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Article ; Online: Brazilian primary dental care in a universal health system: Challenges for training and practice.

Bomfim, Rafael Aiello / Della Bona, Alvaro / Cury, Jaime Aparecido / Celeste, Roger Keller

2024 Volume 144, Page(s) 104932

Abstract: Objectives: To report the challenges for training and practice for the Brazilian primary dental care in a universal health system.: Methods: Health, education and protection rights against poverty are guaranteed by the 1988 Brazilian Constitution and ...

Abstract	Objectives: To report the challenges for training and practice for the Brazilian primary dental care in a universal health system. Methods: Health, education and protection rights against poverty are guaranteed by the 1988 Brazilian Constitution and public health in Brazil is provided by the Unified Health System (SUS), one of the largest public health systems in the world. According to SUS, every Brazilian citizen has the right to free primary oral health care as secondary and tertiary care, offering a unique opportunity to integrate oral care within general health care. Results: The Brazilian undergraduate Dental curriculum was updated in 2021 aiming to graduate general practitioners with a major in comprehensive health care in primary health care, integrated with public and general health. This curriculum update requires at least 20% of the academic hours to be exercised outside the university walls (extramural or community work), preferably within the SUS. Conclusions: Considering the World Health Organization (WHO) agenda, Brazil needs to advance the innovative oral health workforce, the integration of oral health into primary care, the population access to essential dental medicines and optimal fluorides for caries control. Clinical significance: It is necessary political action and the engagement of multiple stakeholders, mainly from the health and education sectors, to improve primary health care.
MeSH term(s)	Brazil ; Humans ; Primary Health Care ; Curriculum ; Education, Dental ; Dental Care ; Oral Health ; Universal Health Care ; Health Services Accessibility
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2024.104932
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Román-Fernández, Ilce Valeria / Machado-Contreras, Jesús René / Muñoz-Valle, José Francisco / Cruz, Alvaro / Salazar-Camarena, Diana Celeste / Palafox-Sánchez, Claudia Azucena

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 11

Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with very heterogeneous clinical behavior between affected individuals. Therefore, the search for biomarkers clinically useful for the diagnosis, prognosis, and monitoring of the disease ... ...

Abstract	Systemic lupus erythematosus (SLE) is a complex autoimmune disease with very heterogeneous clinical behavior between affected individuals. Therefore, the search for biomarkers clinically useful for the diagnosis, prognosis, and monitoring of the disease is necessary. Here, we determined the association between
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12112859
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Article: Analysis of

Menchaca-Tapia, Paula Annahi / Marín-Rosales, Miguel / Salazar-Camarena, Diana Celeste / Cruz, Alvaro / Oregon-Romero, Edith / Tapia-Llanos, Raziel / Muñoz-Valle, José Francisco / Palafox-Sánchez, Claudia Azucena

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 5

Abstract: Background: Primary Sjögren's syndrome (pSS) is an autoimmune exocrinopathy characterized by lymphocytic infiltration, glandular dysfunction and systemic manifestations. Lyp protein is a negative regulator of the T cell receptor encoded by the : ... ...

Abstract	Background: Primary Sjögren's syndrome (pSS) is an autoimmune exocrinopathy characterized by lymphocytic infiltration, glandular dysfunction and systemic manifestations. Lyp protein is a negative regulator of the T cell receptor encoded by the Methods: One hundred fifty pSS patients and 180 healthy controls (HCs) were included. Genotypes of Results: Allele and genotype frequencies for all SNPs studied were similar in both groups ( Conclusions: Our findings demonstrate that the
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13050899
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Article ; Online: Analysis of PTPN22 −1123 G>C, +788 G>A and +1858 C>T Polymorphisms in Patients with Primary Sjögren’s Syndrome

Paula Annahi Menchaca-Tapia / Miguel Marín-Rosales / Diana Celeste Salazar-Camarena / Alvaro Cruz / Edith Oregon-Romero / Raziel Tapia-Llanos / José Francisco Muñoz-Valle / Claudia Azucena Palafox-Sánchez

Diagnostics, Vol 13, Iss 899, p

2023 Volume 899

Abstract: Background: Primary Sjögren’s syndrome (pSS) is an autoimmune exocrinopathy characterized by lymphocytic infiltration, glandular dysfunction and systemic manifestations. Lyp protein is a negative regulator of the T cell receptor encoded by the tyrosine ... ...

Abstract	Background: Primary Sjögren’s syndrome (pSS) is an autoimmune exocrinopathy characterized by lymphocytic infiltration, glandular dysfunction and systemic manifestations. Lyp protein is a negative regulator of the T cell receptor encoded by the tyrosine phosphatase nonreceptor-type 22 ( PTPN22 ) gene. Multiple single-nucleotide polymorphisms (SNPs) in the PTPN22 gene have been associated with susceptibility to autoimmune diseases. This study aimed to investigate the association of PTPN22 SNPs rs2488457 (−1123 G>C), rs33996649 (+788 G>A), rs2476601 (+1858 C>T) with pSS susceptibility in Mexican mestizo subjects. Methods: One hundred fifty pSS patients and 180 healthy controls (HCs) were included. Genotypes of PTPN22 SNPs were identified by PCR-RFLP. PTPN22 expression was evaluated through RT–PCR analysis. Serum anti-SSA/Ro and anti-SSB/La levels were measured using an ELISA kit. Results: Allele and genotype frequencies for all SNPs studied were similar in both groups ( p > 0.05). pSS patients showed 17-fold higher expression of PTNP22 than HCs, and mRNA levels correlated with SSDAI score ( r 2 = 0.499, p = 0.008) and levels of anti-SSA/Ro and anti-SSB/La autoantibodies ( r 2 = 0.200, p = 0.03 and r 2 = 0.175, p = 0.04, respectively). Positive anti-SSA/Ro pSS patients expressed higher PTPN22 mRNA levels ( p = 0.008), with high focus scores by histopathology ( p = 0.02). Moreover, PTPN22 expression had high diagnostic accuracy in pSS patients, with an AUC = 0.985. Conclusions: Our findings demonstrate that the PTPN22 SNPs rs2488457 (−1123 G>C), rs33996649 (+788 G>A) and rs2476601 (+1858 C>T) are not associated with the disease susceptibility in the western Mexican population. Additionally, PTPN22 expression may be helpful as a diagnostic biomarker in pSS.
Keywords	PTPN22 polymorphisms ; primary Sjögren’s Syndrome ; PTPN22 expression ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: BAFF system expression in double negative 2, activated naïve and activated memory B cells in systemic lupus erythematosus.

Álvarez Gómez, Jhonatan Antonio / Salazar-Camarena, Diana Celeste / Román-Fernández, Ilce Valeria / Ortiz-Lazareno, Pablo César / Cruz, Alvaro / Muñoz-Valle, José Francisco / Marín-Rosales, Miguel / Espinoza-García, Noemí / Sagrero-Fabela, Nefertari / Palafox-Sánchez, Claudia Azucena

Frontiers in immunology

2023 Volume 14, Page(s) 1235937

Abstract: Introduction: B cell activating factor (BAFF) has an important role in normal B cell development. The aberrant expression of BAFF is related with the autoimmune diseases development like Systemic Lupus Erythematosus (SLE) for promoting self-reactive B ... ...

Abstract	Introduction: B cell activating factor (BAFF) has an important role in normal B cell development. The aberrant expression of BAFF is related with the autoimmune diseases development like Systemic Lupus Erythematosus (SLE) for promoting self-reactive B cells survival. BAFF functions are exerted through its receptors BAFF-R (BR3), transmembrane activator calcium modulator and cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) that are reported to have differential expression on B cells in SLE. Recently, atypical B cells that express CD11c have been associated with SLE because they are prone to develop into antibody-secreting cells, however the relationship with BAFF remains unclear. This study aims to analyze the BAFF system expression on CXCR5 Methods: Forty-five SLE patients and 15 healthy subjects (HS) were included. Flow cytometry was used to evaluate the expression of the receptors in the B cell subpopulations. Enzyme-linked immunosorbent assay (ELISA) was performed to quantify the soluble levels of BAFF (sBAFF) and IL-21. Results: We found increased frequency of CXCR5 Discussion: These results suggest a participation of the BAFF system in CXCR5
MeSH term(s)	Humans ; Memory B Cells ; B-Cell Activating Factor ; B-Cell Maturation Antigen ; B-Lymphocytes ; Lupus Erythematosus, Systemic ; Autoimmune Diseases
Chemical Substances	B-Cell Activating Factor ; B-Cell Maturation Antigen
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1235937
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Article ; Online: Evaluation of Serum Levels of Cytokines in Acute Apical Abscess: A Longitudinal Observational Study.

Palafox-Sánchez, Claudia Azucena / Cruz, Alvaro / Salazar-Camarena, Diana Celeste / Gascón, Luis Gerardo / Cintra, Luciano Tavares Angelo / Muñoz-Valle, José Francisco / García-Arellano, Samuel / Estrela, Carlos / Menchaca-Tapia, Paula Annahi

Journal of endodontics

2023 Volume 49, Issue 9, Page(s) 1090–1098

Abstract: Introduction: Cytokine levels are related to the aethiopathogenia of acute apical abscesses (AAA); however, the specific cytokine profiles in these cases are unclear. This study aimed to investigate the changes in systemic cytokine levels in patients ... ...

Abstract	Introduction: Cytokine levels are related to the aethiopathogenia of acute apical abscesses (AAA); however, the specific cytokine profiles in these cases are unclear. This study aimed to investigate the changes in systemic cytokine levels in patients with AAA and trismus onset, postantibiotic treatment, and postroot canal disinfection. Methods: In total, 46 AAA patients with trismus and 32 control subjects were included. After seven days of antibiotic therapy, root canal disinfection was performed in the AAA patients. The serum levels of cytokines were evaluated at basal, seven, and 14 days after endodontic treatment. Quantification of cytokines from T helper (Th) 1, Th2, Th17, and regulatory T cells profiles was determined using the BioPlex MagPix system, and the obtained data were analyzed using SPSS statistical software (P < .05). Results: AAA patients showed higher tumor necrosis factor-alpha (TNF-α), interleukin (IL) -6, and IL-10 levels than control subjects, at basal measurement (P < .05); there were similar levels of interferon gamma, IL-1β, IL-4, and IL-17 between groups (P > .05). IL-6 and IL-10 levels decreased after antibiotic treatment (P < .05), which was also associated with clinical improvement in patients with AAA and trismus. Patients with AAA had a positive correlation with higher serum levels of IL-6 and IL-10. In addition, TNF-α levels decreased only after antibiotic and endodontic treatment. Conclusions: In conclusion, patients with AAA had increased systemic serum levels of TNF-α, IL-6, and IL-10. Moreover, increased levels of IL-6 and IL-10 are associated with acute inflammatory symptoms. However, IL-6 and IL-10 levels decreased after antibiotic treatment, while TNF-α levels decreased after antibiotic and endodontic treatment.
MeSH term(s)	Humans ; Cytokines ; Interleukin-10 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Abscess ; Trismus ; Periapical Abscess
Chemical Substances	Cytokines ; Interleukin-10 (130068-27-8) ; Interleukin-6 ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-07-08
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2023.07.001
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Article ; Online: Renal Tissue Expression of BAFF and BAFF Receptors Is Associated with Proliferative Lupus Nephritis

Miguel Marín-Rosales / Claudia Azucena Palafox-Sánchez / Ramón Antonio Franco-Topete / Francisco Josué Carrillo-Ballesteros / Alvaro Cruz / Diana Celeste Salazar-Camarena / José Francisco Muñoz-Valle / Francisco Ramos-Solano

Journal of Clinical Medicine, Vol 12, Iss 1, p

2022 Volume 71

Abstract: Background: The B-cell activating factor (BAFF) controls the maturation and survival of B cells. An imbalance in this cytokine has been associated with systemic autoimmunity in SLE and lupus nephritis (LN). However, few investigations have evaluated the ... ...

Abstract	Background: The B-cell activating factor (BAFF) controls the maturation and survival of B cells. An imbalance in this cytokine has been associated with systemic autoimmunity in SLE and lupus nephritis (LN). However, few investigations have evaluated the tissular expression of BAFF in LN. This study aimed to associate BAFF system expression at the tissular level with the proliferative LN classes. Methods: The analysis included eighteen kidney tissues, with sixteen LN (class III = 5, class IV = 6, class III/IV+V = 4, and class V = 1), and two controls. The tissular expression was evaluated with an immunochemistry assay. A Cytation5 imaging reader and ImageJ software were used to analyze the quantitative expression. A p -value < 0.05 was considered significant. Results: The expressions of BAFF, A proliferation-inducing ligand (APRIL), and their receptors were observed in glomerular, tubular, and interstitial zones, with BAFF being the most strongly expressed in the overall analysis. BAFF-Receptor (BR3), transmembrane activator and CALM interactor (TACI), and B-Cell maturation antigen (BCMA) displayed higher expressions in LN class IV in all zones analyzed ( p < 0.05). Additionally, a positive correlation was found between APRIL, TACI, and BCMA at the glomerular level; BCMA and APRIL in the interstitial zone; and BR3, TACI, and BCMA in the tubule ( p < 0.05). Conclusions: The expression of BAFF and BAFF receptors is mainly associated with LN class IV, emphasizing the participation of these receptors as an essential pathogenic factor in kidney involvement in SLE patients.
Keywords	systemic lupus erythematosus ; proliferative lupus nephritis ; BAFF system expression ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Dendritic cells, headhunters for anti-tumor CD8

Luri-Rey, Carlos / Manzanal, Almudena / Pinci, Beatrice / Teijeira, Alvaro

Med (New York, N.Y.)

2023 Volume 4, Issue 6, Page(s) 341–343

Abstract: How do we identify patients most likely to benefit from immune checkpoint blockade therapies? This month in Med, Wu and ... ...

Abstract	How do we identify patients most likely to benefit from immune checkpoint blockade therapies? This month in Med, Wu and colleagues
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; Triple Negative Breast Neoplasms/drug therapy ; Dendritic Cells
Language	English
Publishing date	2023-06-03
Publishing country	United States
Document type	Journal Article
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2023.05.004
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Article ; Online: Analysis of the receptor BCMA as a biomarker in systemic lupus erythematosus patients

Diana Celeste Salazar-Camarena / Claudia Azucena Palafox-Sánchez / Alvaro Cruz / Miguel Marín-Rosales / José Francisco Muñoz-Valle

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) play central roles in B cell development and maturation. Soluble forms of their receptors can be generated by proteolytic cleavage; however, their physiological and ... ...

Abstract	Abstract B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) play central roles in B cell development and maturation. Soluble forms of their receptors can be generated by proteolytic cleavage; however, their physiological and clinical roles are unknown. This study aimed to assess the relationships between the receptor soluble B cell maturation antigen (sBCMA) and clinical variables in systemic lupus erythematosus (SLE) patients. Serum cytokine concentrations were measured by ELISA for 129 SLE patients and 34 healthy controls (HCs), and the expression of the receptor BCMA was evaluated on B and plasma cells from 40 subjects. SLE patients showed aberrant expression of the receptor BCMA on B and plasma cells. Soluble levels of the receptor sBCMA and its ligands sAPRIL and sBAFF were increased in SLE patients compared with HCs. Additionally, sBCMA (rs = 0.6177) and sAPRIL (rs = 0.4952) correlated strongly with disease activity. Active SLE patients who achieved low disease activity showed decreased sBCMA (53.30 vs 35.30 ng/mL; p < 0.05) and sBAFF (4.48 vs 2.27 ng/mL; p < 0.05) serum levels after treatment, while sAPRIL expression remained unchanged. At a cutoff value of 22.40 ng/mL, sAPRIL showed high sensitivity (96.12%) and specificity (94.12%) for discrimination between HCs and SLE patients, while sBAFF showed lower sensitivity (82.2%) but higher specificity (94.1%) at a cutoff of 1.195 ng/mL. Relatively high levels of sAPRIL and sBCMA clustered active SLE patients. The receptor sBCMA could be a potential biomarker of disease activity in SLE.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: Side effects of a mixture of essential oils on Psyttalia concolor.

Alves, Thiago J S / Murcia-Meseguer, Ana / Azpiazu, Celeste / Wanumen, Andrea / Wanderley-Teixeira, Valéria / Teixeira, Álvaro A C / Ortiz, Antonio / Medina, Pilar

Ecotoxicology (London, England)

2020 Volume 29, Issue 9, Page(s) 1358–1367

Abstract: Integrated Pest Management programs do not always prioritize natural enemies when selecting control methods; too often these important pest reducing agents are negatively affected by the action of other methods in agroecosystems. The aim of this research ...

Abstract	Integrated Pest Management programs do not always prioritize natural enemies when selecting control methods; too often these important pest reducing agents are negatively affected by the action of other methods in agroecosystems. The aim of this research was to evaluate side effects of a bioinsecticide, developed from the mixture of cedar (Cedrus atlantica), eucalyptus (Corymbia citriodora) and lemon grass (Cymbopogon citratus) essential oils (EOs), in a ratio of 1:1:1, on Psyttalia concolor (Szèpligeti) (Hymenoptera: Braconidae) which is a parasitoid of some pests of the Tephritidae family, as Ceratitis capitata. The LD
MeSH term(s)	Animals ; Female ; Insecta/physiology ; Male ; Oils, Volatile/toxicity ; Pest Control/methods
Chemical Substances	Oils, Volatile
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	34042-x
ISSN	1573-3017 ; 0963-9292
ISSN (online)	1573-3017
ISSN	0963-9292
DOI	10.1007/s10646-020-02258-5
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