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  1. Article: QTLs and Genes for Salt Stress Tolerance: A Journey from Seed to Seed Continued.

    Tiwari, Keshav / Tiwari, Sushma / Kumar, Nivesh / Sinha, Shikha / Krishnamurthy, Saraswathipura L / Singh, Renu / Kalia, Sanjay / Singh, Nagendra Kumar / Rai, Vandna

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 8

    Abstract: Rice ( ...

    Abstract Rice (
    Language English
    Publishing date 2024-04-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13081099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Drought and Oxidative Stress in Flax (

    Dash, Prasanta K / Rai, Rhitu / Pradhan, Sharat Kumar / Shivaraj, Sheelavanta Matha / Deshmukh, Rupesh / Sreevathsa, Rohini / Singh, Nagendra K

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Flax ( ...

    Abstract Flax (
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12040950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Corrigendum to "Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain, optic nerve and retina" [Toxicology and Applied Pharmacology 273 (2013) 242-258].

    Rai, Nagendra Kumar / Ashok, Anushruti / Rai, Asit / Tripathi, Sachin / Nagar, Geet Kumar / Mitra, Kalyan / Bandyopadhyay, Sanghamitra

    Toxicology and applied pharmacology

    2022  Volume 450, Page(s) 116165

    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2022.116165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Investigating NAC Transcription Factor Role in Redox Homeostasis in

    Rai, Nagendra / Rai, Krishna Kumar / Singh, Manish Kumar / Singh, Jagdish / Kaushik, Prashant

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 21

    Abstract: NAC transcription factors regulate stress-defence pathways and developmental processes in crop plants. However, their detailed functional characterization in tomatoes needs to be investigated comprehensively. In the present study, tomato hybrids ... ...

    Abstract NAC transcription factors regulate stress-defence pathways and developmental processes in crop plants. However, their detailed functional characterization in tomatoes needs to be investigated comprehensively. In the present study, tomato hybrids subjected to 60 and 80 days of drought stress conditions showed a significant increase in membrane damage and reduced relative water, chlorophyll and proline content. However, hybrids viz., VRTH-16-3 and VRTH-17-68 showed superior growth under drought stress, as they were marked with low electrolytic leakage, enhanced relative water content, proline content and an enhanced activity of enzymatic antioxidants, along with the upregulation of NAC and other stress-defence pathway genes. Candidate gene(s) exhibiting maximum expression in all the hybrids under drought stress were subjected to detailed in silico characterization to provide significant insight into its structural and functional classification. The homology modelling and superimposition analysis of predicted tomato NAC protein showed that similar amino acid residues were involved in forming the conserved WKAT domain. DNA docking discovered that the SlNAC1 protein becomes activated and exerts a stress-defence response after the possible interaction of conserved DNA elements using Pro
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11212930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Untargeted Metabolomics of

    Singh, Dhananjaya Pratap / Bisen, Mansi Singh / Prabha, Ratna / Maurya, Sudarshan / Yerasu, Suresh Reddy / Shukla, Renu / Tiwari, Jagesh Kumar / Chaturvedi, Krishna Kumar / Farooqi, Md Samir / Srivastava, Sudhir / Rai, Anil / Sarma, Birinchi Kumar / Rai, Nagendra / Singh, Prabhakar Mohan / Behera, Tusar Kanti / Farag, Mohamed A

    Metabolites

    2023  Volume 13, Issue 5

    Abstract: Untargeted metabolomics of moderately resistant wild tomato ... ...

    Abstract Untargeted metabolomics of moderately resistant wild tomato species
    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13050585
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  6. Article ; Online: Salicylic Acid and Nitric Oxide

    Krishna Kumar Rai / Neha Pandey / Nagendra Rai / Sanjay Kumar Rai / Shashi Pandey-Rai

    Frontiers in Agronomy, Vol

    Insight Into the Transcriptional Regulation of Their Metabolism and Regulatory Functions in Plants

    2021  Volume 3

    Abstract: Salicylic acid (SA) and nitric oxide (NO) are key signaling molecules required to activate the plant's innate immunity against abiotic stresses and biotrophic attackers. Stress-induced signaling and accumulation of SA and NO triggers extensive ... ...

    Abstract Salicylic acid (SA) and nitric oxide (NO) are key signaling molecules required to activate the plant's innate immunity against abiotic stresses and biotrophic attackers. Stress-induced signaling and accumulation of SA and NO triggers extensive transcriptional reprogramming of defense-related genes, induced biosynthesis of secondary metabolites and anti-microbial compounds, thereby protecting/steering plant growth and immunity. Transcriptional regulation of SA and NO signaling are crucial for fine-tuning important cellular and metabolic functions, thus making plant defense impervious against many pathogens. The development of an impenetrable immune response is often associated with an unavoidable trade-off in the form of active suppression of plant growth and reproduction. Therefore, we highlighted recent advancements and research to unravel transcriptional regulation of SA and NO signaling essential for fulfilling their role as defense signaling molecules. We also emphasized comprehensive knowledge related to transcriptional reprogramming of SA and NO signaling important in strengthening plant growth-immunity trade-off. We also highlighted the progress on SA and NO signaling playing an indispensable role in stimulating plant-microbe interaction to modulate crucial plant functions.
    Keywords salicylic acid ; nitric oxide ; plant immunity ; transcriptional regulation ; strigolactones ; Agriculture ; S ; Plant culture ; SB1-1110
    Subject code 580
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Salicylic Acid and Nitric Oxide: Insight Into the Transcriptional Regulation of Their Metabolism and Regulatory Functions in Plants

    Krishna Kumar Rai / Neha Pandey / Nagendra Rai / Sanjay Kumar Rai / Shashi Pandey-Rai

    Frontiers in agronomy. 2021 Dec., v. 3

    2021  

    Abstract: Salicylic acid (SA) and nitric oxide (NO) are key signaling molecules required to activate the plant's innate immunity against abiotic stresses and biotrophic attackers. Stress-induced signaling and accumulation of SA and NO triggers extensive ... ...

    Abstract Salicylic acid (SA) and nitric oxide (NO) are key signaling molecules required to activate the plant's innate immunity against abiotic stresses and biotrophic attackers. Stress-induced signaling and accumulation of SA and NO triggers extensive transcriptional reprogramming of defense-related genes, induced biosynthesis of secondary metabolites and anti-microbial compounds, thereby protecting/steering plant growth and immunity. Transcriptional regulation of SA and NO signaling are crucial for fine-tuning important cellular and metabolic functions, thus making plant defense impervious against many pathogens. The development of an impenetrable immune response is often associated with an unavoidable trade-off in the form of active suppression of plant growth and reproduction. Therefore, we highlighted recent advancements and research to unravel transcriptional regulation of SA and NO signaling essential for fulfilling their role as defense signaling molecules. We also emphasized comprehensive knowledge related to transcriptional reprogramming of SA and NO signaling important in strengthening plant growth-immunity trade-off. We also highlighted the progress on SA and NO signaling playing an indispensable role in stimulating plant-microbe interaction to modulate crucial plant functions.
    Keywords agronomy ; biosynthesis ; immune response ; innate immunity ; nitric oxide ; plant growth ; reproduction ; salicylic acid ; secondary metabolites ; transcription (genetics)
    Language English
    Dates of publication 2021-12
    Publishing place Frontiers Media S.A.
    Document type Article
    ISSN 2673-3218
    DOI 10.3389/fagro.2021.781027
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: IFN-Induced Protein with Tetratricopeptide Repeats 2 Limits Autoimmune Inflammation by Regulating Myeloid Cell Activation and Metabolic Activity.

    Kim, Dongkyun / Rai, Nagendra Kumar / Burrows, Amy / Kim, Sohee / Tripathi, Ajai / Weinberg, Samuel E / Dutta, Ranjan / Sen, Ganes C / Min, Booki

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 210, Issue 6, Page(s) 721–731

    Abstract: Besides antiviral functions, type I IFN expresses potent anti-inflammatory properties and is being widely used to treat certain autoimmune conditions, such as multiple sclerosis. In a murine model of multiple sclerosis, experimental autoimmune ... ...

    Abstract Besides antiviral functions, type I IFN expresses potent anti-inflammatory properties and is being widely used to treat certain autoimmune conditions, such as multiple sclerosis. In a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis, administration of IFN-β effectively attenuates the disease development. However, the precise mechanisms underlying IFN-β-mediated treatment remain elusive. In this study, we report that IFN-induced protein with tetratricopeptide repeats 2 (Ifit2), a type I and type III IFN-stimulated gene, plays a previously unrecognized immune-regulatory role during autoimmune neuroinflammation. Mice deficient in Ifit2 displayed greater susceptibility to experimental autoimmune encephalomyelitis and escalated immune cell infiltration in the CNS. Ifit2 deficiency was also associated with microglial activation and increased myeloid cell infiltration. We also observed that myelin debris clearance and the subsequent remyelination were substantially impaired in Ifit2-/- CNS tissues. Clearing myelin debris is an important function of the reparative-type myeloid cell subset to promote remyelination. Indeed, we observed that bone marrow-derived macrophages, CNS-infiltrating myeloid cells, and microglia from Ifit2-/- mice express cytokine and metabolic genes associated with proinflammatory-type myeloid cell subsets. Taken together, our findings uncover a novel regulatory function of Ifit2 in autoimmune inflammation in part by modulating myeloid cell function and metabolic activity.
    MeSH term(s) Animals ; Mice ; Encephalomyelitis, Autoimmune, Experimental ; Inflammation ; Mice, Inbred C57BL ; Microglia ; Multiple Sclerosis ; Myeloid Cells ; Tetratricopeptide Repeat ; Interferons/pharmacology
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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  9. Article ; Online: Consequences of chemical impact of disinfectants: safe preventive measures against COVID-19.

    Rai, Nagendra Kumar / Ashok, Anushruti / Akondi, Butchi Raju

    Critical reviews in toxicology

    2020  Volume 50, Issue 6, Page(s) 513–520

    Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created a significant threat to global health. It originated in Wuhan, China and caused a total of 83,483 confirmed cases and 4634 deaths until ...

    Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created a significant threat to global health. It originated in Wuhan, China and caused a total of 83,483 confirmed cases and 4634 deaths until June 2020. This novel virus spread primarily through respiratory droplets and close contact. The person-to-person transmission by direct transmittance through cough, sneeze, droplet inhalation, and contact spreading from dry surfaces contaminated with secretions of nose, mouth, and eyes of an infected person has been proven about SARS-CoV-2 transmission. As disease progressed, a series of complications tends to develop, especially in critically ill and immunocompromised patients. Pathological studies showed representative features of acute respiratory distress syndrome (ARDS) and implications on multiple organs as well. However, no specific antiviral drugs or vaccines are immediately available for the treatment of this lethal disease. The efficacy of some promising antivirals needs to be investigated by ongoing clinical trials. In current circumstances, supportive care, precautions, and social distancing are the only preventive options to ameliorate COVID-19. To disinfect the environment, mainly chemical disinfectants are being used robustly. However, due to panic state, fright, and unawareness, people are using it violently, which can have an adverse effect on human health and environment. This review discusses about the potential harmful effect of disinfectants, if used inappropriately. Here, we will also discuss safe preventive options as an alternative to robust use of disinfection methods to fight against COVID-19.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disinfectants/administration & dosage ; Disinfectants/adverse effects ; Disinfection/methods ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances Disinfectants
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1097071-x
    ISSN 1547-6898 ; 1040-8444
    ISSN (online) 1547-6898
    ISSN 1040-8444
    DOI 10.1080/10408444.2020.1790499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Phylogenomic Analysis of micro-RNA Involved in Juvenile to Flowering-Stage Transition in Photophilic Rice and Its Sister Species.

    Dash, Prasanta K / Gupta, Payal / Sreevathsa, Rohini / Pradhan, Sharat Kumar / Sanjay, Tenkabailu Dharmanna / Mohanty, Mihir Ranjan / Roul, Pravat K / Singh, Nagendra K / Rai, Rhitu

    Cells

    2023  Volume 12, Issue 10

    Abstract: Vegetative to reproductive phase transition in phototropic plants is an important developmental process and is sequentially mediated by the expression of micro- ... ...

    Abstract Vegetative to reproductive phase transition in phototropic plants is an important developmental process and is sequentially mediated by the expression of micro-RNA
    MeSH term(s) Oryza/genetics ; Oryza/metabolism ; Phylogeny ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Plant Leaves/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12101370
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