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  1. Article ; Online: Signaling pathways in the regulation of cancer stem cells and associated targeted therapy.

    Manni, Wang / Min, Wu

    MedComm

    2022  Volume 3, Issue 4, Page(s) e176

    Abstract: Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self-renewal, metastasis, and unlimited growth into bulks, which are believed as a major cause of progressive tumor ... ...

    Abstract Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self-renewal, metastasis, and unlimited growth into bulks, which are believed as a major cause of progressive tumor phenotypes, including recurrence, metastasis, and treatment failure. A number of signaling pathways are involved in the maintenance of stem cell properties and survival of CSCs, including well-established intrinsic pathways, such as the Notch, Wnt, and Hedgehog signaling, and extrinsic pathways, such as the vascular microenvironment and tumor-associated immune cells. There is also intricate crosstalk between these signal cascades and other oncogenic pathways. Thus, targeting pathway molecules that regulate CSCs provides a new option for the treatment of therapy-resistant or -refractory tumors. These treatments include small molecule inhibitors, monoclonal antibodies that target key signaling in CSCs, as well as CSC-directed immunotherapies that harness the immune systems to target CSCs. This review aims to provide an overview of the regulating networks and their immune interactions involved in CSC development. We also address the update on the development of CSC-directed therapeutics, with a special focus on those with application approval or under clinical evaluation.
    Language English
    Publishing date 2022-10-05
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting inflammation as cancer therapy.

    Wang, Manni / Chen, Siyuan / He, Xuemei / Yuan, Yong / Wei, Xiawei

    Journal of hematology & oncology

    2024  Volume 17, Issue 1, Page(s) 13

    Abstract: Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis ... ...

    Abstract Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment. Inflammation-targeted agents not only demonstrate the potential to suppress cancer development, but also to improve the efficacy of other therapeutic modalities. In this review, we describe the highly dynamic and complex inflammatory tumor microenvironment, with discussion on key inflammation mediators in cancer including inflammatory cells, inflammatory cytokines, and their downstream intracellular pathways. In addition, we especially address the role of inflammation in cancer development and highlight the action mechanisms of inflammation-targeted therapies in antitumor response. Finally, we summarize the results from both preclinical and clinical studies up to date to illustrate the translation potential of inflammation-targeted therapies.
    MeSH term(s) Humans ; Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cytokines/metabolism ; Inflammation/metabolism ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents ; Cytokines
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429631-4
    ISSN 1756-8722 ; 1756-8722
    ISSN (online) 1756-8722
    ISSN 1756-8722
    DOI 10.1186/s13045-024-01528-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Temporal evolution of speciated volatile organic compound (VOC) emissions from solvent use sources in the Pearl River Delta Region, China (2006-2019).

    Guo, Qing / Wang, Yuzheng / Zheng, Junyu / Zhu, Manni / Sha, Qing'e / Huang, Zhijiong

    The Science of the total environment

    2024  , Page(s) 172888

    Abstract: Volatile organic compounds (VOCs) emitted from solvent use sources constitute an important part of ozone ( ... ...

    Abstract Volatile organic compounds (VOCs) emitted from solvent use sources constitute an important part of ozone (O
    Language English
    Publishing date 2024-04-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172888
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    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Occurrence, distribution, and health risk assessment of pyrethroid and neonicotinoid insecticides in aquatic products of China.

    Wu, Manni / Miao, Jingjing / Zhang, Wenhao / Wang, Qiaoqiao / Sun, Ce / Wang, Lu / Pan, Luqing

    The Science of the total environment

    2024  Volume 919, Page(s) 170880

    Abstract: Synthetic pyrethroid insecticides (SPIs) and neonicotinoid insecticides (NEOs), now dominant in the insecticide market, are increasingly found in aquatic environments. This study focused on six SPIs and five NEOs in aquatic products from four Chinese ... ...

    Abstract Synthetic pyrethroid insecticides (SPIs) and neonicotinoid insecticides (NEOs), now dominant in the insecticide market, are increasingly found in aquatic environments. This study focused on six SPIs and five NEOs in aquatic products from four Chinese provinces (Shandong, Hubei, Shanxi and Zhejiang) and the risk assessment of the safety for the residents was conducted. It revealed significantly higher residues of Σ
    MeSH term(s) Animals ; Humans ; Insecticides/analysis ; Pyrethrins ; Neonicotinoids ; China ; Risk Assessment
    Chemical Substances Insecticides ; Pyrethrins ; Neonicotinoids
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170880
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  5. Article ; Online: JMJD family proteins in cancer and inflammation.

    Manni, Wang / Jianxin, Xue / Weiqi, Hong / Siyuan, Chen / Huashan, Shi

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 304

    Abstract: The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis. Epigenetic changes ... ...

    Abstract The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis. Epigenetic changes such as the dysregulation of enzymes modifying DNA or histones are actively involved in oncogenesis and inflammatory response. The methylation of lysine residues on histone proteins represents a class of post-translational modifications. The human Jumonji C domain-containing (JMJD) protein family consists of more than 30 members. The JMJD proteins have long been identified with histone lysine demethylases (KDM) and histone arginine demethylases activities and thus could function as epigenetic modulators in physiological processes and diseases. Importantly, growing evidence has demonstrated the aberrant expression of JMJD proteins in cancer and inflammatory diseases, which might serve as an underlying mechanism for the initiation and progression of such diseases. Here, we discuss the role of key JMJD proteins in cancer and inflammation, including the intensively studied histone lysine demethylases, as well as the understudied group of JMJD members. In particular, we focused on epigenetic changes induced by each JMJD member and summarized recent research progress evaluating their therapeutic potential for the treatment of cancer and inflammatory diseases.
    MeSH term(s) Carcinogenesis ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Inflammation/genetics ; Jumonji Domain-Containing Histone Demethylases/genetics ; Neoplasms/genetics
    Chemical Substances Histones ; Histone Demethylases (EC 1.14.11.-) ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-)
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01145-1
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  6. Article ; Online: Constrained surfaces

    Manni Wang / Tianxia Lan / Wei Wang

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    promising therapeutic targets for COVID-19 determined by systematically mutational analysis

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Deep Learning-Based Culture-Free Bacteria Detection in Urine Using Large-Volume Microscopy.

    Iriya, Rafael / Braswell, Brandyn / Mo, Manni / Zhang, Fenni / Haydel, Shelley E / Wang, Shaopeng

    Biosensors

    2024  Volume 14, Issue 2

    Abstract: Bacterial infections, increasingly resistant to common antibiotics, pose a global health challenge. Traditional diagnostics often depend on slow cell culturing, leading to empirical treatments that accelerate antibiotic resistance. We present a novel ... ...

    Abstract Bacterial infections, increasingly resistant to common antibiotics, pose a global health challenge. Traditional diagnostics often depend on slow cell culturing, leading to empirical treatments that accelerate antibiotic resistance. We present a novel large-volume microscopy (LVM) system for rapid, point-of-care bacterial detection. This system, using low magnification (1-2×), visualizes sufficient sample volumes, eliminating the need for culture-based enrichment. Employing deep neural networks, our model demonstrates superior accuracy in detecting uropathogenic
    MeSH term(s) Humans ; Deep Learning ; Microscopy ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/microbiology ; Bacterial Infections ; Bacteria ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14020089
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  8. Article: Gastric peroral endoscopic pyloromyotomy for the treatment of congenital hypertrophic pyloric stricture in an infant with a self-made bite block.

    Lu, Yi / Li, Sitao / Xian, Zhenyu / Kang, Manni / Wang, Dejuan / Sun, Jiachen

    Revista espanola de enfermedades digestivas

    2023  

    Abstract: Gastric per-oral endoscopic myotomy (G-POEM) is reported to be a promising treatment for refractory gastroparesis, on the other hand, it is also an effective treatment for congenital hypertrophic pyloric stenosis (CHPS). Here, we want to report a case in ...

    Abstract Gastric per-oral endoscopic myotomy (G-POEM) is reported to be a promising treatment for refractory gastroparesis, on the other hand, it is also an effective treatment for congenital hypertrophic pyloric stenosis (CHPS). Here, we want to report a case in which G-POEM was performed in an infant with CHPS.
    Language English
    Publishing date 2023-09-14
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9875/2023
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 199: Show issues Location:
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  9. Article ; Online: CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer.

    Wang, Binhan / Wang, Manni / Ao, Danyi / Wei, Xiawei

    Biochimica et biophysica acta. Reviews on cancer

    2022  Volume 1877, Issue 5, Page(s) 188799

    Abstract: Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between CXCL13 and its receptor, the G-protein coupled receptor (GPCR) CXCR5, builds a signaling network ... ...

    Abstract Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between CXCL13 and its receptor, the G-protein coupled receptor (GPCR) CXCR5, builds a signaling network that regulates not only normal organisms but also the development of many diseases. However, the precise action mechanism remains unclear. In this review, we discussed the functional mechanisms of the CXCL13-CXCR5 axis under normal conditions, with special focus on its association with diseases. For certain refractory diseases, we emphasize the diagnostic and therapeutic role of CXCL13-CXCR5 axis.
    MeSH term(s) Chemokine CXCL13/genetics ; Humans ; Ligands ; Neoplasms/genetics ; Receptors, CXCR5/genetics ; Signal Transduction
    Chemical Substances CXCL13 protein, human ; CXCR5 protein, human ; Chemokine CXCL13 ; Ligands ; Receptors, CXCR5
    Language English
    Publishing date 2022-09-11
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2022.188799
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    Zs.A 7162: Show issues Location:
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  10. Article: A narrative review of the roles of the miR-15/107 family in heart disease: lessons and prospects for heart disease.

    Zheng, Manni / Wang, Min

    Annals of translational medicine

    2021  Volume 9, Issue 1, Page(s) 66

    Abstract: Heart disease is one of the leading causes of morbidity and mortality globally. To reduce morbidity and mortality among patients with heart disease, it is important to identify drug targets and biomarkers for more effective diagnosis, prognosis, and ... ...

    Abstract Heart disease is one of the leading causes of morbidity and mortality globally. To reduce morbidity and mortality among patients with heart disease, it is important to identify drug targets and biomarkers for more effective diagnosis, prognosis, and treatment. MicroRNAs (miRNAs) are characterized as a group of endogenous, small non-coding RNAs, which function by directly inhibiting target genes. The miR-15/107 family is a group of evolutionarily conserved miRNAs comprising 10 members that share an identical motif of AGCAGC, which determines overlapping target genes and cooperation in the biological process. Accumulating evidence has demonstrated the predominant dysregulation of the miR-15/107 family in cardiovascular disease, neurodegenerative disease, and cancer. In this review, we summarize the current understanding of the miR-15/107 family, focusing on its role in the regulation in the development of the heart and the progression of heart disease. We also discuss the potential of different members of the miR-15/107 family as biomarkers for diverse heart disease, as well as the current applications and challenges in the use of the miR-15/107 family in clinical trials for various disease. This paper hopes to explore the potential of the miR-15/107 family as therapeutic targets or biomarkers and to provide directions for future research.
    Language English
    Publishing date 2021-01-21
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-20-6073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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