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Article ; Online: Structure and dynamics of titania - poly(N-vinyl caprolactam) composite hydrogels.

Timaeva, O I / Kuz'micheva, G M / Pashkin, I I / Czakkel, O / Prevost, S

2019 Volume 16, Issue 1, Page(s) 219–228

Abstract: The morphologies and dynamics of poly(N-vinyl caprolactam) (PVCL) based hydrogels with titania ...

Abstract	The morphologies and dynamics of poly(N-vinyl caprolactam) (PVCL) based hydrogels with titania nanoparticles in different states (native, air-dried to a constant weight and swollen in H
Language	English
Publishing date	2019-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/c9sm01619h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Toxins

Ladant, Daniel / Prévost, Gilles / Popoff, Michel R / Benoit, Evelyne / Prévost, Gilles

Mr Hyde or Dr Jekyll?

2023

Keywords	Medicine ; Medical toxicology ; toxins ; peptide chemistry ; native chemical ligation ; α-bungarotoxin ; click chemistry ; automated patch-clamp ; fluorescent peptide ; TE671 cells ; nicotinic acetylcholine receptor ; animal toxin ; bacterial toxin ; marine toxin ; medical application ; plant toxin ; toxin function/activity ; toxin receptor/target ; toxin structure ; Debaryomyces hansenii ; Wickerhamomyces anomalus ; Saccharomyces cerevisiae ; PDR transporters ; killer toxin ; fetal adrenomedullary chromaffin cell ; gambierol ; potassium currents ; calcium-activated K+ channels ; ATP-sensitive K+ channels ; catecholamine release ; Clostridium tetani ; Clostridium botulinum ; botulinum neurotoxin ; tetanus neurotoxin ; toxin gene regulation ; two-component system ; small RNA ; adenylate cyclase toxin ; Bordetella pertussis ; cyclic nucleotide ; cAMP ; spectrophotometric enzymatic assay ; ASIC ; sodium channels ; peptide ; PcTx1 ; APETx2 ; MitTx ; mambalgin ; pain ; nociception ; clostridial C3 toxin ; C3bot ; C3botE174Q ; dendritic cells ; macrophages ; monocytes ; stimulated emission depletion (STED) ; super-resolution microscopy ; trained immunity ; effector-triggered immunity ; effector-triggered trained immunity ; staphylococcal superantigen ; enterotoxin ; toxin pathogenicity ; immunomodulation ; molecular and cellular targets ; n/a
Language	English
Size	1 electronic resource (226 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030377164
ISBN	9783036569055 ; 3036569057
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Self-Assembly of Short Chain Poly- N-isopropylacrylamid Induced by Superchaotropic Keggin Polyoxometalates: From Globules to Sheets.

Buchecker, Thomas / Schmid, Philipp / Grillo, Isabelle / Prévost, Sylvain / Drechsler, Markus / Diat, Olivier / Pfitzner, Arno / Bauduin, Pierre

Journal of the American Chemical Society

2019 Volume 141, Issue 17, Page(s) 6890–6899

Abstract: We show here for the first time that short chain poly( N-isopropylacrylamide) (PNIPAM), one ...

Abstract	We show here for the first time that short chain poly( N-isopropylacrylamide) (PNIPAM), one of the most famous thermoresponsive polymers, self-assembles in water to form (i) discrete nanometer-globules and (ii) micrometric sheets with nm-thickness upon addition of the well-known Keggin-type polyoxometalate (POM) H
Language	English
Publishing date	2019-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.8b12181
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Article ; Online: Concentration dependent morphology and composition of n-alcohol modified cetyltrimethylammonium bromide micelles.

Schmutzler, Tilo / Schindler, Torben / Goetz, Klaus / Appavou, Marie-Sousai / Lindner, Peter / Prevost, Sylvain / Unruh, Tobias

Journal of physics. Condensed matter : an Institute of Physics journal

2018 Volume 30, Issue 49, Page(s) 495001

Abstract: ... to well defined products but the complex mesoscopic CTAB structures stay mostly unknown. N-alcohols ... In this paper we report about a detailed structure analysis of n-alcohol modified CTAB micelles. In particular ... n-pentanol and n-hexanol exhibit a significantly different influence on the size, shape and ...

Abstract	Cetyltrimethylammonium bromide (CTAB) is one of the most commonly used surfactants in nanoparticle synthesis and stabilization. Usually, CTAB is used in high concentrations besides co-surfactants leading to well defined products but the complex mesoscopic CTAB structures stay mostly unknown. N-alcohols for instance are widely used co-surfactants which modify the properties of native CTAB dispersions. In this paper we report about a detailed structure analysis of n-alcohol modified CTAB micelles. In particular, n-pentanol and n-hexanol exhibit a significantly different influence on the size, shape and composition of CTAB micelles. Using a combination of small-angle x-ray spectroscopy (SAXS) and neutron scattering spectroscopy (SANS), we applied a method for a complete structural characterization of such micelles. The incorporation of n-pentanol into CTAB micelles generally does not influence the morphology but enhances the number of micelles due to the volume of the added alcohol. N-hexanol, however, leads to an elongation of the micelles as a function of its concentration. It was found by extended contrast variation measurements that this difference is caused by a different distribution of the alcohols between the micellar core and shell. N-pentanol molecules are generally located at the core-shell interface of the CTAB micelles with not only the head group but also two additional methylene bridging groups located in the micellar shell. This leads to an increase of its effective head group volume. In comparison, in n-hexanol modified micelles the whole alkyl chain is located within the micellar core. The detailed structure for n-alcohol modified CTAB micelles is described herein for the first time. The knowledge of the structural details found is indispensable for an in-depth understanding of CTAB-n-alcohol-water interfaces in general which is relevant for the synthesis of many functional nanostructures like mesoporous silica and gold or silver nanoparticles.
Language	English
Publishing date	2018-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/aae9c3
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Article: Synthesis and physico-chemical properties of poly(N-vinyl pyrrolidone)-based hydrogels with titania nanoparticles

Timaeva, Olesya / Pashkin, Igor / Mulakov, Sergey / Kuzmicheva, Galina / Konarev, Petr / Terekhova, Raisa / Sadovskaya, Natalia / Czakkel, Orsolya / Prevost, Sylvain

Journal of materials science. 2020 Mar., v. 55, no. 7

2020

Abstract: Poly(N-vinyl pyrrolidone) (PVP)-based hydrogels with titania nanoparticles (TN) were synthesized ...

Abstract	Poly(N-vinyl pyrrolidone) (PVP)-based hydrogels with titania nanoparticles (TN) were synthesized by the sol–gel method for the first time and were characterized in different states (native, freeze-dried, air-dried to constant weight and ground to powder, or swollen to constant weight in H2O or D2O) by various methods such as wide-angle and small-angle X-ray and neutron scattering, neutron spin-echo (NSE) spectroscopy, and scanning electron microscopy. The static (static polymer–polymer correlation length (mesh size), associates of cross-links and PVP microchains) and dynamic (polymer chain relaxation rate, hydrodynamic polymer–polymer correlation length) structural elements were determined. The incorporation of titania nanoparticles into PVP hydrogel slightly increases the size of structural inhomogeneities (an increase in the static and dynamic polymer–polymer correlation length, the formation of associates of cross-links and PVP chains). Titania nanoparticles have an impact on the microstructure of the composite hydrogel and form associates with sizes from 0.5 to 2 μm attached to PVP hydrogel pore walls. The PVP and TN/PVP hydrogels show a high degree of water swelling. Moreover, the presence of titania nanoparticles in TN/PVP increases the number of water adsorption cycles compared to PVP hydrogel. The high swelling degree, bacteria-resistant and antimicrobial properties against Staphylococcus aureus allow considering NT/PVP hydrogels for medical applications as wound coatings.
Keywords	Staphylococcus aureus ; adsorption ; air drying ; antimicrobial properties ; coatings ; crosslinking ; deuterium oxide ; freeze drying ; hydrodynamics ; hydrogels ; microstructure ; nanoparticles ; neutron diffraction ; neutrons ; physicochemical properties ; polymers ; pyrrolidones ; scanning electron microscopy ; small-angle X-ray scattering ; sol-gel processing ; spectroscopy ; titanium dioxide ; covid19
Language	English
Dates of publication	2020-03
Size	p. 3005-3021.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-019-04230-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Self-Assembly of Short Chain Poly-N-isopropylacrylamid Induced by Superchaotropic Keggin Polyoxometalates: From Globules to Sheets

Buchecker, Thomas / Schmid, Philipp / Grillo, Isabelle / Prévost, Sylvain / Drechsler, Markus / Diat, Olivier / Pfitzner, Arno / Bauduin, Pierre

Journal of the American Chemical Society. 2019 Apr. 05, v. 141, no. 17

2019

Abstract: We show here for the first time that short chain poly(N-isopropylacrylamide) (PNIPAM), one ...

Abstract	We show here for the first time that short chain poly(N-isopropylacrylamide) (PNIPAM), one of the most famous thermoresponsive polymers, self-assembles in water to form (i) discrete nanometer-globules and (ii) micrometric sheets with nm-thickness upon addition of the well-known Keggin-type polyoxometalate (POM) H3PW12O40 (PW). The type of self-assembly is controlled by PW concentration: at low PW concentrations, PW adsorbs on PNIPAM chains to form globules consisting of homogeneously distributed PWs in PNIPAM droplets of several nm in size. Upon further addition of PW, a phase transition from globules to micrometric sheets is observed for PNIPAMs above a polymer critical chain length, between 18 and 44 repeating units. The thickness of the sheets is controlled by the PNIPAM chain length, here from 44 to 88 repeating units. The PNIPAM sheets are electrostatically stabilized PWs accumulated on each side of the sheets. The shortest PNIPAM chain with 18 repeating units produces PNIPAM/PW globules with 5–20 nm size but no sheets. The PW/PNIPAM self-assembly arises from a solvent mediated mechanism associated with the partial dehydration of PW and of the PNIPAM, which is related to the general propensity of POMs to adsorb on neutral hydrated surfaces. This effect, known as superchaotropy, is further highlighted by the significant increase in the lower critical solubilization temperature (LCST) of PNIPAM observed upon the addition of PW in the mM range. The influence of the POM nature on the self-assembly of PNIPAM was also investigated by using H4SiW12O40 (SiW) and H3PMo12O40 (PMo), i.e. changing the POM’s charge density or polarizability in order to get deeper understanding on the role of electrostatics and polarizability in the PNIPAM self-assembly process. We show here that the superchaotropic behavior of POMs with PNIPAM polymers enables the formation and the shape control of supramolecular organic–inorganic hybrids.
Keywords	droplets ; phase transition ; polymers ; solubilization ; solvents ; temperature
Language	English
Dates of publication	2019-0405
Size	p. 6890-6899.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.8b12181
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Blood glucose levels and COVID-19. Reply to Sardu C, D'Onofrio N, Balestrieri ML et al [letter] and Lepper PM, Bals R, Jüni P et al [letter].

Cariou, Bertrand / Hadjadj, Samy / Wargny, Matthieu / Pichelin, Matthieu / Al-Salameh, Abdallah / Allix, Ingrid / Amadou, Coralie / Arnault, Gwénaëlle / Baudoux, Florence / Bauduceau, Bernard / Borot, Sophie / Bourgeon-Ghittori, Muriel / Bourron, Olivier / Boutoille, David / Cazenave-Roblot, France / Chaumeil, Claude / Cosson, Emmanuel / Coudol, Sandrine / Darmon, Patrice /

Diabetologia

2020 Volume 63, Issue 11, Page(s) 2491–2494

MeSH term(s)	Betacoronavirus ; Blood Glucose ; COVID-19 ; Coronavirus Infections ; Humans ; Hyperglycemia ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Blood Glucose
Keywords	covid19
Language	English
Publishing date	2020-08-20
Publishing country	Germany
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-020-05255-9
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Article ; Online: Identification of key residues for the binding of glucagon to the N-terminal domain of its receptor: an alanine scan and modeling study.

Prévost, M / Vertongen, P / Waelbroeck, M

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

2012 Volume 44, Issue 11, Page(s) 804–809

Abstract: ... to the glucagon receptor are found to be located on one face of the glucagon helix. Several 3-dimensional models of the N ...

Abstract	Glucagon plays an essential role in the glycemia maintenance during fasting, but also aggravates hyperglycemia in diabetic patients. A series of analogues of glucagon were synthesized replacing each amino acid of the C-terminal region (residues 15-29) with alanine. The residues affecting the binding to the glucagon receptor are found to be located on one face of the glucagon helix. Several 3-dimensional models of the N-terminal domain of the glucagon receptor in complex with its ligand peptide were built and used to analyze the peptide-receptor interface in terms of the nature of the peptide residues and the interactions they form with the receptor. The models suggest that glucagon keeps its native helical structure upon binding, and that a large part of the interface formed with the receptor is hydrophobic. We find that in the C-terminal region, F22, V23, M27, and D15 are the most important residues for peptide binding. They bury a large portion of their solvent accessible surface area and make numerous interactions with the receptor mainly of the hydrophobic type.
MeSH term(s)	Alanine/genetics ; Alanine/metabolism ; Glucagon/analogs & derivatives ; Glucagon/chemistry ; Glucagon/genetics ; Glucagon/metabolism ; Humans ; Kinetics ; Models, Molecular ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Glucagon/chemistry ; Receptors, Glucagon/genetics ; Receptors, Glucagon/metabolism
Chemical Substances	Receptors, Glucagon ; Glucagon (9007-92-5) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2012-10
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/s-0032-1321877
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Article ; Online: Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain.

Prévost, Martine / Vertongen, Pascale / Raussens, Vincent / Roberts, David Jonathan / Cnudde, Johnny / Perret, Jason / Waelbroeck, Magali

The Journal of biological chemistry

2010 Volume 285, Issue 40, Page(s) 30951–30958

Abstract: ... insulinotropic peptide and glucagon-like peptide 1 receptor structures to study the N-terminal domain ...

Abstract	The glucagon receptor belongs to the B family of G-protein coupled receptors. Little structural information is available about this receptor and its association with glucagon. We used the substituted cysteine accessibility method and three-dimensional molecular modeling based on the gastrointestinal insulinotropic peptide and glucagon-like peptide 1 receptor structures to study the N-terminal domain of this receptor, a central element for ligand binding and specificity. Our results showed that Asp(63), Arg(116), and Lys(98) are essential for the receptor structure and/or ligand binding because mutations of these three residues completely disrupted or markedly impaired the receptor function. In agreement with these data, our models revealed that Asp(63) and Arg(116) form a salt bridge, whereas Lys(98) is engaged in cation-π interactions with the conserved tryptophans 68 and 106. The native receptor could not be labeled by hydrophilic cysteine biotinylation reagents, but treatment of intact cells with [2-(trimethylammonium)ethyl]methanethiosulfonate increased the glucagon binding site density. This result suggested that an unidentified protein with at least one free cysteine associated with the receptor prevented glucagon recognition and that [2-(trimethylammonium)ethyl]methanethiosulfonate treatment relieved this inhibition. The substituted cysteine accessibility method was also performed on 15 residues selected using the three-dimensional models. Several receptor mutants, despite a relatively high predicted cysteine accessibility, could not be labeled by specific reagents. The three-dimensional models show that these mutated residues are located on one face of the protein. This could be part of the interface between the receptor and the unidentified inhibitory protein, making these residues inaccessible to biotinylation compounds.
MeSH term(s)	Amino Acid Substitution ; Cell Line ; Cysteine/chemistry ; Cysteine/genetics ; Cysteine/metabolism ; Humans ; Models, Molecular ; Mutagenesis ; Mutation, Missense ; Protein Structure, Tertiary ; Receptors, Glucagon/chemistry ; Receptors, Glucagon/genetics ; Receptors, Glucagon/metabolism
Chemical Substances	Receptors, Glucagon ; Cysteine (K848JZ4886)
Language	English
Publishing date	2010-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M110.102814
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Article ; Online: A stereoselective approach to β-L-arabino nucleoside analogues: synthesis and cyclization of acyclic 1',2'-syn N,O-acetals.

Dostie, Starr / Prévost, Michel / Guindon, Yvan

The Journal of organic chemistry

2012 Volume 77, Issue 17, Page(s) 7176–7186

Abstract: ... L-arabinofuranosyl nucleoside analogues from acyclic N,OTMS-acetals bearing pyrimidine and ... as the nucleophile to generate 2'-oxynucleosides with complete retention of configuration at the C1' acetal center. N ...

Abstract	Reported herein is a novel and versatile strategy for the stereoselective synthesis of unnatural β-L-arabinofuranosyl nucleoside analogues from acyclic N,OTMS-acetals bearing pyrimidine and purine bases. These unusual acetals undergo a C1' to C4' cyclization where the OTMS of the acetal serves as the nucleophile to generate 2'-oxynucleosides with complete retention of configuration at the C1' acetal center. N,OTMS-acetals are obtained diastereoselectively from additions of silylated nucleobases onto acyclic polyalkoxyaldehydes in the presence of MgBr(2)·OEt(2). The strategy reported is addressing important synthetic challenges by providing stereoselective access to unnatural L-nucleosides starting from easily accessible pools of D-sugars and, as importantly, by allowing the formation of the sterically challenging 1',2'-cis nucleosides. A wide variety of nucleoside analogues were synthesized in 7-8 steps from easily accessible D-xylose.
MeSH term(s)	Acetals/chemistry ; Arabinonucleosides/chemical synthesis ; Arabinonucleosides/chemistry ; Cyclization ; Molecular Structure ; Stereoisomerism
Chemical Substances	Acetals ; Arabinonucleosides
Language	English
Publishing date	2012-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo3012754
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