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  1. Book: Advanced craniomaxillofacial surgery

    Ehrenfeld, Michael / Futran, Neal D. / Manson, Paul N. / Prein, Joachim

    tumor, corrective bone surgery and trauma

    2020  

    Institution AOCMF
    Author's details AOCMF ; Michael Ehrenfeld, Neal D. Futran, Paul N. Manson, Joachim Prein
    Keywords Craniomaxillofacial Surgery ; Craniomaxillofacial ; Ehrenfeld ; Advanced ; 816 ; Mund-Kiefer und Gesichtschirurgie ; Gesichtsschädelbruch ; Osteosynthese ; Mund-Kiefer-Gesichts-Chirurgie
    Subject Mund-Kiefer-Gesichtsbereich ; Knochenfixation ; Schraubenosteosynthese ; Gesichtsschädelfraktur
    Subject code 617.156
    Language English
    Size XVIII, 730 Seiten, Illustrationen, 29 cm, 2413 g
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Accompanying material Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020860179
    ISBN 978-3-13-242839-3 ; 3-13-242839-6 ; 9783132428409 ; 313242840X
    Database Catalogue ZB MED Medicine, Health

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    2021 A 277 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline Clinical Insights.

    Saunders, Deborah / Koyfman, Shlomo A / Ismaila, Nofisat / Futran, Neal D / Mowery, Yvonne M / Watson, Erin / Yang, David H / Peterson, Douglas E

    JCO oncology practice

    2024  , Page(s) OP2400182

    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.24.00182
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  3. Article ; Online: Oncologic outcomes of salvage surgery and immune checkpoint inhibitor therapy in recurrent head and neck squamous cell carcinoma: A single-institution retrospective study.

    Konuthula, Neeraja / Do, Olivia A / Gobillot, Ted / Rodriguez, Cristina P / Futran, Neal D / Houlton, Jeffrey / Barber, Brittany R

    Head & neck

    2022  Volume 44, Issue 11, Page(s) 2465–2472

    Abstract: Background: Survival outcomes in recurrent head and neck squamous cell carcinoma (HNSCC) are poor. This study aimed to compare survival outcomes between salvage surgery and immunotherapy in patients with recurrent advanced HNSCC.: Methods: Patients ... ...

    Abstract Background: Survival outcomes in recurrent head and neck squamous cell carcinoma (HNSCC) are poor. This study aimed to compare survival outcomes between salvage surgery and immunotherapy in patients with recurrent advanced HNSCC.
    Methods: Patients with advanced stage (stage III or IV) recurrent HNSCC following treatment with platinum-based chemotherapy were included. Survival was estimated using the Kaplan-Meier method, and Cox regression was used for multivariate logistic regression.
    Results: Two-year overall survival after salvage surgery was 68.6% and after immunotherapy patients was 24.6%. Multivariate logistic regression showed that salvage surgery was associated with improved survival without statistical significance (hazard ratio [HR] 0.12, p = 0.25). Subgroup analysis of patients with oral cavity/oropharyngeal cancer noted improved survival with salvage surgery over immunotherapy (HR 0.006, p = 0.01) and decreased survival with neutrophil-to-lymphocyte ratio (NLR) > 5 (HR 6.4, p = 0.02).
    Conclusion: Our retrospective single-institutional data suggest that resectable advanced stage recurrent HNSCC may have improved survival with salvage surgery in appropriately selected patients, but larger prospective studies are required.
    MeSH term(s) Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/surgery ; Humans ; Immune Checkpoint Inhibitors ; Mouth Neoplasms/pathology ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Salvage Therapy/methods ; Squamous Cell Carcinoma of Head and Neck/therapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27162
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  4. Article ; Online: Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline.

    Peterson, Douglas E / Koyfman, Shlomo A / Yarom, Noam / Lynggaard, Charlotte Duch / Ismaila, Nofisat / Forner, Lone E / Fuller, Clifton David / Mowery, Yvonne M / Murphy, Barbara A / Watson, Erin / Yang, David H / Alajbeg, Ivan / Bossi, Paolo / Fritz, Michael / Futran, Neal D / Gelblum, Daphna Y / King, Edward / Ruggiero, Salvatore / Smith, Derek K /
    Villa, Alessandro / Wu, Jonn S / Saunders, Deborah

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  , Page(s) JCO2302750

    Abstract: Purpose: To provide evidence-based recommendations for prevention and management of osteoradionecrosis (ORN) of the jaw secondary to head and neck radiation therapy in patients with cancer.: Methods: The International Society of Oral Oncology- ... ...

    Abstract Purpose: To provide evidence-based recommendations for prevention and management of osteoradionecrosis (ORN) of the jaw secondary to head and neck radiation therapy in patients with cancer.
    Methods: The International Society of Oral Oncology-Multinational Association for Supportive Care in Cancer (ISOO-MASCC) and ASCO convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. PubMed, EMBASE, and Cochrane Library databases were searched for randomized controlled trials and observational studies, published between January 1, 2009, and December 1, 2023. The guideline also incorporated systematic reviews conducted by ISOO-MASCC, which included studies published from January 1, 1990, through December 31, 2008.
    Results: A total of 1,539 publications were initially identified. There were 487 duplicate publications, resulting in 1,052 studies screened by abstract, 104 screened by full text, and 80 included for systematic review evaluation.
    Recommendations: Due to limitations of available evidence, the guideline relied on informal consensus for some recommendations. Recommendations that were deemed evidence-based with strong evidence by the Expert Panel were those pertaining to best practices in prevention of ORN and surgical management. No recommendation was possible for the utilization of leukocyte- and platelet-rich fibrin or photobiomodulation for prevention of ORN. The use of hyperbaric oxygen in prevention and management of ORN remains largely unjustified, with limited evidence to support its practice.Additional information is available at www.asco.org/head-neck-cancer-guidelines.
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.02750
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  5. Article ; Online: Head and Neck Rhabdomyosarcoma: Clinical and Pathologic Characterization of Seven Cases.

    Chen, Eleanor / Ricciotti, Robert / Futran, Neal / Oda, Dolphine

    Head and neck pathology

    2016  Volume 11, Issue 3, Page(s) 321–326

    Abstract: Head and neck rhabdomyosarcoma occurs frequently in children and adolescents, and has been well studied in that population. In contrast, it is rare in adults and is not as well characterized clinically and pathologically. Seven cases of adult ... ...

    Abstract Head and neck rhabdomyosarcoma occurs frequently in children and adolescents, and has been well studied in that population. In contrast, it is rare in adults and is not as well characterized clinically and pathologically. Seven cases of adult rhabdomyosarcoma occurring in head and neck were retrieved from the archives of Department of Pathology and Division of Oral Pathology at University of Washington. Radiologic findings and clinical history, as well as pathologic findings from hematoxylin and eosin slides and immunohistochemistry for myogenic markers were reviewed. A total of seven cases of rhabdomyosarcoma (two embryonal, three alveolar and two pleomorphic subtype) were reviewed. Patient ages ranged from 18 to 57 years (median 21 years). Classic and unique histologic features for each subtype, including post-treatment morphologic changes, were identified. Clinical follow-up information was available for 4 patients. 3 of 4 patients experienced recurrence, including two with distant metastasis. One patient died of disease progression 41 months after presentation. Head and neck rhabdomyosarcoma in adults can manifest both classic and unique histologic features for each subtype. In addition, recurrence and distant metastasis were observed, suggesting aggressive clinical behavior regardless of subtype.
    MeSH term(s) Adolescent ; Adult ; Female ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Rhabdomyosarcoma/pathology ; Young Adult
    Language English
    Publishing date 2016-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-016-0771-0
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  6. Article ; Online: New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2022.

    Wu, Franklin M / Gorelik, Daniel / Brenner, Michael J / Takashima, Masayoshi / Goyal, Amit / Kita, Ashley E / Rose, Austin S / Hong, Robert S / Abuzeid, Waleed M / Maria, Peter S / Al-Sayed, Ahmed A / Dunham, Michael E / Kadkade, Prajoy / Schaffer, Scott R / Johnson, Alan W / Eshraghi, Adrien A / Samargandy, Shireen / Morrison, Robert J / Weissbrod, Philip A /
    Mitchell, Margaret B / Rabbani, Cyrus C / Futran, Neil / Ahmed, Omar G

    OTO open

    2024  Volume 8, Issue 1, Page(s) e105

    Abstract: Objective: To review new drugs and devices relevant to otolaryngology approved by the Food and Drug Administration (FDA) in 2022.: Data sources: Publicly available FDA data on drugs and devices approved in 2022.: Review methods: A preliminary ... ...

    Abstract Objective: To review new drugs and devices relevant to otolaryngology approved by the Food and Drug Administration (FDA) in 2022.
    Data sources: Publicly available FDA data on drugs and devices approved in 2022.
    Review methods: A preliminary screen was conducted to identify drugs and devices relevant to otolaryngology. A secondary screen by members of the American Academy of Otolaryngology-Head and Neck Surgery's (AAO-HNS) Medical Devices and Drugs Committee differentiated between minor updates and new approvals. The final list of drugs and devices was sent to members of each subspecialty for review and analysis.
    Conclusion: A total of 1251 devices and 37 drugs were identified on preliminary screening. Of these, 329 devices and 5 drugs were sent to subspecialists for further review, from which 37 devices and 2 novel drugs were selected for further analysis. The newly approved devices spanned all subspecialties within otolaryngology. Many of the newly approved devices aimed to enhance patient experience, including over-the-counter hearing aids, sleep monitoring devices, and refined CPAP devices. Other advances aimed to improve surgical access, convenience, or comfort in the operating room and clinic.
    Implications for practice: Many new devices and drugs are approved each year to improve patient care and care delivery. By staying up to date with these advances, otolaryngologists can leverage new innovations to improve the safety and quality of care. Given the recent approval of these devices, further studies are needed to assess long-term impact within the field of otolaryngology.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 2473-974X
    ISSN (online) 2473-974X
    DOI 10.1002/oto2.105
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  7. Article: Retrospective case series of primary and secondary microvascular free tissue transfer reconstruction of midfacial defects.

    Futran, N D

    The Journal of prosthetic dentistry

    2001  Volume 86, Issue 4, Page(s) 369–376

    Abstract: Statement of problem: Midfacial defects arising from tumor extirpation or trauma may involve any portion of the central area of the face, including the palate, maxilla, orbit, lip, and/or nose. Speech, mastication, swallowing, and cosmesis are ... ...

    Abstract Statement of problem: Midfacial defects arising from tumor extirpation or trauma may involve any portion of the central area of the face, including the palate, maxilla, orbit, lip, and/or nose. Speech, mastication, swallowing, and cosmesis are significantly impaired and present a unique challenge to the reconstructive surgeon.
    Purpose: This study evaluated the functional and cosmetic success of both soft tissue and osteocutaneous free flap reconstruction of the midface.
    Material and methods: A retrospective chart review of 34 patients who underwent primary and secondary free flap reconstruction of the midface was conducted. The main outcome measures were perioperative complications, diet, speech intelligibility, type of dental restoration, and cosmetic result.
    Results: Fifteen patients underwent soft tissue free flap reconstruction of the midface. Six of these patients also had additional nonvascularized free cranial bone grafts to improve restoration of the orbitozygomatic region. Nineteen patients who might have required osseointegrated implants to anchor a dental prosthesis underwent osteocutaneous free flap reconstruction. Thirty-three of 34 free flaps survived, and wound complications were minimal. After surgery, 20 patients were able to eat a regular diet and 14 a soft diet. All patients had intelligible speech over the telephone. Ten patients used a dental prosthesis (5 conventional and 5 implant-borne). Cosmesis was judged to be excellent in 12 patients, good in 15 patients, fair in 5 patients, and poor in 2 patients.
    Conclusion: In the patients reviewed, free flap reconstruction of the midface was completed in a single stage and created a reproducible, permanent separation of the oral and sinonasal cavities with adequate speech and swallowing.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Transplantation ; Deglutition/physiology ; Dental Implantation, Endosseous ; Dental Prosthesis, Implant-Supported ; Dental Restoration, Permanent ; Diet ; Esthetics ; Face/surgery ; Facial Bones/surgery ; Female ; Humans ; Intraoperative Complications ; Male ; Mastication/physiology ; Microsurgery ; Middle Aged ; Nasal Cavity/surgery ; Orbit/surgery ; Paranasal Sinuses/surgery ; Postoperative Complications ; Retrospective Studies ; Skin Transplantation ; Speech/physiology ; Speech Intelligibility ; Surgical Flaps ; Treatment Outcome ; Zygoma/surgery
    Language English
    Publishing date 2001-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1067/mpr.2001.118875
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  8. Article ; Online: Trends in Positive Surgical Margins in cT1-T2 Oral Cavity Squamous Cell Carcinoma.

    Robinson, Emily M / Lam, Austin S / Solomon, Isaac / Brady, Jacob S / Pang, John / Faraji, Farhoud / Houlton, Jeffrey J / Futran, Neal D / Barber, Brittany R

    The Laryngoscope

    2022  Volume 132, Issue 10, Page(s) 1962–1970

    Abstract: ... clinical T and N category, presence of lymphovascular invasion, and histologic grade were independent ...

    Abstract Objectives/hypothesis: To evaluate trends in contemporary positive surgical margin incidence in cT1-T2 oral cavity squamous cell carcinoma and to evaluate factors associated with surgical margin status.
    Study design: Retrospective analysis of large dataset.
    Methods: Retrospective analysis of the National Cancer Database.
    Results: Between 2004 and 2016, 39,818 patients with cT1 or cT2 oral cavity squamous cell carcinoma received primary curative-intent surgery. Positive surgical margins were present in 7.95% of patients, and univariable adjusted probability of positive surgical margins over the study period declined by 1% per year (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.0; P = .049). Multivariable regression revealed the annual rate of positive surgical margins declined significantly (OR, 0.95 per year; 95% CI, 0.92-0.97; P < .001). Factors associated with increased odds of positive surgical margins included cT2 disease, subsite, understaged disease, lymphovascular invasion, tumor grade, and positive lymph nodes. Race and socioeconomic status were not associated with surgical margin status. Treatment at an academic center was associated with increased time to definitive surgery (median 35 days IQR 22-50 vs. median 27 days IQR 14-42; P < .001) and a 20% reduction in positive surgical margin rate (OR, 0.80; 95% CI, 0.71-0.90; P < .001). Treatment at high-volume centers was less likely to be associated with positive surgical margins (OR, 0.85; 95% CI, 0.74-0.98; P = .02).
    Conclusion: Surgical subsite, clinical T and N category, presence of lymphovascular invasion, and histologic grade were independent predictors of positive surgical margins. Patients are increasingly being treated at high-volume and academic centers. Overall, the rate of positive surgical margins in cT1-T2 oral cavity squamous cell carcinoma is decreasing.
    Level of evidence: 4 Laryngoscope, 132:1962-1970, 2022.
    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Head and Neck Neoplasms/pathology ; Humans ; Margins of Excision ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/pathology
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30033
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  9. Article ; Online: Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer.

    Galeano Niño, Jorge Luis / Wu, Hanrui / LaCourse, Kaitlyn D / Kempchinsky, Andrew G / Baryiames, Alexander / Barber, Brittany / Futran, Neal / Houlton, Jeffrey / Sather, Cassie / Sicinska, Ewa / Taylor, Alison / Minot, Samuel S / Johnston, Christopher D / Bullman, Susan

    Nature

    2022  Volume 611, Issue 7937, Page(s) 810–817

    Abstract: The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer ... ...

    Abstract The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types
    MeSH term(s) Humans ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/immunology ; Carcinoma, Squamous Cell/microbiology ; Carcinoma, Squamous Cell/pathology ; Microbiota/genetics ; Microbiota/immunology ; Microbiota/physiology ; Mouth Neoplasms/genetics ; Mouth Neoplasms/immunology ; Mouth Neoplasms/microbiology ; Mouth Neoplasms/pathology ; Myeloid Cells/immunology ; Tumor Microenvironment ; Host Microbial Interactions/genetics ; Host Microbial Interactions/immunology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/pathology ; Sequence Analysis, RNA ; Gene Expression Profiling ; Ki-67 Antigen/metabolism ; Disease Progression
    Chemical Substances Ki-67 Antigen
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-05435-0
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  10. Article ; Online: Timing of postoperative radiation therapy and survival in resected salivary gland cancers: Long-term results from a single institution.

    Romine, Perrin E / Voutsinas, Jenna / Wu, Vicky / Tratt, Micah / Liao, Jay / Parvathaneni, Upendra / Barber, Brittany / Dillon, Jasjit / Timoshchuk, Mari-Alina / Futran, Neal / Houlton, Jeffrey / Laramore, George / Martins, Renato / Eaton, Keith D / Rodriguez, Cristina

    Oral oncology

    2021  Volume 123, Page(s) 105626

    Abstract: Objectives: Timely administration of postoperative radiation therapy (PORT) impacts oncologic outcomes in resected squamous cell carcinomas of the head and neck. Salivary gland cancers (SGCs) are uncommon, and timing of PORT has not been extensively ... ...

    Abstract Objectives: Timely administration of postoperative radiation therapy (PORT) impacts oncologic outcomes in resected squamous cell carcinomas of the head and neck. Salivary gland cancers (SGCs) are uncommon, and timing of PORT has not been extensively explored. We aimed to determine if the interval between surgery and PORT impacts outcomes in SGCs.
    Materials and methods: This is a retrospective study of patients with SGCs who underwent curative intent surgical resection followed by adjuvant PORT. Locoregional recurrence free survival (LRFS), disease free survival (DFS), and overall survival (OS) were estimated using the Kaplan Meier method. A multivariate analysis explored the association between demographics, tumor characteristics, and PORT timing with oncologic outcomes using a stepwise Cox proportional hazards model.
    Results: 180 eligible patients were identified. The median time to PORT start was 61 (range 8-121) days. 169 (93.5%) of patients received neutron radiation. With a median follow up of 8.2 years in surviving patients, the 10-year OS and LRFS estimates were 61% and 53%. In a multivariate analysis, nodal involvement, histologic grade, and age at diagnosis were associated with OS, while nodal involvement, tumor size, and age at diagnosis were associated with LRFS and DFS. Time to PORT start or completion was not statistically associated with survival outcomes.
    Conclusion: SGC patients who underwent surgery in our tertiary institution received PORT within a median of 61 days after surgery. With long term follow up, PORT timing in this retrospective series was not associated with worse oncologic outcomes, and support timely administration of PORT.
    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Disease-Free Survival ; Humans ; Neoplasm Staging ; Radiotherapy, Adjuvant ; Retrospective Studies ; Salivary Gland Neoplasms/radiotherapy ; Salivary Gland Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2021.105626
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