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  1. Article ; Online: Mutations of Splicing Regulator RBM20 in Atrial Fibrillation.

    Pitt, Geoffrey S / Long, Yicheng

    JACC. Basic to translational science

    2024  Volume 9, Issue 2, Page(s) 181–184

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: New insights into mechanisms of Alzheimer's disease revealed by a dynamic functional magnetic resonance imaging study.

    Long, Yicheng

    Annals of translational medicine

    2021  Volume 9, Issue 12, Page(s) 1031

    Language English
    Publishing date 2021-04-20
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-21-743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: RNA-Mediated Epigenetic and Transcriptional Regulation.

    Barutcu, A Rasim / Long, Yicheng / Motamedi, Mo

    Frontiers in genetics

    2022  Volume 13, Page(s) 928335

    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.928335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vortioxetine usage in an elderly patient with major depressive disorder and accompanied by multiple physical conditions: A case report.

    Wang, Xiaoman / Ma, Xiaoqian / Long, Yicheng / Wu, Guowei

    Aging medicine (Milton (N.S.W))

    2023  Volume 6, Issue 4, Page(s) 446–449

    Abstract: Elderly patients with depressive disorder always have complex and diverse symptoms, and are mostly combined with chronic physical conditions. This case report presents a case of vortioxetine usage in a 67-year-old male patient with major depressive ... ...

    Abstract Elderly patients with depressive disorder always have complex and diverse symptoms, and are mostly combined with chronic physical conditions. This case report presents a case of vortioxetine usage in a 67-year-old male patient with major depressive disorder and accompanied by multiple physical conditions.
    Language English
    Publishing date 2023-09-12
    Publishing country Australia
    Document type Case Reports
    ISSN 2475-0360
    ISSN (online) 2475-0360
    DOI 10.1002/agm2.12268
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  5. Article: Temporal Stability of the Dynamic Resting-State Functional Brain Network: Current Measures, Clinical Research Progress, and Future Perspectives.

    Long, Yicheng / Liu, Xiawei / Liu, Zhening

    Brain sciences

    2023  Volume 13, Issue 3

    Abstract: Based on functional magnetic resonance imaging and multilayer dynamic network model, the brain network's quantified temporal stability has shown potential in predicting altered brain functions. This manuscript aims to summarize current knowledge, ... ...

    Abstract Based on functional magnetic resonance imaging and multilayer dynamic network model, the brain network's quantified temporal stability has shown potential in predicting altered brain functions. This manuscript aims to summarize current knowledge, clinical research progress, and future perspectives on brain network's temporal stability. There are a variety of widely used measures of temporal stability such as the variance/standard deviation of dynamic functional connectivity strengths, the temporal variability, the flexibility (switching rate), and the temporal clustering coefficient, while there is no consensus to date which measure is the best. The temporal stability of brain networks may be associated with several factors such as sex, age, cognitive functions, head motion, circadian rhythm, and data preprocessing/analyzing strategies, which should be considered in clinical studies. Multiple common psychiatric disorders such as schizophrenia, major depressive disorder, and bipolar disorder have been found to be related to altered temporal stability, especially during the resting state; generally, both excessively decreased and increased temporal stabilities were thought to reflect disorder-related brain dysfunctions. However, the measures of temporal stability are still far from applications in clinical diagnoses for neuropsychiatric disorders partly because of the divergent results. Further studies with larger samples and in transdiagnostic (including schizoaffective disorder) subjects are warranted.
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13030429
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  6. Article ; Online: The relations of psychotic-like experiences (PLEs) and depressive symptoms and the bias of depressive symptoms during the clustering among Chinese adolescents: Findings from the network perspective.

    Cheng, Peng / Liu, Zhening / Sun, Meng / Zhang, Wen / Guo, Rui / Hu, Aimin / Long, Yicheng

    Journal of affective disorders

    2024  Volume 350, Page(s) 867–876

    Abstract: Background: There are rare studies about the network structure of psychotic-like experiences (PLEs) and depressive symptoms among adolescents. Studies have widely acknowledged that PLEs in adolescents confer a higher risk of depressive symptoms, but the ...

    Abstract Background: There are rare studies about the network structure of psychotic-like experiences (PLEs) and depressive symptoms among adolescents. Studies have widely acknowledged that PLEs in adolescents confer a higher risk of depressive symptoms, but the complex interactions remain inadequately understood. Our study aimed to examine the hierarchy and inter-associations of PLEs and depressive symptoms in a large adolescent sample from the network analysis perspective.
    Methods: A total of 5008 Chinese adolescents were enrolled in our sample. Community Assessment of Psychic Experiences-42 (CAPE-42) was applied to build the network. Centrality indexes were calculated to represent the significance of nodes in the network. Community detection was conducted to figure out the specific clustering of nodes. Demographic information was collected for the sub-network comparisons. Accuracy and stability of the network were also tested.
    Results: "Failure", "External control", and "Lack of activity" were the most central nodes. The main bridge nodes linking PLEs and depressive symptoms were "Failure", "Guilty", and "No future". Positive PLE "Odd looks" and negative PLE "Unable to terminate" are the two PLEs that were most relevant to depressive nodes. Community detection further demonstrated the bias of depressive nodes in the data-driven clustering. Comparative sub-network analysis suggested that age was the only demographic factor related to the current network.
    Conclusion: In this study of a large adolescent sample, we first demonstrated the network structure and specific clustering preference of PLEs and depressive symptoms. Our findings may enhance the understanding of the relationship between PLE and depressive symptoms.
    MeSH term(s) Humans ; Adolescent ; Psychotic Disorders/epidemiology ; Psychotic Disorders/diagnosis ; Depression/epidemiology ; Cluster Analysis ; Asian People ; China/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools.

    Long, Yicheng / Cech, Thomas R

    Methods (San Diego, Calif.)

    2021  Volume 191, Page(s) 44–58

    Abstract: Mutagenesis studies have rapidly evolved in the era of CRISPR genome editing. Precise manipulation of genes in human induced pluripotent stem cells (iPSCs) allows biomedical researchers to study the physiological functions of individual genes during ... ...

    Abstract Mutagenesis studies have rapidly evolved in the era of CRISPR genome editing. Precise manipulation of genes in human induced pluripotent stem cells (iPSCs) allows biomedical researchers to study the physiological functions of individual genes during development. Furthermore, such genetic manipulation applied to patient-specific iPSCs allows disease modeling, drug screening and development of therapeutics. Although various genome-editing methods have been developed to introduce or remove mutations in human iPSCs, comprehensive strategic designs taking account of the potential side effects of CRISPR editing are needed. Here we present several novel and highly efficient strategies to introduce point mutations, insertions and deletions in human iPSCs, including step-by-step experimental protocols. These approaches involve the application of drug selection for effortless clone screening and the generation of a wild type control strain along with the mutant. We also present several examples of application of these strategies in human iPSCs and show that they are highly efficient and could be applied to other cell types.
    MeSH term(s) CRISPR-Cas Systems/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Gene Editing ; Humans ; Induced Pluripotent Stem Cells ; Mutagenesis
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2021.01.002
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  8. Article ; Online: MixedFusion: An Efficient Multimodal Data Fusion Framework for 3-D Object Detection and Tracking.

    Zhang, Cheng / Wang, Hai / Chen, Long / Li, Yicheng / Cai, Yingfeng

    IEEE transactions on neural networks and learning systems

    2023  Volume PP

    Abstract: The performance of environmental perception is critical for the safe driving of intelligent connected vehicles (ICVs). Currently, the most prevalent technical solutions are based on multimodal data fusion to achieve a comprehensive perception of the ... ...

    Abstract The performance of environmental perception is critical for the safe driving of intelligent connected vehicles (ICVs). Currently, the most prevalent technical solutions are based on multimodal data fusion to achieve a comprehensive perception of the surrounding environment. However, existing fusion perception methods suffer from issues such as low sensor data utilization and unreasonable fusion strategies, which severely limit their performance in adverse weather conditions. To address these issues, this article proposes a novel multimodal data fusion framework called MixedFusion. In this framework, we introduce two innovative fusion strategies for the data characteristics of each sensor: high-level semantic guidance (HLSG) and multipriority matching (MPM). It not only realizes the efficient utilization of the multimodal data but also further realizes the complementary fusion between the multimodal data. We perform extensive experiments on the nuScenes and K-radar datasets. The experimental results demonstrate that the fusion framework proposed in this article significantly improves the performance of 3-D object detection and tracking in severe weather conditions.
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3325527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: CompleteInst: An Efficient Instance Segmentation Network for Missed Detection Scene of Autonomous Driving.

    Wang, Hai / Zhu, Shilin / Chen, Long / Li, Yicheng / Luo, Tong

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 22

    Abstract: As a fundamental computer vision task, instance segmentation is widely used in the field of autonomous driving because it can perform both instance-level distinction and pixel-level segmentation. We propose CompleteInst based on QueryInst as a solution ... ...

    Abstract As a fundamental computer vision task, instance segmentation is widely used in the field of autonomous driving because it can perform both instance-level distinction and pixel-level segmentation. We propose CompleteInst based on QueryInst as a solution to the problems of missed detection with a network structure designed from the feature level and the instance level. At the feature level, we propose Global Pyramid Networks (GPN) to collect global information of missed instances. Then, we introduce the semantic branch to complete the semantic features of the missed instances. At the instance level, we implement the query-based optimal transport assignment (OTA-Query) sample allocation strategy which enhances the quality of positive samples of missed instances. Both the semantic branch and OTA-Query are parallel, meaning that there is no interference between stages, and they are compatible with the parallel supervision mechanism of QueryInst. We also compare their performance to that of non-parallel structures, highlighting the superiority of the proposed parallel structure. Experiments were conducted on the Cityscapes and COCO dataset, and the recall of CompleteInst reached 56.7% and 54.2%, a 3.5% and 3.2% improvement over the baseline, outperforming other methods.
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23229102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools

    Long, Yicheng / Cech, Thomas R.

    Methods. 2021 July, v. 191

    2021  

    Abstract: Mutagenesis studies have rapidly evolved in the era of CRISPR genome editing. Precise manipulation of genes in human induced pluripotent stem cells (iPSCs) allows biomedical researchers to study the physiological functions of individual genes during ... ...

    Abstract Mutagenesis studies have rapidly evolved in the era of CRISPR genome editing. Precise manipulation of genes in human induced pluripotent stem cells (iPSCs) allows biomedical researchers to study the physiological functions of individual genes during development. Furthermore, such genetic manipulation applied to patient-specific iPSCs allows disease modeling, drug screening and development of therapeutics. Although various genome-editing methods have been developed to introduce or remove mutations in human iPSCs, comprehensive strategic designs taking account of the potential side effects of CRISPR editing are needed. Here we present several novel and highly efficient strategies to introduce point mutations, insertions and deletions in human iPSCs, including step-by-step experimental protocols. These approaches involve the application of drug selection for effortless clone screening and the generation of a wild type control strain along with the mutant. We also present several examples of application of these strategies in human iPSCs and show that they are highly efficient and could be applied to other cell types.
    Keywords drugs ; gene editing ; humans ; mutants ; site-directed mutagenesis ; therapeutics
    Language English
    Dates of publication 2021-07
    Size p. 44-58.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2021.01.002
    Database NAL-Catalogue (AGRICOLA)

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