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Article ; Online: Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group.

Triplett, Katherine E / Collett, Luke W

2020 Volume 214, Issue 1, Page(s) 45–45.e1

MeSH term(s)	Adult ; Airway Management ; COVID-19 ; Humans ; Intubation, Intratracheal ; SARS-CoV-2
Language	English
Publishing date	2020-12-08
Publishing country	Australia
Document type	Letter ; Comment
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.50887
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Article ; Online: Persistent Early Knee Osteoarthritis Symptoms in the First Two Years After ACL Reconstruction.

Harkey, Matthew S / Driban, Jeffrey B / Baez, Shelby E / Genoese, Francesca M / Reiche, Elaine / Collins, Katherine / Walaszek, Michelle C / Triplett, Ashley / Wilcox, C L / Schorfhaar, Andrew / Shingles, Michael / Joseph, Sheeba / Kuenze, Christopher

Journal of athletic training

2024

Abstract: Context: Early identification of knee osteoarthritis (OA) symptoms after anterior cruciate ligament reconstruction (ACLR) could enable timely interventions to improve long-term outcomes. However, little is known about the change in early OA symptoms ... ...

Abstract	Context: Early identification of knee osteoarthritis (OA) symptoms after anterior cruciate ligament reconstruction (ACLR) could enable timely interventions to improve long-term outcomes. However, little is known about the change in early OA symptoms from 6 to 12 months following ACLR. Objective: To evaluate the change over time in meeting classification criteria for early knee OA symptoms from 6 to 12 months following ACLR. Design: Prospective Cohort Study. Setting: Research laboratory. Patients or other participants: 82 participants aged 13-35 years who underwent unilateral primary ACLR. On average, participants' 1st and 2nd visits were 6.2 and 12.1 months post-ACLR. Main outcome measures: Early OA symptoms were classified using generic (Luyten Original) and patient population-specific (Luyten PASS) thresholds on Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales. Changes in meeting early OA criteria were compared between an initial and follow-up visit at an average of 6 and 12 months post-ACLR, respectively. Results: Twenty-two percent of participants exhibited persistent early OA symptoms across both visits using both the Luyten Original and PASS criteria. From initial to follow-up visit, 18-27% had resolution of early OA symptoms while 4-9% developed incident symptoms. In total, 48-51% had no early OA symptoms at either visit. There were no differences between change in early OA status between adults and adolescents. Conclusions: Nearly one quarter of participants exhibited persistent early knee OA symptoms based on KOOS thresholds from 6 to 12 months post-ACLR. Determining if this symptom persistence predicts worse long-term outcomes could inform the need for timely interventions after ACLR. Future research should examine if resolving persistent symptoms in this critical window improves later outcomes. Tracking early OA symptoms over time may identify high-risk patients who could benefit from early treatment.
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2070051-9
ISSN	1938-162X ; 1062-6050
ISSN (online)	1938-162X
ISSN	1062-6050
DOI	10.4085/1062-6050-0470.23
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Article: Normative cerebral microvascular blood flow waveform morphology assessed with diffuse correlation spectroscopy.

Urner, Tara M / Cowdrick, Kyle R / Brothers, Rowan O / Boodooram, Tisha / Zhao, Hongting / Goyal, Vidisha / Sathialingam, Eashani / Quadri, Ayesha / Turrentine, Katherine / Akbar, Mariam M / Triplett, Sydney E / Bai, Shasha / Buckley, Erin M

Biomedical optics express

2023 Volume 14, Issue 7, Page(s) 3635–3653

Abstract: ... normative values for cerebral critical closing pressure, i.e., the minimum pressure required to maintain flow ...

Abstract	Microvascular cerebral blood flow exhibits pulsatility at the cardiac frequency that carries valuable information about cerebrovascular health. This study used diffuse correlation spectroscopy to quantify normative features of these waveforms in a cohort of thirty healthy adults. We demonstrate they are sensitive to changes in vascular tone, as indicated by pronounced morphological changes with hypercapnia. Further, we observe significant sex-based differences in waveform morphology, with females exhibiting higher flow, greater area-under-the-curve, and lower pulsatility. Finally, we quantify normative values for cerebral critical closing pressure, i.e., the minimum pressure required to maintain flow in a given vascular region.
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.489760
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Article ; Online: Lower Extremity Reaction Time in Individuals With Contact Versus Noncontact Anterior Cruciate Ligament Injuries After Reconstruction.

Reiche, Elaine / Collins, Katherine / Genoese, Francesca / Walaszek, Michelle / Triplett, Ashley / Kuenze, Christopher / Harkey, Matthew / Baez, Shelby

Journal of athletic training

2023 Volume 59, Issue 1, Page(s) 66–72

Abstract: Context: Deficits in perceptual-motor function, like visuomotor reaction time (VMRT), are risk factors for primary and secondary anterior cruciate ligament (ACL) injury. Noncontact ACL injuries have been associated with slower reaction time, but whether ...

Abstract	Context: Deficits in perceptual-motor function, like visuomotor reaction time (VMRT), are risk factors for primary and secondary anterior cruciate ligament (ACL) injury. Noncontact ACL injuries have been associated with slower reaction time, but whether this association exists for patients with contact ACL injuries is unknown. Exploring differences in VMRT among individuals with contact versus noncontact ACL injuries may provide a more comprehensive understanding of modifiable risk factors. Objective: To compare lower extremity VMRT (LEVMRT) in individuals with contact or noncontact ACL injuries after ACL reconstruction (ACLR). Design: Cross-sectional study. Setting: Research laboratory. Patients or other participants: A total of 36 participants with primary, unilateral ACLR completed an LEVMRT assessment (contact ACL injury = 20 [56%], noncontact ACL injury = 16 [44%]). Main outcome measure(s): The LEVMRT was assessed bilaterally and collected using a series of wireless light discs deactivated by individuals with their feet. The ACLR-active LEVMRT (ie, ACLR limb is deactivating lights) and ACLR-stable LEVMRT were compared using separate analyses of covariance to determine the association with contact or noncontact injury using time since surgery as a covariate. Results: After controlling for time since surgery, a difference and large effect size between groups was found for the ACLR-stable LEVMRT (P = .010; η2 = 0.250) but not for the ACLR-active (P = .340; η2 = 0.065) condition. The contact group exhibited slower ACLR-stable LEVMRT (521.7 ± 59.3 milliseconds) than the noncontact group (483.4 ± 83.9 milliseconds). Conclusions: Individuals with contact ACL injury demonstrated a slower LEVMRT while their ACLR limb was stabilizing. The group differences during the ACLR-stable LEVMRT task might indicate deficits in perceptual-motor function when the surgical limb maintains postural control during a reaction time task. After ACLR, individuals with contact injuries may need additional motor learning interventions to enhance perceptual-motor functioning.
MeSH term(s)	Humans ; Anterior Cruciate Ligament Injuries/surgery ; Cross-Sectional Studies ; Reaction Time ; Lower Extremity ; Risk Factors
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2070051-9
ISSN	1938-162X ; 1062-6050
ISSN (online)	1938-162X
ISSN	1062-6050
DOI	10.4085/1062-6050-0428.22
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Article ; Online: Enamel thickness variation in the deciduous dentition of extant large-bodied hominoids.

Ortiz, Alejandra / Schander-Triplett, Katherine / Bailey, Shara E / Skinner, Matthew M / Hublin, Jean-Jacques / Schwartz, Gary T

American journal of physical anthropology

2020 Volume 173, Issue 3, Page(s) 500–513

Abstract: Objectives: Enamel thickness features prominently in hominoid evolutionary studies. To date, however, studies of enamel thickness in humans, great apes, and their fossil relatives have focused on the permanent molar row. Comparatively little research ... ...

Abstract	Objectives: Enamel thickness features prominently in hominoid evolutionary studies. To date, however, studies of enamel thickness in humans, great apes, and their fossil relatives have focused on the permanent molar row. Comparatively little research effort has been devoted to tissue proportions within deciduous teeth. Here we attempt to fill this gap by documenting enamel thickness variation in the deciduous dentition of extant large-bodied hominoids. Materials and methods: We used microcomputed tomography to image dental tissues in 80 maxillary and 78 mandibular deciduous premolars of Homo sapiens, Pan troglodytes, Gorilla, and Pongo. Two-dimensional virtual sections were created from the image volumes to quantify average (AET) and relative (RET) enamel thickness, as well as its distribution across the crown. Results: Our results reveal no significant differences in enamel thickness among the great apes. Unlike the pattern present in permanent molars, Pongo does not stand out as having relatively thicker-enameled deciduous premolars than P. troglodytes and Gorilla. Humans, on the other hand, possess significantly thicker deciduous premolar enamel in comparison to great apes. Following expectations from masticatory biomechanics, we also find that the "functional" side (protocone, protoconid) of deciduous premolars generally possesses thicker enamel than the "nonfunctional" side. Discussion: Our study lends empirical support to anecdotal observations that patterns of AET and RET observed for permanent molars of large-bodied apes do not apply to deciduous premolars. By documenting enamel thickness variation in hominoid deciduous teeth, this study provides the comparative context to interpret rates and patterns of wear of deciduous teeth and their utility in life history reconstructions.
MeSH term(s)	Animals ; Bicuspid/anatomy & histology ; Bicuspid/diagnostic imaging ; Dental Enamel/anatomy & histology ; Dental Enamel/diagnostic imaging ; Female ; Fossils ; Hominidae/anatomy & histology ; Humans ; Male ; Tooth, Deciduous/anatomy & histology ; Tooth, Deciduous/diagnostic imaging ; X-Ray Microtomography
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219376-0
ISSN	1096-8644 ; 0002-9483
ISSN (online)	1096-8644
ISSN	0002-9483
DOI	10.1002/ajpa.24106
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Article: Can the blood gas analyser results be believed? A prospective multicentre study comparing haemoglobin, sodium and potassium measurements by blood gas analysers and laboratory auto-analysers.

Triplett, Katherine E / Wibrow, Bradley A / Norman, Richard / Hince, Dana A / Hardy, Liesel E / Tan, Samantha / Ho, Kwok M / Anstey, Matthew H

Anaesthesia and intensive care

2019 Volume 47, Issue 2, Page(s) 120–127

Abstract: Blood gas analysers are point-of-care testing devices used in the management of critically ill patients. Controversy remains over the agreement between the results obtained from blood gas analysers and laboratory auto-analysers for haematological and ... ...

Abstract	Blood gas analysers are point-of-care testing devices used in the management of critically ill patients. Controversy remains over the agreement between the results obtained from blood gas analysers and laboratory auto-analysers for haematological and biochemistry parameters. We conducted a prospective analytical observational study in five intensive care units in Western Australia, in patients who had a full blood count (FBC), urea, electrolytes and creatinine (UEC), and a blood gas performed within 1 h of each other during the first 24 h of their intensive care unit admission. The main outcome measure was to determine the agreement in haemoglobin, sodium, and potassium results between laboratory haematology and biochemistry auto-analysers and blood gas analysers. A total of 219 paired tests were available for haemoglobin and sodium, and 215 for potassium. There was no statistically significant difference between the results of the blood gas and laboratory auto-analysers for haemoglobin (mean difference -0.35 g/L, 95% confidence interval (CI) -1.20 to 0.51, P = 0.425). Although the mean differences between the two methods were statistically significant for sodium (mean difference 1.49 mmol/L, 95% CI 1.23-1.76, P < 0.0001) and potassium (mean difference 0.19 mmol/L, 95% CI 0.15-0.24, P < 0.0001), the mean biases on the Bland-Altman plots were small and independent of the magnitude of the measurements. The two methods of measurement for haemoglobin, sodium and potassium agreed with each other under most clinical situations when their values were within or close to normal range suggesting that routine concurrent blood gas and formal laboratory testing for haemoglobin, sodium and potassium concentrations in the intensive care unit is unwarranted.
MeSH term(s)	Automation ; Blood Gas Analysis/standards ; Hemoglobins/analysis ; Humans ; Point-of-Care Systems ; Potassium/blood ; Prospective Studies ; Sodium/blood ; Western Australia
Chemical Substances	Hemoglobins ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2019-05-09
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	187524-3
ISSN	1448-0271 ; 0310-057X
ISSN (online)	1448-0271
ISSN	0310-057X
DOI	10.1177/0310057X19840046
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Article ; Online: Age-, Sex-, and Graft-Specific Reference Values From 783 Adolescent Patients at 5 to 7 Months After ACL Reconstruction: IKDC, Pedi-IKDC, KOOS, ACL-RSI, Single-Leg Hop, and Thigh Strength.

Kuenze, Christopher / Weaver, Adam / Grindstaff, Terry L / Ulman, Sophia / Norte, Grant E / Roman, Dylan P / Giampetruzzi, Nicholas / Lisee, Caroline M / Birchmeier, Thomas / Triplett, Ashley / Farmer, Brooke / Hopper, Haleigh / Sherman, David A / Ness, Brandon M / Collins, Katherine / Walaszek, Michelle / Baez, Shelby E / Harkey, Matthew S / Tulchin-Francis, Kirsten /

Ellis, Henry / Wilson, Philip L / Chang, Edward S / Wilcox, C Luke / Schorfhaar, Andrew / Shingles, Michael / Hart, Joseph M

The Journal of orthopaedic and sports physical therapy

2023 Volume 53, Issue 4, Page(s) 1–8

Abstract: OBJECTIVE: ...

Abstract	OBJECTIVE:
MeSH term(s)	Female ; Humans ; Adolescent ; Child ; Infant ; Male ; Thigh ; Leg ; Reference Values ; Cross-Sectional Studies ; Anterior Cruciate Ligament Injuries/surgery ; Knee Joint ; Quadriceps Muscle ; Return to Sport
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2023.11389
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Article ; Online: Kinesiophobia Is Associated with Peak Knee Abduction Angle during Jump Landing after ACL Reconstruction.

Baez, Shelby / Collins, Katherine / Harkey, Matthew / Birchmeier, Thomas / Triplett, Ashley / Pietrosimone, Brian / Kuenze, Christopher

Medicine and science in sports and exercise

2022 Volume 55, Issue 3, Page(s) 462–468

Abstract: ... When accounting for time since surgery and biological sex, every 1-point increase on the TSK-11 (i.e., increase ... in kinesiophobia) associated with a 0.37° increase (i.e., a 7.1% increase) in ACLR limb KAA ( P = 0.02 ...

Abstract	Introduction: This study aimed to investigate the associations between kinesiophobia, knee abduction angle (KAA) during the first 100 ms of landing, and knee flexion excursion (KFE) in individuals 5-12 months after anterior cruciate ligament reconstruction (ACLR). We hypothesized that greater kinesiophobia would be associated with greater peak KAA and lesser KFE during landing on the ACLR limb, but not on the contralateral limb. Methods: Thirty-six participants between 14 and 35 yr old (females = 19, age = 19.9 ± 5.1 yr, height = 172.5 ± 9.4 cm, weight = 76.7 ± 20.0 kg, time since surgery =7.2 ± 1.7 months) were recruited from a sports medicine clinic at 5-12 months after primary unilateral ACLR. Participants completed the Tampa Scale of Kinesiophobia-11 (TSK-11) to measure kinesiophobia and three successful trials of a standard drop vertical jump task. A 10-camera three-dimensional motion capture system synchronized with two embedded force plate platforms was used to capture jump-landing kinematics. Separate stepwise linear regression models were used to examine the associations between kinesiophobia, peak KAA, and KFE on the ACLR and contralateral limbs after accounting for time since surgery and biological sex. Results: When accounting for time since surgery and biological sex, every 1-point increase on the TSK-11 (i.e., increase in kinesiophobia) associated with a 0.37° increase (i.e., a 7.1% increase) in ACLR limb KAA ( P = 0.02). Kinesiophobia was not associated with contralateral limb KAA, ACLR limb KFE, or contralateral limb KFE. Conclusions: Higher kinesiophobia was related to greater amounts of peak KAA during landing in individuals 5-12 months post-ACLR. Modifying kinesiophobia may help to decrease KAA and lead to reduced secondary ACL injury risk. Future research should investigate feasible psychological interventions to reduce kinesiophobia and improve KAA in patients post-ACLR.
MeSH term(s)	Female ; Humans ; Adolescent ; Young Adult ; Adult ; Knee Joint ; Knee ; Lower Extremity ; Anterior Cruciate Ligament Injuries/surgery ; Movement ; Biomechanical Phenomena
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0000000000003075
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Zs.A 869: Show issues

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Article ; Online: Outcomes of pediatric patients with therapy-related myeloid neoplasms.

Sharma, Akshay / Huang, Sujuan / Li, Ying / Brooke, Russell J / Ahmed, Ibrahim / Allewelt, Heather B / Amrolia, Persis / Bertaina, Alice / Bhatt, Neel S / Bierings, Marc B / Bies, Joshua / Brisset, Claire / Brondon, Jennifer E / Dahlberg, Ann / Dalle, Jean-Hugues / Eissa, Hesham / Fahd, Mony / Gassas, Adam / Gloude, Nicholas J /

Goebel, W Scott / Goeckerman, Erika S / Harris, Katherine / Ho, Richard / Hudspeth, Michelle P / Huo, Jeffrey S / Jacobsohn, David / Kasow, Kimberly A / Katsanis, Emmanuel / Kaviany, Saara / Keating, Amy K / Kernan, Nancy A / Ktena, Yiouli P / Lauhan, Colette R / López-Hernandez, Gerardo / Martin, Paul L / Myers, Kasiani C / Naik, Swati / Olaya-Vargas, Alberto / Onishi, Toshihiro / Radhi, Mohamed / Ramachandran, Shanti / Ramos, Kristie / Rangarajan, Hemalatha G / Roehrs, Philip A / Sampson, Megan E / Shaw, Peter J / Skiles, Jodi L / Somers, Katherine / Symons, Heather J / de Tersant, Marie / Uber, Allison N / Versluys, Birgitta / Cheng, Cheng / Triplett, Brandon M

Bone marrow transplantation

2021 Volume 56, Issue 12, Page(s) 2997–3007

Abstract: Long-term outcomes after allogeneic hematopoietic cell transplantation (HCT) for therapy-related myeloid neoplasms (tMNs) are dismal. There are few multicenter studies defining prognostic factors in pediatric patients with tMNs. We have accumulated the ... ...

Abstract	Long-term outcomes after allogeneic hematopoietic cell transplantation (HCT) for therapy-related myeloid neoplasms (tMNs) are dismal. There are few multicenter studies defining prognostic factors in pediatric patients with tMNs. We have accumulated the largest cohort of pediatric patients who have undergone HCT for a tMN to perform a multivariate analysis defining factors predictive of long-term survival. Sixty-eight percent of the 401 patients underwent HCT using a myeloablative conditioning (MAC) regimen, but there were no statistically significant differences in the overall survival (OS), event-free survival (EFS), or cumulative incidence of relapse and non-relapse mortality based on the conditioning intensity. Among the recipients of MAC regimens, 38.4% of deaths were from treatment-related causes, especially acute graft versus host disease (GVHD) and end-organ failure, as compared to only 20.9% of deaths in the reduced-intensity conditioning (RIC) cohort. Exposure to total body irradiation (TBI) during conditioning and experiencing grade III/IV acute GVHD was associated with worse OS. In addition, a diagnosis of therapy-related myelodysplastic syndrome and having a structurally complex karyotype at tMN diagnosis were associated with worse EFS. Reduced-toxicity (but not reduced-intensity) regimens might help to decrease relapse while limiting mortality associated with TBI-based HCT conditioning in pediatric patients with tMNs.
MeSH term(s)	Child ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Leukemia, Myeloid, Acute/complications ; Neoplasm Recurrence, Local ; Retrospective Studies ; Transplantation Conditioning/adverse effects
Language	English
Publishing date	2021-09-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-021-01448-x
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Article ; Online: Temporal and region-specific effects of sleep fragmentation on gut microbiota and intestinal morphology in Sprague Dawley rats.

Triplett, Judy / Ellis, David / Braddock, Amber / Roberts, Erin / Ingram, Katherine / Perez, Eric / Short, Amanda / Brown, Dominique / Hutzley, Victoria / Webb, Chelsey / Soto, Armando / Chan, Victor

Gut microbes

2020 Volume 11, Issue 4, Page(s) 706–720

Abstract: Sleep is a fundamental biological process, that when repeatedly disrupted, can result in severe health consequences. Recent studies suggest that both sleep fragmentation (SF) and dysbiosis of the gut microbiome can lead to metabolic disorders, though the ...

Abstract	Sleep is a fundamental biological process, that when repeatedly disrupted, can result in severe health consequences. Recent studies suggest that both sleep fragmentation (SF) and dysbiosis of the gut microbiome can lead to metabolic disorders, though the underlying mechanisms are largely unclear. To better understand the consequences of SF, we investigated the effects of acute (6 days) and chronic (6 weeks) SF on rats by examining taxonomic profiles of microbiota in the distal ileum, cecum and proximal colon, as well as assessing structural and functional integrity of the gastrointestinal barrier. We further assayed the impact of SF on a host function by evaluating inflammation and immune response. Both acute and chronic SF induced microbial dysbiosis, more dramatically in the distal ileum (compared to other two regions studied), as noted by significant perturbations in alpha- and beta-diversity; though, specific microbial populations were significantly altered throughout each of the three regions. Furthermore, chronic SF resulted in increased crypt depth in the distal ileum and an increase in the number of villi lining both the cecum and proximal colon. Additional changes were noted with chronic SF, including: decreased microbial adhesion and penetration in the distal ileum and cecum, elevation in serum levels of the cytokine KC/GRO, and depressed levels of corticotropin. Importantly, our data show that perturbations to microbial ecology and intestinal morphology intensify in response to prolonged SF and these changes are habitat specific. Together, these results reveal consequences to gut microbiota homeostasis and host response following acute and chronic SF in rats.
MeSH term(s)	Animals ; Bacterial Adhesion ; Bacterial Physiological Phenomena ; Cecum/microbiology ; Cecum/pathology ; Colon/microbiology ; Colon/pathology ; Cytokines/analysis ; Endotoxins/analysis ; Gastrointestinal Microbiome ; Hypothalamo-Hypophyseal System/physiology ; Ileum/microbiology ; Ileum/pathology ; Phylogeny ; Rats ; Rats, Sprague-Dawley ; Sleep Deprivation/microbiology ; Sleep Deprivation/pathology ; Sleep Deprivation/physiopathology
Chemical Substances	Cytokines ; Endotoxins
Language	English
Publishing date	2020-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1949-0984
ISSN (online)	1949-0984
DOI	10.1080/19490976.2019.1701352
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