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  1. Article ; Online: Implementation of a novel color additive for bleach disinfectant wipes enhances cleaning performance in an academic medical center.

    Tyan, Kevin / Kang, Jason

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 12, Page(s) 2089–2091

    Abstract: Effective hospital environmental cleaning requires proper technique and training. Highlight is a novel additive that colorizes bleach wipes to help visualize wiped surfaces and fades to colorless to confirm effective cleaning. In a 401-bed hospital study, ...

    Abstract Effective hospital environmental cleaning requires proper technique and training. Highlight is a novel additive that colorizes bleach wipes to help visualize wiped surfaces and fades to colorless to confirm effective cleaning. In a 401-bed hospital study, Highlight reduced fluorescent marker removal failure rates from a baseline of 12.4% to 0.6%.
    MeSH term(s) Humans ; Disinfectants/pharmacology ; Disinfection/methods ; Anti-Infective Agents ; Hospitals ; Academic Medical Centers
    Chemical Substances Disinfectants ; Anti-Infective Agents
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.61
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1714: Show issues Location:
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  2. Article ; Online: Private Equity Acquisition of Oncology Clinics in the US From 2003 to 2022.

    Tyan, Kevin / Lam, Miranda B / Milligan, Michael

    JAMA internal medicine

    2023  Volume 183, Issue 6, Page(s) 621–623

    MeSH term(s) Humans ; Delivery of Health Care ; Ambulatory Care Facilities
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.0334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Investing in Our First Line of Defense: Environmental Services Workers.

    Tyan, Kevin / Cohen, Pieter A

    Annals of internal medicine

    2020  Volume 173, Issue 4, Page(s) 306–307

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Cross Infection/prevention & control ; Disinfection/standards ; Health Facility Environment/standards ; Housekeeping, Hospital/organization & administration ; Humans ; Infection Control/standards ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Editorial ; Video-Audio Media
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-2237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Antibiotic prescribing practices for treating uncomplicated UTIs at a hospital ED.

    Fasig, Karina / Tyan, Kevin / Mason, Whitney / Zdziarski-Horodyski, Laura / Baker, Alden / Coombs, Jennifer

    JAAPA : official journal of the American Academy of Physician Assistants

    2023  Volume 36, Issue 12, Page(s) 1

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/complications ; Hospitals ; Emergency Service, Hospital ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2415226-2
    ISSN 0893-7400 ; 1547-1896
    ISSN (online) 0893-7400
    ISSN 1547-1896
    DOI 10.1097/01.JAA.0000994960.35397.82
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Shear Decline.

    Ostrominski, John W / Vaidya, Anand / Parnes, Aric D / Tyan, Kevin / Tsai, Frederick D

    The New England journal of medicine

    2022  Volume 387, Issue 17, Page(s) e41

    MeSH term(s) Humans ; Endothelium, Vascular ; Stress, Mechanical
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMimc2117464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A novel color additive for bleach wipes indicates surface coverage and contact time to improve thoroughness of cleaning.

    Tyan, Kevin / Jin, Katherine / Kang, Jason

    Infection control and hospital epidemiology

    2018  Volume 40, Issue 2, Page(s) 256–258

    MeSH term(s) Anti-Infective Agents ; Clostridium Infections/prevention & control ; Clostridium difficile/drug effects ; Coloring Agents ; Cross Infection/prevention & control ; Housekeeping, Hospital/methods ; Humans ; Infection Control/instrumentation ; Infection Control/methods
    Chemical Substances Anti-Infective Agents ; Coloring Agents
    Language English
    Publishing date 2018-12-07
    Publishing country United States
    Document type Letter
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2018.323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1714: Show issues Location:
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  8. Article ; Online: Multiple high-grade and rare immune-related adverse events in a colon cancer patient with genomic and cytokine profiling.

    Tyan, Kevin / Abu-Shawer, Osama / Baginska, Joanna / Severgnini, Mariano / Manos, Michael / Vaitkevicius, Henrikas / Grover, Shilpa / Hodi, F Stephen / Rahma, Osama E

    Immunotherapy

    2022  Volume 14, Issue 11, Page(s) 843–850

    Abstract: We report a case of multiple high-grade and rare immune-related adverse events (irAEs) in a patient with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). A middle-aged MSI-H mCRC patient with metastases to the lungs and lymph ... ...

    Abstract We report a case of multiple high-grade and rare immune-related adverse events (irAEs) in a patient with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). A middle-aged MSI-H mCRC patient with metastases to the lungs and lymph nodes received several lines of chemotherapy and immunotherapy and developed five different high-grade irAEs during immunotherapy, including lymphadenitis, pneumonitis, hypophysitis, thyroiditis and transverse myelitis. Genomic profiling revealed high tumor mutational burden of 43 Muts/Mb. Cytokine profiling showed a threefold increase in MMP-9 shortly prior to the onset of lymphadenitis and a fourfold increase of Ang-1 1 week after the resolution of lymphadenitis. Further studies are warranted to investigate the association of MSI-H mCRC with irAEs and the role of cytokines in predicting irAEs.
    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; Colonic Neoplasms/drug therapy ; Cytokines ; Genomics ; Humans ; Immune System Diseases ; Immunotherapy/adverse effects ; Lymphadenitis/chemically induced ; Middle Aged ; Programmed Cell Death 1 Receptor ; Retrospective Studies
    Chemical Substances Antineoplastic Agents, Immunological ; Cytokines ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2021-0298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Novel color additive for chlorine disinfectants corrects deficiencies in spray surface coverage and wet-contact time and checks for correct chlorine concentration.

    Tyan, Kevin / Jin, Katherine / Kang, Jason / Kyle, Aaron M

    American journal of infection control

    2018  Volume 46, Issue 10, Page(s) 1188–1191

    Abstract: Bleach sprays suffer from poor surface coverage, dry out before reaching proper contact time, and can be inadvertently over-diluted to ineffective concentrations. ... ...

    Abstract Bleach sprays suffer from poor surface coverage, dry out before reaching proper contact time, and can be inadvertently over-diluted to ineffective concentrations. Highlight
    MeSH term(s) Chlorine/chemistry ; Chlorine/pharmacology ; Coloring Agents/chemistry ; Disinfectants/chemistry ; Disinfection ; Health Facility Environment ; Sodium Hypochlorite/chemistry ; Surface Properties
    Chemical Substances Coloring Agents ; Disinfectants ; Chlorine (4R7X1O2820) ; Sodium Hypochlorite (DY38VHM5OD)
    Language English
    Publishing date 2018-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2018.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1773: Show issues Location:
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  10. Article ; Online: A multiphase intervention of novel color additive for bleach disinfectant wipes improves thoroughness of cleaning in an academic medical center.

    Tyan, Kevin / Zuckerman, Jerry M / Cutler, Constance / Modupe, Kunle / Ray, Dennis / Marmolejo, Luis / Kang, Jason

    American journal of infection control

    2021  Volume 50, Issue 4, Page(s) 469–472

    Abstract: Surface disinfection is critical for preventing health care-associated infections; however, sustaining high-quality cleaning technique is challenging without constant feedback and training of staff. A novel color additive to bleach wipes, Highlight, ... ...

    Abstract Surface disinfection is critical for preventing health care-associated infections; however, sustaining high-quality cleaning technique is challenging without constant feedback and training of staff. A novel color additive to bleach wipes, Highlight, indicates where surfaces have been wiped and fades to colorless to provide real-time visual feedback of cleaning. In a multiphase interventional study, Highlight reduced failure rates of cleaning based on fluorescent marker removal (15.0%-4.5%) and adenosine triphosphate bioluminescence assay (3.6%-2.5%).
    MeSH term(s) Academic Medical Centers ; Anti-Infective Agents ; Cross Infection/prevention & control ; Disinfectants/pharmacology ; Disinfection/methods ; Humans
    Chemical Substances Anti-Infective Agents ; Disinfectants
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2021.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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