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  1. Article: Construct a Knowledge Graph for China Coronavirus (COVID-19) Patient Information Tracking.

    Wu, Jiajing

    Risk management and healthcare policy

    2021  Volume 14, Page(s) 4321–4337

    Abstract: Since first outbreak of respiratory disease in China, the Coronavirus epidemic (COVID-19) spread on a large scale, causing huge losses to individuals, families, communities and society in the country. The conventional research on the transmission process ...

    Abstract Since first outbreak of respiratory disease in China, the Coronavirus epidemic (COVID-19) spread on a large scale, causing huge losses to individuals, families, communities and society in the country. The conventional research on the transmission process is basically to study the law or trend of the transmission of infectious diseases from a macro perspective. For in-depth study of the critical data of the newly confirmed patients, one effective way to improve the social isolation measures requires the formation of an organized tracking knowledge system for the confirmed patients and the personnel who have been removed, and the deep data mining and application. Knowledge graph (KG) is one of the irreplaceable techniques to quickly gather patient contact information and outbreak event, which reflecting the relationship between knowledge evolution and structure of novel Coronavirus. Therefore, this paper proposes a method for the analysis of COVID-19 epidemic situation using knowledge graph combined with interactive visual analysis. Firstly, based on the key factors of novel Coronavirus disease, the entity model of the patient, the relationship type of the patient and the expression of knowledge modeling were proposed, and the knowledge graph of the action track of the COVID-19 patient was deeply explored and comparative summarized. Secondly, in the process of constructing knowledge graph, conditional random field (CRF) algorithm is used to extract entity and knowledge. Meanwhile, to better analyze the disease relationship between patients, the semantic relationship of knowledge graph was combined with the visualization of knowledge graph, and the semantic model was verified by deep learning calculation and node attribute similarity. To discover the community detection of patients in the patient knowledge graph, this paper uses PageRank combined with Label propagation algorithms to discover community propagation in the network. Finally, COVID-19 epidemic situation was analyzed from confirmed patient data and multi-view collaborative interactions, such as map distribution visualization, knowledge graph visualization, and track visualization. The results show that the construction of a knowledge graph of COVID-19 patient activity is feasible for the transmission process, analysis of key nodes and tracing of activity tracks.
    Language English
    Publishing date 2021-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S309732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Isolated Ni-atom catalyst supported on Ti

    Yang, Haosen / Wu, Pengfei / Pei, Jiajing / Peng, Bo / Liu, Qingqing

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 6, Page(s) 718–721

    Abstract: Single-atom catalysts (SACs), distinguished by their exceptional atomic efficiency and modifiable coordination structures, find wide-ranging applicability, notably in the context of the hydrogen evolution reaction (HER). Herein, we synthesized a ... ...

    Abstract Single-atom catalysts (SACs), distinguished by their exceptional atomic efficiency and modifiable coordination structures, find wide-ranging applicability, notably in the context of the hydrogen evolution reaction (HER). Herein, we synthesized a Ti
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04930b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potassium hydroxide treatment of layered WSe

    Yue, Dewu / Tang, Cheng / Wu, Jiajing / Luo, Xiaohui / Chen, Hongyu / Qian, Yongteng

    Nanoscale

    2024  

    Abstract: ... 2D ... ...

    Abstract 2D WSe
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr05432b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Blockchain-Based Decentralized Application

    Peilin Zheng / Zigui Jiang / Jiajing Wu / Zibin Zheng

    IEEE Open Journal of the Computer Society, Vol 4, Pp 121-

    A Survey

    2023  Volume 133

    Abstract: Blockchain-based decentralized applications (DApp) draw more attention with the increasing development and wide application of blockchain technologies. A wealth of funds are invested into the crowd-funding of various types of DApp. As reported in August ... ...

    Abstract Blockchain-based decentralized applications (DApp) draw more attention with the increasing development and wide application of blockchain technologies. A wealth of funds are invested into the crowd-funding of various types of DApp. As reported in August 2022, there are more than 5,000 DApps with more than 1.67 million daily Unique Active Wallets (users). However, the definition, architectures, and classifications of the DApps are still not cleared up till now. This survey aims to provide a comprehensive overview of DApps for further research. First, the definitions and typical architectures of DApps are presented. Then we collect 3,118 popular DApps and categorize them into different types, and summarize their typical advantages and challenges. Finally, we provide an overview of the recent research problems of DApps from the perspectives of economics, security, and performance and then figure out promising research opportunities in the future.
    Keywords Blockchain ; decentralized application ; Electronic computers. Computer science ; QA75.5-76.95 ; Information technology ; T58.5-58.64
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IEEE
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Creating a supportive environment for older adults in China --exploring factors associated with the need for home modifications based on a cross-sectional survey in Central China.

    Li, Jiajing / Wu, Bei / Wang, Jing

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 795

    Abstract: Background: A supportive home environment is critical to the safety and quality of life of older adults. Home modification is an effective way to build a supportive home environment for older adults' aging in place. However, there is a lack of knowledge ...

    Abstract Background: A supportive home environment is critical to the safety and quality of life of older adults. Home modification is an effective way to build a supportive home environment for older adults' aging in place. However, there is a lack of knowledge on older adults' need for home modifications in China.
    Methods: We conducted a cross-sectional survey in three provinces of China (Hubei, Hunan, and Henan) using stratified and cluster sampling methods in 2021. A total of 5485 older adults aged 60 and over were included. The outcome variables were: need for home modifications, level of need, and type of modification needed. Exposure variables included: demographic and socioeconomic characteristics, as well as health conditions. Logistic and Poisson regressions were applied to examine the needs for home modifications and its associated factors.
    Results: Nearly 30% of the older adults needed home modifications. The most common choice of home modification was the need for handrails at the bedside, toilet, or threshold (31.64%), and paving un-slip tiles or vinyl flooring (17.45%). Age (IRR = 1.01, P < 0.001), education (IRR = 1.11, P < 0.01), and level of assistance (IRR = 2.31, P < 0.001) were more likely to be positively associated with needs for modification. Participants in the age group of 70 to 79 years, with primary school education, and low-level physically dependent had significantly higher needs for modifications than those of advanced age, lower level of education, or higher level of physically dependent (p < 0.01).
    Conclusions: The overall need for home modifications in China is low. Home modification programs are needed to tailor individuals' needs and provide services to those with the most home modification need.
    MeSH term(s) Aged ; Humans ; Middle Aged ; Independent Living ; Cross-Sectional Studies ; Quality of Life ; Socioeconomic Factors ; Educational Status ; China/epidemiology
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-04458-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pseudotyped Viruses for Phlebovirus.

    Wu, Jiajing / Huang, Weijin / Wang, Youchun

    Advances in experimental medicine and biology

    2023  Volume 1407, Page(s) 253–264

    Abstract: Rift Valley fever virus (RVFV) is a member of the Phlebovirus genus, one of the 20 genera in the Phenuiviridae family. RVFV causes disease in animals and humans and is transmitted by sandflies or ticks. However, research into RVFV is limited by the ... ...

    Abstract Rift Valley fever virus (RVFV) is a member of the Phlebovirus genus, one of the 20 genera in the Phenuiviridae family. RVFV causes disease in animals and humans and is transmitted by sandflies or ticks. However, research into RVFV is limited by the requirement for biosafety level 3 (BSL-3) containment. Pseudotyped virus overcomes this limitation as it can be handled in a BSL-2 environment. Pseudotyped RVFV possesses an identical envelope protein structure to that of the authentic virus, simulating the same process of receptor binding and membrane fusion to host cells. Pseudotyped phleboviruses are therefore useful tools to study the infection mechanism of these viruses and for the screening of inhibitory drugs and the development of therapeutic monoclonal antibodies.
    MeSH term(s) Animals ; Humans ; Phlebovirus/genetics ; Rift Valley Fever/prevention & control ; Viral Pseudotyping ; Rift Valley fever virus/genetics
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-99-0113-5_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pseudotyped Viruses for the Alphavirus Chikungunya Virus.

    Wu, Jiajing / Huang, Weijin / Wang, Youchun

    Advances in experimental medicine and biology

    2023  Volume 1407, Page(s) 299–312

    Abstract: Members of the genus Alphavirus are mostly mosquito-borne pathogens that cause disease in their vertebrate hosts. Chikungunya virus (CHIKV), which is one member of the genus Alphavirus [1], has been a major health problem in endemic areas since its re- ... ...

    Abstract Members of the genus Alphavirus are mostly mosquito-borne pathogens that cause disease in their vertebrate hosts. Chikungunya virus (CHIKV), which is one member of the genus Alphavirus [1], has been a major health problem in endemic areas since its re-emergence in 2006. CHIKV is transmitted to mammalian hosts by the Aedes mosquito, causing persistent debilitating symptoms in many cases. At present, there is no specific treatment or vaccine. Experiments involving live CHIKV need to be performed in BSL-3 facilities, which limits vaccine and drug research. The emergence of pseudotyped virus technology offered the potential for the development of a safe and effective evaluation method. In this chapter, we review the construction and application of pseudotyped CHIKVs, the findings from which have enhanced our understanding of CHIKV. This will, in turn, enable the exploration of promising therapeutic strategies in animal models, with the ultimate aim of developing effective treatments and vaccines against CHIKV and other related viruses.
    MeSH term(s) Animals ; Chikungunya virus/genetics ; Chikungunya Fever/prevention & control ; Viral Pseudotyping ; Aedes ; Viral Vaccines ; Mammals
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-99-0113-5_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prostate carcinoma metastasizing to the colon.

    Qiu, Renhui / Zhang, Jiajing / Wu, Weizhen / Xiao, Chunhong

    Asian journal of surgery

    2022  Volume 45, Issue 10, Page(s) 2083–2084

    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Colon/pathology ; Humans ; Male ; Prostate ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2022-05-03
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.04.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Shared Manifold Regularized Joint Feature Selection for Joint Classification and Regression in Alzheimer's Disease Diagnosis.

    Chen, Zhi / Liu, Yongguo / Zhang, Yun / Zhu, Jiajing / Li, Qiaoqin / Wu, Xindong

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2024  Volume 33, Page(s) 2730–2745

    Abstract: In Alzheimer's disease (AD) diagnosis, joint feature selection for predicting disease labels (classification) and estimating cognitive scores (regression) with neuroimaging data has received increasing attention. In this paper, we propose a model named ... ...

    Abstract In Alzheimer's disease (AD) diagnosis, joint feature selection for predicting disease labels (classification) and estimating cognitive scores (regression) with neuroimaging data has received increasing attention. In this paper, we propose a model named Shared Manifold regularized Joint Feature Selection (SMJFS) that performs classification and regression in a unified framework for AD diagnosis. For classification, unlike the existing works that build least squares regression models which are insufficient in the ability of extracting discriminative information for classification, we design an objective function that integrates linear discriminant analysis and subspace sparsity regularization for acquiring an informative feature subset. Furthermore, the local data relationships are learned according to the samples' transformed distances to exploit the local data structure adaptively. For regression, in contrast to previous works that overlook the correlations among cognitive scores, we learn a latent score space to capture the correlations and employ the latent space to design a regression model with l
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Alzheimer Disease/diagnostic imaging ; Algorithms
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2024.3382600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inhibition of 14-3-3 proteins increases the intrinsic excitability of mouse hippocampal CA1 pyramidal neurons.

    Logue, Jordan B / Vilmont, Violet / Zhang, Jiajing / Wu, Yuying / Zhou, Yi

    The European journal of neuroscience

    2024  

    Abstract: 14-3-3 proteins are a family of regulatory proteins that are abundantly expressed in the brain and enriched at the synapse. Dysfunctions of these proteins have been linked to neurodevelopmental and neuropsychiatric disorders. Our group has previously ... ...

    Abstract 14-3-3 proteins are a family of regulatory proteins that are abundantly expressed in the brain and enriched at the synapse. Dysfunctions of these proteins have been linked to neurodevelopmental and neuropsychiatric disorders. Our group has previously shown that functional inhibition of these proteins by a peptide inhibitor, difopein, in the mouse brain causes behavioural alterations and synaptic plasticity impairment in the hippocampus. Recently, we found an increased cFOS expression in difopein-expressing dorsal CA1 pyramidal neurons, indicating enhanced neuronal activity by 14-3-3 inhibition in these cells. In this study, we used slice electrophysiology to determine the effects of 14-3-3 inhibition on the intrinsic excitability of CA1 pyramidal neurons from a transgenic 14-3-3 functional knockout (FKO) mouse line. Our data demonstrate an increase in intrinsic excitability associated with 14-3-3 inhibition, as well as reveal action potential firing pattern shifts after novelty-induced hyperlocomotion in the 14-3-3 FKO mice. These results provide novel information on the role 14-3-3 proteins play in regulating intrinsic and activity-dependent neuronal excitability in the hippocampus.
    Language English
    Publishing date 2024-04-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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