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  1. Article ; Online: Iron Availability and Homeostasis in Plants: A Review of Responses, Adaptive Mechanisms, and Signaling.

    Kermeur, Nolenn / Pédrot, Mathieu / Cabello-Hurtado, Francisco

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2642, Page(s) 49–81

    Abstract: Iron is an essential element for all living organisms, playing a major role in plant biochemistry as a redox catalyst based on iron redox properties. Iron is the fourth most abundant element of the Earth's crust, but its uptake by plants is complex ... ...

    Abstract Iron is an essential element for all living organisms, playing a major role in plant biochemistry as a redox catalyst based on iron redox properties. Iron is the fourth most abundant element of the Earth's crust, but its uptake by plants is complex because it is often in insoluble forms that are not easily accessible for plants to use. The physical and chemical speciation of iron, as well as rhizosphere activity, are key factors controlling the bioavailability of Fe. Iron can be under reduced (Fe
    MeSH term(s) Iron/metabolism ; Hydrogen Peroxide/metabolism ; Plants/genetics ; Homeostasis ; Biological Transport ; Antioxidants/metabolism
    Chemical Substances Iron (E1UOL152H7) ; Hydrogen Peroxide (BBX060AN9V) ; Antioxidants
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3044-0_3
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  2. Article ; Online: Tympanic hemangioma.

    Puerta-Sanabria, Enrique / Padilla-Cabello, Javier / Chiquero-Ortiz, Francisco

    Acta otorrinolaringologica espanola

    2023  Volume 74, Issue 1, Page(s) 66–67

    MeSH term(s) Humans ; Hemangioma ; Tympanic Membrane ; Ear, Middle
    Language English
    Publishing date 2023-01-25
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5735
    ISSN (online) 2173-5735
    DOI 10.1016/j.otoeng.2022.03.002
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  3. Article ; Online: Iron oxide nanoparticles improving multimetal phytoextraction in Helianthus annuus.

    Mounier, Léa / Pédrot, Mathieu / Bouhnik-Le-Coz, Martine / Cabello-Hurtado, Francisco

    Chemosphere

    2024  Volume 353, Page(s) 141534

    Abstract: This study assessed the phytotoxicity of a mixture of five different trace elements (TEs) frequently found as pollutants in soils: arsenic, cadmium, copper, lead and zinc. On the other hand, the plant response to a magnetite ( ... ...

    Abstract This study assessed the phytotoxicity of a mixture of five different trace elements (TEs) frequently found as pollutants in soils: arsenic, cadmium, copper, lead and zinc. On the other hand, the plant response to a magnetite (Fe
    MeSH term(s) Copper/analysis ; Cadmium/analysis ; Helianthus ; Arsenic/pharmacology ; Antioxidants/pharmacology ; Ferrosoferric Oxide ; Soil Pollutants/analysis ; Trace Elements/analysis ; Biodegradation, Environmental ; Soil/chemistry ; Citric Acid/pharmacology ; Water/pharmacology ; Magnetic Iron Oxide Nanoparticles
    Chemical Substances Copper (789U1901C5) ; Cadmium (00BH33GNGH) ; Arsenic (N712M78A8G) ; Antioxidants ; Ferrosoferric Oxide (XM0M87F357) ; Soil Pollutants ; Trace Elements ; Soil ; Citric Acid (2968PHW8QP) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141534
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Meal frequency strategies for the management of type 2 diabetes subjects: A systematic review.

    Gómez-Ruiz, Roxana Paola / Cabello-Hernández, Abraham Isaí / Gómez-Pérez, Francisco Javier / Gómez-Sámano, Miguel Ángel

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0298531

    Abstract: Background: Effective nutrition management is fundamental in the comprehensive treatment of individuals with type 2 diabetes. Various strategies have been explored in this regard, demonstrating their potential usefulness in improving clinical outcomes. ... ...

    Abstract Background: Effective nutrition management is fundamental in the comprehensive treatment of individuals with type 2 diabetes. Various strategies have been explored in this regard, demonstrating their potential usefulness in improving clinical outcomes. This systematic review aims to assess the impact of meals frequency on the well-being of these patients.
    Methods and findings: In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar databases were searched until July 10th, 2023. We included studies from the last 10 years in people with type 2 diabetes that had an intervention regarding their meal frequency. The risk of bias was evaluated based on the Cochrane tool according to the type of study. Of 77 retrieval articles, 13 studies matched our inclusion criteria. The primary focus of each study was to evaluate glycemic control as the major outcome. Studies suggest that meal frequency, time-restricted feeding, breakfast skipping, bedtime snacking, and chrononutrition practices all play roles in type 2 diabetes management and risk.
    Conclusions: Restricting feeding to 2 to 3 meals per day and practicing time restricted feeding with less than 10 hours of daily food intake promotes weight loss and glycemic control in patients with type 2 diabetes. Aligning food consumption with the body's natural rhythm is beneficial, whereas skipping breakfast disrupts this rhythm. Snacking after evening or waiting 3-4 hours after meal helps control glucose levels, but consuming pre-bedtime snacks do not provide the same benefits.
    Prospero registration number: CRD42023431785.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Meals ; Snacks ; Breakfast ; Databases, Factual
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298531
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  5. Article: Role of the ubiquitin-proteasome system in the sarcopenic-like phenotype induced by CCL5/RANTES.

    Conejeros-Lillo, Sabrina / Aguirre, Francisco / Cabrera, Daniel / Simon, Felipe / Peñailillo, Luis / Cabello-Verrugio, Claudio

    European journal of translational myology

    2024  Volume 34, Issue 1

    Abstract: Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ... ...

    Abstract Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquitin ligases belonging to UPS, leading to proteolysis mediated by the PSMB 5, 6, and 7 subunits of 20S proteasome. CCL5/RANTES induces a sarcopenic-like effect in muscle cells. The present work explored the impact of CCL5 on UPS components and the influence of UPS on its sarcopenic-like effect. We demonstrated that CCL5 increased MuRF-1 and atrogin-1 protein levels and mRNA levels of subunits PSMB 5, 6, and 7. We used the MG132 inhibitor to elucidate the role of the 20S proteasome in the CCL5-induced sarcopenic-like effect. This inhibitor prevented the decrease in troponin and MHC protein levels and partially prevented the reduction in the diameter of single-isolated FDB muscle fibers induced by CCL5. These findings indicate that CCL5 actively modulates the UPS. Moreover, our results show the direct participation of UPS in the sarcopenic-like phenotype induced by CCL5.
    Language English
    Publishing date 2024-02-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2545577-1
    ISSN 2037-7460 ; 2037-7452
    ISSN (online) 2037-7460
    ISSN 2037-7452
    DOI 10.4081/ejtm.2024.12249
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  6. Article ; Online: Impact of lactic acid bacteria inoculation on fungal diversity during Spanish-style green table olive fermentations.

    López-García, Elio / Romero-Gil, Verónica / Arroyo-López, Francisco Noé / Benítez-Cabello, Antonio

    International journal of food microbiology

    2024  Volume 417, Page(s) 110689

    Abstract: This study delved into the evolution of fungal population during the fermentation of Spanish-style green table olives (Manzanilla cultivar), determining the influence of different factors such as fermentation matrix (brine or fruit) or the use of a ... ...

    Abstract This study delved into the evolution of fungal population during the fermentation of Spanish-style green table olives (Manzanilla cultivar), determining the influence of different factors such as fermentation matrix (brine or fruit) or the use of a lactic acid bacteria inoculum, on its distribution. The samples (n = 24) were directly obtained from industrial fermentation vessels with approximately 10.000 kg of fruits and 6.000 L of brines. Our findings showcased a synchronized uptick in lactic acid bacteria counts alongside fungi proliferation. Metataxonomic analysis of the Internal Transcribed Spacer (ITS) region unearthed noteworthy disparities across different fermentation time points (0, 24, and 83 days). Statistical analysis pinpointed two Amplicon Sequence Variants (ASV), Candida and Aureobasidium, as accountable for the observed variances among the different fermentation time samples. Notably, Candida exhibited a marked increase during 83 days of fermentation, opposite to Aureobasidium, which demonstrated a decline. Fungal biodiversity was slightly higher in brines than in fruits, whilst no effect of inoculation was noticed. At the onset of fermentation, prominently detected genera were also Mycosphaerella (19.82 %) and Apohysomyces (16.31 %), hitherto unreported in the context of table olive processing. However, their prevalence dwindled to nearly negligible levels from 24th day fermentation onwards (<2 %). On the contrary, they were replaced by the fermentative yeasts Saccharomyces and Isstachenkia. Results obtained in this work will be useful for designing new strategies for better control of table olive fermentations.
    MeSH term(s) Olea/microbiology ; Fermentation ; Biodiversity ; Lactobacillales/genetics ; Lactobacillales/classification ; Lactobacillales/metabolism ; Lactobacillales/isolation & purification ; Food Microbiology ; Fungi/genetics ; Fungi/classification ; Fungi/isolation & purification ; Fungi/metabolism ; Spain ; Fruit/microbiology ; Salts
    Chemical Substances brine ; Salts
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2024.110689
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Understanding the transcriptomic response of

    López-García, Elio / Benítez-Cabello, Antonio / Tronchoni, Jordi / Arroyo-López, Francisco Noé

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1264341

    Abstract: Lactiplantibacillus ... ...

    Abstract Lactiplantibacillus pentosus
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1264341
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  8. Article ; Online: Microenvironmental Snail1-induced immunosuppression promotes melanoma growth.

    Arumi-Planas, Marta / Rodriguez-Baena, Francisco Javier / Cabello-Torres, Francisco / Gracia, Francisco / Lopez-Blau, Cristina / Nieto, M Angela / Sanchez-Laorden, Berta

    Oncogene

    2023  Volume 42, Issue 36, Page(s) 2659–2672

    Abstract: Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells reside in a heterogeneous tumour microenvironment that acts as a crucial regulator of its progression. Snail1 is an epithelial- ... ...

    Abstract Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells reside in a heterogeneous tumour microenvironment that acts as a crucial regulator of its progression. Snail1 is an epithelial-to-mesenchymal transition transcription factor expressed during development and reactivated in pathological situations including fibrosis and cancer. In this work, we show that Snail1 is activated in the melanoma microenvironment, particularly in fibroblasts. Analysis of mouse models that allow stromal Snail1 depletion and therapeutic Snail1 blockade indicate that targeting Snail1 in the tumour microenvironment decreases melanoma growth and lung metastatic burden, extending mice survival. Transcriptomic analysis of melanoma-associated fibroblasts and analysis of the tumours indicate that stromal Snail1 induces melanoma growth by promoting an immunosuppressive microenvironment and a decrease in anti-tumour immunity. This study unveils a novel role of Snail1 in melanoma biology and supports its potential as a therapeutic target.
    MeSH term(s) Animals ; Mice ; Epithelial-Mesenchymal Transition ; Immunosuppression Therapy ; Melanoma/genetics ; Skin Neoplasms/genetics ; Snail Family Transcription Factors/antagonists & inhibitors ; Snail Family Transcription Factors/immunology ; Snail Family Transcription Factors/metabolism ; Transcription Factors/genetics ; Tumor Microenvironment
    Chemical Substances Snail Family Transcription Factors ; Transcription Factors ; Snai1 protein, mouse
    Language English
    Publishing date 2023-07-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-023-02793-5
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    Zs.A 2218: Show issues Location:
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  9. Article ; Online: MRP-PCI

    Francisco Ruiz / José Manuel Cabello

    Sustainability, Vol 13, Iss 3, p

    A Multiple Reference Point Based Partially Compensatory Composite Indicator for Sustainability Assessment

    2021  Volume 1261

    Abstract: Assessing different types of sustainability is a complex procedure, which implies considering aspects of very different nature. One way to do this is using a system of single indicators measuring all these different aspects and aggregating them in an ... ...

    Abstract Assessing different types of sustainability is a complex procedure, which implies considering aspects of very different nature. One way to do this is using a system of single indicators measuring all these different aspects and aggregating them in an overall composite indicator. In line with the concepts of weak and strong sustainability, the compensability degree among the indicators allowed by the aggregation procedure is a crucial issue. There exist methods that allow for full compensability, zero compensability, or partial compensability. In most of them, the compensation degree is established in a global way, that is, it is the same for all the indicators. In this paper, we develop the Multiple Reference Point Partially Compensatory Indicator (MRP-PCI), where a different compensation index can be established for each indicator. The resulting method can be applied to any system of indicators, and successfully considers the compensation indices given. Some examples and comparisons are used to illustrate its behavior.
    Keywords sustainability ; composite indicators ; partial compensation ; multiple reference point methodology ; multiple criteria decision making ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 650
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Functional features of the exopolysaccharide extracts produced by

    López-García, Elio / Marín-Gordillo, Ana / Sánchez-Hidalgo, Marina / Ávila-Román, Javier / Romero-Gil, Verónica / Bermúdez-Oria, Alejandra / Benítez-Cabello, Antonio / Garrido-Fernández, Antonio / Rodríguez-Gómez, Francisco / Arroyo-López, Francisco Noé

    Food & function

    2024  Volume 15, Issue 4, Page(s) 1938–1947

    Abstract: This study evaluates the functional characteristics of the exopolysaccharide (EPS) extracts produced by various strains ... ...

    Abstract This study evaluates the functional characteristics of the exopolysaccharide (EPS) extracts produced by various strains of
    MeSH term(s) Humans ; Polysaccharides, Bacterial/chemistry ; Olea ; Dietary Supplements ; Culture Media ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Anti-Inflammatory Agents
    Chemical Substances Polysaccharides, Bacterial ; Culture Media ; Antioxidants ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04223e
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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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