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Article ; Online: Intermittent abdominal pressure ventilation management in neuromuscular diseases: a Delphi panel Consensus.

Annunziata, Anna / Pierucci, Paola / Banfi, Paolo Innocente / Carlucci, Annalisa / Coppola, Antonietta / Rao, Fabrizio / Schisano, Matteo / Simioli, Francesca / Crimi, Claudia / Esquinas, Antonio M / Karakurt, Zuhal / Mattei, Alessio / Marotta, Antonella / Bach, John R / Fiorentino, Giuseppe

Expert review of respiratory medicine

2023 Volume 17, Issue 6, Page(s) 517–525

Abstract: Background: Intermittent abdominal pressure ventilator (IAPV) use started in the 1930s for ventilatory assistance with muscular dystrophy patients. Later, the device was perfected and expanded for other neuromuscular disorders (NMD). In recent years, ... ...

Abstract	Background: Intermittent abdominal pressure ventilator (IAPV) use started in the 1930s for ventilatory assistance with muscular dystrophy patients. Later, the device was perfected and expanded for other neuromuscular disorders (NMD). In recent years, the morbidity and mortality tracheotomies and trach tubes related renewed the interest around IAPV. However, there are no guidelines for its use. This study aimed to establish a consensus among physicians involved in its practice to provide IAPV suggestions for the treatment of patients with NMD. Method: A 3-step modified Delphi method was used to establish consensus. Fourteen respiratory physicians and one psychiatrist with strong experience in IAPV use and/or who published manuscripts on the topic participated in the panel. A systematic review of the literature was carried out according to the PRISMA to identify existing evidence on IAPV for patients with neuromuscular disorders. Results: In the first round, 34 statements were circulated. Panel members marked 'agree' or 'disagree' for each statement and provided comments. The agreement was reached after the second voting session for all 34 statements. Conclusions: Panel members agreed and IAPV indications, parameter settings (including procedure protocol), potential limitations, contraindications, complications, monitoring, and follow-up are described. This is the first expert consensus on IAPV.
MeSH term(s)	Humans ; Consensus ; Neuromuscular Diseases/complications ; Neuromuscular Diseases/therapy ; Ventilators, Mechanical ; Delphi Technique
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2479146-5
ISSN	1747-6356 ; 1747-6348
ISSN (online)	1747-6356
ISSN	1747-6348
DOI	10.1080/17476348.2023.2226391
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Article ; Online: Cálculo de la presión transpulmonar a través del monitoreo con balón esofágico durante la fase de soporte total de la ventilación mecánica invasiva

Romina Belen Mattei

Argentinian Journal of Respiratory and Physical Therapy, Vol 5, Iss

2023 Volume 3

Abstract: ... El objetivo del siguiente paso a paso es describir el cálculo de la Ptp, con ambos métodos, durante la fase ...

Abstract	La presión transpulmonar (Ptp) es la diferencia entre la presión en la vía aérea (Pva) y la presión pleural (Ppl). La medición de la presión esofágica (Pes), como subrogado de la Ppl, permite el cálculo de la Ptp diferenciando la mecánica pulmonar y de la caja torácica. Para ello, existen dos métodos, el de Talmor y el definido por Gattinoni. Ambos métodos aportan información útil, particularmente en sujetos con síndrome de distrés respiratorio agudo (SDRA) para individualizar la estrategia de protección pulmonar. El objetivo del siguiente paso a paso es describir el cálculo de la Ptp, con ambos métodos, durante la fase de soporte total de la ventilación mecánica invasiva.
Keywords	mecánica respiratoria ; respiración artificial ; manometría esofágica ; síndrome de distrés respiratorio agudo ; Medicine ; R
Language	Spanish
Publishing date	2023-10-01T00:00:00Z
Publisher	Argentinian Journal of Respiratory & Physical Therapy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A política econômica brasileira diante da Covid-19

Lauro Mattei

Cadernos de Ciências Sociais Aplicadas, Vol 17, Iss

2020 Volume 30

Abstract: Neste artigo são discutidas as bases da política econômica destinada ao combate da Covid-19. De um modo geral, notou-se que a ideologia econômica neoliberal determinou os rumos das ações econômicas do governo atual. Após analisar um conjunto de medidas ... ...

Abstract	Neste artigo são discutidas as bases da política econômica destinada ao combate da Covid-19. De um modo geral, notou-se que a ideologia econômica neoliberal determinou os rumos das ações econômicas do governo atual. Após analisar um conjunto de medidas de apoio aos empresários, trabalhadores e segmentos sociais vulneráveis, concluiu-se que a política econômica fracassou e, consequentemente, estimulou o aumento do número de empresas que encerraram suas atividades, bem como contribuiu para elevar fortemente o nível de desemprego que, registre-se, já era elevado anteriormente ao início da pandemia.
Keywords	rasil. Covid-19. Política Econômica ; Social Sciences ; H
Language	Portuguese
Publishing date	2020-09-01T00:00:00Z
Publisher	Universidade Estadual do Sudoeste da Bahia
Document type	Article ; Online
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Article ; Online: Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.

Pichler, Martin / Rodriguez-Aguayo, Cristian / Nam, Su Youn / Dragomir, Mihnea Paul / Bayraktar, Recep / Anfossi, Simone / Knutsen, Erik / Ivan, Cristina / Fuentes-Mattei, Enrique / Lee, Sang Kil / Ling, Hui / Catela Ivkovic, Tina / Huang, Guoliang / Huang, Li / Okugawa, Yoshinaga / Katayama, Hiroyuki / Taguchi, Ayumu / Bayraktar, Emine / Bhattacharya, Rajat /

Gut

2020 Volume 69, Issue 10, Page(s) 1818–1831

Abstract: Objective: To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target.: ... ...

Abstract	Objective: To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target. Design: FLANC expression was analysed in 349 tumours from four cohorts and correlated to clinical data. In a series of multiple in vitro and in vivo models and molecular analyses, we characterised the fundamental biological roles of this lncRNA. We further explored the therapeutic potential of targeting FLANC in a mouse model of colorectal cancer (CRC) metastases. Results: FLANC, a primate-specific lncRNA feebly expressed in normal colon cells, was significantly upregulated in cancer cells compared with normal colon samples in two independent cohorts. High levels of FLANC were associated with poor survival in two additional independent CRC patient cohorts. Both in vitro and in vivo experiments demonstrated that the modulation of FLANC expression influenced cellular growth, apoptosis, migration, angiogenesis and metastases formation ability of CRC cells. In vivo pharmacological targeting of FLANC by administration of 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine nanoparticles loaded with a specific small interfering RNA, induced significant decrease in metastases, without evident tissue toxicity or pro-inflammatory effects. Mechanistically, FLANC upregulated and prolonged the half-life of phosphorylated STAT3, inducing the overexpression of VEGFA, a key regulator of angiogenesis. Conclusions: Based on our findings, we discovered, FLANC as a novel primate-specific lncRNA that is highly upregulated in CRC cells and regulates metastases formation. Targeting primate-specific transcripts such as FLANC may represent a novel and low toxic therapeutic strategy for the treatment of patients.
MeSH term(s)	Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Drug Discovery ; Gene Expression Regulation, Neoplastic ; Genetic Markers ; Genetic Therapy ; Humans ; Mice ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Pharmacogenomic Testing ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; STAT3 Transcription Factor/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Biomarkers, Tumor ; Genetic Markers ; RNA, Long Noncoding ; STAT3 Transcription Factor ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-01-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2019-318903
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Article ; Conference proceedings: NON-INVASIVE COLORECTAL NEOPLASMS REFERRED TO SURGERY: A PERFORMANCE KEY MEASURE FOR SCREENING PROGRAMS

Iacopini, F / Hassan, C / Frontespezi, S / Mattei, E / Ceci, V / Brighi, S / Fedeli, P / Angeletti, S / Fanello, G / D’Ovidio, V / De Palo, MG / Cocco, A / Forte, A / Forti, G / Grossi, C / Altavilla, N / Dimito, G / Occhigrossi, G / Di Giulio, E /

Bazuro, M / Ballanti, R / Faggiani, R / Scozzarro, A / Capezzuto, E / Baldi, F / Baiocchi, D / Barca, A / Costamagna, G

Endoscopy

2020 Volume 52, Issue S 01

Event/congress	ESGE Days, Dublin, Ireland, 2020-04-23
Language	German
Publishing date	2020-04-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0040-1704711
Database	Thieme publisher's database

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Article ; Online: Syphilis: a reemerging infection.

Mattei, Peter L / Beachkofsky, Thomas M / Gilson, Robert T / Wisco, Oliver J

American family physician

2012 Volume 86, Issue 5, Page(s) 433–440

Abstract: Rates of primary and secondary syphilis have increased in the past decade, warranting renewed attention to the diagnosis and treatment of this disease. Men who have sex with men are particularly affected; however, increases in infection rates have also ... ...

Abstract	Rates of primary and secondary syphilis have increased in the past decade, warranting renewed attention to the diagnosis and treatment of this disease. Men who have sex with men are particularly affected; however, increases in infection rates have also been noted in women, as well as in all age groups and ethnicities. Physicians need to vigilantly screen high-risk patients. The concurrent rise in congenital syphilis also requires special attention and reemphasizes the need for continued early prenatal care and syphilis screening for all pregnant women. Syphilis infection in patients coinfected with human immunodeficiency virus has also become more common. New experimental diagnostic approaches, including using the B cell chemoattractant chemokine (CXC motif) ligand 13 as a cerebrospinal fluid marker, may help identify suspected neurosyphilis cases. Additionally, point-of-care immunochromatographic strip testing has been suggested for screening high-risk populations in developing countries. Nontreponemal screening tests followed by treponemal confirmatory tests continue to be standard diagnostics; however, interpreting false-negative and false-positive test results, and identifying serofast reactions, can be challenging. Although doxycycline, tetracycline, ceftriaxone, and azithromycin have been used to successfully treat syphilis, penicillin remains the drug of choice in all stages of infection and is the therapy recommended by the Centers for Disease Control and Prevention. Close follow-up is necessary to ensure treatment success.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Coinfection ; Disease Progression ; Female ; HIV Infections/epidemiology ; Humans ; Male ; Neurosyphilis/diagnosis ; Neurosyphilis/pathology ; Penicillin G/therapeutic use ; Pregnancy ; Syphilis/diagnosis ; Syphilis/drug therapy ; Syphilis/epidemiology ; Syphilis, Congenital/diagnosis ; Syphilis, Latent/diagnosis ; Syphilis, Latent/pathology ; United States/epidemiology
Chemical Substances	Anti-Bacterial Agents ; Penicillin G (Q42T66VG0C)
Language	English
Publishing date	2012-09-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	412694-4
ISSN	1532-0650 ; 0002-838X ; 0572-3612
ISSN (online)	1532-0650
ISSN	0002-838X ; 0572-3612
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A reforma agrária brasileira

Lauro Mattei

Estudos Sociedade e Agricultura, Vol 20, Iss 1, Pp 301-

evolução do número de famílias assentadas no período pós-redemocratização do país

2012 Volume 325

Abstract: O artigo discute a reforma agrária no Brasil desde a década de 1980, realçando as contradições envolvidas neste processo. Inicialmente, faz-se uma breve síntese das políticas adotadas pelos diferentes governos entre 1975 e 2010. Em seguida, são ... ...

Abstract	O artigo discute a reforma agrária no Brasil desde a década de 1980, realçando as contradições envolvidas neste processo. Inicialmente, faz-se uma breve síntese das políticas adotadas pelos diferentes governos entre 1975 e 2010. Em seguida, são analisadas diversas informações relativas à quantidade total de famílias assentadas no país, bem como à quantidade de assentados em cada período específico. A principal conclusão do estudo é que a política agrária brasileira, além de assentar pouca gente em um período tão longo, não tem provocado alterações importantes no processo de concentração de terras no Brasil, uma vez que o Índice de Gini ainda continua bastante elevado.
Keywords	brasil ; reforma agrária ; assentamentos rurais ; Agriculture (General) ; S1-972 ; Land use ; HD101-1395.5 ; Agricultural industries ; HD9000-9495
Language	Portuguese
Publishing date	2012-04-01T00:00:00Z
Publisher	Universidade Federal Rural do Rio de Janeiro
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: De hisn a madina

Bilal Sarr / Luca Mattei

Espacio, Tiempo y Forma. Serie III, Historia Medieval, Vol 0, Iss

la evolución del urbanismo en el surco intrabético : Guadix, Loja y otros espacios menores. Un estado de la cuestión

2011 Volume 24

Abstract: ... constatar cómo los principales espacios siguen una evolución muy similar pasando de husún con albacar a ... finales del siglo IX a mudun ya en el siglo XI, mientras que el resto de núcleos menores se verán ... evidence found to date. We are able to confirm that the main settlements follow a common evolution from ...

Abstract	En este artículo pretendemos establecer un estado de la cuestión sobre la evolución de las principales ciudades, villas y otros espacios menores que flanquean Granada, comprendidos entre Guadix y Loja. Para ello hemos hecho uso tanto de las fuentes escritas como de los datos que la Arqueología nos ha suministrado hasta el momento. Y hemos podido constatar cómo los principales espacios siguen una evolución muy similar pasando de husún con albacar a finales del siglo IX a mudun ya en el siglo XI, mientras que el resto de núcleos menores se verán muy determinados por su ubicación en un espacio fronterizo castellano-nazarí. The aim of this study is to present the state of the question on the evolution of the main towns, villages and other minor settlements that surround Granada from Guadix to Loja. We have made use of written records and archaeological evidence found to date. We are able to confirm that the main settlements follow a common evolution from husun (fortresses) with an albacar (refuge) at the end of the ninth century to that of mudun (towns) by the eleventh century, whereas smaller settlements are conditioned by their location on the Castilian-Nasrid frontier.
Keywords	Guadix ; Loja ; Colomera ; Montefrío ; arqueología medieval ; History (General) and history of Europe ; D ; History (General) ; D1-2009 ; Medieval history ; D111-203
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Universidad Nacional de Educación a Distancia (UNED)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Application of Nonlinear Analysis to the Study of Complex Systems in Neuroscience and Behavioral Research

Mattei, Tobias A.

2016

Abstract: Although nonlinear dynamics have been mastered by physicists and mathematicians for a long time (as most physical systems are inherently nonlinear in nature), the recent successful application of nonlinear methods to modeling and predicting several ... ...

Abstract	Although nonlinear dynamics have been mastered by physicists and mathematicians for a long time (as most physical systems are inherently nonlinear in nature), the recent successful application of nonlinear methods to modeling and predicting several evolutionary, ecological, physiological, and biochemical processes has generated great interest and enthusiasm among researchers in computational neuroscience and cognitive psychology. Additionally, in the last years it has been demonstrated that nonlinear analysis can be successfully used to model not only basic cellular and molecular data but also complex cognitive processes and behavioral interactions. The theoretical features of nonlinear systems (such unstable periodic orbits, period-doubling bifurcations and phase space dynamics) have already been successfully applied by several research groups to analyze the behavior of a variety of neuronal and cognitive processes.- Additionally the concept of strange attractors has lead to a new understanding of information processing which considers higher cognitive functions (such as language, attention, memory and decision making) as complex systems emerging from the dynamic interaction between parallel streams of information flowing between highly interconnected neuronal clusters organized in a widely distributed circuit and modulated by key central nodes. Furthermore, the paradigm of self-organization derived from the nonlinear dynamics theory has offered an interesting account of the phenomenon of emergence of new complex cognitive structures from random and non-deterministic patterns, similarly to what has been previously observed in nonlinear studies of fluid dynamics.- Finally, the challenges of coupling massive amount of data related to brain function generated from new research fields in experimental neuroscience (such as magnetoencephalography, optogenetics and single-cell intra-operative recordings of neuronal activity) have generated the necessity of new research strategies which incorporate complex pattern analysis as an important feature of their algorithms. Up to now nonlinear dynamics has already been successfully employed to model both basic single and multiple neurons activity (such as single-cell firing patterns, neural networks synchronization, autonomic activity, electroencephalographic measurements, and noise modulation in the cerebellum), as well as higher cognitive functions and complex psychiatric disorders. Similarly, previous experimental studies have suggested that several cognitive functions can be successfully modeled with basis on the transient activity of large-scale brain networks in the presence of noise.-
Keywords	Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General)
Size	1 electronic resource (271 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020090710
ISBN	9782889199969 ; 2889199967
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Sensibilidad de aislamientos de Candida albicans de hemocultivos a 3 fármacos: estudio retrospectivo en Rio Grande do Sul, Brasil, 1999 a 2009.

Mattei, Antonella Souza / Alves, Sydney Hartz / Mario, Débora Alves / Watte, Guilherme / Severo, Cecília Bittencourt / Guazzelli, Luciana da Silva / Oliveira, Flávio de Mattos / Severo, Luiz Carlos

Revista iberoamericana de micologia

2013 Volume 30, Issue 4, Page(s) 243–247

Abstract: Background: Candidiasis is one of the most important among recurrent invasive yeast infections in patients, thus antifungal treatment becomes a challenge.: Aims: The aim of this study was to evaluate the in vitro activity of clinical Candida albicans ...

Title translation	Susceptibility of Candida albicans blood isolates to 3 antifungal drugs: retrospective study in Rio Grande do Sul, Brazil, 1999-2009.
Abstract	Background: Candidiasis is one of the most important among recurrent invasive yeast infections in patients, thus antifungal treatment becomes a challenge. Aims: The aim of this study was to evaluate the in vitro activity of clinical Candida albicans isolates from blood cultures to fluconazole, amphotericin B and anidulafungin, in a hospital from Rio Grande do Sul, Brazil. Methods: The susceptibility of 153 isolates to the 3 drugs mentioned was tested according to Clinical and Laboratory Standars Institute. Minimal inhibitory and fungicidal concentrations (MIC, MFC, respectively) of each drug were determined, as well as the epidemiological cutoff value (ECV). Results: All of the isolates were susceptible to anidulafungin, MIC and MFC ≤ 1 μg/ml; however, when compared with ECV, 3% of the isolates exhibited higher values against fluconazole, 96% were susceptible, 3% susceptible dose-dependent, and 1% resistant. Also, it was observed that 21% of the isolates exhibited higher values than ECV. One isolate was resistant to amphotericin B; the other ones, susceptible, based on the MFC; furthermore, 1.5% of the isolates exhibited higher values. Conclusions: C. albicans isolates exhibited more susceptibility to anidulafungin, and 90% of them (MIC90) exhibited the lowest values against amphotericin B. Based on ECV and Pfaller classification, isolates could be resistant to fluconazole, demonstrating the importance of the combination of these parameters.
MeSH term(s)	Amphotericin B/pharmacology ; Antifungal Agents/pharmacology ; Brazil ; Candida albicans/drug effects ; Candida albicans/isolation & purification ; Candidemia/microbiology ; Dose-Response Relationship, Drug ; Drug Resistance, Fungal ; Echinocandins/pharmacology ; Fluconazole/pharmacology ; Humans ; Microbial Sensitivity Tests ; Retrospective Studies
Chemical Substances	Antifungal Agents ; Echinocandins ; Amphotericin B (7XU7A7DROE) ; Fluconazole (8VZV102JFY) ; anidulafungin (9HLM53094I)
Language	Spanish
Publishing date	2013-10
Publishing country	Spain
Document type	Comparative Study ; English Abstract ; Journal Article
ISSN	2173-9188
ISSN (online)	2173-9188
DOI	10.1016/j.riam.2013.02.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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