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  1. Article: [

    Zhang, Lei / Wang, Jun-Yi / He, Xiang / Wu, Min / Li, Guo-Ping / Vincent, Kam-Wai-Wong

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2024  Volume 46, Issue 1, Page(s) 1–10

    Abstract: Objective To investigate the impact ... ...

    Abstract Objective To investigate the impact of
    MeSH term(s) Humans ; Animals ; Mice ; Endothelial Cells ; Pseudomonas aeruginosa ; Calcium ; Pseudomonas Infections ; Transcription Factors ; Lung ; Pneumonia ; Lactates ; RNA, Messenger
    Chemical Substances Calcium (SY7Q814VUP) ; Transcription Factors ; Lactates ; RNA, Messenger
    Language Chinese
    Publishing date 2024-03-04
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response to Letter to the Editor: Nasal nitric oxide and chronic rhinosinusitis with nasal polyps: Is it a matter of inflammation or mechanical obstruction?

    Wu, Vincent / Lee, John M

    International forum of allergy & rhinology

    2023  Volume 13, Issue 12, Page(s) 2268

    MeSH term(s) Humans ; Nasal Polyps ; Nitric Oxide ; Inflammation ; Sinusitis ; Nose
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dissecting host-microbiome interaction effects on phytoplankton microbiome composition and diversity.

    Yang, Jinny Wu / Denef, Vincent J

    Environmental microbiology

    2024  Volume 26, Issue 2, Page(s) e16585

    Abstract: Phytoplankton and their associated microbiomes of heterotrophic bacteria are foundational to primary production, energy transfer, and biogeochemical cycling in aquatic systems. While it is known that these microbiomes are shaped by host-released ... ...

    Abstract Phytoplankton and their associated microbiomes of heterotrophic bacteria are foundational to primary production, energy transfer, and biogeochemical cycling in aquatic systems. While it is known that these microbiomes are shaped by host-released dissolved organic matter (DOM), the extent to which dynamic phytoplankton-bacteria interactions shape bacterial community assembly remains to be examined. Here, we investigated the effects of two mechanisms in host-microbiome interactions on phytoplankton bacterial microbiome formation: (i) innate host selection and (ii) host-microbiome feedback. For the former, phytoplankton-produced DOM composition is based solely on the host's properties (species or physiological state); for the latter, the presence of the microbiome modifies host DOM production. The microbiome of Chlorella sorokiniana was extracted and exposed to six ratios of the two effects. We found that microbiome composition changed along with the six host-microbiome feedback versus innate host selection ratios, with the highest compositional distance between communities under the strongest and the weakest ratio of the two effects. This indicates that each mechanism selects for different bacterial species. In addition, our findings showed that when both selective forces were applied, it led to a higher community richness, while host-microbiome feedback alone reduces community evenness due to its strong species-specific selection.
    MeSH term(s) Phytoplankton/microbiology ; Chlorella ; Microbiota/physiology ; Bacteria/genetics ; Heterotrophic Processes
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.16585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Planar Rooted Phylogenetic Networks.

    Moulton, Vincent / Wu, Taoyang

    IEEE/ACM transactions on computational biology and bioinformatics

    2023  Volume 20, Issue 2, Page(s) 1289–1297

    Abstract: A rooted phylogenetic network is a directed acyclic graph with a single root, whose sinks correspond to a set of species. As such networks are useful for representing the evolution of species that have undergone reticulate evolution, there has been great ...

    Abstract A rooted phylogenetic network is a directed acyclic graph with a single root, whose sinks correspond to a set of species. As such networks are useful for representing the evolution of species that have undergone reticulate evolution, there has been great interest in developing the theory behind and algorithms for constructing them. However, unlike evolutionary trees, these networks can be highly non-planar, which can make them difficult to visualise and interpret. Here we investigate properties of planar rooted phylogenetic networks and algorithms for deciding whether or not rooted networks have certain special planarity properties. In particular, we introduce three natural subclasses of planar rooted phylogenetic networks and show that they form a hierarchy. In addition, for the well-known level- k networks, we show that level-1, -2, -3 networks are always outer, terminal, and upward planar, respectively, and that level-4 networks are not necessarily planar. Finally, we show that a regular network is terminal planar if and only if it is pyramidal. Our results make use of the highly developed field of planar digraphs, and we believe that the link between phylogenetic networks and planar graphs should prove useful in future for developing new approaches to both construct and visualise phylogenetic networks.
    MeSH term(s) Phylogeny ; Algorithms
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1557-9964
    ISSN (online) 1557-9964
    DOI 10.1109/TCBB.2022.3185670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Idiopathic Slow Transit Constipation: Pathophysiology, Diagnosis, and Management.

    Vlismas, Luke J / Wu, William / Ho, Vincent

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 1

    Abstract: Slow transit constipation (STC) has an estimated prevalence of 2-4% of the general population, and although it is the least prevalent of the chronic constipation phenotypes, it more commonly causes refractory symptoms and is associated with significant ... ...

    Abstract Slow transit constipation (STC) has an estimated prevalence of 2-4% of the general population, and although it is the least prevalent of the chronic constipation phenotypes, it more commonly causes refractory symptoms and is associated with significant psychosocial stress, poor quality of life, and high healthcare costs. This review provides an overview of the pathophysiology, diagnosis, and management options in STC. STC occurs due to colonic dysmotility and is thought to be a neuromuscular disorder of the colon. Several pathophysiologic features have been observed in STC, including reduced contractions on manometry, delayed emptying on transit studies, reduced numbers of interstitial cells of Cajal on histology, and reduced amounts of excitatory neurotransmitters within myenteric plexuses. The underlying aetiology is uncertain, but autoimmune and hormonal mechanisms have been hypothesised. Diagnosing STC may be challenging, and there is substantial overlap with the other clinical constipation phenotypes. Prior to making a diagnosis of STC, other primary constipation phenotypes and secondary causes of constipation need to be ruled out. An assessment of colonic transit time is required for the diagnosis and can be performed by a number of different methods. There are several different management options for constipation, including lifestyle, dietary, pharmacologic, interventional, and surgical. The effectiveness of the available therapies in STC differs from that of the other constipation phenotypes, and prokinetics often make up the mainstay for those who fail standard laxatives. There are few available management options for patients with medically refractory STC, but patients may respond well to surgical intervention. STC is a common condition associated with a significant burden of disease. It can present a clinical challenge, but a structured approach to the diagnosis and management can be of great value to the clinician. There are many therapeutic options available, with some having more benefits than others.
    MeSH term(s) Humans ; Quality of Life ; Constipation/diagnosis ; Constipation/therapy ; Health Care Costs ; Histological Techniques ; Interstitial Cells of Cajal
    Language English
    Publishing date 2024-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Precision Oncology in Breast Cancer Surgery.

    Abbasi, Ali Benjamin / Wu, Vincent / Lang, Julie E / Esserman, Laura J

    Surgical oncology clinics of North America

    2024  Volume 33, Issue 2, Page(s) 293–310

    Abstract: Outcomes for patients with breast cancer have improved over time due to increased screening and the availability of more effective therapies. It is important to recognize that breast cancer is a heterogeneous disease that requires treatment based on ... ...

    Abstract Outcomes for patients with breast cancer have improved over time due to increased screening and the availability of more effective therapies. It is important to recognize that breast cancer is a heterogeneous disease that requires treatment based on molecular characteristics. Early endpoints such as pathologic complete response correlate with event-free survival, allowing the opportunity to consider de-escalation of certain cancer treatments to avoid overtreatment. This article discusses clinical trials of tailoring treatment (eg, I-SPY2) and screening (eg, WISDOM) to individual patients based on their unique risk features.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Precision Medicine ; Medical Oncology ; Risk Factors
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Association of Longitudinal Changes in Cerebral Microstructure with Cognitive Functioning in Breast Cancer Survivors after Adjuvant Chemotherapy.

    Chen, Vincent Chin-Hung / Wu, Yi-Fang / Tsai, Yuan-Hsiung / Weng, Jun-Cheng

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Thoracoscopic Excision of Mediastinal Bronchogenic Cysts in Children: A Case Series.

    Schmoke, Nicholas / Porigow, Chloe / Wu, Yeu Sanz / Alexander, Matthew / Chalphin, Alexander V / Rothenberg, Steven / Duron, Vincent

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0385
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  9. Article ; Online: Recurrent Arciform Plaque on the Face.

    Ho, Bao Vincent K / Wu, Dominic / Prouty, Megan

    Cutis

    2022  Volume 109, Issue 5, Page(s) E13–E15

    MeSH term(s) Humans ; Skin Abnormalities
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SMR peptide antagonizes

    Huang, Ming-Bo / Brena, Dara / Wu, Jennifer Y / Shelton, Martin / Bond, Vincent C

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0258323

    Abstract: The emergence and international dissemination of multi-drug ... ...

    Abstract The emergence and international dissemination of multi-drug resistant
    MeSH term(s) Humans ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Staphylococcal Infections/microbiology ; Biofilms ; Peptides/pharmacology ; Molecular Chaperones ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Peptides ; Molecular Chaperones
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02583-23
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