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  1. Article ; Online: Platelet Plugs Prevent Vascular Hemorrhage at Sites of Neutrophil Diapedesis.

    Vargas, Alex / Simon, Scott I

    The Journal of investigative dermatology

    2022  Volume 142, Issue 10, Page(s) 2558–2560

    MeSH term(s) Blood Platelets ; Hemorrhage/prevention & control ; Humans ; Neutrophils ; Transendothelial and Transepithelial Migration
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of Sociodemographics and Inflation-Related Stress in the US.

    Wu, Cary / Louie, Patricia / Bierman, Alex / Schieman, Scott

    JAMA network open

    2023  Volume 6, Issue 5, Page(s) e2313431

    MeSH term(s) Humans ; Ethnicity ; White
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.13431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Conservative Management of Kienbock's Disease in a 7-year Old: A Case Report.

    Lendrum, James / Lencioni, Alex / Calkins, Ryan / Scott, Frank

    Journal of wrist surgery

    2022  Volume 12, Issue 4, Page(s) 364–367

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2678060-4
    ISSN 2163-3924 ; 2163-3916
    ISSN (online) 2163-3924
    ISSN 2163-3916
    DOI 10.1055/s-0042-1744492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Superpolynomial smoothed complexity of 3-FLIP in Local Max-Cut

    Michel, Lukas / Scott, Alex

    2023  

    Abstract: We construct a graph with $n$ vertices where the smoothed runtime of the 3-FLIP algorithm for the 3-Opt Local Max-Cut problem can be as large as $2^{\Omega(\sqrt{n})}$. This provides the first example where a local search algorithm for the Max-Cut ... ...

    Abstract We construct a graph with $n$ vertices where the smoothed runtime of the 3-FLIP algorithm for the 3-Opt Local Max-Cut problem can be as large as $2^{\Omega(\sqrt{n})}$. This provides the first example where a local search algorithm for the Max-Cut problem can fail to be efficient in the framework of smoothed analysis. We also give a new construction of graphs where the runtime of the FLIP algorithm for the Local Max-Cut problem is $2^{\Omega(n)}$ for any pivot rule. This graph is much smaller and has a simpler structure than previous constructions.

    Comment: 18 pages, 3 figures
    Keywords Computer Science - Data Structures and Algorithms ; Computer Science - Computational Complexity
    Publishing date 2023-10-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Splanchnic Vein Thrombosis: The State-of-the-Art on Anticoagulant Treatment.

    Custo, Scott / Tabone, Emma / Aquilina, Alexia / Gatt, Alex / Riva, Nicoletta

    Hamostaseologie

    2024  

    Abstract: Splanchnic vein thrombosis (SVT) is a rare type of venous thromboembolism occurring within the splanchnic venous system. Portal vein thrombosis is the most common presentation, while Budd-Chiari syndrome is the least common. Liver cirrhosis and abdominal ...

    Abstract Splanchnic vein thrombosis (SVT) is a rare type of venous thromboembolism occurring within the splanchnic venous system. Portal vein thrombosis is the most common presentation, while Budd-Chiari syndrome is the least common. Liver cirrhosis and abdominal solid cancer are the main local risk factors for SVT, whereas myeloproliferative neoplasms are the predominant systemic risk factors. Signs and symptoms of SVT are nonspecific and include abdominal pain, gastrointestinal bleeding, and ascites. Asymptomatic SVT is not uncommon, and the majority would be detected incidentally on routine abdominal imaging performed for the follow-up of liver diseases and tumors. The management of SVT aims to prevent thrombus progression, promote vessel recanalization, and prevent recurrent venous thromboembolism. Anticoagulation should be started early in order to increase the chances of vessel recanalization and reduce the risk of portal hypertension-related complications. Direct oral anticoagulants have been included in recent guidelines, as alternatives to vitamin K antagonists, after clinical stability has been reached; however, caution is required in patients with liver or kidney dysfunction. Treatment duration is based on the presence (or absence) and type (transient vs. permanent) of risk factors. This narrative review aims to summarize the latest evidence on SVT, with a particular focus on the anticoagulant treatment in special categories of patients (e.g., liver cirrhosis, solid cancer, myeloproliferative neoplasms, pancreatitis, incidentally detected SVT, Budd-Chiari syndrome, and chronic SVT).
    Language English
    Publishing date 2024-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-2232-5480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Are We Finally Ready for Total Joint Replacement of the Spine? An Extension of Charnley's Vision.

    Humphreys, S Craig / Hodges, Scott D / Sielatycki, J Alex / Sivaganesan, Ahilan / Block, Jon E

    International journal of spine surgery

    2024  Volume 18, Issue 1, Page(s) 24–31

    Abstract: Professor Sir John Charnley has been rightfully hailed as a visionary innovator for conceiving, designing, and validating ... ...

    Abstract Professor Sir John Charnley has been rightfully hailed as a visionary innovator for conceiving, designing, and validating the
    Language English
    Publishing date 2024-03-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-4599
    ISSN 2211-4599
    DOI 10.14444/8538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Individual risk evaluation for landslides: key details.

    Strouth, Alex / McDougall, Scott

    Landslides

    2022  Volume 19, Issue 4, Page(s) 977–991

    Abstract: Risk-taking is an essential part of life. As individuals, we evaluate risks intuitively and often subconsciously by comparing the perceived risks with expected benefits. We do this so commonly that it passes unnoticed, like when we decide to speed home ... ...

    Abstract Risk-taking is an essential part of life. As individuals, we evaluate risks intuitively and often subconsciously by comparing the perceived risks with expected benefits. We do this so commonly that it passes unnoticed, like when we decide to speed home from work or go for a swim. The comparison changes, however, when one entity (such as a government) imposes a risk evaluation on another person. For example, in a quantitative risk management framework, the estimated risk is compared with a tolerable risk threshold to decide if the person is 'safe enough'. Landslide risk management methods are well established and there is consensus on tolerable life-loss risk thresholds. However, beneath this consensus lie several key details that are explored by this article, along with suggestions for refinement. Specifically, we suggest using the risk unit, micromort (one micromort equals a life loss risk of 1 in 1 million), in describing risk estimates and thresholds, to improve risk communication. For risk estimation, we provide guidance for defining and combining landslide scenarios and for recognizing where unquantified risk from low-probability/high-consequence scenarios ought to inform risk management decisions. For risk tolerance thresholds, we highlight the pitfalls of selecting unachievably low thresholds and suggest that there is no single universal threshold. Additionally, we argue that
    Language English
    Publishing date 2022-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2141883-4
    ISSN 1612-5118 ; 1612-510X
    ISSN (online) 1612-5118
    ISSN 1612-510X
    DOI 10.1007/s10346-021-01838-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy: Letter to the Editor.

    Scott, Alex

    The American journal of sports medicine

    2016  Volume 44, Issue 10, Page(s) NP54–NP55

    MeSH term(s) Humans ; Platelet-Rich Plasma ; Tendinopathy ; Treatment Outcome
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/0363546516669321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development and validation of a duplex RT-qPCR assay for norovirus quantification in wastewater samples.

    Alex-Sanders, Natasha / Woodhall, Nick / Farkas, Kata / Scott, George / Jones, Davey L / Walker, David I

    Journal of virological methods

    2023  Volume 321, Page(s) 114804

    Abstract: Norovirus (NoV) is a highly contagious enteric virus that causes widespread outbreaks and a substantial number of deaths across communities. As clinical surveillance is often insufficient, wastewater-based epidemiology (WBE) may provide novel pathways of ...

    Abstract Norovirus (NoV) is a highly contagious enteric virus that causes widespread outbreaks and a substantial number of deaths across communities. As clinical surveillance is often insufficient, wastewater-based epidemiology (WBE) may provide novel pathways of tracking outbreaks. To utilise WBE, it is important to use accurate and sensitive methods for viral quantification. In this study, we developed a one-step duplex RT-qPCR assay to simultaneously test the two main human pathogenic NoV genogroups, GI and GII, in wastewater samples. The assay had low limits of detection (LOD), namely 0.52 genome copies (gc)/µl for NoVGI and 1.37 gc/µl for NoVGII. No significant concentration-dependent interactions were noted for both NoVGI and for NoVGII when the two targets were mixed at different concentrations in the samples. When tested on wastewater-derived RNA eluents, no significant difference between duplex and singleplex concentrations were found for either target. Low levels of inhibition (up to 32 %) were noted due to organic matter present in the wastewater extracts. From these results we argue that the duplex RT-qPCR assay developed enables the sensitive detection of both NoVGI and NoVGII in wastewater-derived RNA eluents, in a time and cost-effective way and may be used for surveillance to monitor public and environmental health.
    MeSH term(s) Humans ; Norovirus/genetics ; Wastewater ; Biological Assay ; Disease Outbreaks ; RNA
    Chemical Substances Wastewater ; RNA (63231-63-0)
    Language English
    Publishing date 2023-08-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2023.114804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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