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Article ; Online: Electrical stimulation induced structural 3D human engineered neural tissue with well-developed neuronal network and functional connectivity.

Meng, Xiaoting / Yu, Xiyao / Lu, Yingli / Pei, Zhe / Wang, Guoqiang / Qi, Mingran / Liu, Rongrong / Zhou, Jiaying / Guo, Xiaopin / Zhou, Zhengjie / Wang, Fang

Journal of neural engineering

2023 Volume 20, Issue 4

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Mice ; Animals ; Neurons/physiology ; Nerve Tissue ; Neural Stem Cells ; Neurites ; Electric Stimulation ; Cell Differentiation
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ace658
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Article ; Online: The Abundance and Function of Neutrophils in the Endometriosis Systemic and Pelvic Microenvironment.

Wang, Xinlei / Jia, Yan / Li, Danyang / Guo, Xiaopin / Zhou, Zhengjie / Qi, Mingran / Wang, Guoqiang / Wang, Fang

Mediators of inflammation

2023 Volume 2023, Page(s) 1481489

Abstract: Endometriosis is a common inflammatory illness in which endometrial tissue grows outside the uterine cavity. Immune dysfunction is now widely acknowledged as the primary cause of endometriosis. The immune cell population represented by neutrophils is ... ...

Abstract	Endometriosis is a common inflammatory illness in which endometrial tissue grows outside the uterine cavity. Immune dysfunction is now widely acknowledged as the primary cause of endometriosis. The immune cell population represented by neutrophils is thought to play an essential role in the etiology, pathophysiology, and associated clinical outcome. There is growing evidence that neutrophils have a role in chronic and aseptic inflammatory diseases, and endometriosis patients have increased levels of neutrophils in plasma, peritoneal fluid, and ectopic endometrium. Here, we sought to review the function of neutrophils in the pathogenesis of endometriosis, with an emphasis on the role of neutrophils in regulating endometrial angiogenesis and the local inflammatory microenvironment.
MeSH term(s)	Female ; Humans ; Neutrophils ; Endometriosis ; Ascitic Fluid ; Endometrium/pathology
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2023/1481489
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Article ; Online: The Role of Metabolomics and Microbiology in Urinary Tract Infection.

Zheng, Haoyu / Wang, Chao / Yu, Xiao / Zheng, Wenxue / An, Yiming / Zhang, Jiaqi / Zhang, Yuhan / Wang, Guoqiang / Qi, Mingran / Lin, Hongqiang / Wang, Fang

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: One of the common illnesses that affect women's physical and mental health is urinary tract infection (UTI). The disappointing results of empirical anti-infective treatment and the lengthy time required for urine bacterial culture are two issues. ... ...

Abstract	One of the common illnesses that affect women's physical and mental health is urinary tract infection (UTI). The disappointing results of empirical anti-infective treatment and the lengthy time required for urine bacterial culture are two issues. Antibiotic misuse is common, especially in females who experience recurrent UTI (rUTI). This leads to a higher prevalence of antibiotic resistance in the microorganisms that cause the infection. Antibiotic therapy will face major challenges in the future, prompting clinicians to update their practices. New testing techniques are making the potential association between the urogenital microbiota and UTIs increasingly apparent. Monitoring changes in female urinary tract (UT) microbiota, as well as metabolites, may be useful in exploring newer preventive treatments for UTIs. This review focuses on advances in urogenital microbiology and organismal metabolites relevant to the identification and handling of UTIs in an attempt to provide novel methods for the identification and management of infections of the UT. Particular attention is paid to the microbiota and metabolites in the patient's urine in relation to their role in supporting host health.
MeSH term(s)	Female ; Humans ; Urinary Tract Infections/etiology ; Anti-Bacterial Agents/therapeutic use ; Urogenital System ; Urinary Tract ; Urinalysis
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063134
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Article ; Online: Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation

Qingyu Meng / Luya Pu / Mingran Qi / Shuai Li / Banghao Sun / Yaru Wang / Bin Liu / Fan Li

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 13

Abstract: The transcriptional response to laminar sheer stress in human aortic endothelial cells reveals a pathway leading to inhibition of endothelial cell inflammation by autophagy induction. ...

Abstract	The transcriptional response to laminar sheer stress in human aortic endothelial cells reveals a pathway leading to inhibition of endothelial cell inflammation by autophagy induction.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integrating microbiome and metabolome revealed microbe-metabolism interactions in the stomach of patients with different severity of peptic ulcer disease.

Wang, Chao / Yu, Xiao / Lin, Hongqiang / Wang, Guoqiang / Liu, Jianming / Gao, Chencheng / Qi, Mingran / Wang, Dan / Wang, Fang

Frontiers in immunology

2023 Volume 14, Page(s) 1134369

Abstract: Background: Peptic ulcer disease (PUD) is a multi-cause illness with an unknown role for gastric flora and metabolism in its pathogenesis. In order to further understand the pathogenesis of gastric flora and metabolism in PUD, this study used ... ...

Abstract	Background: Peptic ulcer disease (PUD) is a multi-cause illness with an unknown role for gastric flora and metabolism in its pathogenesis. In order to further understand the pathogenesis of gastric flora and metabolism in PUD, this study used histological techniques to analyze the microbiome and metabolome of gastric biopsy tissue. In this paper, our work described the complex interactions of phenotype-microbial-metabolite-metabolic pathways in PUD patients at different pathological stages. Methods: Gastric biopsy tissue samples from 32 patients with chronic non-atrophic gastritis, 24 patients with mucosal erosions, and 8 patients with ulcers were collected for the microbiome. UPLC-MS metabolomics was also used to detect gastric tissue samples. These datasets were analyzed individually and integrated using various bioinformatics methods. Results: Our work found reduced diversity of gastric flora in patients with PUD. PUD patients at different pathological stages presented their own unique flora, and there were significant differences in flora phenotypes. Conclusion: Our research results provided substantial evidence to support some data on the analysis of the microbial community and its metabolism in the stomach, and they demonstrated many specific interactions between the gastric microbiome and the metabolome. Our study can help reveal the pathogenesis of PUD and indicate plausible disease-specific mechanisms for future studies from a new perspective.
MeSH term(s)	Humans ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Peptic Ulcer ; Gastritis, Atrophic ; Metabolome ; Microbiota
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1134369
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Article: Construction and Investigation of Competing Endogenous RNA Networks and Candidate Genes Involved in SARS-CoV-2 Infection.

Qi, Mingran / Liu, Bin / Li, Shuai / Ni, Zhaohui / Li, Fan

International journal of general medicine

2021 Volume 14, Page(s) 6647–6659

Abstract: Introduction: The current COVID-19 pandemic caused by a novel coronavirus SARS-CoV-2 is a quickly developing global health crisis, yet the mechanisms of pathogenesis in COVID-19 are not fully understood.: Methods: The RNA sequencing data of SARS-CoV- ... ...

Abstract	Introduction: The current COVID-19 pandemic caused by a novel coronavirus SARS-CoV-2 is a quickly developing global health crisis, yet the mechanisms of pathogenesis in COVID-19 are not fully understood. Methods: The RNA sequencing data of SARS-CoV-2-infected cells was obtained from the Gene Expression Omnibus (GEO). The differentially expressed mRNAs (DEmRNAs), long non-coding RNAs (DElncRNAs), and microRNAs (DEmiRNAs) were identified by edgeR, and the SARS-CoV-2-associated competing endogenous RNA (ceRNA) network was constructed based on the prediction of bioinformatic databases. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted with the SARS-CoV-2-related DEmRNAs, and the protein-protein interaction network was also built basing on STRING database. The ROC analysis was performed for assessing the diagnostic efficiency of hub genes. Results: The results indicated that SARS-CoV-2-related DEmRNAs were associated with the interferon signaling pathway and other antiviral processes, such as IFNL3, IFNL1 and CH25H. Our analysis suggested that lncRNA NEAT1 might regulate the host immune response through two miRNAs, hsa-miR-374-5p and hsa-miR-155-5p, which control the expression of SOCS1, IL6, IL1B, CSF1R, CD274, TLR6, and TNF. Additionally, IFI6, HRASLS2, IGFBP4 and PTN may be potential targets based on an analysis comparing the transcriptional responses of SARS-CoV-2 infection with that of other respiratory viruses. Discussion: The unique ceRNA network identified potential non-coding RNAs and their possible targets as well as a new perspective to understand the molecular mechanisms of the host immune response to SARS-CoV-2. This study may also aid in the development of innovative diagnostic and therapeutic strategies.
Language	English
Publishing date	2021-10-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S335162
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Article ; Online: Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer.

Qi, Mingran / Yu, Bingxin / Yu, Huiyuan / Li, Fan

Cancer medicine

2020 Volume 9, Issue 5, Page(s) 1798–1817

Abstract: Long noncoding RNAs (lncRNAs) have important biological functions as competing endogenous RNAs (ceRNAs) in tumors, yet the functions and regulatory mechanisms of lncRNA-related ceRNAs in gastric cancer have not been fully elucidated. In this study, we ... ...

Abstract	Long noncoding RNAs (lncRNAs) have important biological functions as competing endogenous RNAs (ceRNAs) in tumors, yet the functions and regulatory mechanisms of lncRNA-related ceRNAs in gastric cancer have not been fully elucidated. In this study, we constructed a lncRNA-miRNA-mRNA ceRNA network and identified potential lncRNA biomarkers in gastric cancer. Basing on the RNA profiles downloaded from The Cancer Genome Atlas (TCGA) platform, the gastric cancer-specific differentially expressed lncRNAs, miRNAs, and mRNAs were screened for constructing a ceRNA network using bioinformatic tools. The enrichment analysis of the biological processes in Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes pathways was performed on the ceRNA-related DEmRNAs. According to the modularization of protein-protein interaction (PPI) network, we extracted a ceRNA subnetwork and analyzed the correlation between the expression of the lncRNAs involved and specific clinical features of patients. Next, the expression of highly up-regulated in liver cancer (HULC) and RP11-314B1.2 showed significant changes in several pathological processes involved in gastric cancer, and nine lncRNAs were found to be correlated with the overall survival of patients with gastric cancer. Through the univariate and multivariate Cox regression analyses, two lncRNAs (LINC00106 and RP11-999E24.3) were identified and utilized to establish a risk score model for assessing the prognosis of patients. The analysis results were also partially verified using quantitative real-time PCR. The findings from this study indicate that HULC, RP11-314B1.2, LINC00106, and RP11-999E24.3 could be considered as potential therapeutic targets or prognostic biomarkers in gastric cancer, and provide a new perspective for cancer pathogenesis research.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Computational Biology ; Datasets as Topic ; Female ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Kaplan-Meier Estimate ; Male ; MicroRNAs/metabolism ; Middle Aged ; Prognosis ; Protein Interaction Maps/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism ; RNA-Seq ; Stomach/pathology ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger
Language	English
Publishing date	2020-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2045-7634
ISSN (online)	2045-7634
DOI	10.1002/cam4.2760
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Article ; Online: From 2D to 3D Co-Culture Systems: A Review of Co-Culture Models to Study the Neural Cells Interaction.

Liu, Rongrong / Meng, Xiaoting / Yu, Xiyao / Wang, Guoqiang / Dong, Zhiyong / Zhou, Zhengjie / Qi, Mingran / Yu, Xiao / Ji, Tong / Wang, Fang

International journal of molecular sciences

2022 Volume 23, Issue 21

Abstract: The central nervous system (CNS) controls and regulates the functional activities of the organ systems and maintains the unity between the body and the external environment. The advent of co-culture systems has made it possible to elucidate the ... ...

Abstract	The central nervous system (CNS) controls and regulates the functional activities of the organ systems and maintains the unity between the body and the external environment. The advent of co-culture systems has made it possible to elucidate the interactions between neural cells in vitro and to reproduce complex neural circuits. Here, we classified the co-culture system as a two-dimensional (2D) co-culture system, a cell-based three-dimensional (3D) co-culture system, a tissue slice-based 3D co-culture system, an organoid-based 3D co-culture system, and a microfluidic platform-based 3D co-culture system. We provide an overview of these different co-culture models and their applications in the study of neural cell interaction. The application of co-culture systems in virus-infected CNS disease models is also discussed here. Finally, the direction of the co-culture system in future research is prospected.
MeSH term(s)	Coculture Techniques ; Cell Culture Techniques/methods ; Organoids ; Neurons ; Cell Communication
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232113116
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Article ; Online: From 2D to 3D Co-Culture Systems

Rongrong Liu / Xiaoting Meng / Xiyao Yu / Guoqiang Wang / Zhiyong Dong / Zhengjie Zhou / Mingran Qi / Xiao Yu / Tong Ji / Fang Wang

International Journal of Molecular Sciences, Vol 23, Iss 13116, p

A Review of Co-Culture Models to Study the Neural Cells Interaction

2022 Volume 13116

Abstract	The central nervous system (CNS) controls and regulates the functional activities of the organ systems and maintains the unity between the body and the external environment. The advent of co-culture systems has made it possible to elucidate the interactions between neural cells in vitro and to reproduce complex neural circuits. Here, we classified the co-culture system as a two-dimensional (2D) co-culture system, a cell-based three-dimensional (3D) co-culture system, a tissue slice-based 3D co-culture system, an organoid-based 3D co-culture system, and a microfluidic platform-based 3D co-culture system. We provide an overview of these different co-culture models and their applications in the study of neural cell interaction. The application of co-culture systems in virus-infected CNS disease models is also discussed here. Finally, the direction of the co-culture system in future research is prospected.
Keywords	neural cells interaction ; co-culture system ; three-dimension (3D) ; organoids ; assembloids ; microfluidic platform ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Physiological Electric Field

Xiyao Yu / Xiaoting Meng / Zhe Pei / Guoqiang Wang / Rongrong Liu / Mingran Qi / Jiaying Zhou / Fang Wang

International Journal of Molecular Sciences, Vol 23, Iss 3877, p

A Potential Construction Regulator of Human Brain Organoids

2022 Volume 3877

Abstract: Brain organoids can reproduce the regional three-dimensional (3D) tissue structure of human brains, following the in vivo developmental trajectory at the cellular level; therefore, they are considered to present one of the best brain simulation model ... ...

Abstract	Brain organoids can reproduce the regional three-dimensional (3D) tissue structure of human brains, following the in vivo developmental trajectory at the cellular level; therefore, they are considered to present one of the best brain simulation model systems. By briefly summarizing the latest research concerning brain organoid construction methods, the basic principles, and challenges, this review intends to identify the potential role of the physiological electric field (EF) in the construction of brain organoids because of its important regulatory function in neurogenesis. EFs could initiate neural tissue formation, inducing the neuronal differentiation of NSCs, both of which capabilities make it an important element of the in vitro construction of brain organoids. More importantly, by adjusting the stimulation protocol and special/temporal distributions of EFs, neural organoids might be created following a predesigned 3D framework, particularly a specific neural network, because this promotes the orderly growth of neural processes, coordinate neuronal migration and maturation, and stimulate synapse and myelin sheath formation. Thus, the application of EF for constructing brain organoids in a3D matrix could be a promising future direction in neural tissue engineering.
Keywords	brain organoids ; physiological electric field ; neurogenesis ; neuronal differentiation ; neural network ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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