collect viral sequence data from hospitals. Some Nodes have prioritised access to their national cloud and compute facilities for all COVID-19 research projects, while others have developed tools to search, access and share all data related to the pandemic in a national healthcare setting.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #261174
    Database COVID19

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  9. Article ; Online: Danish Drowning Formula for identification of out-of-hospital cardiac arrest from drowning.

    Breindahl, Niklas / Wolthers, Signe A / Jensen, Theo W / Holgersen, Mathias G / Blomberg, Stig N F / Steinmetz, Jacob / Christensen, Helle C

    The American journal of emergency medicine

    2023  Volume 73, Page(s) 55–62

    Abstract: Background: Accurate, reliable, and sufficient data is required to reduce the burden of drowning by targeting preventive measures and improving treatment. Today's drowning statistics are informed by various methods sometimes based on data sources with ... ...

    Abstract Background: Accurate, reliable, and sufficient data is required to reduce the burden of drowning by targeting preventive measures and improving treatment. Today's drowning statistics are informed by various methods sometimes based on data sources with questionable reliability. These methods are likely responsible for a systematic and significant underreporting of drowning. This study's aim was to assess the 30-day survival of patients with out-of-hospital cardiac arrest (OHCA) identified in the Danish Cardiac Arrest Registry (DCAR) after applying the Danish Drowning Formula.
    Methods: This nationwide, cohort, registry-based study with 30-day follow-up used the Danish Drowning Formula to identify drowning-related OHCA with a resuscitation attempt from the DCAR from January 1st, 2016, through December 31st, 2021. The Danish Drowning Formula is a text-search algorithm constructed for this study based on trigger-words identified from the prehospital medical records of validated drowning cases. The primary outcome was 30-day survival from OHCA. Data were analyzed using multiple logistic regression.
    Results: Drowning-related OHCA occurred in 374 (1%) patients registered in the DCAR compared to 29,882 patients with OHCA from other causes. Drowning-related OHCA more frequently occurred at a public location (87% vs 25%, p < 0.001) and were more frequently witnessed by bystanders (80% vs 55%, p < 0.001). Both 30-day and 1-year survival for patients with drowning-related OHCA were significantly higher compared to OHCA from other causes (33% vs 14% and 32% vs 13%, respectively, p < 0.001). The adjusted odds ratio for 30-day survival for drowning-related OHCA and other causes of OHCA was 2.3 [1.7-3.2], p < 0.001. Increased 30-day survival was observed for drowning-related OHCA occurring at swimming pools compared to public location OHCA from other causes with an OR of 11.6 [6.0-22.6], p < 0.001.
    Conclusions: This study found higher 30-day survival among drowning-related OHCA compared to OHCA from other causes. This study proposed that a text-search algorithm (Danish Drowning Formula) could explore unstructured text fields to identify drowning persons. This method may present a low-resource solution to inform the drowning statistics in the future.
    Registration: This study was registered at ClinicalTrials.gov before analyses (NCT05323097).
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.08.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2005: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Association between using a prehospital assessment unit and hospital admission and mortality: a matched cohort study.

    Wolthers, Signe Amalie / Blomberg, Stig Nikolaj Fasmer / Breindahl, Niklas / Anjum, Sair / Hägi-Pedersen, Daniel / Ersbøll, Annette / Andersen, Lars Bredevang / Christensen, Helle Collatz

    BMJ open

    2023  Volume 13, Issue 9, Page(s) e075592

    Abstract: Objectives: This study aimed to compare hospital admission and 30-day mortality between patients assessed by the prehospital assessment unit (PAU) and patients not assessed by the PAU.: Design: This was a matched cohort study.: Setting: This study ...

    Abstract Objectives: This study aimed to compare hospital admission and 30-day mortality between patients assessed by the prehospital assessment unit (PAU) and patients not assessed by the PAU.
    Design: This was a matched cohort study.
    Setting: This study was conducted between November 2021 and October 2022 in Region Zealand, Denmark.
    Participants: 989 patients aged >18, assessed by the PAU, were identified, and 9860 patients not assessed by the PAU were selected from the emergency calls using exposure density sampling.
    Exposure: Patients assessed by the PAU. The PAU is operated by paramedics with access to point-of-care test facilities. The PAU is an alternative response vehicle without the capability of transporting patients.
    Primary and secondary outcome measures: The primary outcome was hospital admission within 48 hours after the initial call. The key secondary outcomes were admission within 7 days, 30-day mortality and admission within 6 hours. Descriptive statistical analyses were conducted, and logistic regression models were used to estimate adjusted OR (aOR) and 95% CI.
    Results: Among the PAU assessed, 44.1% were admitted within 48 hours, compared with 72.9% of the non-PAU assessed, p<0.001. The multivariable analysis showed a lower risk of admission within 48 hours and 7 days among the PAU patients, aOR 0.31 (95% CI 0.26 to 0.38) and aOR 0.50 (95% CI 0.38 to 0.64), respectively. The 30-day mortality rate was 3.8% in the PAU-assessed patients vs 5.5% in the non-PAU-assessed patients, p=0.03. In the multivariable analysis, no significant difference was found in mortality aOR 0.99 (95% CI 0.71 to 1.42). No deaths were observed in PAU-assessed patients without subsequent follow-up.
    Conclusion: The recently introduced PAU aims for patient-centred emergency care. The PAU-assessed patients had reduced admissions within 48 hours and 7 days after the initial call. Study findings indicate that the PAU is safe since we identified no significant differences in 30-day mortality.
    Trial registration number: NCT05654909.
    MeSH term(s) Humans ; Cohort Studies ; Emergency Medical Services ; Hospitalization ; Hospitals
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-075592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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