Article: Abrogation of Rb Tumor Suppression Initiates GBM in Differentiated Astrocytes by Driving a Progenitor Cell Program.
2022 Volume 12, Page(s) 904479
Abstract: Glioblastoma (GBM) remains lethal with no effective treatments. Despite the comprehensive identification of commonly perturbed molecular pathways, little is known about the disease's etiology, particularly in early stages. Several studies indicate that ... ...
Abstract | Glioblastoma (GBM) remains lethal with no effective treatments. Despite the comprehensive identification of commonly perturbed molecular pathways, little is known about the disease's etiology, particularly in early stages. Several studies indicate that GBM is initiated in neural progenitor and/or stem cells. Here, we report that differentiated astrocytes are susceptible to GBM development when initiated by perturbation of the RB pathway, which induces a progenitor phenotype. |
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Language | English |
Publishing date | 2022-06-24 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2649216-7 |
ISSN | 2234-943X |
ISSN | 2234-943X |
DOI | 10.3389/fonc.2022.904479 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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