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Article ; Online: Social norm compliance and involvement with Covid-19

Roger Mason / Karen M. Corbishley / Thomas Dobbelstein

International Journal of Research In Business and Social Science, Vol 11, Iss 5, Pp 406-

2022 Volume 422

Abstract: Consumer decisions are influenced by various variables, including compliance with society’s social norms and by involvement by consumers with the issue under consideration. Both variables have influenced consumers’ actions during previous pandemics. ... ...

Abstract	Consumer decisions are influenced by various variables, including compliance with society’s social norms and by involvement by consumers with the issue under consideration. Both variables have influenced consumers’ actions during previous pandemics. Therefore, this study investigated involvement with the Covid-19 pandemic, together with social norm compliance (SNC), their mutual influence, and how demographic characteristics and country of residence influenced these three issues. The methodology involved a quantitative descriptive cross-sectional survey, with a quota sample of 1096 responses, based on age, gender, education, habitation, and income. The research was conducted with populations representing the consumers who patronize major retailers in a developed country (Germany) and a developing one (South Africa). Data was collected via questionnaires e-mailed to commercial consumer panels covering both countries. The findings showed that involvement is influenced by gender, age, education, habitation, and country of residence, but that SNC is not influenced by demographics but does differ according to country. Further findings were that involvement with Covid-19 strongly influences SNC and, similarly, SNC also strongly influences involvement with Covid-19. Furthermore demographics, excluding habitation, also influence these variables. However, the relationship between the involvement and SNC variables does not differ between the two countries. This study has provided a better understanding of consumers’ involvement with Covid-19 and SNC as components of consumer behavior, which is important since, during the Covid-19 pandemic, retailers have been instrumental in implementing health protocols. Therefore, understanding the relationship between involvement with Covid-19 and SNC, and how they are influenced by consumer demographics, is important.
Keywords	covid-19 ; pandemic ; demographics ; involvement ; social norms ; consumer decisions ; social norm compliance ; Social Sciences ; H
Subject code	300
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Center for Strategic Studies in Business & Finance
Document type	Article ; Online
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Article ; Online: Internal vascular channel architecture in human auditory ossicles.

Manoharan, Shivani M / Gray, Roger / Hamilton, John / Mason, Matthew J

Journal of anatomy

2022 Volume 241, Issue 2, Page(s) 245–258

Abstract: The vascular supply of the human auditory ossicles has long been of anatomical and clinical interest. While the external blood supply has been well-described, there is only limited information available regarding the internal vascular architecture of the ...

Abstract	The vascular supply of the human auditory ossicles has long been of anatomical and clinical interest. While the external blood supply has been well-described, there is only limited information available regarding the internal vascular architecture of the ossicles, and there has been little comparison of this between individuals. Based on high-resolution micro-CT scans, we made reconstructions of the internal vascular channels and cavities in 12 sets of ossicles from elderly donors. Despite considerable individual variation, a common basic pattern was identified. The presence of channels within the stapes footplate was confirmed. The long process of the incus and neck of the stapes showed signs of bony erosion in all specimens examined. More severe erosion was associated with interruption of some or all of the main internal vascular channels which normally pass down the incudal long process; internal excavation of the proximal process could interrupt vascular channels in ossicles which did not appear to be badly damaged from exterior inspection. An awareness of this possibility may be helpful for surgical procedures that compromise the mucosal blood supply. We also calculated ossicular densities, finding that the malleus tends to be denser than the incus. This is mainly due to a lower proportion of vascular channels and cavities within the malleus.
MeSH term(s)	Aged ; Ear Ossicles ; Ear, Middle ; Humans ; Incus ; Malleus ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2955-5
ISSN	1469-7580 ; 0021-8782
ISSN (online)	1469-7580
ISSN	0021-8782
DOI	10.1111/joa.13661
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Article ; Online: The Effect of Daily Heart Rate Workloads on Preseason, Midseason, and Postseason Oxygen Consumption in Division I Basketball.

Howard, Mason / Sanders, Gabriel J / Kollock, Roger O / Peacock, Corey A / Freire, Raul

Journal of strength and conditioning research

2023 Volume 38, Issue 4, Page(s) 704–708

Abstract: Abstract: Howard, M, Sanders, GJ, Kollock, RO, Peacock, CA, and Freire, R. The effect of daily ...

Abstract	Abstract: Howard, M, Sanders, GJ, Kollock, RO, Peacock, CA, and Freire, R. The effect of daily heart rate workloads on preseason, midseason, and postseason oxygen consumption in Division I basketball. J Strength Cond Res 38(4): 704-708, 2024-Basketball is a dynamic sport, requiring athletes to elicit a high-level of physical, tactical, technical, and psychological attributes and athletes must possess a robustly trained aerobic energy system. There is no research to assess how objectively measured training loads throughout a season influence aerobic capacity. The following study was a retrospective analysis of an NCAA Division I women's basketball team throughout a 5-month (23-week) competitive season. Data were sorted into season half totals and maximal oxygen consumption was recorded before, at the midway point and within 1-week postseason. Twelve athletes were monitored during each practice, pregame shoot around, scrimmage, and game for a total of 1,378 recorded sessions with a valid heart rate-based wearable microsensor (Polar Team Pro) during the season. There was a main effect of time for V̇O 2max throughout the season ( p < 0.001). Post hoc analysis revealed there was a significant increase in V̇O 2max from preseason to postseason ( p < 0.001). Interestingly, there were significant ( p ≤ 0.001 for all) decreases from the first half to the second half of the season for training load, and time allocated to HR Zone1-4 , but no difference in time for the most intense zone, HR zone5 . Conclusion: Oxygen consumption significantly increased 7.5% from preseason to postseason despite a reduction in overall work. The only training intensity that was not different from the first half to second half of the season was time in the highest heart rate intensity zone ≥85% of HR max .
MeSH term(s)	Humans ; Female ; Basketball/physiology ; Workload ; Heart Rate/physiology ; Retrospective Studies ; Oxygen Consumption/physiology ; Athletes
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000004692
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Article ; Online: Fell-Muir lecture: Connective tissue growth factor (CCN2) -- a pernicious and pleiotropic player in the development of kidney fibrosis.

Mason, Roger M

International journal of experimental pathology

2012 Volume 94, Issue 1, Page(s) 1–16

Abstract: ... hepatocyte growth factor, CCN3 and Oncostatin M, are discussed. These may determine whether injured tissue heals or ...

Abstract	Connective tissue growth factor (CTGF, CCN2) is a member of the CCN family of matricellular proteins. It interacts with many other proteins, including plasma membrane proteins, modulating cell function. It is expressed at low levels in normal adult kidney cells but is increased in kidney diseases, playing important roles in inflammation and in the development of glomerular and interstitial fibrosis in chronic disease. This review reports the evidence for its expression in human and animal models of chronic kidney disease and summarizes data showing that anti-CTGF therapy can successfully attenuate fibrotic changes in several such models, suggesting that therapies targeting CTGF and events downstream of it in renal cells may be useful for the treatment of human kidney fibrosis. Connective tissue growth factor stimulates the development of fibrosis in the kidney in many ways including activating cells to increase extracellular matrix synthesis, inducing cell cycle arrest and hypertrophy, and prolonging survival of activated cells. The relationship between CTGF and the pro-fibrotic factor TGFβ is examined and mechanisms by which CTGF promotes signalling by the latter are discussed. No specific cellular receptors for CTGF have been discovered but it interacts with and activates several plasma membrane proteins including low-density lipoprotein receptor-related protein (LRP)-1, LRP-6, tropomyosin-related kinase A, integrins and heparan sulphate proteoglycans. Intracellular signalling and downstream events triggered by such interactions are reviewed. Finally, the relationships between CTGF and several anti-fibrotic factors, such as bone morphogenetic factor-4 (BMP4), BMP7, hepatocyte growth factor, CCN3 and Oncostatin M, are discussed. These may determine whether injured tissue heals or progresses to fibrosis.
MeSH term(s)	Animals ; Connective Tissue Growth Factor/genetics ; Connective Tissue Growth Factor/metabolism ; Cytokines/metabolism ; Disease Progression ; Fibrosis ; Humans ; Inflammation Mediators/metabolism ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Prognosis ; Signal Transduction ; Transforming Growth Factor beta/metabolism
Chemical Substances	CCN2 protein, human ; Cytokines ; Inflammation Mediators ; Transforming Growth Factor beta ; Connective Tissue Growth Factor (139568-91-5)
Language	English
Publishing date	2012-10-30
Publishing country	England
Document type	Address ; Research Support, Non-U.S. Gov't
ZDB-ID	1016006-1
ISSN	1365-2613 ; 0958-4625 ; 0007-1021 ; 0959-9673
ISSN (online)	1365-2613
ISSN	0958-4625 ; 0007-1021 ; 0959-9673
DOI	10.1111/j.1365-2613.2012.00845.x
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Article: Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?

Mason, Roger M

Journal of cell communication and signaling

2009 Volume 3, Issue 2, Page(s) 95–104

Abstract: Connective tissue growth factor (CTGF/CCN2) is a member of the CCN family of matricellular proteins. Its expression is induced by a number of factors including TGF-beta. It has been associated with fibrosis in various tissues including the kidney. ... ...

Abstract	Connective tissue growth factor (CTGF/CCN2) is a member of the CCN family of matricellular proteins. Its expression is induced by a number of factors including TGF-beta. It has been associated with fibrosis in various tissues including the kidney. Diabetic nephropathy (DN) develops in about 30% of patients with diabetes and is characterized by thickening of renal basement membranes, fibrosis in the glomerulus (glomerulosclerosis), tubular atrophy and interstitial fibrosis, all of which compromise kidney function. This review examines changes in CTGF expression in the kidney in DN, the effects they have on glomerular mesangial and podocyte cells and the tubulointerstitium, and how these contribute to driving fibrotic changes in the disease. CTGF can bind to several other growth factors modifying their function. CTGF is also able to interact with receptors on cells, including integrins, tyrosine receptor kinase A (TrkA), low density lipoprotein receptor-related protein (LRP) and heparan sulphate proteoglycans. These interactions, the intracellular signalling pathways they activate, and the cellular responses evoked are reviewed. CTGF also induces the expression of chemokines which themselves have pharmacological actions on cells. CTGF may prompt some responses by acting through several different mechanisms, possibly simultaneously. For example, CTGF is often described as an effector of TGF-beta. It can promote TGF-beta signalling by binding directly to the growth factor, promoting its interaction with the TGF-beta receptor; by triggering intracellular signalling on binding the TrkA receptor, which leads to the transcriptional repression of Smad7, an inhibitor of the TGF-beta signalling pathway; and by binding to BMP-7 whose own signalling pathway opposing TGF-beta is inhibited, leading to enhanced TGF-beta signalling.
Language	English
Publishing date	2009-02-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2299380-0
ISSN	1873-961X ; 1873-9601
ISSN (online)	1873-961X
ISSN	1873-9601
DOI	10.1007/s12079-009-0038-6
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Article: Problems with Social Cognition and Decision-Making in Huntington's Disease: Why Is it Important?

Mason, Sarah L / Schaepers, Miriam / Barker, Roger A

Brain sciences

2021 Volume 11, Issue 7

Abstract: Huntington's disease starts slowly and progresses over a 15-20 year period. Motor changes begin subtly, often going unnoticed by patients although they are typically visible to those close to them. At this point, it is the early non-motor problems of HD ... ...

Abstract	Huntington's disease starts slowly and progresses over a 15-20 year period. Motor changes begin subtly, often going unnoticed by patients although they are typically visible to those close to them. At this point, it is the early non-motor problems of HD that arguably cause the most functional impairment. Approximately 65% of gene carriers will experience a reduction in their occupational level, and just under half will feel unable to manage their finances independently before a clinical diagnosis is made. Understanding what drives this impairment in activities of daily living is the key to helping people with HD to live more independently for longer, especially in early disease. Early cognitive decline is likely to play a contributory factor although few studies have looked directly at this relationship. Recently, it has been shown that along with the well documented dysexecutive syndrome seen in HD, changes in social cognition and decision-making are more common than previously thought. Furthermore, some of the early neuropathological and neurochemical changes seen in HD disrupt networks known to be involved in social functioning. In this review, we explore how HD changes the way individuals interact in a social world. Specifically, we summarise the literature on both classical and social decision-making (value-based decision-making in a social context) along with studies of theory of mind, empathy, alexithymia, and emotion recognition in HD. The literature specific to HD is discussed and supported by evidence from similar neurodegenerative disorders and healthy individuals to propose future directions and potential therapeutic avenues to be explored.
Language	English
Publishing date	2021-06-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11070838
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Article ; Online: Incidence, molecular characteristics, and imaging features of "clinically-defined pseudoprogression" in newly diagnosed glioblastoma treated with chemoradiation.

Hagiwara, Akifumi / Schlossman, Jacob / Shabani, Soroush / Raymond, Catalina / Tatekawa, Hiroyuki / Abrey, Lauren E / Garcia, Josep / Chinot, Olivier / Saran, Frank / Nishikawa, Ryo / Henriksson, Roger / Mason, Warren P / Wick, Wolfgang / Cloughesy, Timothy F / Ellingson, Benjamin M

Journal of neuro-oncology

2022 Volume 159, Issue 3, Page(s) 509–518

Abstract: Purpose: Pseudoprogression (PsP) remains an elusive and clinically important, yet ill-defined, phenomena that, generally, involves a period of early radiographic progression (enhancement) followed by a period of radiographic stability or regression. In ... ...

Abstract	Purpose: Pseudoprogression (PsP) remains an elusive and clinically important, yet ill-defined, phenomena that, generally, involves a period of early radiographic progression (enhancement) followed by a period of radiographic stability or regression. In the current study, we utilized data from the control arm of a phase III clinical trial in newly-diagnosed glioblastoma to explore imaging characteristics of "clinically-defined PsP", or early radiographic progression (PFS < 6 months from chemoradiation) followed by a long post-progression residual overall survival (ROS > 12 months). Methods: One hundred sixty-nine patients with newly-diagnosed GBM from the control arm of the AVAglio trial (NCT00943826) who presented with early radiographic progressive disease (PD) (< 6 months) were included. Clinical characteristics, topographical patterns, and radiomic features were compared between newly-diagnosed GBM exhibiting early PD and early death (< 12-month ROS, "true PD") with those exhibiting early PD and a long residual survival (> 12-month ROS, "clinically-defined PsP"). Results: "Clinically-defined PsP" occurred to 38.5% of patients with early PD, and was more associated with MGMT methylation (P = 0.02), younger age (P = 0.003), better neurological performance (P = 0.01), and lower contrast-enhancing tumor volume (P = 0.002) at baseline. GBM showing "true PD" occurred more frequently in the right internal capsule, thalamus, lentiform nucleus, and temporal lobe than those with "clinical PsP". Radiomic analysis predicted "clinical PsP" with > 70% accuracy on the validation dataset. Conclusion: Patients with early PD that eventually exhibit "clinically-defined PsP" have distinct clinical, molecular, and MRI characteristics. This information may be useful for treating clinicians to better understand the potential risks and outcome in patients exhibiting early radiographic changes following chemoradiation.
MeSH term(s)	Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/therapy ; Chemoradiotherapy/methods ; Disease Progression ; Glioblastoma/diagnostic imaging ; Glioblastoma/therapy ; Humans ; Incidence ; Magnetic Resonance Imaging ; Reactive Oxygen Species
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2022-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-022-04088-3
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Article ; Online: The Clinical Features and Progression of Late-Onset Versus Younger-Onset in an Adult Cohort of Huntington's Disease Patients.

Anil, Megha / Mason, Sarah L / Barker, Roger A

Journal of Huntington's disease

2020 Volume 9, Issue 3, Page(s) 275–282

Abstract: Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that typically manifests between the ages of 30 and 50 years. However, the disease can present at any age, and phenotypic differences between younger and later- ... ...

Abstract	Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that typically manifests between the ages of 30 and 50 years. However, the disease can present at any age, and phenotypic differences between younger and later-onset patients have received limited attention. Objective: To compare clinical features of late- (>70 years of age) and younger-onset (<30 years of age) HD patients. Methods: Patients presenting to our regional NHS HD clinic with new-onset manifest HD diagnosed over the age of 70 years (LoHD) (n = 18) were compared with a younger cohort who developed disease under the age of 30 years (YoHD) (n = 12). Rate of progression over time on standard cognitive and motor measures was compared. Results: At first clinic presentation, both groups had the same total UHDRS scores. However, the LoHD group had higher chorea scores (F (1,28) = 6.52, p = 0.016), while the YoHD group had more dystonia (F (1,28) = 8.69, p = 0.006) and eye movement abnormalities (F (1,28) = 16.991, p < 0.001). The YoHD group also had a greater rate of motor progression, especially for bulbar measures (F (1, 28) = 6.96, p = 0.013) and bradykinesia (F (1, 28) = 7.99, p = 0.009). No differences were found in the rate of cognitive change (F (1,21) = 1.727, p = 0.203) nor functional capacity (F (1,28) = 1.388, p = 0.249) between the groups. Conclusion: Phenotypic differences between YoHD and LoHD patients were found in terms of initial presentation and rate of motor progression. This has implications for therapeutic trials involving HD patients of different ages, given their different clinical features and progression.
MeSH term(s)	Adult ; Age of Onset ; Aged ; Brain Stem/physiopathology ; Cohort Studies ; Disease Progression ; Dystonia/etiology ; Dystonia/physiopathology ; Female ; Functional Status ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Humans ; Huntington Disease/complications ; Huntington Disease/physiopathology ; Hypokinesia/etiology ; Hypokinesia/physiopathology ; Male ; Ocular Motility Disorders/etiology ; Ocular Motility Disorders/physiopathology ; Phenotype ; Severity of Illness Index ; Speech Disorders/etiology ; Speech Disorders/physiopathology ; Young Adult
Language	English
Publishing date	2020-07-13
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2673033-9
ISSN	1879-6400 ; 1879-6397
ISSN (online)	1879-6400
ISSN	1879-6397
DOI	10.3233/JHD-200404
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Article: Factors that influence the marketing of professional services

Enerson, Meg / Corbishley, Karen M / Mason, Roger Burford

Investment management and financial innovations Vol. 13, No. 3 , p. 118-130

2016 Volume 13, Issue 3, Page(s) 118–130

Author's details	Meg Enerson, Roger B. Mason, Karen M. Corbishley
Keywords	professional practioners ; professional services ; marketing mix ; 7Ps ; services
Language	English
Publisher	Publishing Company "Business Perspectives"
Publishing place	Sumy
Document type	Article
Note	Zusammenfassung in ukrainischer Sprache
ZDB-ID	2467221X
ISSN	1810-4967
Database	ECONomics Information System

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Article ; Online: Addendum: Histological and molecular analysis of a progressive diffuse intrinsic pontine glioma and synchronous metastatic lesions: a case report.

Nazarian, Javad / Mason, Gary E / Ho, Cheng Ying / Panditharatna, Eshini / Kambhampati, Madhuri / Vezina, L Gilbert / Packer, Roger J / Hwang, Eugene I

Oncotarget

2023 Volume 14, Page(s) 449

Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28286
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