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Article ; Online: Impact of a focused review course in cardiovascular and thoracic surgery on test performance.

Doty, John R / Nguyen, Michael / Snyder, Richard J / McCann, Ulysse G / Doty, Donald B

JTCVS open

2021 Volume 7, Page(s) 274–285

Abstract: Background: The Core Curriculum Review Course in Cardiovascular and Thoracic Surgery is a 4-day educational program consisting of 77 didactic lectures that provide a comprehensive review of the material required for surgeons preparing for the American ... ...

Abstract	Background: The Core Curriculum Review Course in Cardiovascular and Thoracic Surgery is a 4-day educational program consisting of 77 didactic lectures that provide a comprehensive review of the material required for surgeons preparing for the American Board of Thoracic Surgery competency written examination. The lectures are supplemented with a written syllabus and interactive audience participation system. We sought to determine whether participation in this course could improve participants' performance on a cardiothoracic subject-based test. Methods: Sixty-five participants attended the 2018 course. Before beginning the course lectures, a multiple-choice pretest consisting of 77 questions was administered via mobile application to gauge the participants' baseline knowledge. A second multiple-choice posttest was made available beginning 7 weeks after the course, also by mobile application. Results: Twenty-nine participants completed both the pretest and the posttest. The median pretest score was 47% (36 of 77 correct answers). The median posttest score was 61% (47 of 77 correct answers), representing an increase of 14%. The Wilcoxon signed-rank test indicated a significant difference between the pretest and posttest scores ( Conclusions: The core curriculum review course was successful in improving participants' performance on the course tests, indicating that the participants' fund of knowledge was likely increased by attendance at the program. Additional strategies should be considered to address particular areas of study both for individual participants and for residents currently in training.
Language	English
Publishing date	2021-07-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-2736
ISSN (online)	2666-2736
DOI	10.1016/j.xjon.2021.07.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Muscle Activation Patterns of the Proximal Medial and Distal Biceps Femoris and Gluteus Maximus Among 6 Hip Extension and Knee Flexion Exercises in Trained Women.

Stevens, Bryn M / Nichols, Ben R / Doty, Holly I / Korak, J Adam

International journal of exercise science

2022 Volume 15, Issue 1, Page(s) 1179–1189

Abstract: The biceps femoris (BF) is a double-jointed muscle that performs both hip extension and knee flexion, making it a challenging muscle to train during common resistance training movements. An imbalance between the posterior and anterior chain increases the ...

Abstract	The biceps femoris (BF) is a double-jointed muscle that performs both hip extension and knee flexion, making it a challenging muscle to train during common resistance training movements. An imbalance between the posterior and anterior chain increases the risk of lower-extremity injury. The purpose of this study was to compare BF proximal (BFprox), BF medial (BFmed), and BF distal (BFdist) peak and mean muscle activation among four hip hinging movements and two knee flexion movements. A secondary variable was gluteus maximus (GMax) muscle activation among the same six movements. Fifteen trained females completed three repetitions at 75% estimated 1-repetition max among the following exercises: Romanian-deadlift (RDL), step-up, hip-extension, kickbacks, Nordic hamstring curls (Nordics), and legcurls. Repetition voltage was normalized to percent maximal voluntary isometric contractions. Eight separate one-way repeated measures ANOVAs with Sidak post hoc analysis indicated the BFprox elicited greater voltage in the kickback, Nordic, and leg-curl exercise compared to the RDL, step-up and hip-extension (
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2411342-6
ISSN	1939-795X
ISSN	1939-795X
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Article: Does Self-Reassurance Reduce Neural and Self-Report Reactivity to Negative Life Events?

Kim, Jeffrey J / Doty, James R / Cunnington, Ross / Kirby, James N

Frontiers in psychology

2021 Volume 12, Page(s) 658118

Abstract: Whilst research has shown how self-criticism may increase both neural and self-report markers of negative emotion, less well-known is how self-reassurance-a compassionately-motivated cognitive self-relating style-may regulate negative emotion. Using fMRI, ...

Abstract	Whilst research has shown how self-criticism may increase both neural and self-report markers of negative emotion, less well-known is how self-reassurance-a compassionately-motivated cognitive self-relating style-may regulate negative emotion. Using fMRI, we invited participants to engage in self-criticism and self-reassurance toward written descriptions of negative life events (mistakes, setbacks, failures). Our results identify that neural markers of negative emotion and self-report markers of trial intensity during fMRI are down-regulated under conditions of self-reassurance, relative to self-criticism. Future work to control for autobiographical memory during this fMRI task is needed, as are controls for how well participants can engage in both thinking styles, to explore how memory/task engagement can contribute to self-reassurance and self-criticism. Engagement in self-reassurance can reduce the "sting" of negative life-events, both neural and self-report, which holds important implications for therapy.
Language	English
Publishing date	2021-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.658118
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Article ; Online: Unlocking Performance Excellence: Review of Evidence-Based Mindful Meditation.

Safran, Tyler / Vorstenbosch, Joshua / Doty, James R / Davison, Peter

Plastic and reconstructive surgery

2022 Volume 150, Issue 4, Page(s) 903e–908e

Abstract: Summary: Mindfulness has recently been implemented by advanced military combatants, firefighters, and those in other very intellectually demanding and fast-paced professions. A surgeon, similarly, is faced with many difficult challenges, whether it be a ...

Abstract	Summary: Mindfulness has recently been implemented by advanced military combatants, firefighters, and those in other very intellectually demanding and fast-paced professions. A surgeon, similarly, is faced with many difficult challenges, whether it be a complex and meticulous surgery, extensive clinical responsibilities, or simply the challenges faced in residency. In current curricula, there is no training to introspectively deal with these stressors. Regardless of what we face in our personal lives, the lives of patients are literately in our hands. Would it not be prudent and wise to train our brain to not only deliver care to our patients but also be able to take care of us and maybe even improve our performance? Regular practice of mindfulness has been shown to decrease rates of burnout, decrease medical errors, improve sleep, and even improve surgical performance. With the ever-changing pandemic situation and increasing stressors in the hospital, mindful meditation is perfectly primed to be added to our armamentarium as surgeons and physicians. This review aims to explain how mindfulness can enhance a surgeon's performance, mindset, interactions, and execution through a review of recent scientific advancements and evidence.
MeSH term(s)	Brain ; Burnout, Professional ; Humans ; Meditation ; Mindfulness ; Surgeons
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000009500
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 293: Show issues

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Article: Serotonin syndrome in the acute treatment landscape of migraine: the lasmiditan experience.

Blumenfeld, Andrew / Tepper, Stewart J / Khanna, Rashna / Doty, Erin / Vincent, Maurice / Miller, Sheila I

Frontiers in neurology

2023 Volume 14, Page(s) 1291102

Abstract: Background: Serotonin syndrome (SS) symptoms overlap with adverse events associated with lasmiditan, a 5-HT (serotonin): Methods: Results of eight phase 2 and phase 3 lasmiditan trials (: Results: Of 6,004 lasmiditan-treated clinical trial ... ...

Abstract	Background: Serotonin syndrome (SS) symptoms overlap with adverse events associated with lasmiditan, a 5-HT (serotonin) Methods: Results of eight phase 2 and phase 3 lasmiditan trials ( Results: Of 6,004 lasmiditan-treated clinical trial patients, 15 reported ≥1 treatment-emergent adverse event consistent with signs and symptom(s) of SS. After review, one case met Sternbach and Hunter criteria, two cases potentially met Sternbach criteria, and three cases reported as SS had limited/no information to determine if either criterion was met. During post-marketing surveillance (approximately 13,400 lasmiditan prescriptions), 17 cases with symptom complexes consistent with SS were reported; 3/17 cases had adequate case descriptions to apply predefined criteria. Of these, two met Sternbach and Hunter criteria, and one met Sternbach criteria. Conclusion: Awareness of clinical symptomatology and diagnostic criteria of SS can help clinicians with recognition of rare instances of SS that may occur with lasmiditan. Clinical trial registration: NCT03670810, NCT00384774, NCT00883051, NCT02565186.
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1291102
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Article ; Online: Evaluating Stage Motion for Automated Electron Microscopy.

Fiedler, Kevin R / Olszta, Matthew J / Yano, Kayla H / Doty, Christina / Hopkins, Derek / Akers, Sarah / Spurgeon, Steven R

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue 6, Page(s) 1931–1939

Abstract: Precise control is an essential and elusive quality of emerging self-driving transmission electron microscopes (TEMs). It is widely understood these instruments must be capable of performing rapid, high-volume, and arbitrary movements for practical self- ... ...

Abstract	Precise control is an essential and elusive quality of emerging self-driving transmission electron microscopes (TEMs). It is widely understood these instruments must be capable of performing rapid, high-volume, and arbitrary movements for practical self-driving operation. However, stage movements are difficult to automate at scale, owing to mechanical instability, hysteresis, and thermal drift. Such difficulties pose major barriers to artificial intelligence-directed microscope designs that require repeatable, precise movements. To guide design of emerging instruments, it is necessary to understand the behavior of existing mechanisms to identify rate limiting steps for full autonomy. Here, we describe a general framework to evaluate stage motion in any TEM. We define metrics to evaluate stage degrees of freedom, propose solutions to improve performance, and comment on fundamental limits to automated experimentation using present hardware.
Language	English
Publishing date	2023-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad108
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Article ; Online: The Ross operation after removal of a transcatheter aortic valve replacement in pediatric patients.

Eckhauser, Aaron W / Nonu, J Luti / Hobbs, Reilly D / Griffiths, Eric R / Husain, S Adil / Doty, John

JTCVS techniques

2022 Volume 17, Page(s) 129–132

Language	English
Publishing date	2022-12-06
Publishing country	United States
Document type	Journal Article
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2022.10.020
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Article ; Online: The Weekly Calendar Planning Activity to Assess Functional Cognition in Parkinson Disease.

Foster, Erin R / Carson, Lisa / Jonas, Jill / Kang, Eunyoung / Doty, Tasha / Toglia, Joan

OTJR : occupation, participation and health

2022 Volume 42, Issue 4, Page(s) 315–323

Abstract: The Weekly Calendar Planning Activity (WCPA) may improve understanding of functional cognition in people with Parkinson disease (PwPD) without dementia. We aimed to determine if WCPA performance (a) discriminates between PwPD with and without cognitive ... ...

Abstract	The Weekly Calendar Planning Activity (WCPA) may improve understanding of functional cognition in people with Parkinson disease (PwPD) without dementia. We aimed to determine if WCPA performance (a) discriminates between PwPD with and without cognitive impairment and healthy controls and (b) correlates with other indicators of cognition and daily function. This was a cross-sectional study. Parkinson disease (PD) participants without dementia were divided into normal cognition (PD-NC,
MeSH term(s)	Cognition ; Cross-Sectional Studies ; Dementia ; Humans ; Neuropsychological Tests ; Parkinson Disease/psychology
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2081243-7
ISSN	1938-2383 ; 1539-4492 ; 0276-1599
ISSN (online)	1938-2383
ISSN	1539-4492 ; 0276-1599
DOI	10.1177/15394492221104075
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Zs.A 1917: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Sleep duration prior to an enterotoxigenic Escherichia coli challenge predicts diarrhea severity during infection.

Mantua, Janna / Gutierrez, Ramiro L / Isidean, Sandra D / Alcala, Ashley N / Testa, Kayla J / Talaat, Kawsar R / Doty, Tracy Jill / Porter, Chad K

Sleep medicine

2022 Volume 100, Page(s) 404–409

Abstract: Background: Acute diarrhea is the most frequent diagnosis among ill travelers. Sleep loss may weaken the body's defense against pathogens and increase susceptibility to infection. The relationship between sleep and infectious diarrhea has not been ... ...

Abstract	Background: Acute diarrhea is the most frequent diagnosis among ill travelers. Sleep loss may weaken the body's defense against pathogens and increase susceptibility to infection. The relationship between sleep and infectious diarrhea has not been studied and was assessed utilizing data from a controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC). Methods: During a CHIM assessing the efficacy of an immunoprophylactic targeting ETEC against moderate-to-severe diarrhea (MSD) following challenge, we measured sleep via actigraphy over an 8-day inpatient period. We hypothesized better sleep pre-challenge would predict illness symptomatology following challenge. Results: Among 57 participants (aged 34.4 ± 8.1 years, 64% male), there was no relationship between sleep metrics and incidence of MSD. However, longer total sleep time the night preceding ETEC challenge was associated with lower maximum 24 h diarrhea volume (B = -1.80, p = 0.01) and total diarrhea volume (B = -2.45, p = 0.01). Conclusions: This novel study showed that shorter sleep duration predicted diarrhea severity over the course of an ETEC infection. Future work should experimentally manipulate sleep to further clarify its impact on diarrhea-related outcomes for ETEC and other important enteric pathogens.
MeSH term(s)	Male ; Humans ; Female ; Enterotoxigenic Escherichia coli ; Antibodies, Bacterial ; Diarrhea/prevention & control ; Escherichia coli Infections/prevention & control ; Sleep
Chemical Substances	Antibodies, Bacterial
Language	English
Publishing date	2022-09-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2022.09.008
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 635: Show issues

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Article: Feasibility of gabapentin as an intervention for neurorecovery after an acute spinal cord injury: Protocol.

Wilson, James R / Doty, Samuel / Petitt, Jordan C / El-Abtah, Mohamed / Francis, John J / Sharpe, Megan G / Kelly, Michael L / Anderson, Kim D

Frontiers in neurology

2022 Volume 13, Page(s) 1033386

Abstract: Introduction: This protocol is describing the first ever prospective, mock-efficacy, dose exploration trial design testing the feasibility of administering gabapentin in the acute setting as an intervention for neurorecovery. Gabapentin is an FDA- ... ...

Abstract	Introduction: This protocol is describing the first ever prospective, mock-efficacy, dose exploration trial design testing the feasibility of administering gabapentin in the acute setting as an intervention for neurorecovery. Gabapentin is an FDA-approved medication for treating seizures and postherpetic neuralgia and is used broadly off-label for neuropathic pain management for many conditions, including spinal cord injury. Emerging data suggests that when given early after spinal cord injury onset and in low-medium doses, gabapentin may have properties that promote recovery of neurological function. The objective of this trial is to assess the feasibility of conducting an efficacy trial in which gabapentin is started early after injury, is restricted in its dose, and is not used for pain management. Methods and analysis: Forty-two people aged 18 years or older with any level and any severity of spinal cord injury induced by a trauma will be enrolled, randomized, and have the first dose of study medication by 120 h post-injury onset. Participants will be randomly assigned to one of three groups: 600, 1,800 mg/day gabapentin, or placebo. Study medication will be given for a 90-day duration. Blinded assessments will be obtained at 7 days post-injury (baseline), 30 days post-injury (interim), after the 90-day treatment duration/approximately 3 months post-injury (end of treatment), and at 6 months post-injury (end of study). The key analysis parameters will evaluate feasibility of recruitment of target population, delivery of drug treatment protocol, maintenance of blinding, and retention of participants. Discussion: Outputs from this trial will inform research and clinical practice on the effects of manipulating gabapentin for non-pain management purposes in the acute setting and will guide the development of a properly powered efficacy trial of gabapentin as an intervention for neurorecovery in spinal cord injury. Ethics and dissemination: The study was approved by the MetroHealth Institutional Review Board (IRB21-00609) and registered at clinicaltrials.gov prior to enrolling any participants. Dissemination will include peer-reviewed publications, presentations at professional conferences and in the community, and through other healthcare and public venues. Clinical trial registration: www.ClinicalTrials.gov, identifier: NCT05302999; protocol version 1.1 approved 05/23/2022. Trial funding: National Institute on Disability, Independent Living and Rehabilitation Research.
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.1033386
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