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  1. Article: Selpercatinib in patients with

    Stinchcombe, Thomas E

    Translational lung cancer research

    2023  Volume 12, Issue 7, Page(s) 1655–1657

    Language English
    Publishing date 2023-05-23
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Flashback Foreword: Cisplatin/Pemetrexed in Non-Small-Cell Lung Cancer.

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 14, Page(s) 2455–2456

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Pemetrexed/therapeutic use ; Cisplatin/therapeutic use ; Lung Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Treatment Outcome
    Chemical Substances Pemetrexed (04Q9AIZ7NO) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  3. Article ; Online: Flashback Foreword: Bevacizumab + Carboplatin/Paclitaxel in NSCLC.

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 13, Page(s) 2303–2304

    MeSH term(s) Humans ; Bevacizumab/therapeutic use ; Carboplatin/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Paclitaxel/therapeutic use ; Lung Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  4. Article ; Online: Flashback Foreword: Pemetrexed and Cisplatin in Mesothelioma.

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 12, Page(s) 2123–2124

    MeSH term(s) Humans ; Cisplatin/therapeutic use ; Pemetrexed/therapeutic use ; Mesothelioma, Malignant ; Mesothelioma/drug therapy ; Pleural Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols ; Lung Neoplasms/drug therapy
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Pemetrexed (04Q9AIZ7NO)
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  5. Article ; Online: Flashback Foreword: Gefitinib in Non-Small-Cell Lung Cancer: The IDEAL 1 Trial.

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 6, Page(s) 1159–1160

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Gefitinib/therapeutic use ; Lung Neoplasms/drug therapy ; Methacrylates/therapeutic use ; Antineoplastic Agents/therapeutic use
    Chemical Substances Gefitinib (S65743JHBS) ; High-Q-Bond ; Methacrylates ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  6. Article ; Online: Flashback Foreword: Docetaxel Versus Best Supportive Care in Non-Small-Cell Lung Cancer and Pemetrexed Versus Docetaxel in Second-Line Non-Small-Cell Lung Cancer.

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 15, Page(s) 2671–2672

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Pemetrexed/therapeutic use ; Docetaxel/therapeutic use ; Lung Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Treatment Outcome ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Pemetrexed (04Q9AIZ7NO) ; Docetaxel (15H5577CQD) ; Antineoplastic Agents
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  7. Article ; Online: Flashback Foreword: Afatinib for the Treatment of Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer.

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 16, Page(s) 2867–2868

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Afatinib/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Protein Kinase Inhibitors/therapeutic use ; Mutation ; ErbB Receptors/genetics
    Chemical Substances Afatinib (41UD74L59M) ; Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  8. Article ; Online: Encorafenib and Binimetinib: A New Treatment Option for

    Stinchcombe, Thomas E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 21, Page(s) 3679–3681

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cetuximab/therapeutic use ; Colorectal Neoplasms/drug therapy
    Chemical Substances encorafenib (8L7891MRB6) ; binimetinib (181R97MR71) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Cetuximab (PQX0D8J21J) ; BRAF protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  9. Article: Narrative review: blood and tumor biomarker testing in non-small cell lung cancer without an oncogenic driver.

    Stinchcombe, Thomas E

    Translational lung cancer research

    2023  Volume 12, Issue 1, Page(s) 158–167

    Abstract: Background and objective: For patients with metastatic non-small cell lung cancer (NSCLC) without an oncogenic driver, systemic therapy with immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy have significantly improved the ... ...

    Abstract Background and objective: For patients with metastatic non-small cell lung cancer (NSCLC) without an oncogenic driver, systemic therapy with immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy have significantly improved the outcomes. However, the majority of patients do not have a durable response, and there is a need for additional predictive biomarkers. The objective of this narrative review is to describe potential biomarkers for immunotherapy.
    Methods: Narrative overview of the literature synthesizing the findings of literature reporting retrospective, prospective, and subset analyses of studies investigating potential predictive biomarkers for ICI.
    Key content and findings: Tumor expression of programmed death ligand-1 (PD-L1) is the only clinically available biomarker for patients receiving ICI-based therapy. However, PD-L1 has significant limitations and studies have investigated the predictive value of higher PD-L1 expression levels. There has been interest in tumor mutation burden (TMB) based on the premise that a higher TMB would be associated with a more neoantigens, which would increase the likelihood of an immune response. The studies to date have not revealed a consistent association with TMB level and survival benefit. Kelch-like ECH Associated Protein 1 (
    Conclusions: None of the current biomarkers in development are validated for use in routine clinical care. Given the complexity of NSCLC biology and immune response to ICI most likely a composite biomarker using multiple biomarkers will need to be develop.
    Language English
    Publishing date 2023-01-16
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-22-530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Current management of

    Stinchcombe, Thomas E

    Therapeutic advances in medical oncology

    2020  Volume 12, Page(s) 1758835920928634

    Abstract: The identification of oncogenic drivers, and the subsequent development of targeted therapies established biomarker-based care for metastatic non-small cell lung cancer (NSCLC). Biomarker testing is standard of care in NSCLC patients with adenocarcinoma ... ...

    Abstract The identification of oncogenic drivers, and the subsequent development of targeted therapies established biomarker-based care for metastatic non-small cell lung cancer (NSCLC). Biomarker testing is standard of care in NSCLC patients with adenocarcinoma because multiple targeted therapies are available. Rearranged during transfection (
    Language English
    Publishing date 2020-07-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/1758835920928634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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