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  1. Article ; Online: D-PLEX

    Ramot, Yuval / Nedvetzki, Shlomo / Rosenfeld, Sefi / Rousselle, Serge D / Nyska, Abraham / Emanuel, Noam

    Toxicologic pathology

    2020  Volume 48, Issue 5, Page(s) 677–685

    Abstract: ... of doxycycline (doxycycline/polymer-lipid encapsulation matrix [D-PLEX]) has been developed. The aim ... of this comprehensive study was to evaluate the potential safety of D-PLEX ...

    Abstract Surgical site infections (SSIs) are a common surgical-related complication. To avoid these complications, a new biodegradable polymer-lipid encapsulation matrix that provides controlled release of doxycycline (doxycycline/polymer-lipid encapsulation matrix [D-PLEX]) has been developed. The aim of this comprehensive study was to evaluate the potential safety of D-PLEX
    MeSH term(s) Animals ; Doxycycline/administration & dosage ; Drug Delivery Systems ; Humans ; Models, Animal ; Surgical Wound Infection ; Swine ; Swine, Miniature
    Chemical Substances Doxycycline (N12000U13O)
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 841009-4
    ISSN 1533-1601 ; 0192-6233
    ISSN (online) 1533-1601
    ISSN 0192-6233
    DOI 10.1177/0192623320928902
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Pyridine-d

    Bakhmutov, Vladimir I / Elliott, Douglas W / Wylie, Gregory P / Clearfield, Abraham / Contreras-Ramirez, Aida / Zhou, Hong-Cai

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 25, Page(s) 3653–3656

    Abstract: Isotropic and anisotropic motions and molecular states of pyridine-d ...

    Abstract Isotropic and anisotropic motions and molecular states of pyridine-d
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc09254d
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  3. Article ; Online: The Moderately (D)efficient Enzyme: Catalysis-Related Damage

    Bathe, Ulschan / Leong, Bryan J / McCarty, Donald R / Henry, Christopher S / Abraham, Paul E / Wilson, Mark A / Hanson, Andrew D

    Biochemistry

    2021  Volume 60, Issue 47, Page(s) 3555–3565

    Abstract: ... Enzymes ... ...

    Abstract Enzymes have
    MeSH term(s) Biocatalysis ; Catalytic Domain ; Enzyme Stability ; Systems Biology
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.1c00613
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  4. Article ; Online: Vitamin D Status and Association of

    Ahmed, Jemal Hussien / Makonnen, Eyasu / Fotoohi, Alan / Yimer, Getnet / Seifu, Daniel / Assefa, Mathewos / Tigeneh, Wondmagegnehu / Aseffa, Abraham / Howe, Rawleigh / Aklillu, Eleni

    Nutrients

    2019  Volume 11, Issue 2

    Abstract: Emerging evidence associates vitamin D deficiency and vitamin D receptor ( ...

    Abstract Emerging evidence associates vitamin D deficiency and vitamin D receptor (
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Breast Neoplasms/genetics ; Calcifediol/blood ; Ethiopia/epidemiology ; Female ; Gene Expression Regulation/drug effects ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Receptors, Calcitriol/genetics ; Tamoxifen/therapeutic use ; Vitamin D/administration & dosage ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology
    Chemical Substances Antineoplastic Agents ; Receptors, Calcitriol ; VDR protein, human ; Tamoxifen (094ZI81Y45) ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2019-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11020289
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  5. Article ; Online: Benzene-d

    Contreras, Aida R / Bakhmutov, Vladimir I / Elliott, Douglas W / Clearfield, Abraham

    Magnetic resonance in chemistry : MRC

    2018  Volume 56, Issue 12, Page(s) 1158–1167

    Abstract: ... IV) phosphonate materials have been investigated by studying mobility of guest molecules, benzene-d ...

    Abstract For the first time, pore spaces in the Zr (IV) phosphonate (1) as a representative of layered metal (IV) phosphonate materials have been investigated by studying mobility of guest molecules, benzene-d
    Language English
    Publishing date 2018-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.4779
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  6. Article: Study on Vitamin D Levels in 30 to 40-Year-Old Females With Low Back Pain.

    V, Nimisha / Nair, Gautham G / Jose, Biju C / Abraham, Angel

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54238

    Abstract: Background: Vitamin D is associated with many skeletal-related processes in the body. A major ... proved that chronic pain improves with Vitamin D supplementation. This study aimed to explore ... the correlation between vitamin D levels and the occurrence of LBP in women aged 30 to 40.: Materials and ...

    Abstract Background: Vitamin D is associated with many skeletal-related processes in the body. A major health problem concerning decreased quality of life is chronic low back pain (LBP). Many studies have proved that chronic pain improves with Vitamin D supplementation. This study aimed to explore the correlation between vitamin D levels and the occurrence of LBP in women aged 30 to 40.
    Materials and methods: A case-control study was taken up at PK Das Institute of Medical Sciences wherein 50 cases (women aged 30-34 years who had chronic LBP >3 months) and 50 age-matched controls were included. Frequencies of Vitamin D deficiency, inadequacy, and sufficiency were studied. The t-test for examining statistical significance was employed to compare means. Keeping a 95% confidence interval (p<0.05), the odds ratio was calculated.
    Results: Vitamin D deficiency diagnosed when Vitamin D level is <20ng/mL was found in 74% of cases and 48% of controls. Vitamin D levels were not found to be statistically different between cases and controls. The odds ratio was found to be 3.083 (p=0.009), showing that participants with LBP are more expected to be deficient in Vitamin D compared to those without LBP.
    Conclusions: Although a higher frequency of Vitamin D deficiency was found in cases compared to controls, the mean value of Vitamin D levels was not found to be statistically different amongst cases and controls. A significant Odds ratio establishes a positive association between LBP and Vitamin D deficiency. The reason could be due to most people being restricted indoors due to COVID-19 restrictions. It is essential to standardize the biochemical analysis of Vitamin D and establish appropriate Vitamin D level ranges specifically tailored for the Indian population.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54238
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  7. Article ; Online: Individual therapeutic DAS28-d

    Koehm, Michaela / McIntosh, Matthew J / Hofmann, Michael W / Abraham, Varghese / Gabay, Cem / Choy, Ernest H / Kavanaugh, Arthur / Burkhardt, Harald / Behrens, Frank

    Rheumatology international

    2020  Volume 40, Issue 5, Page(s) 747–755

    Abstract: ... Activity Score-28 joints critical difference for improvement (DAS28-d ...

    Abstract Assessment of individual therapeutic responses provides valuable information concerning treatment benefits in individual patients. We evaluated individual therapeutic responses as determined by the Disease Activity Score-28 joints critical difference for improvement (DAS28-d
    MeSH term(s) Antibodies, Monoclonal, Humanized/administration & dosage ; Antirheumatic Agents/administration & dosage ; Arthritis, Rheumatoid/drug therapy ; Blood Sedimentation/drug effects ; Humans ; Observational Studies as Topic ; Patient Reported Outcome Measures ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Tumor Necrosis Factor Inhibitors/administration & dosage
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; Tumor Necrosis Factor Inhibitors ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2020-02-10
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04514-7
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  8. Article ; Online: The Role of Vitamin D in Patients with Inflammatory Bowel Disease Treated with Vedolizumab.

    Abraham, Bincy P / Fan, Christopher / Thurston, Theresa / Moskow, Joshua / Malaty, Hoda M

    Nutrients

    2023  Volume 15, Issue 22

    Abstract: ... to the initiation of therapy that best predicted treatment response, with an emphasis on vitamin D levels and ... with vitamin D ≥ 30 ng/mL at the initiation of vedolizumab therapy, UC Endoscopic Index of Severity (UCEIS ... D levels (1.5 vs. 3.87, : Conclusions: Our results show higher pre-treatment vitamin D levels ...

    Abstract Background: Many clinical factors can contribute to the efficacy of medical therapy in Inflammatory Bowel Disease (IBD). We assessed their effects on the efficacy of vedolizumab therapy in a cohort of patients with IBD.
    Methods: We conducted a retrospective study on patients between 18 and 80 years of age with ulcerative colitis (UC) or Crohn's disease (CD) who were seen in the IBD program at Houston Methodist in Houston, TX and treated with vedolizumab for at least 6 months from 2018 to 2022. We investigated factors prior to the initiation of therapy that best predicted treatment response, with an emphasis on vitamin D levels and examined several variables including patients' demographics and clinical information on disease location and severity and nutritional status before and after the initiation of vedolizumab. Post-treatment data were gathered after a minimum of 6 months of vedolizumab therapy. The clinical parameters used for the study were the Harvey-Bradshaw Index for CD and the Activity Index for UC.
    Results: There were 88 patients included in our study of whom 44 had CD and 44 had UC.; median age was 39.5 (31.0, 53.25) years; 34% patients were male; and 80.7% were Caucasian. All patients received an induction dosing of 300 mg vedolizumab at 0, 2, and 6 weeks then maintenance dosing as standard of care every 8 weeks. Among UC patients with vitamin D ≥ 30 ng/mL at the initiation of vedolizumab therapy, UC Endoscopic Index of Severity (UCEIS) scores after 6 months of therapy were significantly lower than in those who had low pre-treatment vitamin D levels (1.5 vs. 3.87,
    Conclusions: Our results show higher pre-treatment vitamin D levels predicted significant endoscopic improvement in patients with ulcerative colitis (UC). Improving vitamin D levels lowered C-reactive protein levels significantly in CD patients. Higher vitamin D levels were seen after treatment in both UC and CD patients. Vitamin D can play a role in clinical and endoscopic outcomes and should be assessed routinely and optimized in patients with IBD.
    MeSH term(s) Humans ; Male ; Adult ; Infant ; Female ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/chemically induced ; Vitamin D/therapeutic use ; Retrospective Studies ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/chemically induced ; Crohn Disease/drug therapy ; Crohn Disease/chemically induced ; Vitamins/therapeutic use ; Gastrointestinal Agents ; Treatment Outcome
    Chemical Substances vedolizumab (9RV78Q2002) ; Vitamin D (1406-16-2) ; Vitamins ; Gastrointestinal Agents
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15224847
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  9. Article ; Online: An evaluation of serum Otolin-1 & Vitamin-D in benign paroxysmal positional vertigo.

    Yadav, Harsha / Irugu, Dvk / Ramakrishanan, Lakshmy / Singh, Archana / Abraham, Ransi / Sikka, Kapil / Thakar, Alok / Verma, Hitesh

    Journal of vestibular research : equilibrium & orientation

    2021  Volume 31, Issue 6, Page(s) 433–440

    Abstract: ... of vestibule and cochlea. Serum otolin-1 is found to be quantifiable in patients with BPPV. Low Vitamin-D is ... associated with pathogenesis of BPPV. Since otoconia degeneration contributes to BPPV, lack of Vitamin-D ... and significance of vit-D in BPPV.: Material and method: 23 patients in test and control groups ...

    Abstract Background: Serum otolin-1 is an inner ear protein exclusively expressed in otoconia and cells of vestibule and cochlea. Serum otolin-1 is found to be quantifiable in patients with BPPV. Low Vitamin-D is associated with pathogenesis of BPPV. Since otoconia degeneration contributes to BPPV, lack of Vitamin-D may impact otoconia structure and integrity.
    Objective: We aimed at studying the s.otolin-1 as biomarker and significance of vit-D in BPPV.
    Material and method: 23 patients in test and control groups respectively were chosen within the age of 20 to 65 years. All the patients were diagnosed using Dix Hallpike menouver and head roll test, patients were treated with appropriate Canal Reposition Menouver (CRM).
    Results: Serum Otolin-1 levels among the test ranged from 366 to 882 pg/mL with mean of 585.17 pg/mL whereas in control group ranged from 223 to 462 pg/mL with mean of 335.26 pg/mL. Mean Vitamin-D levels among the test group was 22.67 ng/mL (Range = 6.3-68.4) and that of control 15.43 pg/mL (Range = 5.4-27.7) respectively. The relationship between the serum Otolin-1 and Vitamin-D was not statistically significant.
    Conclusion: Otolin-1 levels is increased in BPPV patients and is sensitive in BPPV, specificity needs to be validated. Role of vitamin-D with respect to inner ear proteins needs further investigation.
    MeSH term(s) Adult ; Aged ; Benign Paroxysmal Positional Vertigo/blood ; Benign Paroxysmal Positional Vertigo/diagnosis ; Extracellular Matrix Proteins/blood ; Humans ; Middle Aged ; Otolithic Membrane ; Vitamin D/blood ; Vitamins ; Young Adult
    Chemical Substances Extracellular Matrix Proteins ; Vitamins ; otolin-1 ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-11-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1051840-x
    ISSN 1878-6464 ; 0957-4271
    ISSN (online) 1878-6464
    ISSN 0957-4271
    DOI 10.3233/VES-201601
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  10. Article ; Online: Defect Control in the Synthesis of 2 D MoS

    Abraham, Alyson / Wang, Lei / Quilty, Calvin D / Lutz, Diana M / McCarthy, Alison H / Tang, Christopher R / Dunkin, Mikaela R / Housel, Lisa M / Takeuchi, Esther S / Marschilok, Amy C / Takeuchi, Kenneth J

    ChemSusChem

    2019  Volume 13, Issue 6, Page(s) 1517–1528

    Abstract: ... the possible benefit of defective 2 D MoS ...

    Abstract One of the inherent challenges with Li-S batteries is polysulfide dissolution, in which soluble polysulfide species can contribute to the active material loss from the cathode and undergo shuttling reactions inhibiting the ability to effectively charge the battery. Prior theoretical studies have proposed the possible benefit of defective 2 D MoS
    Language English
    Publishing date 2019-12-19
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.201903028
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