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Article ; Online: Domestic Violence, Mental Health, and Resilience Among Older Adults in the U.S. During COVID-19.

Yoon, Sukyung / Mahapatra, Neely

2023 Volume 36, Issue 3-4, Page(s) 194–206

Abstract: ... outcomes among older adults in U.S. during COVID-19.: Method: Participants included 522 older adults ...

Abstract	Objectives: The current study based on the Stress Process Model investigated the impact of experiences of domestic violence on mental health as well as resilience against negative mental health outcomes among older adults in U.S. during COVID-19. Method: Participants included 522 older adults (ages 51-80 and older) living in US at the time of the survey. Path analysis using Mplus was employed.
MeSH term(s)	Humans ; Aged ; Mental Health ; Resilience, Psychological ; COVID-19 ; Domestic Violence ; Anxiety/epidemiology
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1045392-1
ISSN	1552-6887 ; 0898-2643
ISSN (online)	1552-6887
ISSN	0898-2643
DOI	10.1177/08982643231181753
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Article ; Online: Tenon’s patch graft to the rescue during COVID-19 pandemic

Panigrahi, Suchitra / Mahapatra, Bidisha / Baskey, Swarnamayee

GMS Ophthalmology Cases - An Open Access Journal

2023 Volume 13, Page(s) 10

Abstract: Objective: To report a case of bilateral Mooren’s ulcer with impending corneal perforation ... in the right eye and perforated peripheral corneal ulcer in the left eye which successfully underwent Tenon’s ... Tenon’s grafting with overlay amniotic membrane grafting in the left eye with perforation and ...

Abstract	Objective: To report a case of bilateral Mooren’s ulcer with impending corneal perforation in the right eye and perforated peripheral corneal ulcer in the left eye which successfully underwent Tenon’s patch graft (TPG) with multilayered amniotic membrane grafting (AMG) as globe salvaging procedure during COVID-19 pandemic. Methods: Conjunctival resection was done on both the eyes followed by autologous Tenon’s grafting with overlay amniotic membrane grafting in the left eye with perforation and multilayered AMG with AMG overlay in the right eye with impending perforation. Post-operatively topical antibiotics and steroids were prescribed. Results: At one month follow-up, the Tenon’s graft and multilayered AMG were well-integrated with the surrounding healthy cornea with a good anatomical and visual outcome. Conclusion: Autologous Tenon’s patch graft is a simple and cost-effective alternative to preserve globe integrity and prevent complications in emergency cases when immediate access to cornea transplantation is practically challenging.
Keywords	Medizin, Gesundheit ; Tenon’s graft ; Mooren’s ulcer ; COVID-19 ; amniotic membrane
Publishing date	2023-03-01
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Article ; Online
ISSN	2193-1496
ISSN (online)	2193-1496
DOI	10.3205/oc000218
Database	German Medical Science

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Article ; Online: Protein profiling and immunoinformatic analysis of the secretome of a metal-resistant environmental isolate Pseudomonas aeruginosa S-8.

Kumari, Kiran / Dey, Jyotirmayee / Mahapatra, Soumya Ranjan / Ma, Ying / Sharma, Parva Kumar / Misra, Namrata / Singh, Rajnish Prakash

Folia microbiologica

2024

Abstract: ... to characterize the secretome of an environmental isolate Pseudomonas aeruginosa S-8 by analyzing trypsin-digested ...

Abstract	The bacterial secretome represents a comprehensive catalog of proteins released extracellularly that have multiple important roles in virulence and intercellular communication. This study aimed to characterize the secretome of an environmental isolate Pseudomonas aeruginosa S-8 by analyzing trypsin-digested culture supernatant proteins using nano-LC-MS/MS tool. Using a combined approach of bioinformatics and mass spectrometry, 1088 proteins in the secretome were analyzed by PREDLIPO, SecretomeP 2.0, SignalP 4.1, and PSORTb tool for their subcellular localization and further categorization of secretome proteins according to signal peptides. Using the gene ontology tool, secretome proteins were categorized into different functional categories. KEGG pathway analysis identified the secreted proteins into different metabolic functional pathways. Moreover, our LC-MS/MS data revealed the secretion of various CAZymes into the extracellular milieu, which suggests its strong biotechnological applications to breakdown complex carbohydrate polymers. The identified immunodominant epitopes from the secretome of P. aeruginosa showed the characteristic of being non-allergenic, highly antigenic, nontoxic, and having a low risk of triggering autoimmune responses, which highlights their potential as successful vaccine targets. Overall, the identification of secreted proteins of P. aeruginosa could be important for both diagnostic purposes and the development of an effective candidate vaccine.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-024-01152-5
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Article ; Online: Protein S-nitrosylation: Nitric oxide signalling during anuran tail regression.

Mahapatra, Cuckoo / Achary, A Sarada / Patra, Diptimayee

Acta histochemica

2022 Volume 124, Issue 5, Page(s) 151899

Abstract: ... as compared to the early climactic stages and pre-regressing tails. S-nitrosylated proteins were detected ... in the late climactic stages is suggested to cause S-nitrosylation of proteins and subsequent apoptosis ...

Abstract	Tail regression is a remarkable process where a complex organ like the tail is completely resorbed by cell death during anuran metamorphosis. Nitric oxide is a signalling molecule involved in various physiological processes and along with reactive nitrogen species induces apoptosis. The present study describes the contribution of nitric oxide and reactive nitrogen species (nitrosative stress) during tail regression in the tadpoles of Indian tree frog, Polypedates maculatus. Spectrophotometric estimation revealed significantly higher levels of nitrite, nitrate and peroxynitrite in the regressing tails of the late climactic stages as compared to the early climactic stages and pre-regressing tails. S-nitrosylated proteins were detected in the apoptotic cells of epidermis and muscle, denervated and fragmented myofibres, outer notochordal sheath of the degenerating notochord, endothelium of blood vessels, blood cells and spinal cord of the regressing tail of the late climactic stages using fluorescent detection methods. Thus, a higher level of nitrosative stress in the late climactic stages is suggested to cause S-nitrosylation of proteins and subsequent apoptosis in the tail tissues. Macrophages were found engulfing the apoptotic cells and cell debris at the distal end of the regressing tail. Interestingly, macrophages were always found to be associated with melanocytes suggesting a close association for clearing cell debris by phagocytosis.
MeSH term(s)	Animals ; Anura ; Larva/metabolism ; Metamorphosis, Biological/physiology ; Nitric Oxide/metabolism ; Protein S/metabolism
Chemical Substances	Protein S ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2022-05-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	77-2
ISSN	1618-0372 ; 0065-1281
ISSN (online)	1618-0372
ISSN	0065-1281
DOI	10.1016/j.acthis.2022.151899
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Article ; Online: Coumarin derivatives as promising antibacterial agent(s)

Chita Ranjan Sahoo / Jyotirmaya Sahoo / Monalisa Mahapatra / Debananda Lenka / Pratap Kumar Sahu / Budheswar Dehury / Rabindra Nath Padhy / Sudhir Kumar Paidesetty

Arabian Journal of Chemistry, Vol 14, Iss 2, Pp 102922- (2021)

2021

Abstract: ... candidate(s) is required against the broad spectrum of MDR bacteria. Indeed, the phytochemical coumarin and ...

Abstract	Nowadays, bacterial infections epitomize significant health threats globally with an increased morbidity and mortality. Most contemporary antibacterial agents are resisted by pathogenic bacteria - the multidrug resistant (MDR) bacterial strains arising from cross resistances operative in natural bacterial consortia inside human body and in environments. Consequently, the development of newer potential drug candidate(s) is required against the broad spectrum of MDR bacteria. Indeed, the phytochemical coumarin and its derivatives had been reported with broad biological inhibitory properties, including antibacterial activities. In this review, several methods of synthetic strategies of coumarin derivatives as antibacterials were considered with individual schematic compounds by structure-activity relationship (SAR) studies as essential corollaries. Overall, substituents at positions C-3 and C-4 of coumarin are coveted for the development of newer antibacterial agents.
Keywords	Coumarin ; Semi-synthesis ; Antibacterial ; Structural-activity-relationship ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The N-terminus region of Drp1, a Rint1 family protein is essential for cell survival and its interaction with Rad50 protein in fission yeast S.pombe.

Gaurav, Sachin / Ranjan, Rajeev / Kuldeep, Jitendra / Dhiman, Kanika / Mahapatra, Pinaki Prasad / Ashish / Siddiqi, Mohammad Imran / Ahmed, Shakil

Biochimica et biophysica acta. General subjects

2020 Volume 1865, Issue 1, Page(s) 129739

Abstract: ... to genomic instability. Earlier we have shown that S.pombe Drp1, a Rint1/Tip1 family protein is required for the recovery ...

Abstract	Background: Defects in DNA repair pathway can lead to double-strand breaks leading to genomic instability. Earlier we have shown that S.pombe Drp1, a Rint1/Tip1 family protein is required for the recovery from DNA damage. Methods: Various truncations of Drp1 protein were constructed and their role in DNA damage response and interaction with Rad50 protein has been studied by co-immunoprecipitation and pull-down assays. Results: The structural and functional analysis of Drp1 protein revealed that the N-terminus region of Drp1 is indispensable for the survival. The C-terminus truncation mutants, drp1C1Δ and drp1C2Δ exhibit temperature sensitive phenotype and are hypersensitive against DNA damaging agents with elevated level of Rad52-YFP foci at non-permissive temperature indicating the impairment for DNA damage repair pathway. The essential N-terminus region of Drp1 interacts with the C-terminus region of Rad50 and might be involved in influencing the MRN/X function. Small-angle X-ray (SAXS) analysis revealed three-domain like shapes in Drp1 protein while the C-terminus region of Rad50 exhibit unusual bulges. Computational docking studies revealed the amino acid residues at the C-terminus region of Rad50 that are involved in the interaction with the residues present at the N-terminal region of Drp1 indicating the importance of the N-terminal region of Drp1 protein. Conclusions: We have identified the region of Drp1 and Rad50 proteins that are involved in the interaction and their role in the DNA damage response pathway has been analyzed. General significance: The functional and structural aspects of fission yeast Drp1 protein and its interaction with Rad50 have been elucidated.
MeSH term(s)	DNA Damage ; DNA Repair ; Models, Molecular ; Protein Interaction Domains and Motifs ; Protein Interaction Maps ; Scattering, Small Angle ; Schizosaccharomyces/chemistry ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/chemistry ; Schizosaccharomyces pombe Proteins/metabolism ; X-Ray Diffraction
Chemical Substances	Rad50 protein, S pombe ; Schizosaccharomyces pombe Proteins
Language	English
Publishing date	2020-09-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2020.129739
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Article ; Online: Dupuytren’s Contracture

Swagat Mahapatra / Sachin Awasthi / Pankaj Aggarwal / SS Tripathy / Rajiv Ratan Singh Yadav / Chandrasekhar Verma / Siddharth Tiwari

Journal of Clinical and Diagnostic Research, Vol 12, Iss 12, Pp RC09-RC

Epidemiological Patterns and Results Following Radical Fasciectomy

2018 Volume 12

Abstract: Introduction: Dupuytren’s disease is a debilitating condition, affecting the palmar fascia ... parameters associated with Dupuytren’s contracture and to study the results following Radical Fasciectomy ... Institute of Medical Sciences. A total of 26 patients with Dupuytren’s disease, fulfilling the inclusion ...

Abstract	Introduction: Dupuytren’s disease is a debilitating condition, affecting the palmar fascia of the hand. Patients develop a flexion contracture and have difficulties in activities of daily living. Treatment is usually surgical, and a wide range of options are available. Aim: To study the epidemiological parameters associated with Dupuytren’s contracture and to study the results following Radical Fasciectomy. Materials and Methods: This was a prospective, interventional, institutional based study conducted at Dr RML Institute of Medical Sciences. A total of 26 patients with Dupuytren’s disease, fulfilling the inclusion criteria, were treated with radical fasciectomy. Epidemiological parameters and postoperative improvement in form of Digitopalmer Distance (DPD), extension lag and Quick DASH scores were recorded. Data was analysed using SPSS version 21 software. Continuous data was analysed by student's t-test and categorical data was analysed by chisquare test and p-value less than 0.05 was considered as significant. Results: Mean age of involvement in the present study was 54.82±7.34 years. An 84% (22 patients) of patients were male and 16% (4 patients) female. Bilateral hand involvement was seen in 84.61% and single hand involvement was seen in 15.38%. Dominant hand involvement was seen in 69.23% cases, nondominant hand in 15.38% cases and bilateral hands equally in 15.38% cases. Thenar Band and Commissural Band was noticed in 19% of cases. A total of 27% of all cases were diabetics, and 15% were known smokers. One patient in the entire series was a known epileptic on medications. DPD following surgery at two weeks and three months postoperatively was satisfactory as more than 60% of patients had full closure and more than 90% had a DPD of less than two centimeters. Extension Lag at MCP and PIP joints was found to be satisfactory as full opening at both MCP and PIP joints was found in more than 80% patients postoperatively at two weeks and three months. Conclusion: Outcomes following radical fasciectomy are very ...
Keywords	epidemiology ; flexion contracture ; palmer fascia ; Medicine ; R
Subject code	616
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Doctor YouTube’s opinion on seasonal influenza

Akhil Kallur / Ahmad Albalbissi / Ismael Carillo-Martin / Boonphiphop Boonpheng / Lakshmi Kallur / Yaman Kherallah / Akhilesh Mahajan / Shayan Mahapatra / Kaushik Mohan / Priyasree Mohan / Keerti Reddy / Pratyaksha Sankhyan / Sonia Lopez-Alvarez / Dima Youssef / Adel M El Abbassi / Alexei Gonzalez-Estrada

Digital Health, Vol

A critical appraisal of the information available to patients

2020 Volume 6

Abstract: Background Seasonal influenza is a respiratory illness caused by the influenza virus. During the 2017–2018 flu season, the Centers for Disease Control and Prevention noted approximately 959,000 hospitalizations and 79,400 deaths from influenza. We sought ...

Abstract	Background Seasonal influenza is a respiratory illness caused by the influenza virus. During the 2017–2018 flu season, the Centers for Disease Control and Prevention noted approximately 959,000 hospitalizations and 79,400 deaths from influenza. We sought to evaluate the educational quality of informational videos pertaining to seasonal influenza on the popular social media forum, YouTube. Methods Using the keywords “seasonal influenza,” all videos from 28 January to 5 February 2017 were included and analyzed for characteristics, source, and content. The source was further classified as healthcare provider, alternative-medicine provider, the patient and/or their parents, company, media, or professional society. Videos about other categories of influenza (e.g. swine or Spanish) or in foreign languages were excluded. A total of 10 blinded reviewers scored each video independently. Results Overall, 300 videos were analyzed, with a median of 341.50 views, 1.00 likes, 0 dislikes, and 0 comments. Based on the average scores of videos by source, there was statistically significant difference in the average score among videos by video source ( p < 0.01). Healthcare provider videos had the highest mean scores whereas alternative medicine provider videos had the lowest. Conclusions Although the aforementioned video sources scored higher than others, these videos did not fulfill our criteria as far as educating patients thoroughly. Our data also suggest alternative medicine and patient source videos were misleading for patients. Clinical implications: Although videos by healthcare providers were a better source of information, videos on seasonal influenza were shown to be poor sources of valid healthcare information. This study reiterates the need for higher-quality educational videos on seasonal influenza by the medical community.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	020
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The N-terminus region of Drp1, a Rint1 family protein is essential for cell survival and its interaction with Rad50 protein in fission yeast S.pombe

Gaurav, Sachin / Ranjan, Rajeev / Kuldeep, Jitendra / Dhiman, Kanika / Mahapatra, Pinaki Prasad / Ashish / Siddiqi, Mohammad Imran / Ahmed, Shakil

Biochimica et biophysica acta. 2021 Jan., v. 1865, no. 1

2021

Abstract: ... Earlier we have shown that S.pombe Drp1, a Rint1/Tip1 family protein is required for the recovery from DNA ...

Abstract	Defects in DNA repair pathway can lead to double-strand breaks leading to genomic instability. Earlier we have shown that S.pombe Drp1, a Rint1/Tip1 family protein is required for the recovery from DNA damage.Various truncations of Drp1 protein were constructed and their role in DNA damage response and interaction with Rad50 protein has been studied by co-immunoprecipitation and pull-down assays.The structural and functional analysis of Drp1 protein revealed that the N-terminus region of Drp1 is indispensable for the survival. The C-terminus truncation mutants, drp1C1Δ and drp1C2Δ exhibit temperature sensitive phenotype and are hypersensitive against DNA damaging agents with elevated level of Rad52-YFP foci at non-permissive temperature indicating the impairment for DNA damage repair pathway. The essential N-terminus region of Drp1 interacts with the C-terminus region of Rad50 and might be involved in influencing the MRN/X function. Small-angle X-ray (SAXS) analysis revealed three-domain like shapes in Drp1 protein while the C-terminus region of Rad50 exhibit unusual bulges. Computational docking studies revealed the amino acid residues at the C-terminus region of Rad50 that are involved in the interaction with the residues present at the N-terminal region of Drp1 indicating the importance of the N-terminal region of Drp1 protein.We have identified the region of Drp1 and Rad50 proteins that are involved in the interaction and their role in the DNA damage response pathway has been analyzed.The functional and structural aspects of fission yeast Drp1 protein and its interaction with Rad50 have been elucidated.
Keywords	DNA damage ; DNA repair ; DNA-binding proteins ; Schizosaccharomyces pombe ; amino acid sequences ; cell viability ; dynamins ; fungal proteins ; genetic instability ; mutants ; phenotype ; structure-activity relationships ; yeasts
Language	English
Dates of publication	2021-01
Publishing place	Elsevier B.V.
Document type	Article
Note	golden set
ZDB-ID	840755-1
ISSN	0304-4165
ISSN	0304-4165
DOI	10.1016/j.bbagen.2020.129739
Database	NAL-Catalogue (AGRICOLA)

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Article: SuFEx Activation with Ca(NTf₂)₂: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides

Mahapatra, Subham / Woroch, Cristian P / Butler, Todd W / Carneiro, Sabrina N / Kwan, Sabrina C / Khasnavis, Samuel R / Gu, Junha / Dutra, Jason K / Vetelino, Beth C / Bellenger, Justin / am Ende, Christopher W / Ball, Nicholas D

Organic letters. 2020 May 27, v. 22, no. 11

2020

Abstract: ... we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S ...

Abstract	A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.
Keywords	ambient temperature ; calcium ; sulfamates
Language	English
Dates of publication	2020-0527
Size	p. 4389-4394.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1523-7052
DOI	10.1021/acs.orglett.0c01397
Database	NAL-Catalogue (AGRICOLA)

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